Sultan Funda GÖRKEM
@eskisehir.edu.tr
Chemistry Department/ Faculty of Science
Eskişehir Technical University
RESEARCH INTERESTS
Organic Synthesis, Computational Chemistry, Electrochemistry, Organic Electronics
Scopus Publications
Scopus Publications
Sultan Funda Ekti, Merve Akış, and Uğur Öner
Wiley
Recep Isci, Melis Unal, Gizem Kucukcakir, Naime A. Gurbuz, Sultan F. Gorkem, and Turan Ozturk
American Chemical Society (ACS)
A wide series of 10 new triphenylamine (TPA)/4,4'-dimethoxytriphenylamine (TPA(OMe)2)-functionalized thieno[3,2-b]thiophene (TT) fluorophores, 4a-e and 5a-e, bearing different electron-donating and electron-withdrawing substituents (-PhCN, -PhF, -PhOMe, -Ph, and -C6H13) at the terminal thienothiophene units were designed and synthesized by the Suzuki coupling reaction. Their optical and electrochemical properties were investigated by experimental and computational studies. Solid-state fluorescent quantum yields were recorded to be from 20 to 69%, and the maximum solution-state quantum efficiency reached 97%. Moreover, the photophysical characterization of the novel chromophores demonstrated a significant Stokes shift, reaching 179 nm with a bathochromic shift. They exhibited tuning color emission from orange to dark blue in solution and showed fluorescence lifetime reaching 4.70 ns. The relationship between triphenylamine (TPA)/4,4'-dimethoxytriphenylamine (TPA(OMe)2)-derived triarylamines and different functional groups on thieno[3,2-b] thiophene units was discussed.
Gaiëlle Sonfack, Cedric Fossi Tchinda, Ingrid Konga Simo, Gabin Thierry M. Bitchagno, Blaise Kemajou Nganou, İlhami Çelik, Mathieu Tene, Sultan Funda Görkem, Till Opatz, Veronique Penlap Beng,et al.
Informa UK Limited
An unprecedented saponin is being reported herein together with five known compounds from the methanol extract of the roots of Albizia adianthifolia. The metabolites were obtained over repeated open column chromatography methods and spectroscopic followed by spectrometric techniques. The isolated compounds were tested against eleven Gram-negative bacteria including multidrug resistant strains. The results revealed considerable inhibition of the new saponin against the studied bacteria with MIC values ranging from 16 to 128 μg/mL.
Recep Isci, Emine Tekin, Kerem Kaya, Selin Piravadili Mucur, Sultan Funda Gorkem, and Turan Ozturk
Royal Society of Chemistry (RSC)
TPE units at the periphery of two TTs and a DTT affect the structures, properties and OLED characteristics of these three synthetically easily accessible novel conjugated compounds for materials chemistry.
Cedric F. Tchinda, Gaiëlle Sonfack, Ingrid K. Simo, İlhami Çelik, Igor K. Voukeng, Blaise K. Nganou, Gabin T. M. Bitchagno, Sultan Funda Ekti, Mathieu Tene, Pierre Tane,et al.
Springer Science and Business Media LLC
BackgroundAlbizia adianthifolia (Schum.) is medicinally used in Cameroon to manage bronchitis and skin diseases. Our previous study documented the antibacterial potential of its roots’ methanol extract. In this study, methanol roots extract was subjected to chromatography techniques and fractions (AARa and AARb), sub-fractions (AARa1–4, AARb1–2 and AARb11–14) together with isolated phytochemicals were assessed for their antimicrobial as well as their antibiotic-potentiating effects towards Gram-negative multidrug resistant (MDR) bacteria.MethodsThe antibacterial activities of the samples (determination of Minimal Inhibitory « MIC » and Minimal Bactericidal Concentration « MBC ») were determined by the modified rapid p-iodonitrotetrazolium chloride (INT) colorimetric assay, as well as those of antibiotics in association with the compounds. Column chromatography was applied to isolate phytochemicals from roots extract and their chemical structures were determined using spectroscopic techniques.ResultsThe phytochemicals isolated were stearic acid (1), a mixture (1:1) of stigmasterol and β-sitosterol (2 + 3), β-sitosterol 3-O-β-D-glucopyranoside (4), palmatin (5), homomangiferin (6) and mangiferin (7). Fraction AARa exhibited selective inhibitory effects whilst all tested bacteria were inhibited by AARb in MIC ranges of 8 to 1024 μg/mL. Sub-fractions AARb1–2 had MIC values between 8 μg/mL and 1024 μg/mL on all tested bacteria. Phytochemicals 4, 2 + 3 and 7 inhibited the growth of 54.54% (6/11), 45.45% (5/11) and 27.27% (3/11) tested bacterial strains, respectively. When tested with an efflux pumps inhibitor (Phenylalanine-Arginine-β-Naphthylamide or PAβN), the inhibitory effects of compounds 2 + 3 and 4 increased towards all the tested bacteria. In association with erythromycin (ERY), streptomycin (STR) and tetracycline (TET), compounds 2 + 3 and 4 had the most significant synergistic activity on the seven selected bacteria.ConclusionThe present study provides information on the possible use of Albizia adianthifolia and its constituents in the control of Gram-negative infections including MDR phenotypes.
Deniz Hür, Sultan Funda Ekti Dal, Görkem Ali Varol, and Evrim Hür
Elsevier BV
Abstract In this study, crystalline and chirally stable carboxyl-protected and novel unprotected N- ferrocenoyl amino acid derivatives of Ser, Cys, Ala, Phe, Trp, Asp and Asn have been prepared. These amino acids undergo substitution reaction with 1-(ferrocenylcarbonyl)-1 H -benzotriazole, 1 , in partially aqueous media under microwave irradiation.
Deniz Hür, Sultan Funda Ekti, and Hakan Dal
Elsevier BV
Abstract A new synthesis methodology has been presented for the preparation of the ferrocenoyl esters. Ferrocene carboxylic acid was derivatized using direct 1 H -benzotriazole/SOCl 2 methodology to prepare N -ferrocenoyl benzotriazole as a convenient tool for the functionalization of ferrocene ring. N -ferrocenoyl benzotriazole was reacted with alcohols in mild conditions to prepare ferrocenoyl esters in high purity and in good yield. The solid state structure of benzyl-1-ferrocenoate, 2f , has also been determined by X-ray crystallography. In the crystal structure, intermolecular C–H···O hydrogen bonds link the molecules into a two-dimensional network. The π···π contacts between the cyclopentadiene rings and cyclopentadiene and phenyl rings, [centroid–centroid distances = 3.296(1) and 3.750(1) A] may further stabilize the structure. Two weak C–H···π interactions are also found.
S. Funda Ekti and Deniz Hür
Elsevier BV
Abstract A new microwave assisted synthesis methodology has been presented for the preparation of the ferrocene amides. Ferrocene carboxylic acid was derivatised using direct 1 H -Benzotriazole/SOCl 2 methodolgy to prepare N -ferrocenoyl benzotriazole as a new starting material for the functionalization of ferrocene ring. N -ferrocenoyl benzotriazole was reacted with mono- and di-amines under microwave irradiation to prepare ferrocene mono- and di-amides in high purity and in good yield.
Deniz Hur, Sultan Ekti, and Ridvan Say
Bentham Science Publishers Ltd.