Badrkhan Rashwan Ismael

The effect of aerobic training on the mir-195 gene expression in heart tissue of type 2 diabetic rats

Introduction and Purpose: Recently, a very close relationship between miRNA and diabetes and cardiovascular diseases has been found. Therefore, this study aimed to investigate the changes induced by aerobic training in miR-195 heart tissue: beneficial regulatory effects in type 2 diabetes. Materials and Methods: For this purpose, 18 male Wistar rats (mean weight 240 gr and mean age of 8 weeks) were randomly divided into three groups: 1) healthy control, 2) diabetic control, and 3) diabetic training. To induce type 2 diabetes, First, a high-fat diet (60%) was administered for two weeks, and then streptozocin injection was performed while fasting. The training protocol was obtained on the treadmill five days a week by observing the principle of overload in the first week at a speed of 5-10 m/min for 10-15 minutes and in the eighth week at a speed of 18-24 m/min for 60 minutes. Real-time PCR was used to evaluate miR-195 gene expression. One-way analysis of variance and Tukey's post hoc te