Run Zhang
@uq.edu.au
NHMRC Emerging Leadership Fellow, Australian Institute for Bioengineering and Nanotechnology
University of Queensland, Australia
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Zhuye Shang, Miaomiao Wu, Qingtao Meng, Yang Jiao, Zhiqiang Zhang, and Run Zhang
Elsevier BV
Yiming Zhang, Zexi Zhang, Miaomiao Wu, and Run Zhang
American Chemical Society (ACS)
Run Zhang
Elsevier BV
Yixin Chang, Xin Xu, Run Zhang, Hui Peng, Kun Liu, Andrew K. Whittaker, and Changkui Fu
American Chemical Society (ACS)
Mazen Alanazi, Jiaxi Yong, Miaomiao Wu, Zexi Zhang, Dihua Tian, and Run Zhang
Wiley
AbstractHydroxyl radical (•OH), a highly reactive oxygen species (ROS), is assumed as one of the most aggressive free radicals. This radical has a detrimental impact on cells as it can react with different biological substrates leading to pathophysiological disorders, including inflammation, mitochondrion dysfunction, and cancer. Quantification of this free radical in‐situ plays critical roles in early diagnosis and treatment monitoring of various disorders, like macrophage polarization and tumor cell development. Luminescence analysis using responsive probes has been an emerging and reliable technique for in‐situ detection of various cellular ROS, and some recently developed •OH responsive nanoprobes have confirmed the association with cancer development. This paper aims to summarize the recent advances in the characterization of •OH in living organisms using responsive nanoprobes, covering the production, the sources of •OH, and biological function, especially in the development of related diseases followed by the discussion of luminescence nanoprobes for •OH detection.
Jiaxi Yong, Miaomiao Wu, Bernard J. Carroll, Zhi Ping Xu, and Run Zhang
Elsevier BV
Zhuye Shang, Shengye Tian, Yue Wang, Cheng Zhang, Qingtao Meng, Run Zhang, and Zhiqiang Zhang
Elsevier BV
Zexi Zhang, Huayue Zhang, Dihua Tian, Anh Phan, Maral Seididamyeh, Mazen Alanazi, Zhi Ping Xu, Yasmina Sultanbawa, and Run Zhang
Elsevier BV
Xiaona Gao, Wenzhu Zhang, Zhiyuan Dong, Junyu Ren, Bo Song, Run Zhang, and Jingli Yuan
American Chemical Society (ACS)
Epilepsy is a chronic neurological disorder characterized by recurrent seizures globally, imposing a substantial burden on patients and their families. The pathological role of peroxynitrite (ONOO-), which can trigger oxidative stress, inflammation, and neuronal hyperexcitability, is critical in epilepsy. However, the development of reliable, in situ, and real-time optical imaging tools to detect ONOO- in the brain encounters some challenges related to the depth of tissue penetration, background interference, optical bleaching, and spectral overlapping. To address these limitations, we present Ir-CBM, a new one-photon and two-photon excitable and long-lived ratiometric luminescent probe designed specifically for precise detection of ONOO- in epilepsy-based on the Förster resonance energy transfer mechanism by combining an iridium(III) complex with an organic fluorophore. Ir-CBM possesses the advantages of rapid response, one-/two-photon excitation, and ratiometric luminescent imaging for monitoring the cellular levels of ONOO- and evaluating the effects of different therapeutic drugs on ONOO- in the brain of an epilepsy model rat. The development and utilization of Ir-CBM offer valuable insights into the design of ratiometric luminescent probes. Furthermore, Ir-CBM serves as a rapid imaging and screening tool for antiepileptic drugs, thereby accelerating the exploration of novel antiepileptic drug screening and improving preventive and therapeutic strategies in epilepsy research.
Miaomiao Wu, Jiaxi Yong, Huayue Zhang, Zhiliang Wang, Zhi Ping Xu, and Run Zhang
Wiley
Sonodynamic therapy (SDT) combines ultrasound and sonosensitizers to produce toxic reactive oxygen species (ROS) for cancer cell killing. As the high penetration depth of US, SDT breaks the depth penetration barrier of conventional photodynamic therapy for the treatment of deeply seated tumours. A key point to enhance the therapeutic efficiency of SDT is the development of novel sonosensitizers with promoted ability for ROS production. Herein, ultrathin Fe-doped bismuth oxychloride nanosheets with rich oxygen vacancies and bovine serum albumin coating on surface are designed as piezoelectric sonosensitizers (BOC-Fe NSs) for enhanced SDT. The oxygen vacancies of BOC-Fe NSs provide electron trapping sites to promote the separation of e- -h+ from the band structure, which facilitates the ROS production under the ultrasonic waves. The piezoelectric BOC-Fe NSs create a build-in field and the bending bands, further accelerating the ROS generation with ultrasound irradiation. Furthermore, BOC-Fe NSs could induce ROS generation by a Fenton reaction catalysed by Fe ion with endogenous H2 O2 in tumour tissues for chemodynamic therapy. The as-prepared BOC-Fe NSs efficiently inhibited breast cancer cell growth in both in vitro and in vivo tests. The successfully development of BOC-Fe NSs provides a new nano-sonosensitiser option for enhanced SDT for cancer therapy. This article is protected by copyright. All rights reserved.
Zhuye Shang, Qingtao Meng, Dihua Tian, Yue Wang, Zexi Zhang, Zhiqiang Zhang, and Run Zhang
Elsevier BV
Zhuye Shang, Qingtao Meng, Run Zhang, and Zhiqiang Zhang
Elsevier BV
Zhuye Shang, Yue Wang, Qingtao Meng, Run Zhang, and Zhiqiang Zhang
Elsevier BV
Run Zhang
Elsevier BV
Qian Song, Bin Chi, Haiqing Gao, Junke Wang, Miaomiao Wu, Yi Xu, Yingxi Wang, Zushun Xu, Ling Li, Jing Wang,et al.
Royal Society of Chemistry (RSC)
We report the development of Zr/Ce-MOFs/DOX/MnO2 as a new nanozyme for enhanced combination catalytic therapy and chemotherapy of cancer in vitro and in vivo.
Zexi Zhang, Miaomiao Wu, Anh Phan, Mazen Alanazi, Jiaxi Yong, Zhi Ping Xu, Yasmina Sultanbawa, and Run Zhang
Elsevier BV
Run Zhang and Tony D. James
Wiley
This special collection highlights the recent state-of-the-art progress in the research of molecular probes, chemosensors, nanosensors, and applications in molecular recognition, sensing, and imaging. In their Guest Editorial, Run Zhang and Tony James provide an outline of the field and introduce the contributions to the special collection.
Yaw Opoku-Damoah, Run Zhang, Hang T. Ta, and Zhi Ping Xu
American Chemical Society (ACS)
Gas therapy has gained noteworthy attention in biomedical research, with the rise of gas-releasing molecules enhancing their therapeutic potential, especially when integrated into nano-based drug delivery systems. Herein, we present a lipid-coated gas delivery system to simultaneously shuttle two gas-releasing molecules carrying nitric oxide (NO) and carbon monoxide (CO), respectively. Upconversion nanoparticles (UCNPs) are designed to generate photons at 360 nm upon 808 nm of near-infrared (NIR) irradiation. These in situ-generated UV photons trigger simultaneous NO and CO release from S-nitrosoglutathione (GSNO) and the CO-releasing molecule (CORM), respectively, which are coloaded into lipid-coated UCNP/GSNO/CORM/FA nanoparticles (LUGCF). LUGCF with a GSNO/CORM mass ratio of 2:1 is determined to be optimal in terms of synergistically instigating apoptosis in HCT116 and CT26 colon cancer cells, where both NO/CO are released and subsequent production of ROS are detected. This CO/NO combination nanoplatform exhibits a very effective inhibition of colon tumor growth in vivo at relatively low doses upon a mild 808 nm irradiation. Overall, we effectively integrated two therapeutic gas-releasing molecules in one NIR-responsive nanosystem, presenting a promising therapeutic strategy for future biomedical applications in dual-gas cancer therapy.
Huayue Zhang, Miaomiao Wu, Hang Thu Ta, Zhi Ping Xu, and Run Zhang
Wiley
Jianping Liu, Li Li, Run Zhang, and Zhi Ping Xu
Royal Society of Chemistry (RSC)
Magnetic resonance imaging (MRI) is one key technology in modern diagnostic medicine.
Jiaxi Yong, Miaomiao Wu, Run Zhang, Shengnan Bi, Christopher W G Mann, Neena Mitter, Bernard J Carroll, and Zhi Ping Xu
Oxford University Press (OUP)
Abstract RNA interference is triggered in plants by the exogenous application of double-stranded RNA or small interfering RNA (siRNA) to silence the expression of target genes. This approach can potentially provide insights into metabolic pathways and gene function and afford plant protection against viruses and other plant pathogens. However, the effective delivery of biomolecules such as siRNA into plant cells is difficult because of the unique barrier imposed by the plant cell wall. Here, we demonstrate that 40-nm layered double hydroxide (LDH) nanoparticles are rapidly taken up by intact Nicotiana benthamiana leaf cells and by chloroplasts, following their application via infiltration. We also describe the distribution of infiltrated LDH nanoparticles in leaves and demonstrate their translocation through the apoplast and vasculature system. Furthermore, we show that 40-nm LDH nanoparticles can greatly enhance the internalization of nucleic acids by N. benthamiana leaf cells to facilitate siRNA-mediated downregulation of targeted transgene mRNA by >70% within 1 day of exogenous application. Together, our results show that 40-nm LDH nanoparticle is an effective platform for delivery of siRNA into intact plant leaf cells.
Liuen Liang, Arun V. Everest-Dass, Alexey B. Kostyuk, Zahra Khabir, Run Zhang, Daria B. Trushina, and Andrei V. Zvyagin
MDPI AG
Applications of nanoparticles (NPs) in the life sciences require control over their properties in protein-rich biological fluids, as an NP quickly acquires a layer of proteins on the surface, forming the so-called “protein corona” (PC). Understanding the composition and kinetics of the PC at the molecular level is of considerable importance for controlling NP interaction with cells. Here, we present a systematic study of hard PC formation on the surface of upconversion nanoparticles (UCNPs) coated with positively-charged polyethyleneimine (PEI) and negatively-charged poly (acrylic acid) (PAA) polymers in serum-supplemented cell culture medium. The rationale behind the choice of UCNP is two-fold: UCNP represents a convenient model of NP with a size ranging from 5 nm to >200 nm, while the unique photoluminescent properties of UCNP enable direct observation of the PC formation, which may provide new insight into this complex process. The non-linear optical properties of UCNP were utilised for direct observation of PC formation by means of fluorescence correlation spectroscopy. Our findings indicated that the charge of the surface polymer coating was the key factor for the formation of PC on UCNPs, with an ensuing effect on the NP–cell interactions.
Cailing He, Jiayuan Zhu, Huayue Zhang, Ruirui Qiao, and Run Zhang
MDPI AG
Photoacoustic imaging (PAI), an emerging biomedical imaging technology, capitalizes on a wide range of endogenous chromophores and exogenous contrast agents to offer detailed information related to the functional and molecular content of diseased biological tissues. Compared with traditional imaging technologies, PAI offers outstanding advantages, such as a higher spatial resolution, deeper penetrability in biological tissues, and improved imaging contrast. Based on nanomaterials and small molecular organic dyes, a huge number of contrast agents have recently been developed as PAI probes for disease diagnosis and treatment. Herein, we report the recent advances in the development of nanomaterials and organic dye-based PAI probes. The current challenges in the field and future research directions for the designing and fabrication of PAI probes are proposed.
Zhuye Shang, Li Shu, Jianhua Liu, Qingtao Meng, Yue Wang, Jianguo Sun, Run Zhang, and Zhiqiang Zhang
Royal Society of Chemistry (RSC)
A triphenylamine-copper(ii)-based fluorescence probe (NZ-Cu2+) has been developed for the detection of NO in vivo.
Zhuye Shang, Jianhua Liu, Qingtao Meng, Hongmin Jia, Yun Gao, Cheng Zhang, Run Zhang, and Zhiqiang Zhang
Royal Society of Chemistry (RSC)
A carbazole-based near-infrared (NIR)-emitting fluorescent probe (QPM) was successfully developed for the detection of HSO3− in live animals and in real food samples.