Maher Helmy Helal
@helwan.edu.eg
Faculty of Science Chemistry Departement
helwan university
RESEARCH INTERESTS
Organic Chemistry
Textile
Scopus Publications
Scopus Publications
Eman A. E. El-Helw, Mahmoud Asran, Mohammad E. Azab, Maher H. Helal, and Sayed K. Ramadan
Informa UK Limited
Rafat M. Mohareb, Maher H. E. Helal, Amany E. Mayhoub, and Amira E. M. Abdallah
African Journals Online (AJOL)
ABSTRACT. This study demonstrated the synthesis of a number of pyrazolo[1,5-a]quinazoline derivatives about 24 products based on the starting material 4-(2-phenylhydrazono)-4H-pyrazol-3-amine derivatives 1a-f. Moreover, other ring systems including thiophene, pyrazole, thiazole and pyran (16 compounds) were prepared based on another starting compounds 2-(furan-2-ylmethylene)cyclohexane-1,3-dione 10 and 5,5-dimethyl-3-phenyl-2-thioxo-2,3,5,6-tetrahydrobenzo[d]thiazol-7(4H)-one 18. The multi-component reaction was used to prepare all the previous compounds. The structures of all the synthesised compounds were confirmed by the analytical and spectral data. Some selected compounds were chosen to test their anticancer activity against six cancer cell lines, namely A549, HT-29, MKN-45, U87MG, SMMC-7721 and, H460 utilizing foretinib as the positive control and the standard MTT assay in vitro. Toward the tested cell lines, nine compounds were the most cytotoxic compounds. The results obtained revealed that the synthesized compounds are good cytotoxic agents and of great impact for future work.
 KEY WORDS: Multi-component reactions, Pyrazolo[1,5-a]quinazoline, Thiophene, Thiazole, Cytotoxicity
 Bull. Chem. Soc. Ethiop. 2023, 37(6), 1521-1538. DOI: https://dx.doi.org/10.4314/bcse.v37i6.17
Mahmoud Asran, Eman A. E. El-Helw, Mohammad E. Azab, Sayed K. Ramadan, and Maher H. Helal
Springer Science and Business Media LLC
AbstractA new series of benzoquinoline-based heterocycles was synthesized utilizing the building block synthon, 2-((3-chlorobenzo[f]quinolin-2-yl)methylene)hydrazine-1-carbothioamide via the condensation of 3-chlorobenzo[f]quinoline-2-carbaldehyde with thiosemicarbazide. The titled thiosemicarbazone scaffold was conducted with some carbon-centered electrophilic reagents such as acetic anhydride, chloroacetyl chloride, chloroacetic acid, 2-bromo-1-(3-nitrophenyl)ethan-1-one, 2-chloro-N-phenylacetamide, and dimethyl but-2-ynedioate to achieve triazolethione, imidazolone, thiazolidinone, and thiazole derivatives. In turn, the hydrazinolysis of this substrate did not proceed as expected but it afforded the azine derivative. The antioxidant activity screening of the produced compounds revealed that thiazole and triazolethione derivatives were the most potent.
Amira E. M. Abdallah, Rafat M. Mohareb, Maher H. E. Helal, and Mariam M. Abd Elkader
Slovenian Chemical Society
Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in (mM) as respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were the widely effective compounds against the three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (gastric cancer) compared to the standard reference control foretinib.
Rafat M. Mohareb, Maher H.E. Helal, Amany E. Mayhoub, and Amira E.M. Abdallah
African Journals Online (AJOL)
ABSTRACT. A new approaches for the synthesis of novel pyrazolo[1,5-a]quinazoline 8a-f and pyrazolo[1,5-a]quinazolin-6-one 10a-s and 12a-s derivatives were obtained using 4-(2-phenylhydrazono)-4H-pyrazol-3-amine derivatives 5a-f via their multi-component reactions. The later pyrazole derivatives were prepared via arylhydrazone derivatives 3a-f. The structures of the synthesized compounds were established based on their respective analytical data. On the other hand, the cytotoxic effects of the synthesized compounds were obtained against the six cancer cell lines, namely A549, HT-29, MKN-45, U87MG, SMMC-7721 and, H460 utilizing foretinib as the positive control and the standard MTT assay in vitro. The obtained results showed that compounds 8c, 8f, 10c, 10i, 10l, 10p, 10s, 12c, 12i, 12l, 12p and, 12s were the most cytotoxic compounds. In most cases the presence of the electronegative Cl group enhanced the cytotoxicity of the tested compound.
 
 KEY WORDS: Multi-component reactions, Pyrazolo[1,5-a]quinazoline, Pyrazolo[1,5-a]quinazolin-6-one, Cytotoxicity
 Bull. Chem. Soc. Ethiop. 2023, 37(3), 717-734. 
 DOI: https://dx.doi.org/10.4314/bcse.v37i3.14
Ahmed G. El-Deen, Heba K. El-kholly, Mohammed Eid M. Ali, Hanan S. Ibrahim, M.K. Zahran, M.H. Helal, and Jae-Hwan Choi
Elsevier BV
Heba El-Kholly
Egypts Presidential Specialized Council for Education and Scientific Research
Ahmed Bakry, Marzouk Adel, Ahmed El Naggar, and maher Helal
Egypts Presidential Specialized Council for Education and Scientific Research
Rafat M. Mohareb, Maher H. E. Helal, Sara S. Mohamed, and Amira E. M. Abdallah
Bentham Science Publishers Ltd.
Background: Due to their biological applications, many tetrahydrobenzo[d]thiazole derivatives were considered the most important class of heterocyclic compounds. There are many drugs known in the market containing the thiazole moiety responsible for the high drug activity. Objective: This work aimed to produce novel heterocyclic compounds such as pyrazole, isoxazole, thiophene, chromeno[7,8-d]thiazole, and thiazolo[4,5-h]quinoline derivatives. The newly synthesized heterocyclic compounds were evaluated against anticancer cell lines followed by c-Met enzymatic activity and tyrosine kinases inhibition for the most active compounds. Methods: In this work, the 3-phenyl-2-thioxo-2,3,5,6-tetrahydrobenzo[d]thiazol-7(4H)-one (3) was synthesized through the reaction of cyclohexane-1,3-dione with phenyl isothiocyanate and elemental sulfur. Compound 3 showed interesting activity toward some chemical reagents producing new heterocyclic compounds that can not be obtained another way. The newly synthesized compounds were evaluated towards the six cancer cell lines. The most active compounds were selected and tested toward the c-Met enzyme by taking foretinib as the positive control. Also, the inhibitions toward the PC-3 cell line using the reference SGI-1776 were measured. Finally, the inhibitions towards the five tyrosine kinases were also tested. Results: The synthesized quinoline and chromene derivatives were evaluated toward the c-Met enzyme using foretinib as the positive control. The obtained results showed that twelve compounds exhibited IC50 values less than 1.30 nM. On the other hand, sixteen compounds showed higher inhibitions than the reference SGI-1776 (IC50 4.86 nM) toward the PC-3 cell line. Conclusion: Novel, heterocyclic compounds were synthesized with a high impact on biological activities. All synthesized compounds were screened for their anti-proliferative effect, and most of them revealed high potent effects. In addition, the c-Met and prostate cancer cell line PC-3 inhibitions for the most active compounds showed that these compounds exhibited high inhibitions. Anti-proliferative activity of selected compounds toward cancer cell lines classified according to the disease showed that most compounds exhibited high inhibitions.
Mohamed Abdo, Hanan Ahmed, Maher Helal, Medhat Fekry, and Ahmed Abdelhamid
Egypts Presidential Specialized Council for Education and Scientific Research
Shorouk Shawky, Dalia R.Abd El-Hafiz, Nasser H. Shalaby, S. Said, Maher Helmy Helal, and Sahar K. Mohamed
Elsevier BV
A. M. AlSabagh, Tahany Mahmoud Abdel-Hamid, Maher H. Helal, Abdellatief M. Abdelrahman, Amira E. Abdallah, and Mona EL-Rayes
Informa UK Limited
Hanan B. Ahmed, Maher H. Helal, Mohamed H. Abdo, Medhat M. Fekry, and Ahmed E. Abdelhamid
Elsevier BV
Amira E. M. Abdallah, Rafat M. Mohareb, Maher H. E. Helal, and Germeen J. Mofeed
Slovenian Chemical Society
Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied. The structure of the newly synthesized compounds was established based on elemental analysis and spectral data. Furthermore, twenty compounds of the synthesized systems were selected and evaluated in (μM) as significant anticancer agents towards three human cancer cell lines [MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer)] and normal fibroblasts human cell line (WI-38). The results showed that compounds 9 and 14a displayed higher effeciency than the reference doxorubicin.
Soha El-Namoury, Galal El-gemeie, Saber Ibrahim, maher Helal, and hamada mashaly
Egypts Presidential Specialized Council for Education and Scientific Research
In this work dispersed red- 153 dye was converted to nanoscale using mini emulsion polymerization The particle size and zeta potential was investigated by dynamic light scattering. Dyeing of polyester fabrics was carried out to coated and non-coated polyester fabric before dying process in the temperature range 50-135 ℃ and compared with the polyester fabrics coated and non-coated before dying process with the same dyes in normal size by detecting their ks values. Kinetic study for the dying process was carried out for the nano and normal dye and different fastness properties (washing, light and rubbing) for all dyed fabric were carried out.
Rasha A. Azzam, Rafat M. Mohareb, Maher H. Helal, and Kholoud K. Eisa
Wiley
Hossam E. Emam, Hanan B. Ahmed, Eslam Gomaa, Maher H. Helal, and Reda M. Abdelhameed
Springer Science and Business Media LLC
Photocatalysts are highly applicable in treatment of the water pollution. However, most of the applied photocatalysts suffer from the inapplicability and non-recyclability which limited their application. Herein, applicable and recyclable effective photocatalyst composites of Ag2WO4@MIL-125-NH2@cotton and Ag3VO4@MIL-125-NH2@cotton successfully prepared by direct synthesis of MIL-125-NH2 and Ag2WO4 or Ag3VO4 within the cotton fabric as supported template, sequentially. Agglomerated rock structure of Ag2WO4@MIL-125-NH2 and smaller particles of Ag3VO4@MIL-125-NH2 formed onto the cotton. The prepared composites applied as photocatalysts in the degradation of Methylene Blue (MB) and Rhodamine B (RhB) dyes in the visible light. The highest photodegradtion of dyes observed for Ag2WO4@MIL-125-NH2@cotton and Ag3VO4@MIL-125-NH2@cotton composites because of their low optical band gaps (2.36 eV and 1.87 eV) and their quenching in luminescent spectrum which helped in the ease transfer of photoexcited electrons. The rate constant (k2) for the photodegradation of MB (RhB) dye reduced significantly from 1.78 × 10–3 (2.8 × 10–3) L/mg min to 0.43 × 10–3 (1.04 × 10–3) L/mg min and 0.29 × 10–3 (0.79 × 10–3) L/mg min, when Ag2WO4 and Ag3VO4 incorporated in MIL-125-NH2@cotton composite, respectively. After 4 recycling process, the photodegradation activity of the applied composites diminished from 86–92% (68–80%) to 58–65% (47–54%). The obtained results declared the topmost photocatalytic activity in daylight of the recyclable prepared tri-component composites, reflecting their promising potentials in environmental applications.
Hossam E. Emam, Hanan B. Ahmed, Eslam Gomaa, Maher H. Helal, and Reda M. Abdelhameed
Elsevier BV
Abstract Recently, the increment in environmental pollution has challenged the investigation of photocatalytic systems. However, metal organic framework MOFs have superior photocatalytic action, it exhibits low efficiency of light energy because of their large effective band gap. Hence, the current study presents an innovative strategy for enhancing the photocatalytic activity of Ti-containing MOF (MIL-125-NH2) by doping of silver vanadate (Ag3VO4) and silver tungstate (Ag2WO4) nanoparticles. For the prepared composites, spherical nanoparticles of Ag3VO4 and Ag2WO4 were deposited on size regulated microcrystals of MIL-125-NH2. After doping of Ag2WO4 and Ag3VO4, the optical band gap of MIL-125-NH2 was decreased from 2.65 eV to 2.56 eV and 2.27 eV, respectively. The effect of doped nanoparticles on the photocatalysis of MIL-125-NH2 was monitored in the degradation reaction of Methylene Blue (MB) and Rhodamine B (RhB) dyes under UV and Visible light. The degradation of dyes (MB & RhB) was significantly enhanced by doping of nanoparticles. The rate of dye degradation (k1) was accelerated by factor of 1.6–2.1 and 2.1–4.9 due to doping of Ag2WO4 and Ag3VO4, respectively. Ag3VO4@MIL-125-NH2 exhibited the highest photocatalytic activity logically due to the lowest band gap. The efficiency of Ag3VO4@MIL-125-NH2 as photocatalyst was reduced by only 25.9–31 % after 5 regeneration cycles. The prepared composites are promising to apply as recyclable photocatalysts in the degradation of dyes in the sunlight, able to reuse for many cycles with substantial degradation efficiency.
Sarah A. Abdel-Latef, Atef S. Darwish, Sameh A. Rizk, Sayed K. Atya, and Maher H.E. Helal
Elsevier BV
Abstract Herein, iron-rich Sinai clay (ATT) was chemically-modified by inventive azacoumarin (Az), spiropyrrolidine (Sp) and imidazothiadiazole (Im) compounds forming clay-containing hematite particles. Interplay between the chemistry of organo-compounds and the clay-sheet structure was interpreted by running DFT-calculations and physicochemical studies (XRD, FTIR, DLS, HR-TEM, N2-physisorption and magnetic analyses). The planar/nucleophilic Az-molecules preferentially occupied clay interlayer-spacings and weaken the combination between silicate-layers, forming large-sizes of completely intercalated clay layers of mesoporous structure with poor physicochemical properties. Besides, angstrom-size hematite particles (
Ahmed Al-Sabagh, Tahany Mahmoud, Maher Helal, Abd Ellatif Abd Elrahman, amira el-said, and Mona El-Rayes
Egypts Presidential Specialized Council for Education and Scientific Research
This work was focused on an investigating of flow ability of waxy crude oil by nontraditional polymer compound. For this propose, a spirocompound consisted of benzaldehyede and triethanolamine 6,6'-(((phenylmethylene) bis (oxy)) bis (ethane-2,1-diyl)) bis (2-phenyl-1,3,6-dioxazocane) [SB] was synthesized using zeolite as a catalyst. The chemical structure of the [SB] was investigated by FT-IR, TGA,GPC, H1NMR and Mass spectroscopy. The rheological behavior and pour point depression of waxy crude oil were also studied different dosages and temperatures. The results showed a significant reduction in the viscosity at different temperatures and dosages. Moreover, it was noticed a decrease in the apparent viscosity and the Bingham yield value for [SB] 437.7, 367.1, and 307.1 cp and 0.48, 0.39 and 0.31 Pa at 15 oC, 20 oC and 30 oC and concentration 1000 ppm respectively. While the blank experiment displayed 743.1, 694.2 and 607.2 cp and 0.74, 0.69 and 0.60 Pa at the same temperatures. This study included blends between [SB] and the acrylate based polymers abbreviated as (B1, B2, B3 and B4). Furthermore, the rheological behavior and the pour point for these blends exhibited that the blend [B4] shew more reduction in the apparent viscosity than [SB] being alone. The apparent viscosity and yield value for [B4] were; 267.8, 249.2 and 212.7 cp and 0.22, 0.11 and 0.09 Pa at 15oC, 20oC and 30oC and concentration 1000 ppm respectively. The pour point depression (Δpp) of [SB] was 9oC while the blank pour point was 27 o C and the B4 was achieved the maximum depression in the pour point (Δpp= 18 o C) at a concentration of 1000 ppm. This result means that the addition of [SB] to [B4] showed the most positive synergistic effect.
Huda SA Alnassar, Maher HE Helal, Ahmed A Askar, Doaa M Masoud, and Amira EM Abdallah
Informa UK Limited
Aim Aiming to produce pyridine azo disperse dyes with good fastness properties and promising antimicrobial activity, a number of novel systems of polyfunctionalized pyridine azo dyes and their selenium nanoparticles (SeNPs) were synthesized. Materials and methods The synthesized products were formed by the reaction of diazotized aniline derivatives or diazotized amino antipyrene with any of dibenzoyl methane or benzoyl acetone and cyanoacetamide in boiling ethanolic sodium ethoxide. The structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Moreover, (SeNPs) of the pyridine azo disperse dyes were characterized by Ultra-Violet -Visible spectrophotometry, dynamic light scattering , X-ray diffraction, and transmission electron microscope analysis. On the other hand, the synthesized dyes and its (SeNPs) were applied for disperse dyeing of nylon 66 and their fastness properties were measured, such as washing, rubbing, perspiration, and light fastness. In addition, the antimicrobial activities for all the synthesized compounds and for (SeNPs) prepared compounds (2bN, 2cN, 2fN, 2gN, 2hN) were evaluated. Results Compounds 2bN, 2c, 2cN, 2fN, 2gN, 2h, 2hN, and 2i were the most active compounds against all Gram-positive and Gram-negative bacterial species. While, compounds 2b, 2f, 2g, and 5b were the most active toward some of the bacterial strains (at least two from the selected four strains). Moreover, compounds 2bN, 2cN, 2fN, 2gN, 2h, 2hN showed higher activity toward the fungal strain. Also, the minimal inhibitory concentrations for all the most active compounds were determined. Conclusion Finally, all the (SeNPs) compounds revealed higher activity against bacterial and fungal strains than the other synthesized compounds.
Abdel-Zaher A. Elassar, Saleh M. Al-Mousawi, Maher Helmi Helal, and Mohamed E. Elgazzar
Emerald
Purpose The purpose of this paper is to prepare new disperse dyes and apply for dying polyester fabrics. Design/methodology/approach The synthetic reaction was carried out through two steps: preparation of arylhydrazones and alkylation using enaminone and dimethylaminovinyl-pyridazine. The high temperature method was used to apply these dyes to polyester fibres. Findings The study revealed that there is a significant effect of the new prepared disperse dyes on polyester fabrics. The structures of the prepared dyes were established based on elemental analysis and spectral data (infra red (IR), mass spectrometry (MS) and proton nuclear magnetic resonance (1H-NMR), carbon 13th nuclear magnetic resonance (13C-NMR)). Research limitations/implications Disperse dyes containing heterocyclic moiety have attracted great academic and industrial attention owing to their significant. The potential of using disperse dyes easily prepared from arylhydrazones are promise broad applications for these dyes. Practical implications The presence of N-thienyl and N-pyridazinyl in the structure of the synthesised disperse dyes would be expected to add the bioactivity advantage. Also, it can be used in formulating the antimicrobial fabrics. Social implications The N-thienyl and N-pyrdiazinyl derivatives of azo dyes are expected to be superior to in the application for fabrics. It may be useful for other applications like painting. Originality/value This paper helps to synthesise novel thiophene or pyridazine-based dyestuff for application in dying properties on polyester fabric and study their fastness properties.
Rafat M. Mohareb, Amira E. M. Abdallah, Maher H. E. Helal, and Somiya M. H. Shaloof
Walter de Gruyter GmbH
Abstract Attempting to produce cyclized systems with potential anti-proliferative activity, a series of novel thiophene and benzothiophene derivatives were designed and synthesized. The reactivity of the latter derivatives towards different chemical reagents was studied. Twenty-one compounds were synthesized and evaluated as anti-cancer agents. The results showed that ethyl 5-amino-3-(4-chlorostyryl)-4-cyanothiophene-2-carboxylate (5b), ethyl 5-amino-4-((4-methoxyphenyl)carbonyl)-3-methylhiophene-2-carboxylate (8c) and 5-3-(ethoxy-3-oxopropanamido)-3-methyl-4-(phenylcarbamoyl)thiophene-2-carboxylate (9) were the most active compounds towards three tumor cell lines – MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer) and a normal fibro-blast human cell line (WI-38) compared to the anti-proliferative effects of the reference control doxorubicin.
G.H. Elgemeie, K.A. Ahmed, E.A. Ahmed, M.H. Helal, and D.M. Masoud
Emerald
Purpose The purpose of this study is to successfully implement microwave irradiation for the rapid synthesis of novel fluorescent dyes. The prepared dyes are then applied for printing of polyester and polyamide by silk screen printing process. Design/methodology/approach A series of new N′-(methylene)-2-imino-2H-chromene-3-carbohydrazide derivatives 3a–r were synthesised in excellent yield and high atom economy by the Knoevenagel condensation of salicylaldehyde derivatives 1 and cyano-N′-methyleneaceto-hydrazide derivatives 2 in the presence of piperidine catalyst. The optical properties of the synthesised compounds were recorded; all of the compounds were found to be fluorescent in 1, 4-dioxane solution; they all emitted blue light (440-460 nm). This work shows that the optical properties strongly depend on the nature of the substituent, and indicate which type of substituent is favourable for a given application. It confirms that iminocoumarin derivatives could lead to a new generation of fluorescent probes, prone to easy modification of their chemical structure. These synthesised dyes are used to print polyester and polyamide fabrics using synthetic thickener in the printing paste for silk screen technique. Findings The structures of synthesised dyes were established and confirmed for the reaction products on the basis of their elemental analysis and spectral data (MS, IR and 1H-NMR). The suitability of the prepared dyestuffs for traditional printing on polyester and polyamide fabrics has been investigated. The prints obtained using the synthesised dyes were found to possess high colour strength and excellent overall fastness properties but relatively low light fastness. Research limitations/implications The synthesised fluorescent dyes were prepared by a simple reaction process in microwave. The optical properties for obtained dyes show include the fact that it will have various important applications. In addition, they were used for printing synthetic fabrics and were found to have good results. Practical implications The new fluorescent dyes’ system has excellent printing properties. Also they are superior in terms of yield, purity, colour strength and fastness properties which may lend them valuable commercial production. Originality/value The result of this work aimed to define the scope and limitation of the procedures for the synthesis of novel iminocoumarin dyes via a simple and economic way.