SONALI LABHADE
@57192
Assistant Professor
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research,Pimpri, Pune
EDUCATION
PhD Pharmaceutical Sciences, Banasthali Vidyapith, Rajasthan
RESEARCH, TEACHING, or OTHER INTERESTS
Hepatology, Cancer Research, Cell Biology, Chemistry
FUTURE PROJECTS
Molecular glues
Molecular glues represent a promising class of small molecules that facilitate targeted protein degradation, offering novel therapeutic avenues in cancer and tuberculosis (TB) treatment. These compounds work by promoting the interaction between disease-associated proteins and E3 ubiquitin ligases, leading to selective protein degradation. Research has highlighted the potential of molecular glues to address the limitations of traditional therapies, particularly in resistant cancers and persistent TB infections.The exploration of molecular glues is gaining traction, with ongoing studies aiming to further elucidate their mechanisms and optimize their efficacy for clinical applications in oncology and infectious diseases
Applications Invited
Collaborators for research work.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Smita Jain, Ritesh Bhole, and Sonali Labhade
Wiley
AbstractAge‐related dementia is mostly brought on by Alzheimer's disease (AD). As of right now, there are no effective treatments to halt, slow down, or reverse the progression of the illness. Dietary bioactive phytochemicals, particularly flavonoids, have been shown in many studies to impact the pathophysiological mechanisms behind AD. When combined with other medicines, flavonoids are an effective treatment for neurodegenerative disorders. Microtubulin is also a major target in biology for the development of anti‐Alzheimer's drugs linked to the tau protein, which is mostly found in axons and is hyperphosphorylated in AD, perhaps due to the production of pro‐inflammatory cytokines. In this work, 191 flavonoids' in silico ADMET characteristics were analyzed, and then molecular docking was performed using Tubulin protein's VP7 binding site (Id 7jxx). To further examine the stability of the protein‐ligand complex, the best conformation from each flavonoid subcategory with the highest docking score was exposed to 100 ns of molecular dynamics. Using molecular dynamic investigations, several parameters for the four flavonoids were computed, including RMSD, RMSF, rGy, and SASA. There is compelling evidence from this in silico research using molecular docking and molecular dynamics simulation that flavonoids are good anti‐micro‐tubulin drugs for treating AD.
Sonali Labhade, Ritesh Bhole, Pawan Karwa, Harshad Kapare, and Subhashini Singh
Springer Science and Business Media LLC
Arati Patil, Nagesh Aloorkar, Anand Kakde, Sonali Labhade, and Aniket Garud
Agricultural Research Communication Center
Background: The poultry industry generates vast amounts of waste, including eggshells, which can be utilized as a source of nanohydroxyapatite (nHAp). This sustainable approach can reduce waste disposal costs, minimize environmental pollution and provide valuable biomaterials for various applications. Methods: Indian Hen eggshells, hybrid Hen eggshells and a commercially available nHAp sample (as a reference) were used in this study. The biologically derived nHAp samples were synthesized via a precipitation method and the antioxidant activity and cytotoxicity of the nHAp samples were evaluated via the DPPH (1,1-Diphenyl-2-picrylhydrazyl) assay and MTT (Cell sensitivity) assay, respectively. Result: The results of the DPPH assay revealed that 3.125 μg/mL ascorbic acid was equivalent to 250 μg/mL Indian Hen eggshell-derived nHAp (IE1), whereas 1.56 μg/mL ascorbic acid was equivalent to 50 μg/mL hybrid Hen eggshell-derived nHAp (HE1). The reference sample showed that 0.78 μg/mL ascorbic acid was equivalent to 1 μg/mL ascorbic acid. The MTT assay revealed that all three nHAp samples were noncytotoxic and presented varying IC50 values (IE1: 1797 μg/mL, HE1: 1348 μg/mL, reference: 1972 μg/mL), indicating potential suitability for biomedical applications.
Pawan Karwa, Atharva Kharul, Vaibhav Parekar, Sonali Labhade, Nikhil Sakle, Ritesh Bhole, and Harshad Kapare
Springer Science and Business Media LLC
Harshad S. Kapare, Mayuri Bhosale, Pawan Karwa, Deepak Kulkarni, Ritesh Bhole, and Sonali Labhade
MDPI AG
Objective: This study aimed to develop eco-friendly zinc oxide nanoparticles (ZnO NPs) using Punica granatum (pomegranate) peel extract and to evaluate their antioxidant, antimicrobial, and photoprotective potential. Method: ZnO NPs were synthesized via a green chemistry route employing polyphenol- and flavonoid-rich peel extract as reducing and stabilizing agents. The nanoparticles were characterized using FTIR, SEM, XRD, DSC, DLS, and UV–Vis spectroscopy. Biological activities were assessed through in vitro assays including antioxidant (DPPH), anti-collagenase, anti-elastase, anti-tyrosinase, antimicrobial activity, and SPF determination. In vivo photoprotective efficacy was further evaluated in UVB-irradiated rat models, with histological analysis to confirm structural skin changes. Results: The optimized ZnO NPs exhibited an average particle size of ~194 nm with a zeta potential of −18.2 mV, indicating good stability. They demonstrated notable antioxidant activity (DPPH IC50 = 52.91 µg/mL), substantial tyrosinase inhibition (72% at 200 µg/mL), and antibacterial activity with inhibition zones up to 19 mm against S. aureus and 17 mm against E. coli. The nanoparticles also showed excellent UV absorption, with an SPF value of 29.8, exceeding the FDA threshold for effective sun protection. In vivo, topical application of ZnO NPs in UVB-exposed rats led to a 69% reduction in epidermal thickness and preservation of collagen fibers compared with UV controls. Conclusions: These findings confirm that P. granatum peel extract–mediated ZnO NPs possess significant antioxidant, antimicrobial, and photoprotective activities.
Chinchu Praisthy L J, Ravi Kushwah, Sachin Dubey, Sonali Labhade, Pawan Karwa, and Smita Jain
Elsevier BV
Ritesh Bhole, Jagruti Shinkar, Sonali Labhade, Pawan Karwa, and Harshad Kapare
Springer Science and Business Media LLC
Ritesh Bhole, Harshad Kapare, Pawan Karwa, and Sonali Labhade
Egyptian Knowledge Bank
Karishma Rathi, Sonali Labhade, Nayana S. Jayachandran, and Tanvi Sarode
BSP Books Private Limited
Medication Error (ME) is a preventable event that is caused due to inappropriate medication use, leading to patient misery while the drug is being regulated by healthcare specialists or end-users. The aim of this study is to become acquainted with medication errors and their types: Prescribing, Administering Dispensing, Monitoring errors and the role of clinical pharmacist in preventing medication errors. A thorough analysis of the literature on MEs by referring to electronic databases such as Embase, Pubmed, EBSCO, Web of Science, Science Direct, Google Scholar, Medline, PsycINFoand Scopus. From the study, it was found that medication errors are prevalent throughout the world and are mostly due to human errors that can be avoided. The various types of medication errors taking place in India as well as other countries were identified and the causes of these errors were assessed. The role of clinical pharmacist was found to play an important role in preventing medication errors by providing ward-based clinical pharmacist’s services, educating nursing staff regarding proper drug administration, bar code assisted drug administration, using health information technology (HIT) and proper follow-up. The remedy to reduce ME is to identify the problems and their causes and then implement solutions through clinical pharmacist services rather than accusing, degrading, and gruelling staff. It is also necessary to create a safe work environment by working on the development of a system for better tracking and record keeping of errors and looking at ME as a challenge that has to be conquered. Also all healthcare settings and hospitals need to consider having a clinical pharmacist in their system.
Atharva Kharul, Umesh Bargal, Pawan Karwa, Ritesh Bhole, and Sonali Labhade
BSP Books Private Limited
Ritesh P. Bhole, Sonali Labhade, and Shilendra S. Gurav
Informa UK Limited
PROTACs are reshaping drug discovery by enabling targeted protein degradation, overcoming the limitations of traditional inhibitors, and addressing previously "undruggable" proteins. The present perspective explores advancements in PROTAC molecular design, focusing on ligand discovery, E3 ligase recruitment, and ternary complex optimization. Integrating AI-driven modeling, FBDD, and SBDD accelerates PROTAC development. In contrast, emerging innovations, such as PHOTACs, hypoxia-responsive systems, and Ab-PROTACs, enhance precision and reduce systemic toxicity. Clinical successes, including ARV-110 for castration-resistant prostate cancer and ARV-471 for breast cancer, exemplify their ability to overcome resistance and provide durable effects. PROTACs are expanding into neurodegenerative diseases and rare conditions, highlighting their versatility. By addressing challenges in pharmacokinetics, safety, and scalability, PROTACs are poised to revolutionize precision medicine. This article presents a forward-looking perspective on conquering the molecular design and drugability of PROTACs, paving the path for transformative therapies.
Sonali Labhade, Pranali Jadhav, Ritesh Bhole, and Sohan Chitlange
Bentham Science Publishers Ltd.
<i>Punica granatum</i> L. (Punicaceae) generally identified as pomegranate, seeded or granular fruit, has been widely used for centuries in many cultures. P. granatum exhibits a wide variety of medicinal activities, viz., anticancer, antioxidant, antimicrobial, anti-inflammatory, etc. A variety of ethnomedical uses of <i>P. granatum</i> in several formulations, like powder, pulp, decoction and extract on its own or in blend with additional herbs against various diseases, like inflammation, skin disorders, cancer, microbial infections, and asthma, have been recorded. A wide variety of phytochemicals, including polyphenols, terpenoids, fatty acids, sugars, amino acids, tocopherols, sterols, alkaloids, amino acids, etc., have been isolated and identified from P. granatum, amongst which punicalagin, the major polyphenolic component of pomegranate extract, has been well thought of as the main effective component of plant. Thorough information related to P. granatum was gathered using the keywords Punica granatum or pomegranate in various computerized databases, including Pubmed, ACS, Science Direct, Google Scholar, WoS, Springer Link, Sci Finder, and Wiley. All full-text articles and abstracts were reviewed. Additionally, book chapters and monographs were also screened. The current study has highlighted the botany, ethnopharmacology, phytochemical profile, pharmacological activity, and toxicological studies of <i>P. granatum</i>. The ethnopharmacological importance of pomegranate has been discussed in recent pharmacological studies, indicating its medicinal and nutritional benefits in varied human disorders. Moreover, inquiries related to various facets of <i>P. granatum</i> relating to safety, toxicity and quality control are yet unanswered. Additionally, the article has provided a thorough knowledge of the herb, including its mechanism of action, structure activity relationships, safety as well as toxicity, as reported in clinical studies.
Ritesh P. Bhole, Gayatri S. Maldhure, Harshad S. Kapare, Sonali D. Labhade, and Shailendra S. Gurav
Bentham Science Publishers Ltd.
Abstract: Sodium‒glucose cotransporter 2 (SGLT2) inhibitors have become viable therapeutic options for treating breast cancer. Diabetes is the primary source of these medications. This research examines how SGLT2 blockers can induce apoptosis, decrease the amount of glucose taken up by cancer cells, and modify key signaling pathways, such as the PI3K/AKT/mTOR and MAPK pathways. The effects of four different SGLT2 inhibitors on breast cancer cells were investigated in this study via both in vitro and in vivo testing: dapagliflozin, ipragliflozin, canagliflozin, and empagliflozin. The potential synergistic effects of these inhibitors with conventional chemotherapy medications were also examined. This review explores the complex relationship between SGLT2 inhibitors and breast cancer, examining how drugs interact with this disease at various stages of its development. Additionally, this study highlights how SGLT2 inhibitors may be used in conjunction with precision medicine techniques to treat breast cancer. Although encouraging outcomes have been noted, this review highlights the necessity of additional clinical studies to evaluate the safety and effectiveness of SGLT2 blockers in patients with breast cancer, in addition to ongoing research into the molecular mechanisms underlying the anticancer effects of these drugs.
Ritesh P. Bhole, Nishigandha kadam, Pawan N. Karwa, Sonali D. Labhade, Harshad S. Kapare, and Shailendra Gurav
Springer Science and Business Media LLC
Sonali Labhade, Ritesh Bhole, and Smita Jain
Hong Kong Academy of Medicine Press
This review aims to determine the role of S-adenosylmethionine (SAMe) supplementation as an alternative therapeutic option, particularly for individuals with inadequate responses to conventional antidepressive treatments. The effects of SAMe on depression are analysed through its role in modulating neurotransmitter metabolism, reducing neuroinflammation, enhancing neuroplasticity, and regulating gene expression. These mechanisms may contribute to the efficacy of SAMe in treating depression, particularly in treatment-resistant cases. The review also addresses SAMe's potential use in managing other psychiatric disorders and neurological diseases.
Sonali D Labhade, Harshad S Kapare, Juilee S Jagtap, Sohan S Chitlange, and Karishma M Rathi
IP Innovative Publication Pvt Ltd
Fungal skin infections are a prevalent health issue that requires investigation into safe and efficient alternative remedies. Herbal components are a good option for cosmetics formulations because they have historically shown antifungal capabilities. Building on this idea, the research seeks to create a novel antifungal herbal bath bomb by utilizing the medicinal properties of plants.The aim of this project is to develop evaluate a herbal bath bomb, with an emphasis on its antifungal qualities. The main goal is to create a bath bomb with carefully chosen herbal elements that have been suggested to have antifungal properties.The study employed a systematic approach to construct the herbal bath bomb, including a variety of herbal ingredients recognized for their antifungal properties. Precise measurement and blending were necessary during the material preparation process to ensure optimal efficacy. The effectiveness of the herbal bath bomb against common fungus strains was evaluated in the lab along with antifungal testing.The results reveal promising antifungal properties of the developed herbal bath bomb, as evidenced by its efficacy against common fungal strains. This study contributes valuable insights into the potential of herbal-based hygiene products for combating fungal skin conditions. The findings support the conclusion that the formulated bath bomb holds promise as a natural and effective solution, paving the way for further exploration and development in the realm of herbal skincare products.
Sonali Labhade, Smita Jain, Sohan Chitlange, Sarvesh Paliwal, and Swapnil Sharma
Elsevier BV
Sonali Dnyaneshwar Labhade, Swapnil Sharma, Sarvesh Paliwal, and Shivani Desai
College of Pharmacy University of Baghdad
In folk medicine there are various medicinal amalgamation possessing hepatoprotective activity. This activity is of significance because several toxins cause liver injury. Hence, many pharmaceutical companies are targeting herbal medicines for the treatment of liver abnormalities and towards evolving a safe and effective formulation with desired route of administration. In current review we have focused on the studies showing hepatoprotective effect using marine compounds and plant derived compounds. Liver disorder, a global health problem, usually include acute or chronic hepatitis, heptoses, and cirrhosis. It may be due to toxic chemicals and certain antibiotics. Uncontrolled consumption of alcohol also affects liver in an unhealthy way. To cure liver disorders several formulations of medicinal plants are being used. It is observed that hepatoprotective effect of plant is mostly due to flavonoids, alkaloids, terpenoids, steroids, and glycoside. A single drug cannot be useful for all the types of liver disorders. Several plant extracts for liver illness results from poisonous chemicals, viruses, extra alcohol consumption, and repeated administration of medication. By using standards of protection and efficacy, manufacture of plant products need to be ruled out. Current review provides an understanding of ethnopharmocology, toxicology of several medicinal plants manifesting hepatoprotective potential. Despite of varied database analysis new discoveries and their probabilities, evidences on viral hepatitis treatment or liver cirrhosis is inadequate. Further information about phytotherapy, toxicology, quality control studies shall be endorsed. Further in depth studies are required to discover quality trait like SAR, MOA, safety and toxicity and therapeutic potential of phytoconstituents in clinical settings.
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
Publications
Research Paper Entitled “Spectrophotmetric Determination and Validation of Glimeperide Concentration in Bulk and Dosage Form” In American Journal of Pharmatech Research, 2015; 5(3):208-13. (Impact Factor: 0.9832).
Research Paper entitled “Formulation and Evaluation of Carvedilol loaded Solid Lipid Nanoparticles” In International Journal of Scientific Progress &Research (IJSPR), 2015; 13(2): 74-78. (Impact factor:1.815)
Research Paper entitled “Development and Validation of RP-HPLC Method for Simultaneous Determination of Diclofenac Sodium and Tizanidine Hydrochloride in bulk and Tablet Formulation” In International Journal of Scientific Research in Science and Technology (IJSRST) 2018; 4(2) Page: 1413-1417.
Review article entitled “Biopolymer Conjugated Protein Based Hydrogel Scaffolds for Tissue Engineering Application” in International Journal of Pharmacy and Pharmaceutical Research, Jan 2020, 17(2) Page: 286-316.
10. N-butanol fraction of Decalepis hamiltonii root shows potential to possess antiproliferative activity and combat oxidative damage in European Chemical Bulletin 2023; 12(5) 3896-3923.
11. Development And Validation of Rp-Hplc Method For Assay of Fluticasone Furoate From Nasal Spray Formulation in European Chemical Bulletin 2023; (Special Issue 1) 2543-2555.
12. S. D. Labhade, S. Jain, S. S. Chitlange, S. Paliwal, S. Sharma, “Decalepis hamiltonii root fraction alleviates CCl4 hepatotoxicity in a rat model via inhibiting oxidative stress, proinflammatory cytokin
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Patent on Synthesis of PROTAC derivatives as anticancer agents
Publication date: 09/08/2024