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Green-synthesized silver nanoparticles for antimalarial applications: Toxicity and biocompatibility

Malaria remains a significant global health burden, necessitating the development of novel and effective therapeutic strategies. This study investigates the potential of green-synthesized silver nanoparticles (AgNPs) as a promising antimalarial agent. AgNPs were synthesized using Gongronema latifolium leaf extracts and characterized for their size, shape, and optical properties using XRD, TEM, SEM, EDX, surface plasmon resonance, and particular size. The antimalarial activity of the green-synthesized AgNPs was evaluated in vitro against Plasmodium falciparum, by drug sensitivity testing approach. The study has yet to explore the toxicity and biocompatibility of the synthesized AgNPs in mammalian cells and in vivo models to assess their potential for safe clinical translation. Preliminary results demonstrate the promising antimalarial activity of green-synthesized AgNPs. However, further in-depth investigations are warranted to fully understand the mechanism of action...