REYADH RADHI AL-RASHIDI
@alkutcollege.edu.iq
Deprtment of Basic Sciences , College of Dentistry , Kut University
Deprtment of Basic Sciences , College of Dentistry , Kut University
RESEARCH, TEACHING, or OTHER INTERESTS
Molecular Medicine, Plant Science, Pharmacology, Cancer Research
Scopus Publications
Scopus Publications
Houda Haddad, Reyadh R. AL-Rashidi, Ahmed Loghmari, Wissal Sahtout, Raja Boukadida, Rihem Dahmene, Emeny Ettouil, Houcemeddine Othman, Ines Ouahchi, and Amira Zaϊri
Elsevier BV
Reyadh Al-Rashidi, Hana Nasrallah, Amal Bouazzi, and Amira Zaïri
MDPI AG
Haloxylon articulatum is traditionally used for treating infections, digestive issues, and oxidative stress. Despite its ethnopharmacological relevance, its phytochemistry and biological activities, particularly in Iraq, are underexplored. This study investigated the phytochemical composition of H. articulatum extracts and evaluated their antioxidant and anti-Helicobacter pylori activities, supported by molecular docking and in silico ADMET analysis. Methanol/water and ethyl acetate extracts from roots and aerial parts were analyzed using LC-HRMS/MS. Antioxidant capacity was measured via DPPH assay, and anti-H. pylori activity was assessed using broth microdilution. Molecular docking targeted bacterial isoleucyl-tRNA synthetase, and ADMET predictions were carried out with SwissADME and ADMETlab. Phytochemical profiling identified 32 compounds, including phenolamides, flavonoids, alkaloids, and triterpenoid glycosides. Root extracts exhibited stronger antioxidant and antibacterial effects than aerial parts. Ethyl acetate extracts were inactive. Phenolamides, N-caffeoyltyramine, and sinapoyltyramine, present in the extract, showed significant activity (MICs = 54 ± 0.92 and 74 ± 1.05 µg/mL). Docking supported their strong binding to the target enzyme. ADMET results indicated good oral bioavailability and low toxicity. This study is the first to report the anti-H. pylori activity of H. articulatum and to characterize its Iraqi chemotype through advanced metabolomics. The findings highlight the plant’s potential as a source of multifunctional phytochemicals with antioxidant and antibacterial applications, warranting further preclinical development and toxicological investigation.
Huda A. Yaseen, Dhaffar Alwan Majbil, Wathba Mohammed Jabber, Reyadh R. Al-Rashidi, Umelbaneen J. Alalawy, and Sarab M. Zeki Radhi
University Library System, University of Pittsburgh
Objective: Stress is a prevalent issue in the field of dental education, with numerous studies highlighting its impact on students. Creating a supportive and stress-free environment is vital in dental education, not only for the well-being of students but also to minimize hazards which are frequently linked to stress. The main objective of the study was to investigate the top stressors among the clinical years’ dental students. Material and Methods: A modified "Dental Environment Stress" questionnaire-based convenient sample from fourth- and fifth-year dental students in the University of Wasit and Kut University College was collected from November 2023 to December 2023. Prior to data collection, an ethical approval was taken from the Kut University College Research Ethics Committee (KREC) and each participant provided a written informed consent. The data were analysed using the Statistical Package for the Social Sciences statistical software (SPSS version 25.0). Results: 392 students participated with a female to male ratio (2.4: 1). The "Self-efficacy Belief" domain emerged as the most impactful stressor. Fifth-year students experience higher stress related to time management and clinical requirements compared to fourth-year students. Stress levels are similar between students from private and public universities. Conclusion: The study highlights that dental education induces significant stress among students. Efforts to improve patient organization and engagement are recommended to alleviate stress among students.
Saade Abdalkareem Jasim, Yasir Qasim Almajidi, Reyadh R. Al‐Rashidi, Ahmed Hjazi, Irfan Ahmad, Ahmed Hussien Radie Alawadi, Enas R. Alwaily, Hashem O. Alsaab, Ali Haslany, and Mohamood Hameed
Wiley
AbstractAutophagy, as a highly conserved cellular process, participates in cellular homeostasis by degradation and recycling of damaged organelles and proteins. Besides, autophagy has been evidenced to play a dual role through cancer initiation and progression. In the early stage, it may have a tumor‐suppressive function through inducing apoptosis and removing damaged cells and organelles. However, late stages promote tumor progression by maintaining stemness features and induction of chemoresistance. Therefore, identifying and targeting molecular mechanisms involved in autophagy is a potential therapeutic strategy for human cancers. Multiple transcription factors (TFs) are involved in the regulation of autophagy by modulating the expression of autophagy‐related genes (ATGs). In addition, a wide array of long noncoding RNAs (lncRNAs), a group of regulatory ncRNAs, have been evidenced to regulate the function of these autophagy‐related TFs through tumorigenesis. Subsequently, the lncRNAs/TFs/ATGs axis shows great potential as a therapeutic target for human cancers. Therefore, this review aimed to summarize new findings about the role of lncRNAs in regulating autophagy‐related TFs with therapeutic perspectives.
Reyadh R. Al-Rashidi, Sara Abdalrazzaq M. Noraldeen, Ali Kamil Kareem, Aisha Kamal Mahmoud, Wesam R. Kadhum, Andrés Alexis Ramírez-Coronel, Acim Heri Iswanto, Rasha Fadhel Obaid, Abduladheem Turki Jalil, Yasser Fakri Mustafa,et al.
Elsevier BV
Wesam R. Kadhum, Gerard Lee See, Muqdad Alhijjaj, Mustafa M. Kadhim, Florencio Jr. Arce, Ahmed S. Al-Janabi, Reyadh R. Al-Rashidi, and Anees A. Khadom
MDPI AG
The present study aimed to develop polyethylene glycol–liquid crystals (PEG-LC) ointment formulations, assess their formulation characteristics, and establish their biocompatibility and impact on transdermal drug administration. PEG-LC formulations were prepared using a hydrophilic molecule, p-aminobenzoic acid (PAB). Formulation characterizations such as small-angle X-ray scattering, viscosity, pH, zeta potential, and the particle sizes of the formulations were examined to determine the physicochemical properties of the prepared formulations. The drug release profile of PEG-LC ointment formulations was assessed with a dialysis membrane. In vitro skin permeation testing was performed to establish whether the PEG-LC formulations improved drug skin penetration. The MTT and comet assays were performed to assess the biocompatibility of the formulations. Our data showed that the method is effective in forming hexosome-type PEG-LC formulations and that they were biocompatible. Furthermore, the PEG-LC formulations significantly improved PAB skin penetration when compared with commercial PEG. The PEG-LC formulation is a promising carrier for the delivery of hydrophilic drugs.
Redhwan Ahmed Al-Naggar, Hisham Alshaikhli, Reyadh R. Al-Rashidi, and Sharon Murtagh
Veterinary World
Background and Aim: The development of a coronavirus disease 2019 (COVID-19) vaccine is ongoing. This study aimed to prepare for public acceptance of the vaccine. There is a need to identify the current acceptance and potential barriers to receiving a COVID-19 vaccine in Yemen. Understanding the hesitancy and acceptance of a COVID-19 vaccine are crucial to develop local evidence-based interventions. Materials and Methods: Twenty students were interviewed in this study. An interview guide was developed and it addressed the willingness to accept a future COVID-19 vaccine. In-depth interviews were conducted, transcribed, and manually analyzed. Results: The majority of participants agreed that they would take a COVID-19 vaccine for several reasons, including protection for themselves, their families, and others and to stop the spread of COVID-19, for which the vaccine is important, as in other routine vaccinations. However, some participants shared that they would not take the COVID-19 vaccine due to the following reasons: Concerns regarding the safety of the vaccine; feeling fit and healthy, and thus considering themselves to have strong immunity; feeling that the vaccine was manufactured in a rushed manner and thus it would require approval by the World Health Organization; being previously infected with COVID-19 and considering themselves protected, and placing their trust in God and believing no vaccine was needed. Conclusion: The willingness to receive a future COVID-19 vaccine was high among medical students. However, some students hesitated to take the vaccine. Therefore, mass media interventions are required to maximize vaccine uptake.
R. Al-Rashidi, Rusul A Alsaray, Zeid Alsadoon, W. N. Alwan, Wesam R. Kadhum and A. A. Al-Temimi
Since the start of the pandemic of COVID-19, it was clear that vaccination was the best way to combat it. A few vaccines were produced and approved in the last year. Many questions about the vaccinations' efficacy and safety arose due to this unprecedented vaccine development effort. This study aimed to evaluate the short-term side effects after receiving the available COVID-19 vaccines by the students of the Kut university college. This research was conducted as a cross-sectional, retrospective study using an online questionnaire distributed among COVID-19 vaccine recipients. The number of students who are enrolled in this study is 804, nearly (81%) of our study subjects were symptomatic after receiving the vaccination. Participants with a history of SARS-CoV-2 infection, comorbid diseases, females, non-smokers, and AstraZeneca vaccine receivers showed significantly (p<0.05) more severe side effects. In conclusion, the side effects described by our undergraduate students after receiving vaccinations from Pfizer BioNTech, Oxford AstraZeneca, and Sinopharm are similar to those reported in clinical trials, showing that these vaccines have safe profiles. More research is needed to assess the efficiency of current vaccinations in preventing SARS-CoV-2 reinfections. Copyright © 2022 Marmara University Press.
Redhwan Ahmed Al-Naggar, Hisham Alshaikhli, R. R. Al-Rashidi, and Bahaa Saleh
Hindawi Limited
Background. According to the WHO, glaucoma is the second leading cause of blindness worldwide. About 50% of the world’s glaucoma cases come from the Asian population, and in Malaysia itself, the prevalence of glaucoma is increasing. However, glaucoma is still a foreign word to our community despite the high prevalence. Therefore, there is an urgent need to determine the awareness of glaucoma among the community and its associated factors. Results. This study showed that only 25.2% of our respondents were aware of glaucoma and it is associated with ethnicity, religion, education, and household income. Besides, among those who were aware, they fall into the group of poor knowledge of glaucoma. On the other hand, the knowledge of glaucoma was associated with occupation and the awareness of glaucoma by definition. The validated questionnaire was distributed and the data were analyzed by SPSS software using t-test, one-way ANOVA, and chi-square test. Conclusion. Awareness and knowledge of glaucoma in this population is low. These findings suggest that there is a need for an efficient information and education strategy to be designed and conducted to increase the awareness and knowledge of glaucoma so that early detection can be made and effective management of individuals with this condition can be delivered.