Mohammad Safiqul Islam
@nstu.edu.bd
Department of Pharmacy
Noakhali Science and Technology University: Noakhali, Sonapur, BD
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Md. Shafiul Hossen, Md. Abdul Aziz, Md Abdul Barek, and Mohammad Safiqul Islam
Elsevier BV
Mohima Khanom, Md. Shafiul Hossen, Md. Abdul Barek, Md. Shuvo Ahamed, Md. Sohanur Alam, Khokon Kanti Bhowmik, Sarah Jafrin, Md. Abdul Aziz, and Mohammad Safiqul Islam
Wiley
AbstractBackground and AimsBreast cancer is one of the deadliest diseases affecting women in Bangladesh, and its prevalence is increasing year by year. Although several IL‐6 single nucleotide polymorphisms have been implicated in BC susceptibility and prognosis in various studies, no research has been done to investigate the relationship between breast cancer and IL‐6 in Bangladeshi women. This investigation aimed to explore the linkage between the rs1800797 variant of IL‐6 and the susceptibility to breast carcinoma among women in Bangladesh.MethodsThe IL‐6 rs1800797 variant was genotyped in 218 subjects (110 cases and 108 controls) using the tetra‐primer ARMS‐PCR method. The statistical analysis was applied utilizing the SPSS software version 24.0. UALCAN database was used for IL‐6 mRNA analysis, and genotype‐based gene expression was retrieved from GTEx Portal.ResultsThis study found a significant link between IL‐6 rs1800797 variants and increased chance of breast cancer across different genetic inheritance models, including additive model 1 (AG vs. GG: OR = 2.16, p = 0.035); dominant model (AG + AA vs. GG: OR = 2.26, p < 0.05); overdominant model (AG vs. GG + AA: OR = 2.08, p < 0.05); and allelic model (A vs. G: OR = 2.15, p < 0.05). However, an insignificant association of breast cancer was found in both additive model 2 (AA vs. GG: OR = 2.91, p > 0.05) and the recessive model (AA vs. GG + AG: OR = 2.52, p > 0.05). Under the analysis of the probability of false positive reports, no significant values were found in different models when the OR was 1.5, and the prior probability was 0.25.ConclusionsA significant relationship was found between the IL‐6 rs1800797 genetic variant and the risk of breast cancer. However, the findings of the study should be further investigated with a larger sample size to validate the correlation.
Pantha Prodip Ray, Mohammad Ashraful Islam, Mohammad Safiqul Islam, Aixia Han, Peiwu Geng, Md. Abdul Aziz, and Abdullah Al Mamun
Frontiers Media SA
Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a natural lignan, has been found to possess strong anti-cancer activity against several types of human cancers based on emerging research. This study aims to provide an overview of the therapeutic potential of silibinin in the treatment and prevention of cancers. A comprehensive search was conducted using various internet databases such as PubMed, Google Scholar, and ScienceDirect to identify relevant research papers. Silibinin has been shown to exhibit anticancer activity against several types of cancers, including liver, lungs, breast, prostate, colorectal, skin, and bladder cancers. Its multifaceted mechanisms of action contribute to its therapeutic effects. Silibinin exerts antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic activities, making it a promising candidate for cancer therapy. One of the key mechanisms underlying the anticancer effects of silibinin is its ability to modulate multiple signaling pathways involved in cancer development and progression. It can inhibit the activation of various oncogenic pathways, including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK pathways, thereby suppressing cancer cell proliferation, inducing cell cycle arrest, and promoting apoptosis. Silibinin possesses great potential as an effective treatment agent for cancer. The multifaceted mechanisms of action, favorable safety profile, and potential synergistic effects of silibinin with conventional therapies make it an attractive candidate for further investigation and development as a cancer treatment. However, more extensive clinical studies are necessary to fully establish the efficacy, optimal dosage, and long-term effects of silibinin in cancer treatment.
Syed Masudur Rahman Dewan and Mohammad Safiqul Islam
SAGE Publications
Tahmina Akter, Md. Abdul Aziz, Mohammad Safiqul Islam, and Md. Shahid Sarwar
Wiley
AbstractBackground and AimsBreast cancer is a multifactorial malignancy with different clinicopathological and molecular characteristics. It is the most frequent cancer in women in terms of both incidence and mortality. Matrix metallopeptidase 1 or MMP1 is a zinc‐dependent endopeptidase associated with several physiological processes through the modification of the extracellular matrix and tumor microenvironment. However, previous results did not suggest any concluding remarks on the correlation between MMP1 gene polymorphisms and the risk of breast cancer.MethodsA comprehensive literature search was performed in PubMed database to retrieve relevant articles and extract data from suitable ones. The literature written only in English was selected for this review.ResultsA total of 26 articles were included in the present narrative review. From the available studies, it is observed that MMP1 is upregulated in breast cancer tissues and found to be correlated with metastasis and invasion. The expression of MMP1 gene is mediated by numerous factors, including polymorphisms which act as a potential risk factor for the progression of breast cancer. To establish the correlation between genetic polymorphisms in MMP1 and the risk of breast cancer, several case‐control studies, as well as genetic analyses, have been carried out in different ethnicities. The association of genetic polymorphisms in MMP1 with the risk and survival of breast cancer in different populations has been reviewed in this study. Moreover, the structural domain of MMP1 and the role of MMP1 in breast cancer metastasis and invasion are also discussed which will help to understand the potential impact of MMP1 as a genetic biomarker.ConclusionsThis review provides an overview of the MMP1 gene polymorphisms in breast cancer. However, we recommend future studies concentrating on combined analysis of multiple SNPs, gene‐gene interactions, and analysis of epigenetics, proteomics, and posttranscriptional modifications that will provide the best outcome.
Md Abdul Aziz, Sarah Jafrin, Md Abdul Barek, Shamima Nasrin Anonna, and Mohammad Safiqul Islam
Future Medicine Ltd
Purpose: Previous studies of MMP-3 -1171 5A/6A in cancers have produced inconclusive outcomes. This updated meta-analysis was performed to clarify the link between this variant and cancer. Methods: Databases including PubMed, Google Scholar, EMBASE and Cochrane were searched for data collection. The associations were calculated by odds ratios with 95% CIs. Results: 63 eligible studies with 14,252 cases and 15,176 controls were included. The codominant 2, codominant 3, dominant, recessive and allele models were found to be significantly associated with 1.28-, 1.13-, 1.13-, 1.19- and 1.13-fold enhanced overall risk of cancer, respectively. Stratification analysis revealed a 1.28-times enhanced risk of esophageal cancer (codominant 1), 1.29- and 1.26-fold (codominant 3) and 1.18- and 1.28-fold (recessive model) enhanced risk in colorectal and gastrointestinal cancers, respectively, 1.30-, 1.35- and 1.22-times in codominant model 1, dominant and allele models for breast cancer, 1.56-fold (codominant 2) for gynecological cancer and 2.40-times in codominant model 2 for hepatocellular cancer. Conclusion: This meta-analysis suggests a significant association between the MMP-3 -1171 5A/6A variant and cancer. This meta-analysis was registered at INPLASY (registration number: INPLASY202280049).
Amrin Yeasin Proma, Proma Rani Das, Sayma Akter, Syed Masudur Rahman Dewan, and Mohammad Safiqul Islam
Wiley
Abstract Background Disease prevention and healthcare policy choices cannot be made without epidemiology data. Since it is a growing country with rapidly increasing illness rates, this information is in great demand in Bangladesh. This is because there is a shortage of reliable and sufficient data, leading to inadequate preventive and treatment methods. Discussion Poor health concerns and economic conditions mean that not all families can afford to provide the nutrition their members need, leading to an increase in the prevalence of many diseases. The outcome is an ever‐increasing threat of cardiovascular disease (CVD) issues, the leading cause of death in Bangladesh, even though the underlying causes remain unknown. There is a strong demand for accurate information on CVD patients in Bangladesh, however, there is no effective framework for managing epidemiological data. This prevents an in‐depth analysis of the nation's socioeconomic status, dietary practices, and way of life, as well as the implementation of sound healthcare policy. Conclusion In this article, we present arguments on this important issue using the healthcare systems of the developed world and Bangladesh as examples.
Rabeya Tajnur, Refaya Rezwan, Md. Abdul Aziz, and Mohammad Safiqul Islam
Wiley
Coronavirus disease 2019 (COVID‐19), caused by the SARS‐CoV‐2 novel coronavirus, is a highly communicable disease that gave rise to the ongoing pandemic. Despite prompt action across many laboratories in many countries, effective management of this disease is still out of reach. The focus of this review is to describe various vaccination approaches and nanomedicine‐based delivery systems against COVID‐19.
Md. Abdul Barek, Mohammad Anwarul Basher, Md. Abdul Aziz, Md. Shafiul Hossen, Nusrat Jahan, Nahida Afroz, Mobashera Begum, Sarah Jafrin, Mohammad Sarowar Uddin, Md. Shalahuddin Millat,et al.
Elsevier BV
Md. Shaki Mostaid, Md. Abdul Aziz, Jeba Atkia Maisha, Mohammad Safiqul Islam, and Abdullah Al Maruf
Walter de Gruyter GmbH
Abstract Pharmacogenetics (PGx)-guided prescribing is an evidence-based precision medicine strategy. Although the past two decades have reported significant advancements in both the quality and quantity of PGx research studies, they are seldom done in developing countries like Bangladesh. This review identified and summarized PGx studies conducted in the Bangladeshi population by searching PubMed and Google Scholar. Additionally, a quality evaluation of the identified studies was also carried out. Eleven PGx studies were identified that looked at the effects of genetic variants on blood thinners (CYP2C9, VKORC1, and ITGB3), cancer drugs (TPMT, MTHFR, DPYD, ERCC1, GSTP1, XPC, XRCC1, TP53, XPD, and ABCC4), statins (COQ2, CYP2D6, and CYP3A5), and prednisolone (ABCB1, CYP3A5, and NR3C1) in the Bangladeshi population. Most studies were of low to moderate quality. Although the identified studies demonstrated the potential for PGx testing, the limited PGx literature in the Bangladeshi population poses a significant challenge in the widespread implementation of PGx testing in Bangladesh.
Sarah Jafrin, Md. Abdul Aziz, Md. Sajal, Tarzina Akter, Chaity Das, Tahmina Akter, Md. Saddam Hussain, Md. Shalahuddin Millat, Mohammad Sarowar Uddin, Nura Ershad Naznin,et al.
Elsevier BV
Nusrat Jahan, Mobashera Begum, Md Abdul Barek, Md. Abdul Aziz, Md. Shafiul Hossen, Khokon Kanti Bhowmik, Tahmina Akter, Md. Rabiul Islam, Hadi Sajid Abdulabbas, and Mohammad Safiqul Islam
MDPI AG
Breast cancer is considered the most frequent cause of mortality from malignancy among females. Fibroblast growth factor receptor 2 (FGFR2) gene polymorphisms are highly related to the risk of breast cancer. However, no investigation has been carried out to determine the association of FGFR2 gene polymorphisms in the Bangladeshi population. Based on polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP), this study was performed to evaluate the association of FGFR2 (rs1219648, rs2420946, and rs2981582) variants in 446 Bangladeshi women (226 cases and 220 controls). A significant association of the FGFR2 rs1219648 variant with breast malignancy was reported in additive model 1 (aOR = 2.87, p < 0.0001), additive model 2 (aOR = 5.62, p < 0.0001), the dominant model (aOR = 2.87, p < 0.0001), the recessive model (aOR = 4.04, p < 0.0001), and the allelic model (OR = 2.16, p < 0.0001). This investigation also explored the significant association of the rs2981582 variant with the risk of breast cancer in additive model 2 (aOR = 2. 60, p = 0.010), the recessive model (aOR = 2.47, p = 0.006), and the allelic model (OR = 1.39, p = 0.016). However, the FGFR2 rs2420946 polymorphism showed no association with breast cancer except in the overdominant model (aOR = 0.62, p = 0.048). Furthermore, GTT (p < 0.0001) haplotypes showed a correlation with breast cancer risk, and all variants showed strong linkage disequilibrium. Moreover, in silico gene expression analysis showed that the FGFR2 level was upregulated in BC tissues compared to healthy tissues. This study confirms the association of FGFR2 polymorphisms with breast cancer risk.
Khokon Kanti Bhowmik, Jannatul Ferdous, Prodip Kumar Baral, and Mohammad Safiqul Islam
Wiley
The dengue virus is widespread throughout Bangladesh and significantly contributes to morbidity and mortality. One effective method for preventing further dengue epidemics is to reduce mosquito breeding at the most opportune period each year. This study aims to determine dengue prevalence in 2022 by comparing previous years' data and estimating the period of this disease's most significant incidence.
S. M. Naim Uddin, Mahmodul Haque, Md Abdul Barek, Mohammad Nizam Uddin Chowdhury, Abhijit Das, Md. Giash Uddin, and Mohammad Safiqul Islam
Wiley
Pre‐eclampsia is a particular type of pregnancy condition. Although the primary etiology of pre‐eclampsia is unclear, it hypothesizes that the alteration of trace elements and macro‐minerals may play a crucial function in the pathogenesis of Pre‐eclampsia. Therefore, our research sought to ascertain the serum level of trace elements (zinc, iron) and macro‐minerals (sodium, calcium, potassium) and their possible association with pre‐eclampsia.
Md Abdul Aziz, Md Shalahuddin Millat, Tahmina Akter, Md Shahadat Hossain, Md Monirul Islam, Shahriar Mohsin, Farzana Ansari, Asma Kabir, Mohammad Nurul Amin, and Mohammad Safiqul Islam
Elsevier BV
Taposhi Nahid Sultana, Nusrat Islam Chaity, Md. Mehedi Hasan, Ishrat Islam Shrabonee, Sanzana Fareen Rivu, Md. Abdul Aziz, Shaid All Sahaba, Mohd Nazmul Hasan Apu, Noor Ahmed Nahid, Mohammad Safiqul Islam,et al.
Springer Science and Business Media LLC
Md. Abdul Aziz and Mohammad Safiqul Islam
Elsevier
Jannatul Ferdous, Md. Abdul Barek, Md. Shafiul Hossen, Khokon Kanti Bhowmik, and Mohammad Safiqul Islam
Wiley
Monkeypox is a viral zoonotic disease caused by the monkeypox virus, a double‐stranded DNA‐enveloped virus that can be transmitted from animal to human or human to human. Consequently, it emerged as the most important orthopoxvirus for public health. Based on available online literature, this study reviewed the majority of the data representing the outbreak, diagnosis, treatment, and prevention of monkeypox.
Md. Abdul Aziz and Mohammad Safiqul Islam
Wiley
Accumulating studies have evaluated the association between MAP3K1 polymorphisms and cancer prognosis. However, the results of these studies are conflicting. Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta‐analysis was performed to obtain solid and credible evidence.
Mohammad Sarowar Uddin, Md. Abdul Aziz, Md. Shaki Mostaid, Md. Shalahuddin Millat, and Mohammad Safiqul Islam
Elsevier BV
Md. Abdul Aziz, Tahmina Akter, Md. Shahid Sarwar, and Mohammad Safiqul Islam
Springer Science and Business Media LLC
Abstract Background Evidence suggests that circulating resistin levels are altered in colorectal cancer (CRC) and breast cancer (BC). Again, polymorphisms in resistin-encoding gene RETN have been evaluated in CRC and BC. However, there is a scarcity of data establishing the relationship of resistin and RETN polymorphisms (rs1862513 and rs3745367) with these cancers. This study aimed to analyze the relationship of resistin levels and RETN polymorphisms with CRC and BC in a combined meta-analytic approach. Main body of the abstract After a comprehensive online literature search, screening and eligibility check, 41 articles (31 with resistin level and 10 with RETN polymorphisms) were retrieved for meta-analyses. The mean difference (MD) of resistin was calculated and pooled to investigate the effect sizes with a 95% confidence interval (CI), and the connection of genetic polymorphisms was analyzed with an odds ratio (OR) and 95% CI. The analysis showed that resistin level is significantly higher in CRC (MD = 3.39) and BC (MD = 3.91) patients. Subgroup analysis in CRC showed significantly higher resistin in serum (MD = 4.61) and plasma (MD = 0.34), and in BC, a significantly elevated resistin level was reported in premenopausal (MD = 7.82) and postmenopausal (MD = 0.37) patients. Again, RETN rs1862513 showed a significantly strong association with CRC (codominant 1—OR 1.24, codominant 2—OR 1.31, dominant model—OR 1.25, and allele model—OR 1.16) and with BC (codominant 2—OR 1.51, codominant 3—OR 1.51, recessive model—OR 1.51, and allele model—OR 1.21). RETN rs3745367 did not show any association with these cancers. Short conclusion Overall, our analysis indicates that higher circulating resistin levels are associated with an elevated risk of CRC and premenopausal and postmenopausal BC. Besides, rs1862513 in RETN gene is significantly connected with both CRC and BC.
Maria Azmerin, Md. Saddam Hussain, Md. Abdul Aziz, Md. Abdul Barek, Mobashera Begum, Niloy Sen, Md. Abdur Rahman, Mohammad Shahriar, Saleh Salem Baeesa, Ghulam Md Ashraf,et al.
SAGE Publications
Objective Although the prevalence of autism spectrum disorder (ASD) is increasing, appropriate diagnosis and prevention strategies are still lacking. This case–control study was designed to explore the association between ASD and the rs1867503 and rs9951150 polymorphisms of the TF and TCF4 genes, respectively. Methods Ninety-six children with ASD and 118 healthy children were recruited and polymerase chain reaction–restriction fragment length polymorphism technique was applied for genotyping. Results The frequencies of the mutant allele G were 48% and 44% for the rs1867503 and rs9951150 polymorphisms, respectively. In our analysis, both TF and TCF4 polymorphisms were associated with an increased risk of developing ASD. AG heterozygotes (OR = 3.18), GG mutant homozygotes (OR = 2.62), AG + GG combined genotypes (OR = 2.98), and G mutant alleles of TF rs1867503 (OR = 1.94) were associated with a significantly elevated risk of ASD. Likewise, AG heterozygotes (OR = 2.92), GG mutant homozygotes (OR = 2.36), AG + GG combined genotypes (OR = 2.72), and G minor alleles of TCF4 rs9951150 (OR = 1.92) were associated with a significantly elevated risk of ASD. Conclusions Our results indicate that TF rs1867503 and TCF4 rs9951150 polymorphisms may be strongly associated with the development of ASD in Bangladeshi children.
Md. Abdul Aziz and Mohammad Safiqul Islam
Wiley
ACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms could play a critical role in altering the clinical outcomes of SARS‐CoV‐2. The findings of previous studies remained inconclusive. This meta‐analysis was performed to evaluate the association and provide a more reliable outcome.
Sarah Jafrin, Md. Abdul Aziz, and Mohammad Safiqul Islam
SAGE Publications
Objective The TP73 G4C14-A4T14 variant has been associated with elevated cancer risk, but the evidence is inconclusive. We performed a meta-analysis to clarify the role of this variant in cancer development. Methods Eligible literature was selected by searching PubMed, Google Scholar, Cochrane Library, and Embase. The meta-analysis was performed using Review Manager 5.4. Results A meta-analysis of 55 case–control studies showed that the G4C14-A4T14 variant was significantly associated with overall cancer development in five genetic models, including the allele model (AM), codominant model 1 (COD1), COD2, dominant model (DM), and over-dominant model (OD). Sub-group analysis based on ethnicity showed significantly higher risks in Africans in COD2 and RM and in Whites in AM, COD2, DM, and recessive model (RM). Cancer-specific subgroup analysis identified significant risks of gynecological (ovarian, cervical, and endometrial cancer), colorectal, oral, head and neck, and other cancers. Moreover, hospital-based controls revealed significant cancer risks in the AM, COD1, COD2, DM, and RM genetic models. Our findings were confirmed by trial sequential analysis. Conclusion This meta-analysis confirmed that TP73 G4C14-A4T14 significantly elevates the overall cancer risk, especially in White, African, and hospital-based populations, and specifically predisposes individuals to gynecological, colorectal, oral, and head and neck cancers. This meta-analysis was registered at INPLASY (registration number: INPLASY202210070).