Dr Aditya Shiven
@cuchd.in
Assistant Professor, University Institute of Pharma Sciences, Chandigarh University
University Institute of Pharma Sciences, Chandigarh University
EDUCATION
B, Pharmacy awarded in 2012 from Uttrakhand Technical University, Dehradun, Uttrakhand.
M. Pharmacy (Pharmaceutics) awarded in 2014 from Shoolini University, Solan, Himachal Pradesh.
Ph.D. (Pharmaceutical Sciences) awarded in 2020 from Shoolini University, Solan, Himachal Pradesh.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology (medical), Dermatology, General Medicine
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Arti Devi, Vagish Dwibedi, Sahil Jain, Gursharan Kaur, Zaved Ahmed Khan, Sudip Kumar Mandal, Aditya Shiven, Kamal Shah, Hitesh Kumar Dewangan, and Santosh Kumar Rath
Bentham Science Publishers Ltd.
SARS-CoV-2, the virus responsible for COVID-19, has resulted in a devastating global impact with millions of lives lost. Remdesivir and 2-DG are among the few drugs authorized for emergency use against COVID-19, but concerns about their efficacy and side effects persist. Vaccines have been developed and approved, yet the emergence of viral mutations has raised questions about their effectiveness against new variants. Natural compounds with antiviral properties have shown promise in combating SARS-CoV-2. The review highlights the potential of medicinal plant compounds, particularly in targeting the virus' main protease, a crucial component for viral replication. Natural, plant-derived compounds represent a promising avenue for COVID-19 therapeutics. Further clinical validation is necessary to ascertain their efficacy and safety in treating COVID-19. This underscores the importance of continued research into alternative treatments for combating this global health crisis. This review examines the potential of natural, plant-derived compounds as safe and cost-effective alternatives for combating COVID-19. It summarizes the pathogenesis of SARS-CoV- 2 and the ongoing drug studies and identifies natural compounds with known antiviral properties. Additionally, it explores the potential of medicinal plant compounds in targeting the SARS-CoV-2 main protease through in silico and molecular docking studies.
Aditya Shiven, Afroze Alam, Hitesh Kumar Dewangan, Kamal Shah, Perwez Alam, and Deepak N. Kapoor
Informa UK Limited
AIM
The present work is focus on development of anti-psoriasis activity of Karanjin (isolated from Pongamia pinnata seed oil) loaded liposome based lotion for enhancement of skin permeation and retention.
METHOD
Karanjin was isolated using liquid-liquid extraction method and characterised by HPLC analysis and partition coefficient. Further, isolated Karanjin was loaded into liposomes using thin-film hydration technique and optimised by Box-Behnken design. Selected optimised batch was characterised their mean diameter, PDI, zeta potential, and entrapment efficiency, morphology (by TEM), FTIR and ex-vivo skin retention. Additionally, Karanjin loaded liposomes were formulated into lotion and characterise their rheological, spreadability, texture, ex-vivo skin permeation & retention, stability and anti-psoriatic activity in mouse tail model.
RESULT
The yield of Karanjin from seed oil was 0.1% w/v and have lipophilic nature. The optimised liposomal formulation showed 195 ± 1.8 nm mean diameter, 0.271 ± 0.02 PDI, -27.0 ± 2.1 mV zeta potential and 61.97 ± 2.5% EE. TEM image revel the spherical shap of liposome surrounded by single phospholipid bilayer and no interection between drug and excipients. Further, lotion was prepared by 0.1% w/v carbopol and found to 615 mPa.sec viscosity, good thixotropic behaviour, spreadability and texture. There was 22.44% increase in drug permeation for Karanjin loaded liposomal lotion compared to pure Karanjin lotion, confirm by ex-vivo permeation and retention. While, in-vivo study revel the liposomal lotion of Karanjin was found to have 16.09% higher drug activity then 5% w/w conventional Karanjin lotion.
CONCLUSION
Karanjin loaded liposomal lotion have an effective anti-psoriatic agent and showed better skin permeation and retention than the conventional Karanjin lotion.
Aditya Shiven, A. Alam and D. Kapoor
Sarcoptes scabiei is an ectoparasite known to infect different species of mammals. Mite is known to infect mankind since antiquity. Current scabicidal agents are becoming less effective due to resistance generated by the mite. The present review focuses on exploration of various herbal and non-herbal/synthetic agents that are proven to be efficient against scabies mite of different mammalian species. In vitro and in vivo acaricidal activities carried out for different dosage forms developed for these scabicidal agents are also discussed.