wassanm.husein
Verified @gmail.com
physiology
Medical College, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq
RESEARCH, TEACHING, or OTHER INTERESTS
Physiology, Animal Science and Zoology, General Biochemistry, Genetics and Molecular Biology, Biochemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Wassan Mhammed Husain, Israa J. Mohammad, and Dahlia N Al-Saidi
ResearchersLinks Ltd
Wassan Mhammed Husain, Raghad Raad Hwidyii, and Ali Mosa Rashid Al-Yasari
ResearchersLinks Ltd
Mohammed Hayder Asker, Noor AL‐Huda Salah AL‐Zuhairy, Wassan Mhammed Husain, and Mustafa Riyadh Abdullah
Wiley
AbstractBackgroundThere are many forms of anabolic steroids, including stanozolol (Winstrol), which are popular for their muscle‐building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacologica impact of allicin, a natural attribute obtained from garlic, on obstructing cardiac injury in rabbits that received stanozolol.MethodsThirty rabbits were divided into three groups: control, stanozolol‐treated, and stanozolol plus allicin. Cardiac function was assessed by measuring troponin, creatine kinase (CK), Galectin‐3, and GDF‐15. Oxidative stress and antioxidant markers, including malondialdehyde (MDA), glutathione, and catalase, were analyzed. Inflammatory mediators such as C‐reactive protein (CRP), interleukin‐6 (IL‐6), NF‐κB, iNOS, nitric oxide (NO), tumor necrosis factor‐alpha (TNF‐α), and interleukin‐1 beta (IL‐1β) were evaluated. Lipid profile parameters, including total cholesterol, low‐density lipoprotein (LDL), and high‐density lipoprotein (HDL), were measured. Histopathological examination assessed myocardial damage, fibrosis, and collagen deposition.ResultsStanozolol administration significantly increased cardiac damage markers, oxidative stress, and inflammatory mediators while causing dyslipidemia, characterized by elevated LDL and total cholesterol and reduced HDL. Allicin co‐administration effectively countered these effects by reducing oxidative stress and inflammation, restoring antioxidant balance, and improving lipid profiles. Histopathological analysis revealed severe myocardial disorganization, necrosis, and fibrosis in the stanozolol group, whereas the allicin‐treated group exhibited preserved myocardial structure with reduced collagen deposition.ConclusionAllicin significantly mitigates stanozolol‐induced cardiotoxicity by reducing oxidative stress, inflammation, lipid dysregulation, and myocardial damage, as evidenced by biochemical and histopathological findings. These results suggest that allicin may serve as a potential therapeutic agent to counteract the cardiovascular risks associated with anabolic steroid use.
Wassan Mhammed Husain and Zainab Sattar Ali
ResearchersLinks Ltd
Wassan Mhammed Husain, Jawad Kadhim Araak, and Orooba Mohammed Saeed Ibrahim
ResearchersLinks Ltd
| In our study, ZnONPs was prepared and characterized for investigation of pituitary-testes axis function in adult male rats. Fifty healthy adult male rats selected, weighted 300 ± 50 gm, randomly divided to five group each group have ten animals. One of them group consider as control group and other four group designed as (G1, G2, G3 and G4) group which receive oral dose of ZnONPs in different concentration (5, 10, 20 and 40 mg/kgB.W) respectively for 56 day. Blood samples were collected via cardiac puncture for serum collection in (zero time, 28 and 56 day of experiment). The results showed significant (P<0.05) elevation of testosterone and FSH hormones concentration in G3 and G4 after 56 day of experimental period as a compared with zero time and 28 day of experiment, whereas LH and inhibin B hormones concentration showed a significant (P<0.05) decrement in all group at 56 day as a compared with control group and other period time. Histological study of testes and pituitary gland showed different pathological changes on these two gland’s tissue and cells as mild to severe effects especially at dose (20 and 40 mg/kg B.W). Histometric study of seminiferous tubules illustrated a significant (P<0.05) elevation of seminiferous tubules diameters in G4 group, whereas showed non-significant (P˃0.05) differences in number of interstitial cells in treated groups.