Chiara Mameli
@unimi.it
Research Fellow- Department of Pediatrics
V. Buzzi Children's Hospital
Since my education and training at the Medical School of the University of Milan, Italy, I focused my efforts in the area of pediatric diabetology and endocrinology. Until 2008 my training has been based in clinical settings, in particular in the treatment of children and adolescents with type 1 diabetes mellitus and endocrine diseases.
EDUCATION
2001: B.S Liceo Scientifico V.Veneto, Milan, Italy
2007: MD - Medicine University of Milan, Italy M.D.
2013: Residency in Pediatrics, University of Milan, Italy
204-2017/2018- ongoing Research Fellow in Pediatrics University of Milan/Luigi Sacco Hospital
RESEARCH INTERESTS
pediatric endocrinology and diabetology
Vaccine
Scopus Publications
Scopus Publications
Antonio Corsello, Gregorio Paolo Milani, Marina Picca, Roberto Buzzetti, Romeo Carrozzo, Mirko Gambino, Giovanni Chiaffoni, Paola Marchisio, and Chiara Mameli
Springer Science and Business Media LLC
Abstract Background Recurrent Upper Respiratory Tract Infections (R-URTIs) pose a significant challenge in pediatric healthcare, affecting both children and their families. This study aimed to investigate the prevalence, risk factors, and clinical implications of R-URTI in children aged 0–5 years. Methods This observational study involved a sample of 483 children aged 0–5 years, focusing on establishing a practical and dynamic definition of R-URTI. Family pediatricians prospectively collected socio-demographic information, medical history, and recorded the occurrence of URTI episodes. Children were followed from recruitment until March 2021, predating the COVID-19 outbreak. Results A substantial prevalence of R-URTIs was found, estimating it at 5–10% among this age group. To define R-URTI, a practical and dynamic criterion was proposed: children experiencing a minimum of four URTI episodes, each lasting four days or more, within a six-month period, with intervals of well-being in between. Conclusions The study highlighted that specific risk factors for R-URTI were elusive, suggesting that this condition may affect children regardless of their family or clinical history. Moreover, the study’s stratification by age group and times of observation facilitated patient-specific clinical decision-making. The proposed definition may represent a valuable tool for clinicians in diagnosing and addressing R-URTI cases.
Pierachille Santus, Marina Saad, Elisa Giani, Maurizio Rizzi, Chiara Mameli, Maddalena Macedoni, Stefano Pini, Laura Saderi, Moufida Ben Nasr, Ida Pastore,et al.
Springer Science and Business Media LLC
Chiara Mameli, Andrea Rigamonti, Barbara Felappi, Antonio Nicolucci, Giuseppe Lucisano, Stefano Baresi, Giorgia Florini, Maddalena Macedoni, Agnese Petitti, Adelina Hajro,et al.
Mary Ann Liebert Inc
BACKGROUND
Few data are available in children with type 1 diabetes (T1D) using automated insulin delivery systems during physical activity (PA). We evaluated the time in range (TIR) during 2-hours of outdoor PA in children using t:slim X2 with Control-IQ® technology.
MATERIALS AND METHODS
Caucasian children and adolescents, aged 9-18 years using t:slim X2 with Control-IQ® technology were recruited during a local sporting event. Participants were divided into two groups: Group A practiced endurance activities for 60 mins (1000-meter run, a jump circuit) then power activities for 60 mins (80-meter run, long jump); Group B practiced power activities for 60 mins then followed by endurance activities for 60 mins. Ninety minutes before the physical activity, participants had lunch and self administered a low dose insulin, reduced by 50% compared to their regularly calculated meal dose per pump calculator. DexcomG6® data was downloaded.
RESULTS
26 children were recruited, 2 refused physical activity. Participants were divided as follows: 13 in group A [7 males, median age 14.6 years] and 11 in group B [8 males, median age 13.5 year)]. The mean glucose level when PA started was similar between groups (p=0.06). Subjects in group B showed a higher TIR than those in group A (50.4% 95%CI 33.8-75) vs 39.6% (95%CI 26.9-58.3), respectively (p=0.39). A significantly better TIR in Group B (53.8%, 95%CI 30.2-96.1) compared to Group A (17.4%, 95%CI 7.3-41.7, p=0.02) was recorded during the first session. During the second session, TIR increased in both groups. There were no episodes of serious or severe hypoglycemia. Conclusions No serious or severe hypoglycemic episodes were recorded during physical activity performed 90 mins after lunch. Future studies using t:slim X2 with Control IQ® technology are necessary.
Stefano Passanisi, Fortunato Lombardo, Chiara Mameli, Bruno Bombaci, Maddalena Macedoni, Gianvincenzo Zuccotti, Klemen Dovc, Tadej Battelino, Giuseppina Salzano, and Maurizio Delvecchio
Springer Science and Business Media LLC
Andrea E. Scaramuzza, Marco Marigliano, Riccardo Bonfanti, Valentino Cherubini, Riccardo Schiaffini, Sonia Toni, Ivana Rabbone, and
Wiley
Eleonora Bonaventura, Luisella Alberti, Simona Lucchi, Laura Cappelletti, Salvatore Fazzone, Elisa Cattaneo, Matteo Bellini, Giana Izzo, Cecilia Parazzini, Alessandra Bosetti,et al.
Frontiers Media SA
Chiara Mameli, Liliana Guadagni, Massimiliano Orso, Valeria Calcaterra, Malgorzata Gabriela Wasniewska, Tommaso Aversa, Simona Granato, Pietro Bruschini, Daniela d’Angela, Federico Spandonaro,et al.
Springer Science and Business Media LLC
Abstract Objective Growth hormone deficiency (GHD) is the most common pituitary hormone deficiency and is one of the main causes of short stature in children and adolescents. The aim of this study is to evaluate the epidemiology of pediatric GHD worldwide, since no other systematic review has been published so far. Methods We searched PubMed, Embase, and Web of Science up to July 2023 to find epidemiological studies involving children with GHD. Two review authors independently screened articles, extracted data and performed the quality assessment. Results We selected 9 epidemiological studies published from 1974 to 2022. The range of prevalence was 1/1107–1/8,646. A study based on a registry of GH users in the Piedmont region (Italy) reported the highest mean prevalence. In the included studies, the mean incidence ranged from 1/28,800 to 1/46,700 cases per year. One study reported a 20-year cumulative incidence of 127/100,000 for boys and 93/100,000 for girls. Studies were heterogeneous in terms of population (age and GHD etiology) and diagnostic criteria. As for the methodological quality of included studies, all but one study satisfied the majority of the checklist items. Conclusions The included studies are mostly European, so the provided estimates cannot be considered global. International multicentre studies are needed to compare epidemiological estimates of GHD among different ethnical groups. Considering the considerable cost of human recombinant GH, the only available therapy to treat GHD, understanding accurate epidemiological estimates of GHD in each country is fundamental for resource allocation.
Valeria Calcaterra, Chiara Mameli, Maddalena Macedoni, Annalisa De Silvestri, Laura Sgambetterra, Federico Nosenzo, Francesca Chiara Redaelli, Agnese Petitti, Alessandra Bosetti, and Gianvincenzo Zuccotti
Walter de Gruyter GmbH
Abstract Objectives A connection between thyroid hormones (THs) and diverse metabolic pathways has been reported. We evaluated thyroid function and tissue sensitivity to THs in children and adolescents with T1D in comparison to euthyroid controls. Additionally, we investigate whether a relationship exists between sensitivity indices and metabolic parameters. Methods A retrospective analysis was conducted on 80 pediatric patients diagnosed with T1D. Clinical parameters, TSH, FT3, FT4, and the presence of MS were documented. Additionally, indices of peripheral sensitivity (FT3/FT4 ratio) and central sensitivity (TSH index, TSHI; TSH T4 resistance index, TT4RI; TSH T3 resistance index, TT3RI) were assessed. Thirty healthy subjects were considered as controls. Results The overall prevalence of MS was 7.27 %, with MS identified in 8 out of 80 (10 %) T1D subjects; none of the controls manifested MS (p<0.01). No significant differences were observed in indexes of tissue sensitivity to THs between subjects with or without MS (all p>0.05). Correlations between THs and indexes of THs tissue sensitivity and metabolic parameters in controls and T1D patients were noted. Conclusions This study affirms a heightened prevalence of MS in children with T1D compared to controls and underscores the potential role of THs in maintaining metabolic equilibrium.
Roque Cardona-Hernandez, Klemen Dôvc, Torben Biester, Laya Ekhlaspour, Maddalena Macedoni, Martin Tauschmann, and Chiara Mameli
Elsevier BV
Marina Picca, Romeo Carrozzo, Gregorio Paolo Milani, Antonio Corsello, Marina Macchi, Roberto Buzzetti, Paola Marchisio, and Chiara Mameli
Springer Science and Business Media LLC
Abstract Background Antibiotic overuse in children is a significant public health concern, as it can lead to the emergence and spread of antibiotic-resistant bacteria. Although respiratory infections account for most antibiotic prescriptions in children, many of these infections are viral and do not require antibiotics. In this study, we aimed to investigate the use of antibiotics in children with respiratory infections in a primary care setting and to explore the possible role of fever on antibiotic prescription. Methods We conducted a prospective observational study that evaluated preschool children aged 0–5 years who were assessed by their primary care pediatricians for respiratory infectious diseases between October 2019 and March 2021. The study involved 69 public primary care pediatricians and a total of 678 pediatric episodes for respiratory infections. Results Amoxicillin/clavulanate was the most frequently prescribed drug. Bronchitis accounted for most of inappropriate antibiotic prescriptions (73%). Furthermore, the presence of fever was associated with a ~ 300% increase in the likelihood of prescribing antibiotics for respiratory infections that do not typically require antibiotics. Conclusion Our findings emphasize the need for adherence to international guidelines and recommendations in the primary care of children to reduce unnecessary antibiotic use and prevent the development of antibiotic resistance. This study also underscores the potential relevance of new studies to evaluate antibiotic prescription attitudes in other clinical settings and geographical areas.
Alberto Eugenio Tozzi, Francesco Gesualdo, Elisabetta Pandolfi, Diana Ferro, Giulia Cinelli, Elena Bozzola, Tommaso Aversa, Antonio Di Mauro, Chiara Mameli, and Ileana Croci
Springer Science and Business Media LLC
Abstract Background Emerging technologies have demonstrated outstanding potential in improving healthcare, yet their full integration remains a challenge for all medical specialties, including pediatrics. To support the swift implementation of technologies, we identified the current trends through a bibliometric review, and we conducted a survey on Italian pediatricians to gauge educational needs and willingness to integrate technologies into clinical practice. Methods A working group of pediatricians representing various backgrounds designed and coordinated the study. To identify relevant topics for educational strategy development, we focused on virtual reality, telehealth, natural language processing, smartphone applications, robotics, genomics, and artificial intelligence. A bibliometric analysis limited to 2018–2023 was performed to identify trends and emerging applications within each topic. Based on the results, a questionnaire was developed and made available online to all Italian pediatricians. The results were analyzed through descriptive analysis and a multivariable logistic regression to explore associations between technology adoption and sociodemographic characteristics. Results A total of 3,253 publications were found, with Telehealth and Telemedicine having the highest number of publications and Natural Language Processing the lowest. The number of respondents to the online questionnaire was 1,540, predominantly medical doctors with over 20 years of experience working as family pediatricians. Telehealth had the highest level of knowledge (95.2%), followed by smartphone applications (89.1%) and genomics (63.2%). The greatest potential for increased use through education programs was projected for natural language processing (+ 43.1%), artificial intelligence (+ 39.6%), and virtual and mixed reality (+ 38.1%). Female respondents and older individuals were less likely to use emerging technologies. Hospital pediatricians and residents were more likely to use AI. Conclusions We developed a replicable strategy to identify emerging themes in medical technologies relevant to pediatrics and assess the educational needs of pediatricians. A significant gap still exists between current and potential usage of emerging technologies among Italian pediatricians although they showed a positive attitude towards implementing these technologies following specific education programs. The study highlights the need for comprehensive education programs on emerging technologies in pediatrics and recommends addressing gender and age disparities in technology adoption.
Enza D’Auria, Camilla Cattaneo, Simona Panelli, Carlotta Pozzi, Miriam Acunzo, Stella Papaleo, Francesco Comandatore, Chiara Mameli, Claudio Bandi, Gianvincenzo Zuccotti,et al.
Springer Science and Business Media LLC
AbstractCurrently, the mechanisms underlying sensory perception and sensory performance in children with food allergies are far from being understood. As well, only recently, single research afforded the oral host-commensal milieu, addressing oral microbial communities in children with peanut allergies. To bridge the current gaps in knowledge both in the sensory and microbial fields, a psychophysiological case–control study was performed in allergic children (n = 29) and a healthy sex-age-matched control group (n = 30). Taste perception, food neophobia, and liking were compared in allergic and non-allergic children. The same subjects were characterized for their oral microbiota composition by addressing saliva to assess whether specific profiles were associated with the loss of oral tolerance in children with food allergies. Our study evidenced an impaired ability to correctly identify taste qualities in the allergic group compared to controls. These results were also consistent with anatomical data related to the fungiform papillae on the tongue, which are lower in number in the allergic group. Furthermore, distinct oral microbial profiles were associated with allergic disease, with significant down-representations of the phylum Firmicutes and of the genera Veillonella spp., Streptococcus spp., Prevotella spp., and Neisseria spp. For the first time, this study emphasizes the link between sensory perception and food allergy, which is a novel and whole-organism view of this pathology. Our data indicated that an impaired taste perception, as regards both functionality and physiologically, was associated with food allergy, which marginally influences the food neophobia attitude. It is also accompanied by compositional shifts in oral microbiota, which is, in turn, another actor of this complex interplay and is deeply interconnected with mucosal immunity. This multidisciplinary research will likely open exciting new approaches to therapeutic interventions.
Roque Cardona-Hernandez, Klemen Dôvc, Torben Biester, Laya Ekhlaspour, Maddalena Macedoni, Martin Tauschmann, and Chiara Mameli
Elsevier BV
Chiara Mameli, Massimiliano Orso, Valeria Calcaterra, Malgorzata Gabriela Wasniewska, Tommaso Aversa, Simona Granato, Pietro Bruschini, Liliana Guadagni, Daniela d’Angela, Federico Spandonaro,et al.
Elsevier BV
Chiara Mameli, Taylor M. Triolo, Francesco Chiarelli, Marian Rewers, Gianvincenzo Zuccotti, and Kimber M. Simmons
Elsevier BV
Chiara Mameli, Giulia Marie Smylie, Alessio Galati, Biagio Rapone, Roque Cardona-Hernandez, Gianvincenzo Zuccotti, and Maurizio Delvecchio
Springer Science and Business Media LLC
Eleonora Bonaventura, Luisella Alberti, Simona Lucchi, Laura Cappelletti, Salvatore Fazzone, Elisa Cattaneo, Matteo Bellini, Giana Izzo, Cecilia Parazzini, Alessandra Bosetti,et al.
Frontiers Media SA
IntroductionX-linked adrenoleukodystrophy (X-ALD) is the most common inherited peroxisomal disorder caused by variants in the ABCD1 gene. The main phenotypes observed in men with X-ALD are primary adrenal insufficiency, adrenomyeloneuropathy, and cerebral ALD (cALD). Cerebral ALD consists of a demyelinating progressive cerebral white matter (WM) disease associated with rapid clinical decline and is fatal if left untreated. Hematopoietic stem cell transplantation is the standard treatment for cALD as it stabilizes WM degeneration when performed early in the disease. For this reason, early diagnosis is crucial, and several countries have already implemented their newborn screening programs (NBS) with the assessment of C26:0-lysophosphatidylcholine (C26:0-LPC) values as screening for X-ALD.MethodsIn June 2021, an Italian group in Lombardy launched a pilot study for the implementation of X-ALD in the Italian NBS program. A three-tiered approach was adopted, and it involved quantifying the values of C26:0-LPC and other metabolites in dried blood spots with FIA-MS/MS first, followed by the more specific ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique and, finally, the genetic confirmation via focused NGS.DiscussionGenetically confirmed patients are set to undergo a follow-up protocol and are periodically evaluated to promptly start a specific treatment if and when the first signs of brain damage appear, as suggested by international guidelines. A specific disease monitoring protocol has been created based on literature data and personal direct experience.ConclusionThe primary aim of this study was to develop a model able to improve the early diagnosis and subsequent follow-up and timely treatment of X-ALD.EthicsThe study was approved by the local ethics committee. The research was conducted in the absence of any commercial or financial relationship that could be construed as a potential conflict of interest.
Valeria Calcaterra, Vittoria Carlotta Magenes, Virginia Rossi, Valentina Fabiano, Chiara Mameli, and Gianvincenzo Zuccotti
Elsevier BV
S. Cannavò, M. Cappa, D. Ferone, A. M. Isidori, S. Loche, M. Salerno, M. Maghnie, Gianluca Aimaretti, Maria Rosaria Ambrosio, Simonetta Bellone,et al.
Springer Science and Business Media LLC
Valeria CALCATERRA, Chiara MAMELI, Virginia ROSSI, Vittoria C. MAGENES, Giulia MASSINI, Chiara PERAZZI, Elvira VERDUCI, and Gianvincenzo ZUCCOTTI
Edizioni Minerva Medica
INTRODUCTION
Autoimmune diseases account for a cumulative overall prevalence of about 3-5% worlwide. Among them, autoimmune thyroid diseases (ATDs) are the most common and comprise two main entities: Hashimoto's thyroiditis (HT) and Graves-Basedow disease (GD). The pathogenesis of ATDs remains not fully elucidated, however the role of microbioma has been proposed. Gut microbiota exert an important influence on the intestinal barrier, nutrient metabolism and immune system development and functions.
EVIDENCE ACQUISITION
In this narrative review, we describe on the main features of ATDs in pediatrics, focusing on the reciprocal influence between gut microbiota, thyroid hormone metabolism and thyroid autoimmunity and consider the role of probiotics and other microbiotatargeted therapies in thyroid diseases with a perspective on pediatric endocrinology.
EVIDENCE SYNTHESIS
Microbiome affects both endogenous and exogenous thyroid hormone metabolism and influences the absorption of minerals important to the thyroid function, which are iodine, selenium, zinc and iron. The alteration of the gut microbiota, with the consequent modifications in the barrier function and the increased gut permeability, seems involved in the development of autoimmune and chronic inflammatory diseases, including ATDs. The supplementation with probiotics showed beneficial effects on the thyroid hormone and thyroid function because this strategy could restore the intestinal eubiosis and the good strain microorganism proliferation.
CONCLUSIONS
Eventhough the evidence about the interaction between microbiota and ATDs in pediatric patients is limited, the promising results obtained in the adult population, and in other autoimmune disorders affecting children, highlight the need of for further research in the pediatric field.
Chiara Mameli, Carla Carnovale, Federico Ambrogi, Gabriele Infante, Paulina Roux Biejat, Alessandra Napoli, Marco Coazzoli, Valeria Calcaterra, Laura Schneider, Chiara Perazzi,et al.
Springer Science and Business Media LLC
AbstractThe level of secretory acid sphingomyelinase (S-ASM), a key enzyme in the sphingolipid metabolism, is elevated in a variety of human diseases, including in the serum of obese adults. Alterations in S-ASM were also found to induce morphological changes in erythrocytes. Consequently, the inhibition of S-ASM by functional Inhibitors of ASM (FIASMA) may have broad clinical implications. The purpose of this study was to assess S-ASM activity in pediatric patients with obesity and healthy matched controls, as well as to investigate the erythrocyte morphology using transmission electron microscopy. We recruited 46 obese patients (mean age 11 ± 2.9 years) and 44 controls (mean age 10.8 ± 2.9 years). S-ASM activity was significantly higher (Wilcoxon signed-rank test p-value: 0.004) in obese patients (mean 396.4 ± 49.7 pmol/ml/h) than in controls (mean 373.7 ± 23.1 pmol/ml/h). No evidence of morphological differences in erythrocytes was found between the two populations. We then carried out a case–control study based on the spontaneous reporting system database to compare FIASMAs with NON-FIASMAs in terms of weight gain risk. Children who received FIASMA had a significantly lower frequency of weight gain reports than patients who took NON-FIASMA agents (p < 0.001). Our findings suggest there is an intriguing possibility that S-ASM may play a role in pediatric obesity. This pilot study could serve as the basis for future studies in this interesting field of research.
Chiara Mameli, Marina Picca, Roberto Buzzetti, Maria Elisabetta Pace, Raffaele Badolato, Claudio Cravidi, Gian Vincenzo Zuccotti, Paola Marchisio, Marco Sala, Maria Elisabetta Di Cosimo,et al.
Springer Science and Business Media LLC
Abstract Introduction The incidence of acute respiratory tract infections (ARTIs) in children is difficult to estimate because they are typically treated in outpatient settings and the majority of epidemiological data originate from hospital settings and refer to the most severe illnesses. Therefore, the incidence of ARTIs in a real-world setting remains largely unexplored. Therefore, this study aims to estimate the incidence of ARTIs, upper respiratory tract infections (URTIs), and lower respiratory tract infections (LRTIs) in children aged 0–5 years in an outpatient setting. Methods This prospective cohort study was conducted in Lombardy, Italy, from October 1st, 2019, to March 31st, 2021, before and during the COVID-19 pandemic that began in March 2020. Caucasian healthy children aged 0–5 years were recruited from 69 Family Pediatricians (FP) and followed-up in an outpatient setting. Data were collected whenever a child was referred to FP and ARTI was diagnosed (Covid-19 related ARTI were excluded). The primary outcome was an estimate of the incidence of ARTIs. The incidence of ARTIs in different age groups and the effect of the COVID-19 pandemic on the incidence of ARTIs were secondary outcomes. Results We enrolled 484 children, 249 male (51.8%), mean age of 2.39 ± 1.68 years. The mean estimated incidence of ARTIs was 12.1/100 children × 30 days (95% CIs: 9.5–12.9), with the highest value observed in infants aged 1–12 months (24.9/100 children × 30 days; 95% CIs: 17.6–28.9). The mean estimated incidence of URTIs was higher than that of LRTIs (8.3 – CIs: 7.6–8.9 vs 3.8/100 children × 30 days – CIs: 6.4–4.3, respectively). The comparison of ARTIs, which occurred in the pre-pandemic winter, to those measured during the COVID-19 pandemic, revealed an impressive 82.1% drop in the incidence rate (CIs: 77.8–85.7). Conclusions This study showed that infants aged 1–12 months are more likely to develop ARTIs than older children and that COVID-19 pandemic has dramatically altered the epidemiology of ARTIs in children aged 0–5 years.
Antonella Lonero, Massimo Giotta, Giulia Guerrini, Valeria Calcaterra, Elena Galazzi, Lorenzo Iughetti, Alessandra Cassio, Gabriela Malgorzata Wasniewska, Chiara Mameli, Gianluca Tornese,et al.
Springer Science and Business Media LLC
Francesca D’Addio, Ida Pastore, Cristian Loretelli, Alessandro Valderrama-Vasquez, Vera Usuelli, Emma Assi, Chiara Mameli, Maddalena Macedoni, Anna Maestroni, Antonio Rossi,et al.
Springer Science and Business Media LLC
Abstract Aims Abnormalities in the oculomotor system may represent an early sign of diabetic neuropathy and are currently poorly studied. We designed an eye-tracking-based test to evaluate oculomotor function in patients with type 1 diabetes. Methods We used the SRLab—Tobii TX300 Eye tracker®, an eye-tracking device, coupled with software that we developed to test abnormalities in the oculomotor system. The software consists of a series of eye-tracking tasks divided into 4 classes of parameters (Resistance, Wideness, Pursuit and Velocity) to evaluate both smooth and saccadic movement in different directions. We analyzed the oculomotor system in 34 healthy volunteers and in 34 patients with long-standing type 1 diabetes. Results Among the 474 parameters analyzed with the eye-tracking-based system, 11% were significantly altered in patients with type 1 diabetes (p < 0.05), with a higher proportion of abnormalities observed in the Wideness (24%) and Resistance (10%) parameters. Patients with type 1 diabetes without diabetic neuropathy showed more frequently anomalous measurements in the Resistance class (p = 0.02). The classes of Velocity and Pursuit were less frequently altered in patients with type 1 diabetes as compared to healthy subjects, with anomalous measurements mainly observed in patients with diabetic neuropathy. Conclusions Abnormalities in oculomotor system function can be detected in patients with type 1 diabetes using a novel eye-tracking-based test. A larger cohort study may further determine thresholds of normality and validate whether eye-tracking can be used to non-invasively characterize early signs of diabetic neuropathy. Trial: NCT04608890.
Valentino Cherubini, Monica Marino, Andrea E. Scaramuzza, Valentina Tiberi, Adriana Bobbio, Maurizio Delvecchio, Elvira Piccinno, Federica Ortolani, Stefania Innaurato, Barbara Felappi,et al.
Frontiers Media SA
[This corrects the article .].