Ana Laura Costa Oliveira

@ufu.br

Microbiology departament
Universidade Federal de Uberlândia



           

https://researchid.co/analaura15

RESEARCH, TEACHING, or OTHER INTERESTS

Virology, Drug Discovery, Applied Microbiology and Biotechnology

3

Scopus Publications

Scopus Publications

  • The Halogen Effect in [Cu(NHC)X] Compounds: A Case Study on the Anti-Leishmania and Antiviral Activity of [Cu(IPr)X]
    J. V. Fontes, M. E. F. Agnoli, G. Clauss, M. S. A. Garcia, A. V. P. Ferreira, G. A. Antoniucci, A. L. Costa‐Oliveira, A.C.G. Jardim, D. C. Miguel, and C. Abbehausen
    Wiley
    Abstract In this study, we investigated the activity and properties of three neutral Cu(I) N ‐heterocyclic carbene (NHC) complexes—[1,3‐bis(2,6‐diisopropylphenyl) imidazol‐2‐ylidene]copper(I) with Cl, Br, and I, specifically [Cu(IPr)Cl] , [Cu(IPr)Br] , and [Cu(IPr)I] —to evaluate the impact of halogen substitution on anti‐ Leishmania and antiviral activity. The compounds were synthesized using reported methods. 13 C NMR spectroscopy provided insights into the electronic nature of the Cu─X bond by analyzing the NHC C 2 chemical shift. Notably, the iodine derivative exhibited distinct chemical properties compared to its counterparts, displaying a more covalent Cu─I bond. As a result, [Cu(IPr)I] was more susceptible to nucleophilic attack, as confirmed by HOMO–LUMO gap calculations using DFT. Furthermore, this derivative demonstrated the highest lipophilicity and the strongest antioxidant activity in the series, as evidenced by the DPPH assay, surpassing butylated hydroxytoluene (BHT) used as a positive control. Bovine serum albumin (BSA) binding assays indicated weak interaction (10 3 M −1 ) across all compounds, with no significant differences observed. In anti‐ Leishmania assays, [Cu(IPr)I] exhibited the best selectivity index (SI = 4.0), showing greater toxicity to the parasite (EC 50  = 1.5 µM) while being less toxic to the host cell (CC 50  = 6.0 µM). However, this trend did not extend to antiviral studies against the chikungunya virus, where [Cu(IPr)Br] displayed the highest replication inhibition (EC 50  = 0.807 µM) and the best selectivity index (SI = 4.8). Our findings highlight that halogen substitution plays a crucial role in modulating the biological activity of neutral linear metal‐NHC complexes.

  • Development and validation of Mayaro virus with luciferase reporter genes as a tool for antiviral assays
    Mikaela dos Santos Marinho, Ya-Nan Zhang, Natasha Marques Cassani, Igor Andrade Santos, Ana Laura Costa Oliveira, Anna Karla dos Santos Pereira, Pedro Paulo Corbi, Bo Zhang, and Ana Carolina Gomes Jardim
    Elsevier BV

  • Influence of diimine bidentate ligand in the nitrosyl and nitro terpyridine ruthenium complex on the HSA/DNA interaction and antiviral activity
    Naiara Cristina Bessas, Evelyn Christine de Souza Arantes, Natasha Marques Cassani, Uriel Enrique Aquino Ruiz, Igor Andrade Santos, Daniel Oliveira Silva Martins, Ana Laura Costa Oliveira, Giovanna André Antoniucci, Arthur Henrique Cavalcante de Oliveira, Gilson DeFreitas-Silva,et al.
    Elsevier BV