Dr. Handayani, dr, MKes
@unusa.ac.id
Faculty of medicine
Universitas Nahdlatul Ulama Surabaya
RESEARCH INTERESTS
Pharmacology, Herbal Medicine
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Yuda Turana, Putu Asih Primatanti, Wawang S. Sukarya, Marwito Wiyanto, Artha Budi Susila Duarsa, Raditya Wratsangka, Donna Adriani, Poppy Kristina Sasmita, Ecie Budiyanti, Dasti Anditiarina,et al.
Frontiers Media SA
IntroductionThe COVID-19 pandemic has caused disruptions in educational institutions across the country, prompting medical schools to adopt online learning systems. This study aims to determine impact on medical education and the medical student’s attitude, practice, mental health after 1 year of the Covid-19 pandemic in Indonesia.MethodsThis study utilized a cross-sectional design. An online questionnaire was distributed digitally to 49 medical schools in Indonesia from February–May 2021. A total of 7,949 medical students participated in this study. Sampling was carried out based on a purposive technique whose inclusion criteria were active college students. This research used questionnaires distributed in online version among 49 medical faculties that belong to The Association of Indonesian Private Medical Faculty. Instruments included demographic database, medical education status, experience with medical tele-education, ownership types of electronic devices, availability of technologies, programs of education methods, career plans, attitudes toward pandemic, and the mental health of respondents. Univariate and bivariate statistical analysis was conducted to determine the association of variables. All statistical analyses using (IBM) SPSS version 22.0.ResultsMost of the respondents were female (69.4%), the mean age was 20.9 ± 2.1 years. More than half of the respondents (58.7%) reported that they have adequate skills in using digital devices. Most of them (74%) agreed that e-learning can be implemented in Indonesia. The infrastructure aspects that require attention are Internet access and the type of supporting devices. The pandemic also has an impact on the sustainability of the education program. It was found that 28.1% were experiencing financial problems, 2.1% postponed their education due to this problems. The delay of the education process was 32.6% and 47.5% delays in the clinical education phase. Around 4% student being sick, self-isolation and taking care sick family. the pandemic was found to affect students’ interests and future career plans (34%). The majority of students (52.2%) are concerned that the pandemic will limit their opportunities to become specialists. Nearly 40% of respondents expressed anxiety symptoms about a variety of issues for several days. About a third of respondents feel sad, depressed, and hopeless for a few days.ConclusionThe infrastructure and competency of its users are required for E-learning to be successful. The majority of medical students believe that e-learning can be adopted in Indonesia and that their capacity to use electronic devices is good. However, access to the internet remains a problem. On the other side, the pandemic has disrupted the education process and mental health, with fears of being infected with SARS-CoV-2, the loss of opportunities to apply for specialty training, and the potential for increased financial difficulties among medical students. Our findings can be used to assess the current educational process in medical schools and maximize e-learning as an alternative means of preparing doctors for the future.
Handayani and Wiwik Winarningsih
Saber CDCH-UCV
Introduction: Sambiloto plant (Andrographis paniculata) is often used as herbal medicine plant in Indonesia. Previous evidence indicates the use of a whole plant or single-compound approach. Analysis of multi-compounds is needed to determine the therapeutic potential for standardizing herbal medicine to provide a reliable effect. Methods: An exploratory study searching for the active content of A. paniculata was carried out in the Knapsack program. The chemical structure is analyzed computationally using Prediction of Activity Spectra for Substances (PASS) software. The analysis of the mechanism of action of drug molecules was analyzed using the Search Tool for Interacting Chemicals (STITCH) software. Results: The active content of A. paniculata is 46 types, with 5 of them having 6 effects based on chemical bonds and targeting 12 receptor proteins. Five active contents of A. paniculata include andrographidin A, caffeic acid, chlorogenic acid, wogonin 5-glucoside, and cinnamic acid. Analysis of the mechanism of action of A. paniculata based on 12 target proteins from active ingredients using a multi-compound approach shows 6 unique biological processes. Based on the chemical bonds, 5 active contents of A. paniculata have six effects, including anaphylatoxin receptor antagonist, a beta-adrenergic receptor kinase inhibitor, GABA C receptor agonist, G-protein-coupled receptor kinase inhibitor, Aryl hydrocarbon receptor agonist, and Nicotinic alpha6beta3beta4alpha5 receptor antagonist. Conclusion: There is a therapeutic potential of A. paniculata with multi-compounds analysis. A molecular docking analysis is needed to predict the affinity between the ligand (active ingredient) and the target protein.
Handayani and Evi Sylvia Awwalia
Saber CDCH-UCV
Introduction: Respiratory allergies prevalence in Indonesia, Asia, and the world ranges from 4-10%. Patients with respiratory allergies and other chronic respiratory diseases often experienced deterioration of productivity and concentration ability. This study aims to observe the correlation between respiratory allergy and concentration ability in adults.
Fitria Romadoni, Handayani, and Aditya Bhayusakti
Saber CDCH-UCV
Introduction: Prophylactic antibiotics are antibiotics given to patients undergoing surgery to prevent infection due to surgery. Surgical site infection (SSI) is an infection that occurs when microorganisms from the skin, other body parts, or the environment enter the postoperative incision. This study aimed to analyze the relationship between preoperative antibiotics and the occurrence of SSI.
Handayani Handayani, Retno Handajani, Imam Susilo, Achmad Basori, and Hotimah Masdan Salim
African Journals Online (AJOL)
Purpose: To produce an anti-cancer agent from Physalis minima ethanol extract as well as prevent the growth of NMU-induced breast cancer and MCF-7 cell line.Methods: This research used an animal model (Wistar-Furth rats), and cell line used in this study was normal breast-cell line MCF-7. The rats were administered with the ethanol extract of Physalis minima Linn (100, 250 and 400 mg/kg/day) by gavage, once a day for 4 weeks. Meanwhile, MCF-7 cell lines were cultured in medium and incubated in 100 μg/mL of ethanol extract of Physalis minima for 48 h. The samples were analyzed using histology and immunohistochemistry techniques for expression of p53 antibody DO-1 and APAF-1.Results: The results of immunohistological analysis in the breast organ showed that Physalis minima Linn extract significantly (p < 0.05) increased the tumor suppressor protein p53 at doses of 100, 250 and 400 mg/kg/day. In addition, the extract also significantly (p < 0.05) increased APAF-1, which is a gene determining cell death, at doses of 100, 200 and 400 mg/day.Conclusion: Ethanol extract of Physalis minima Linn inhibits the cytotoxic activity of NMU-induced breast cancer by increasing the tumor suppressor protein p53 and APAF-1. Thus, Physalis minima Linn extract can potentially be used as a complementary treatment for inhibiting the growth of breast cancer cells in patients.
 Keywords: Apoptosis protease-activating factor-1, Breast cancer, MCF-7 cell line, Physalis minima, p53
Hafid Algristian, Dian Dakwatul Choiriya, Diaz Syafrie Abdillah, Athiyatul Ulya, Hafizh Auliyan Sodali, Akbar Reza Muhammad, and Handayani Handayani
PAGEPress Publications
Children and adolescents are groups that are vulnerable to the radicalism influence. Curiosity and trial-error behaviour make them tend to do risk-taking behaviours. If it is not accompanied by good self-control ability, it will encourage them to do actions without thinking about the impact of these actions (impulsivity). If it is not accompanied by empathy, then it tends to be behaviour that opposes and disrupts the interests of others (aggressive behaviour). This study aimed to assess the “Children of the Country” program as an effort to de-radicalize children and adolescents. Quasi experimental study was used on 30 children and adolescents in a shelter of street children in Surabaya with a pretest/ post-test design. In order to measure the outcome of the program, a Radical Personality Test (RPT) was developed using big five personality construct. The increase of nationalism and positive behaviour score is not much to compensate the increase of negative radicalism score. This evaluation brings awareness to form a novel de-radicalization strategy for children and adolescents in the future.
- Handayani, Faldi Yaputra, Berkat Hia, Victor Telaumbanua, and I Putu Eka Widyadharma
Scientific Foundation SPIROSKI
BACKGROUND: Access to modern medicine is still limited in some rural areas in Indonesia. This is mostly due to lack of people’s knowledge and concern for their health, especially in orthopaedic cases. Osteomyelitis is generally described as infection and inflammation of the bone, which results in local bone destruction, necrosis, and apposition of new bone. Chronic post-traumatic osteomyelitis (CPTO) is a complex condition and one of the most challenging problems in orthopaedic surgery that cause considerable morbidity.
 CASE PRESENTATION: We present a case of chronic post-traumatic osteomyelitis with radial nerve injury, in which radical surgical debridement and broad-spectrum antibiotic administration were done. A 12-year-old boy with a history of falling from the three-meter-high tree had swollen, deformed, and neglected humerus bone exposed. After stabilisation in the emergency room, surgical limb amputation was scheduled, yet the family refused this medical care and chose debridement instead.
 CONCLUSION: This case is an important addition to the literature about chronic post-traumatic osteomyelitis with neglected bone exposed and the lacking of society’s concern in regards to orthopaedic cases.
Anwar Mallongi, Handayani, Makmur Selomo, Anwar Daud, Stang Abdul Rahman, Apollo Mattangang, and Abdul Muhith
Diva Enterprises Private Limited
At this time 13 provinces and 147 districts/cities with a prevalence rate of more than 1/10, 000 population, one of which is Barru South Sulawesi province where the discovery of a case in 2015 year as many 25 people (prevalence of 1.5/10, 000 population). This research aimed (1) to investigate the spatial spread pattern of leprosy patients using Geographic System Information (GIS) and (2) to describe the risking factors correlated with the leprosy incidences in Barru Regency in 2013-2015. This research type was a descriptive/analytical survey with the cross-sectional design. The research was conducted in Barru Regency to find out the cases of leprosy patients which was 1/100, 000 people. The samples comprised all the leprosy patients in Barru Regency in 2013-2015. The data collection was carried out using observation and interviews. The data were analyzed using statistically using SPSS program and the spatial analysis used ArcView GIS version 10.1. The research results indicated of the leprosy disease in Barru Regency in 2013 was random in the entire sub-districts area, while in 2014 and 2015 was clustered, the map buffer distance between the residences of the lepers were approximately still within the radius of 2-6 km and the health centers. The individual characteristics of the leprosy were about >29 years old: 79.3% in 2013, 64% in 2014 and 73.1% in 2015, male gender: 69% in 2013 and 52% in 2014: race/ethnicity: 100% Buginese in 2013-2015, poor knowledge: 100% in 2013, 88% in 2014 and 92.3% in 2015, bad personal hygiene: 82.8% in 2013, 68% in 2014, BCG vaccine reception 72% in 2013 & 2014 and 53.8% in 2015, and ≤2 years of contact time: 19% in 2013, 72% in 2014 and 69.2% in 2015. Socio-economic characteristics of patients who had in average low education: 100% in 2013, 96% in 2014 and 96.2% in 2015, job with risks: 100% in 2013, 96% in 2014 and 96.2% in 2015, income less than UMR: 100% in 2013 & 2015 and 92% in 2014. The conditions of the patients homes being in average fairly damp, fairly lighted, and having ventilations still met the requirement as prescribed by Kepmenkes, RI No. 29/Menkes/SK/VII/1999.
Handayani, Anwar, and Muh. Tahir Abdullah
ACM Press
This study was aiming to determine leprosy disease spread and spatial study in thematic map of leprosy disease incidence using Geographic Information System and risk factor of leprosy disease in Barru regency between 2013-2015.The study was used the description/analytical survey with cross sectional design. The study was conducted in Barru Regency to find out the cases of the leprosy patients which was 1/100,000 people. The samples comprised all leprosy patients in Barru regency in 2013-2015. The data collection was carried out using observation and interviews. The data were analyzed statistically using SPSS program and spatial analysis used ArcView GIS version 10.1. The leprosy disease distribution pattern in Barru regency in 2013 was randomly distributed in all sub-districts. Meanwhile, leprosy disease cases were clustered in Barru district on 2014 and 2015. The buffer map of distance between leprosy patient and community health center (Puskesmas) was still within 2 to 6 km in Barru regency, only some leprosy patient in Tanete Riaja sub-district was above radius of 6 km from health center, Puskesmas. Most of leprosy disease cases had infected male patients, aged more 29 years, mostly Bugis race/ethnicity, lack of education about leprosy, BCG vaccination, poor personal hygiene, and had contact duration less than 2 years. Based on respondent's socioeconomic factor, average of leprosy patients had low education, worked at risk and their income less than minimum wage. Besides, leprosy patient house environment had met health requirement such as room humidity, room lighting and ventilation. Most of respondents had not met health requirement for room temperature. The community, health officers and previous leprosy patients actively participated in given the leprosy information so that earlier detection on leprosy disease had been performed. In additions, healthy person that had contact exposure took their precaution by doing self-examination and reported to the health center for further treatment.