Dr. Nikunja Kishor Mishra

@cpspuri.com

Professor and HOD
College of Pharmaceutical Sciences, Baliguali, Puri- 752004, Odisha, India



                 

https://researchid.co/montu100

Dr. Nikunja Kishor Mishra began his career as a research trainee at the R&D division of Natural Remedies Pvt. Ltd., Bangalore. His academic and research journey started in 2008 and has continued at various prestigious pharmacy institutions as Principal/HOD across India. Dr. Mishra has accumulated over 700 Google Scholar citations, with an h-index of 11 and an i10-index of 14. He has successfully guided more than 36 M. Pharm students and has authored 1-text book and 4 book chapters and published 38 research/review papers in various Scopus-indexed journals.
Dr. Mishra has delivered oral presentations at numerous national conferences and serves on the editorial board of 8 scientific journals. In 2022, he was invited as a resource person by the Mahatma Gandhi National Council of Rural Education (MGNCRE), Department of Higher Education, Government of India. He has also been invited to evaluate oral presentations for various organizations. Additionally, Dr. Mishra has organized AICTE-sponsor

EDUCATION

M. Pharm, Ph.D

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Pharmacology (nursing), Pharmacology (medical), Plant Science

FUTURE PROJECTS

Crafting a Traditional Herbal Kadha Powder-A Natural Approach to Wellness

Crafting a Traditional Herbal Kadha Powder: A Natural Approach to Wellness falls under the category of Product Innovation in Herbal and Nutraceutical Formulations. This innovation focuses on transforming age-old traditional knowledge of Ayurvedic decoctions into a convenient, ready-to-use powdered form. By combining natural herbs and spices like tulsi, ginger, cinnamon, turmeric, licorice, clove, fennel, ajwani, mint, black pepper, and mulethi, this formulation preserves the therapeutic benefits of kadha while enhancing shelf life, portability, and ease of preparation. It represents a sustainable and health-oriented approach to preventive care, aligning with the growing consumer demand for immunity-boosting, chemical-free, and natural wellness products in the modern nutraceutical and wellness markets.


Applications Invited
Create job opportunities for the rural and urban communities

Innovation in Herbal Dentifrice for the Removal of Pan, Gutka, and Tobacco Stains

This innovation falls under the category of Product Innovation in the Herbal and Natural Oral Healthcare segment. It introduces a novel herbal-based dentifrice (toothpaste) specifically designed to address a unique oral hygiene concern — the removal of stubborn stains caused by pan, gutka, and tobacco usage. Unlike conventional toothpastes, this formulation leverages the natural cleansing, antibacterial, and whitening properties of herbs, minerals, and plant extracts, making it a safer, sustainable, and culturally relevant alternative to chemical-based products.


Applications Invited
Create job opportunities for the rural and urban communities

Development of Heart-Healthy Herbal Noodles Suitable for Children and Elder

Developing heart-healthy herbal noodles suitable for both children and the elderly falls under the category of product innovation. This type of innovation involves the development of a new or significantly improved food product that addresses specific health concerns—in this case, cardiovascular health. By incorporating medicinal herbs and heart-friendly ingredients like natural preservatives instead of chemical preservatives, this product aims to offer enhanced nutritional benefits while catering to the taste preferences and dietary needs of two vulnerable age groups. Additionally, it may also include aspects of process innovation if new techniques or methods are used in formulation, preservation, or preparation to retain the herbal properties and improve shelf life. This innovative approach aligns with the growing demand for functional and health-promoting foods.


Applications Invited
Create job opportunities for the rural and urban communities
6

Scopus Publications

Scopus Publications

  • INVESTIGATING THE EFFECTS OF POLYHERBAL GEL ON PHENOL-INDUCED ORAL APHTHOUS ULCERS IN RATS
    , Nikunja K. Mishra, Uma Mudi, , Jyotirmayee Behera, , Amiyakanta Mishra, and
    Indian Drug Manufacturers' Association (IDMA)
    Aphthous ulcers, commonly known as canker sores, are among the most widespread oral diseases globally. They typically occur on the non-keratinized mucosal surfaces inside the mouth, including the inner lips, floor of the mouth, and the underside of the tongue. Herbal therapy plays an important role in the healing process of diseases without causing any significant side effects. This study investigates the effects of polyherbal gel (PHG) on phenol-induced oral aphthous ulcers in rats. The rats were randomly assigned to five experimental groups; PHG 5%, 10% and 20% w/V were administered topically to the ulcerated mucosa over a period of seven days respectively. PHG at low, middle and higher dose revealed a significant (P < 0.01) improvement in ulceration healing rate and degree of healing of ulcer area and also diminished the severity of edema and hyperemia located at the ulcer. These findings suggest that PHG may enhance the effectiveness of improving oral aphthous ulceration.

  • Investigation of the Antidepressant Effect of Paederia foetida L. (Rubiaceae) in Methanolic Extract using a Mice Model
    Nikunja Kishor Mishra, Jyotirmayee Behera, Uma Mudi, Amiyakanta Mishra, and Ranjan Kumar Jena
    A and V Publications
    Paederia foetida is recognized as ‘skunkvine’ in English, which is having a varied pharmacological importance in therapeutic purpose. Methanolic extract of leaves of P. foetida was administered orally to the swiss albino mice at the doses of 100, 200 and 400mg/kg for 1, 7 or 14 days. All the doses revealed a significant reduction (P ≤ 0.01) in immobility time in a dose-dependent manner compared to the vehicle control group in tail suspension and forced swimming test respectively. A significant increase in locomotor activity (P ≤ 0.01) was observed at all dose levels following oral administration of the extract, compared to the vehicle control group. However, the extract at a dose of 400mg/kg revealed the greatest reduction in immobility time in both the tail suspension and forced swimming tests, as well as an increase in locomotor activity in mice. These results demonstrated that the methanolic extract of P. foetida leaves possesses antidepressant activity.

  • Current Treatment Process and Challenges for Spinal Muscular Atrophy (SMA)
    Nikunja Kishor Mishra, Amiyakanta Mishra, Pravat Kumar Sahoo, and Rosy Priyadarshini
    A and V Publications
    Spinal muscular atrophy (SMA) presents as a pediatric neuromuscular disorder resulting from mutations in the survival motor neuron 1(SMN1) gene, with an incidence of approximately 10-13 per 100,000 live births. This condition manifests primarily through muscle weakness and atrophy, particularly affecting the proximal limb muscles. A homozygous deletion of exon 7 in the SMN1 gene is the most common genetic mutation in SMA and serves as a sensitive diagnostic marker. This article comprehensively explores various aspects of SMA, including its types, diagnostic methods, and management strategies. Pulmonary care, gastrointestinal (GI) management, nutritional supplementation, orthopedic spinal care, and physiotherapy play crucial roles in delaying disease progression. Current pharmacological treatments for SMA are diverse and evolving. Notable among them is Zolgensma (formerly AVXS-101 or Onasemnogene abeparvovec), a gene replacement therapy utilizing an adeno-associated virus vector to boost functional SMN protein levels. Sodium vanadate, a phosphatase inhibitor, and risdiplam (RO703406) are agents that modulate SMN2 splicing to augment the production of functional SMN protein. Riluzole acts as a neuroprotective agent by preventing SMN deficiency, while reldesemtive (CK-2127107) is under development as a muscle-enhancing therapy to ameliorate skeletal muscle function during fatigue. While pharmacological therapies for SMA are advancing, a holistic approach involving comprehensive multidisciplinary care, encompassing pulmonary support, proper nutritional supplementation, and adept orthopedic management, significantly contributes to the effective management of SMA.

  • Microwave mediated organic reaction: A convenient approach for rapid and efficient synthesis of biologically active substituted 1,3-dihydro-2H-indol-2- one derivatives
    Jnyanaranjan Panda, Biswa Mohan Sahoo, Nikunja Kishor Mishra, Sai Krushna Padhi, and Jitendriya Mishra
    Hindawi Limited
    A simple and efficient method has been developed for the synthesis of 1,3-dihydro-2H-indol-2-one derivatives using microwave irradiation technique. By taking advantage of the efficient source of energy of microwave, compound libraries for lead generation and optimization can be assembled in a fraction of time. In the present work, first the Schiff’s bases are synthesized by reaction of isatin with substituted anilines in the presence of acetic acid under microwave heating. Then the condensation of Schiff bases with different secondary amines in the presence of formaldehyde produces Mannich bases. The newly synthesized Mannich bases were characterized by means of spectral data and then evaluated for anthelmintic activity againstPheretima posthuma(Indian earthworm) and compared with standard albendazole. The compounds were evaluated at the concentrations of 10, 20, and 50 mg/mL. The effect of the standard drug albendazole at 10 mg/mL was also evaluated. The results of the present study indicate that some of the test compounds significantly demonstrated paralysis and also caused death of worms in a dose-dependent manner.

  • Synthesis and screening for antibacterial, analgesic and anti-inflammatory activity of Mannich bases derived from 1H-indole-2,3-dione


  • Evaluation of anti-inflammatory activity and potency of herbal formulation consists of different proportions of Curcuma longa and Boswellia Serrata by using cotton pellet granuloma and xylene induced mice ear edema model


RECENT SCHOLAR PUBLICATIONS

    Publications

    Published a text book: A Textbook of Pathophysiology, LAP- LAMBERT Academic Publishing, German, ISBN: 978-3-659-58013-0 in the month of December-2024.

    Published Book-2013 (Polyherbal mixture in Syrup Base: A better Treatment for Arthritis) in International Publisher (LAMBERT ACADEMIC), Germany having ISBN: 978-3-659-36678-9.

    Published 38 papers in National and International- Scopus index/ ELSEVIER-Science Direct journals with various impact factors.

    RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

    1. Guided 38 PG Students (Pharmacology) for their research works as part of their M. Pharm curriculum under Biju Patnaik University of Technology, Orissa and Andhra University Visakhapatnam, A.P.
    2. Guided more than 84 UG students as part of their graduation under Biju Patnaik University of Technology, Odisha and Andhra University Visakhapatnam, A.P.

    CONSULTANCY

    1. Editorial and Reviewer Board of the “Journal of Comprehensive and Advanced Pharmacology” on Jan 03, 2017.
    2. Prestigious Editorial Board Member of “Journal of Pharmaceutical and Biological Sciences” on Jan 23, 2017.
    3. Editorial Board of the “World Journal of Pharmacy and Pharmaceutical sciences” on Feb 18, 2017.
    4. Selected as an Advisory Board Member in “World Journal of Pharmaceutical and Life Science” on July 18, 2017.
    5. Editorial and Advisory Board Member of “Journal of Bio Innovation” on July 30, 2017.
    6. Associate Editor of “Indian Journal of Research in Pharmacy and Biotechnology” on August 02, 2017.
    7. Prestigious Editorial Board Mem ber of “Advances in Pharmacology and Therapeutic Medicine” on January 09, 2018.
    8. Editorial Board Member of “Indian Journal of Pharmaceutical and Biological Research” on January, 2019.
    9. Dr. Nikunja Kishor Mishra, Head of the Department (HOD) of Pharmacology at CPS, Puri has been an active Editorial Board member of Pharmaceutical Sciences & Analytical Research Journal (PSARJ) effective from September 12, 2024.
    10. Dr. Mishra also has been appointed as a Review Board Member of Acta Scientific Pharmaceutical Sciences, an international open-access journal, effective from September 26, 2024.
    11. Editorial Board Member of Minty Publishers- International Journal of Research in Medical and Health Sciences (IJRMHS) on May 5, 2025.
    12. Editorial Board Member of “World Journal of Advance Pharmaceutical Sciences” on May 11, 2025.

    Industry, Institute, or Organisation Collaboration

    Dr. Nikunja Kishor Mishra was invited as Resource Person by the MGNCRE, Dept. of Higher Education, Govt. of India and was delivered a seminar on the topic “Role of Pharmacist in Social and Community Health Care” on the date 27/02/2022.

    INDUSTRY EXPERIENCE

    1 year

    STARTUP

    MSME Business Incubator (BI) Presently working as a Business Incubator under the MSME at CPS, Puri, supporting innovation and entrepreneurship development
    To establish an excellence in the field of Higher Education functions with social concern and commitment, integrating modern scientific knowledge.
    My students form the core of our existence as an institution, and I want to give wings to their dreams. I expect them to be passionate about their dreams and make their family and society proud of their achievements. It is crucial for the parents to keep reminding their wards to remain focused on their education and to instill in them a sense of responsibility and care towards the concerns of fellow beings. It will give them strength and motivation to work hard for a greater cause in life.
    Also to provide the students an educational environment which is second to none, with a strong commitment to impart quality education in the field of research; provide the highest quality education to students, promote intellectual growth and shape their personal development.

    SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

    National Conference Organized:
    • 14 days AICTE sponsored staff development program, 5th-18th July- 2009 at Roland Institute of pharmaceutical sciences, Berhampur, Odisha.
    • 12 days AICTE sponsored staff development program, 28th-9th July- 2009 to 2010 at Roland Institute of pharmaceutical sciences, Berhampur, Odisha.
    • 11th National IPA Student's Congress, 28th and 29th Feb-2020 at Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam.