Trupti N Patel
@vit.ac.in
Professor & Head, Department of Integrative Biology
VIT, Vellore
Highly motivated Cancer Biologist and an Academician with a drive to conduct superior research and inspire people to pursue personal and professional excellence. Academically engaged in generating skilled and perennial learners by stimulating creative learning environment while being committed to pursuing and achieving outstanding research milestones. Over 25 years of teaching and research experience and associations with global scientific community.
EDUCATION
PhD (Life Sciences) Submitted - December 2000
Defended - June 2001
Awarded - March 2002
Title of Research – “Ameliorative effects of some antidotes on Aluminum chloride and Sodium fluoride toxicity in female mammals”
Duties and Responsibilities - June 1996-May 2001 under Sir Dorabji Tata Scholarship - Research: School of Sciences, Dept. of Zoology-Gujarat University - Toxicology and Genotoxicity; Cytogenetic Diagnostics and Counseling at UGC-COSIST Sponsored Human Cytogenetics Clinic; Academic: Assisting Laboratory Classes in Cytogenetics, Physiology, Biochemistry and Biomedical Science.
RESEARCH, TEACHING, or OTHER INTERESTS
Cancer Research, Toxicology, Molecular Biology, Multidisciplinary
FUTURE PROJECTS
Microsatellite instability across various tumor types: diagnostic criteria, methods of detection and bio-clinical associations
Microsatellite instability (MSI) is a specific molecular tumor phenotype recognized by accumulation of mutations in microsatellites. Microsatellites are repetitive DNA sequences consisting of 1-6 nucleotides. MSI is caused by defective DNA mismatch repair, resulting from hereditary or somatic mutations in the MLH1, MSH2, MSH6, PMS2 genes or hypermethylation of the MLH1 promoter. MSI is most often observed in the uterine cancer (≈ 30%), gastric cancer (≈ 20%), colon cancer (≈ 15%) and rectal carcinomas (≈ 6%) and is much less common in other tumor types. MSI testing has become particularly relevant after the establishment of the predictive role of MSI for the efficacy of immune checkpoint inhibitors, one of the most promising and widely used therapeutic agents in oncology today.
Applications Invited
DNA Diagnostics
Scopus Publications
Scopus Publications
Biji C. L, Trupti Patel, Devyani Charan, Mangalam Goutam Sinha, Rupaak S, Medhansh Jain, Ashutosh Bhardwaj, Annanya Gupta, Dheeba J, Athira K,et al.
Elsevier BV
Lucky Parida and Trupti N. Patel
Wiley
ABSTRACT This study investigates the role of lead toxicity in carcinogenesis by analyzing genetic and molecular mechanisms using computational methods. Researchers identified four core genes ( FUS , NAMPT , RBBP4 , WEE1 ) that interact with DNA repair proteins (PARP1, XRCC5, XRCC6, BRCA1) using functional enrichment techniques, STRING‐based protein networks, and GEO microarray datasets. COSMIC identified 62 nsSNPs in these genes linked to cancer; mutations in these genes may destabilize proteins and prevent DNA repair, which, over time, may promote cancer‐related traits. Lead had a strong binding affinity to these targets, according to protein–metal docking simulations, even though six curcumin derivatives from Curcuma species (bisacurone, EF31, UBS109, and compounds 3/88/91) showed protective benefits by stabilizing wild‐type and mutant proteins. Using GROMACS and molecular dynamics, compounds 88 ( Curcuma caesia ) and UBS109 ( Curcuma longa ) were identified as promising candidates for mitigating lead‐induced dysfunction. According to this study, curcumin derivatives are useful stabilizers of proteins targeted by lead, providing a novel approach to reducing the carcinogenicity associated with heavy metals.
Apurwa Mishra and Trupti N. Patel
Springer Science and Business Media LLC
Anjana Jadhav, Aravind J, and Trupti Patel
Springer Science and Business Media LLC
Abstract Oncolytic viruses (OVs) possess the distinctive capability to selectively eliminate malignant cells while exerting reduced impact on healthy tissues compared to traditional therapies. This unique attribute renders them valuable candidates for the development of anti-cancer therapeutics. The recognition of OVs dates to historical observations of tumor regression associated with systemic viral infections. Current advancements in technology enable us to harness this knowledge for therapeutic purposes. However, owing to their inherent pathogenic nature, OVs require genetic modifications to attenuate their virulence, heighten their specificity, and enhance their immunogenic properties. Within the scope of this review, we explore a range of strategies aimed at augmenting the therapeutic potential of OVs. Furthermore, we underscore the synergistic advantages achieved by combining OVs with other cancer treatment modalities. A detailed elucidation of the oncolytic mechanism executed by OVs is provided, and brief mentions are made regarding the positive outcomes observed in clinical trials involving selected OVs. Recent progress in oncolytic viral immunotherapy, exemplified by the utilization of non-infectious Plant virus-based Nanoparticles (PVNPs) in mammals and the application of the Zika virus in glioblastoma treatment, heralds a promising era for innovative therapeutic approaches in the battle against cancer. Graphical Abstract
Apurwa Mishra and Trupti N. Patel
Springer Science and Business Media LLC
Shrikirti Anand and Trupti N. Patel
Springer Science and Business Media LLC
AbstractThe progressive globalization of sedentary lifestyles and diets rich in lipids and processed foods has caused two major public health hazards—diabetes and obesity. The strong interlink between obesity and type 2 diabetes mellitus and their combined burden encompass them into a single term ‘Diabesity’. They have also been tagged as the drivers for the onset of cancer. The clinical association between diabetes, obesity, and several types of human cancer demands an assessment of vital junctions correlating the three. This review focuses on revisiting the molecular axis linking diabetes and obesity to cancer through pathways that get imbalanced owing to metabolic upheaval. We also attempt to describe the functional disruptions of DNA repair mechanisms due to overwhelming oxidative DNA damage caused by diabesity. Genomic instability, a known cancer hallmark results when DNA repair does not work optimally, and as will be inferred from this review the obtruded metabolic homeostasis in diabetes and obesity creates a favorable microenvironment supporting metabolic reprogramming and enabling malignancies. Altered molecular and hormonal landscapes in these two morbidities provide a novel connection between metabolomics and oncogenesis. Understanding various aspects of the tumorigenic process in diabesity-induced cancers might help in the discovery of new biomarkers and prompt targeted therapeutic interventions. Graphical Abstract
Lucky Parida and Trupti N. Patel
Springer Science and Business Media LLC
Sayak Mitra, Priyanjali Bhattacharya, Shampa Sen, and Trupti N. Patel
Elsevier
Priyanjali Bhattacharya and Trupti N. Patel
Springer Science and Business Media LLC
Pavan Kumar Dhanyamraju, Solomon Rotimi, Priyanjali Bhattacharya, and Trupti N. Patel
Springer Science and Business Media LLC
Trupti N. Patel and Pavan Kumar Dhanyamraju
Journal of Biomedical Research
Pavan Kumar Dhanyamraju and Trupti N. Patel
Journal of Biomedical Research
Priyanjali Bhattacharya and Trupti N. Patel
Springer Science and Business Media LLC
AbstractPlant derived products have steadily gained momentum in treatment of cancer over the past decades. Curcuma and its derivatives, in particular, have diverse medicinal properties including anticancer potential with proven safety as supported by numerous in vivo and in vitro studies. A defective Mis-Match Repair (MMR) is implicated in solid tumors but its role in haematologic malignancies is not keenly studied and the current literature suggests that it is limited. Nonetheless, there are multiple pathways interjecting the mismatch repair proteins in haematologic cancers that may have a direct or indirect implication in progression of the disease. Here, through computational analysis, we target proteins that are involved in rewiring of multiple signaling cascades via altered expression in cancer using various curcuma derivatives (Curcuma longa L.andCurcuma caesia Roxb.) which in turn, profoundly controls MMR protein function. These biomolecules were screened to identify their efficacy on selected targets (in blood-related cancers); aberrations of which adversely impacted mismatch repair machinery. The study revealed that of the 536 compounds screened, six of them may have the potential to regulate the expression of identified targets and thus revive the MMR function preventing genomic instability. These results reveal that there may be potential plant derived biomolecules that may have anticancer properties against the tumors driven by deregulated MMR-pathways.
Pavan Kumar Dhanyamraju, Trupti N. Patel, and Sinisa Dovat
Springer Science and Business Media LLC
Trupti N. Patel, Priyanka R., Yash Vashi, and Priyanjali Bhattacharya
Informa UK Limited
Divya Chandel, Pratibha Rathod, Trupti Patel, and Ajesh Desai
Medknow
Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran,et al.
Ferrata Storti Foundation (Haematologica)
Priyanjali Bhattacharya, Pavan Kumar Dhanyamraju, Ankita Sarmah, Mohana Priya Jay, Chris Maria Jose, Sayali Dbritto, Showmeya Mallavarapu, and Trupti N. Patel
Elsevier BV
Trupti N. Patel and Priyanjali Bhattacharya
BENTHAM SCIENCE PUBLISHERS
Fatemeh Rahimi Gharemirshamlu, Maliha Afsar, Taseem A. Mokhdomi, Asif Amin, Shoiab Bukhari, Anbarasu Krishnan, Chundi Vinay Kumar, Kourosh Bamdad, Trupti N. Patel, Raies A. Qadri,et al.
Wiley
AbstractFollicle‐stimulating hormone‐follicle‐stimulating hormone receptor (FSH‐FSHR) interaction is one of the most thoroughly studied signaling pathways primarily because of being implicated in sexual reproduction in mammals by way of maintaining gonadal function and sexual fertility. Despite material advances in understanding the role of point mutations, their mechanistic basis in FSH‐FSHR signaling is still confined to mystically altered behavior of sTYS335 (sulfated tyrosine) yet lacking a substantial theory. To understand the structural basis of receptor modulation, we choose two behaviorally contradicting mutations, namely S128Y (activating) and D224Y (inactivating), found in FSH receptor responsible for ovarian hyperstimulation syndrome and ovarian dysgenesis, respectively. Using short‐term molecular dynamics simulations, the atomic scale investigations reveal that the binding pattern of sTYS with FSH and movement of the thumb region of FSHR show distinct contrasting patterns in the two mutants, which supposedly could be a critical factor for differential FSHR behavior in activating and inactivating mutations.
S.V. Madhunapantula, T.N. Patel, C. Annageldiyev, and A. Sharma
Elsevier
T.N. Patel, S.V. Madhunapantula, C. Annageldiyev, D.C. Claxton, and A. Sharma
Elsevier
Mukunthan K S, Balaji B, and Patrl Tn
Innovare Academic Sciences Pvt Ltd
Objective: Most species have their trademark metabolites or a class of chemicals that are generally disseminated inside the genus variety. Secondary metabolites from the black turmeric are predominantly camphor, terpenes, lactones, alkaloids, and phenols classification. A database was constructed with the predicted absorption, distribution, metabolism, elimination, and toxicity, druglikeliness, and physiochemical properties of the exclusive black turmeric 103 compounds. Methods: The interface has been designed using Microsoft Structured Query Language platform, keeping in mind the ease of use for a researcher. To support this, the entire set of chemicals and their properties was uploaded in database. Database is used as it is very efficient and supports multiple users at the same time.Results: Black turmeric database gives complete data of compounds by means of 4 segments. Physiochemical, pharmacodynamics, pharmacokinetics, druglikeliness, and molecular information are displayed with chemical structure.Conclusion: We solidly believe that the information from this database are the sources to infer novel pharmaceutical chemical compounds for medication.
Priyanjali Bhattacharya and Trupti N. Patel
Informa UK Limited
Trupti N. Patel, Richa Vasan, Manjari Trivedi, Manali Chakraborty, and Priyanjali Bhattacharya
Brieflands