Vedula Nagalakshmi
@chsd-theresacollege.net
Associate Professor
Ch.S.D.St.Theresa's College for Women (A)
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Tejeswararao Reddy, Sivasankar Reddy Akepati, V. Nagalakshmi, D. Jagadeeswara Rao, and Ramakrishna Madaka
Elsevier BV
CH. Subramanyam, K. Kiran Kumar, K. Venkata Ramana, C. Gladis Raja Malar, S. Mohan, and V Nagalakshmi
Informa UK Limited
Abstract A more efficient and ecologically friendly method has been devised for the preparation of α-amino phosphonates by Kabachnik-Fields (K-F) reaction in a solvent-free environment using an ultrasonication technique catalyzed by nano ZnO. Primarily, an in silico ADMET and molecular docking analysis was carried out on each molecule prior to synthesis to get insight into drug-likeliness behavior and their capacity to inhibit α-amylase and α-glucosidase. The structure of the newly synthesized compounds was confirmed using spectroscopic analysis, and each one’s in vitro inhibitory action against α-amylase and α-glucosidase was evaluated. The compounds diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(4-hydroxy-3-nitrophenyl)methylphosphonate (7e) and diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(benzo[d][1,3]dioxol-6-yl)methylphosphonate (7h) exhibited the highest inhibitory activity against α-amylase in comparison to the reference substance acarbose. The compounds diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(4-fluorophenyl)methylphosphonate (7d), diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(3-(trifluoromethyl)phenyl)methylphosphonate (7 g) and diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(benzo[d][1,3]dioxol-6-yl)methylphosphonate (7h) have shown the highest inhibitory activity against α-glucosidase than the reference drug, Acarbose. The remaining compounds have shown equipotent to good inhibitory activity against both the tested enzymes. Graphical Abstract
Mahankali Pavan Phani Kumar, Anuradha Vejendla, C. Gladis Raja Malar, Subramanyam Chennamsetty, Subrahmanyam Talari, and Nagalakshmi Vedula
Informa UK Limited
G. Tejaswini, P. Lakshmi Kishore, V. Naga Lakshmi, and K. Bhagya Lakshmi
Asian Journal of Chemistry
Transition metal oxides have been studied by many workers of fields who want to find new ways to use them in medical devices and other fields. Researchers have done a lot of research on solid-state synthesis methods, which require high temperatures and make molecules that are thermodynamically stable. Transition metal oxides have been used for a wide range of things, from nanoparticles that deliver drugs to systems that store information in more than one state. In materials science and technology research and development, a new era of “green synthesis” methods is getting a great attention. Basically, green synthesis of materials and nanomaterials, which is done through a process of regulation, control, cleaning and remediation, will directly help make them more friendly to the environment. In this review, various green approaches for 3d-series metal oxide nanoparticles and their applications are discussed.
Sarika Chhabria, A. V. Raghavendra Rao, V. Naga Lakshmi, Pravin P. Patil, Harishchander Anandaram, Sumanta Bhattacharya, D. Francisca Kalavathi, A. Dhivya, and Solomon Neway Jida
Hindawi Limited
Increased population growth, industrialization, and modern culture create a variety of consequences, including environmental pollution, heavy metal accumulation, and decreasing energy resources. This perilous position necessitates the development of long-term energy resources and strategies to address environmental threats and power shortages. In this study, an investigation into the use of castor seed oil cake and waste tyres as a feed material for the copyrolysis process for yielding maximum oil production was performed. The copyrolysis experiments were performed by changing the mass percentage of waste tyres with oil cake to make different ratios of 100 : 0, 75 : 25, 50 : 50, 25 : 75, and 0 : 100. At 50 : 50 ratio, the maximum positive synergy on oil production was obtained. At that condition, a maximum of 59.8 wt% oil was produced and characterized to analyze its physiochemical properties. The coprocessing of the selected two feed materials enables the stabilization of the oil, as the produced oil has a lower oxygen content with a maximum heating value of 38.72 MJ/kg. The Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrometry (GC-MS) analysis of the oil showed the existence of aromatic hydrocarbons and phenolic elements. Adding waste tyres to the biomass improved the quality of the oil by increasing carbon content with reduced oxygen content.
K. Raju, M. Balakrishnan, D. V. S. S. S. V. Prasad, V. Nagalakshmi, Pravin P. Patil, S. Kaliappan, B. Arulmurugan, K. Radhakrishnan, B. Velusamy, Prabhu Paramasivam,et al.
Hindawi Limited
The present study focuses on optimization of operating parameters in wire electric discharge machining of AA2024 aluminium alloy reinforced with lithium and silicon nitride particles. Aluminium composite was produced through the two-step stir casting route with the combination of 2% lithium and 10% silicon nitride reinforcements. Experiments were performed using the Taguchi design of experiments to optimize the selected input parameters such as pulse on time, pulse off time, current and wire feed for the response parameter, material removal rate, and surface roughness. An ANOVA-based regression equation with genetic algorithm was used to optimize the input variables. The gray relational grade was also performed to optimize multiple performance characteristics. Taguchi-based optimization analysis results in wire feed as the domination factor for material removal rate and surface roughness. Increased wire feed increases the material removal rate with good surface finish as confirmed from gray relational grade analysis. Regression equation generated results with minimum error (<2%) proving the accuracy of the investigation. A genetic algorithm-based study also confirms the analysis of Taguchi and gray relational grade. The wire feed rate at 3 m/min and pulse on time of 120 microseconds were found to be similar for material removal rate and surface finish. Current at 50 A increases the material removal rate and current at 30 A results in good surface finish.
Nanduri Gayatri Devi, N.V.N.B. Srinivasa Rao, D. Ramachandran, V. Nagalakshmi, and P. Sunila Rani
Rasayan Journal of Chemistry
Densities and viscosities of binary mixtures of Propiophenone with Aniline, N-methylaniline, N, N- dimethylaniline, N, N- diethylaniline were measured over the entire composition range at T = (303.15 to 318.15) K (with 5K interval) and atmospheric pressure. Experimental data were used to calculate the deviation of viscosity Δη, excess Gibb’s free energy G*E activation of viscous flow for each binary system, and these excess thermodynamic properties were fitted to the Redlich-Kister polynomial equation to obtain the fitting coefficients and standard deviations. McAllister’s three-body /four-body interaction models were used for the correlation of viscosity data. The studied systems exhibit good intermolecular interactions due to hydrogen ion transfer and charge dispersion in the carbonyl group and NH2 groups of Aniline and Alkyl Substituted Anilines. Experimental results are useful in various pharmaceutical industries.
V. Nagalakshmi, G. Srinivas Rao, N. Gayathri Devi, and S. Mohan
Radiance Research Academy
Background: Combination therapy of vildagliptin and metformin provides a comprehensive effect on cardiovascular risk factors in the form of preventing hyperinsulinemia and reducing insulin resistance. Objective: To develop a simple, fast, precise, accurate, sensitive RP-HPLC method for simultaneous estimation of metformin and vildagliptin in pure and tablet dosage forms. Method: The mobile phase, a mixture of acetonitrile, methanol and water (15:60:25v/v) pumped at a flow rate of 1.0 ml/min through the column (C18; 5μ, 4.6 X 250 mm, Hypersil) at 35oC temperature. The mobile phase was degassed before use under vacuum by filtration through a 0.2μ nylon membrane. Concentrations were measured at 278 nm by a UV detector at a sensitivity of 20 μl. Results: The linearity lies between 1-5 μg/ml for metformin and 1-5 μg/ml for vildagliptin in the method. The correlation coefficient (r2) was found to be 0.982 and 0.998 for Metformin and vildagliptin, the limit of detection and limit of quantification were found to be 0.617and 1.87 μg/ml for metformin and 0.154 and 0.468 μg/ml for vildagliptin, respectively. The results of the analysis have been validated statistically by recovery studies as per International Conference on Harmonization guidelines. Conclusion: The method showed good reproducibility and recovery with %RSD <2. Hence, the method was found to be rapid, specific, precise, and accurate and can be successfully applied for the routine analysis of metformin and vildagliptin in the pure and combined dosage form.
V. Annapurna, G. Jyothi, V. Nagalakshmi, and B. B. V. Sailaja
Hindawi Limited
Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products. Method A includes the oxidative coupling reaction of PYRA with 3-methyl-2-benzathiazolinone hydrazone (MBTH) in presence of Ce(IV). The formation of oxidative coupling product with 4-amino phenazone (4-AP) in presence of K3Fe(CN)6is incorporated in method B. Precipitation/charge transfer complex formation of the PYRA with tannic acid (TA)/Metol-Cr(VI) in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for each system. Determination of pyrilamine in bulk form and in pharmaceutical formulations were also incorporated.
V. Annapurna, G. Jyothi, V. Nagalakshmi, and B. B. V. Sailaja
Hindawi Limited
Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of FXA based on the oxidative coupling and condensation reactions. Condensation and coupling of the FXA with Ninhydrin-Ascorbic acid is proposed in method A. Method B includes complexation of FXA with cobalt thiocyanate. The ligating property of FXA with sodium nitro prusside is incorporated in method C. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system. Determination of FXA in bulk form and in pharmaceutical formulations were also incorporated.