Mehmet Serif Arslan
@genesishospital.com.tr
Pediatric Surgeon
Private Genesis Hospital
RESEARCH, TEACHING, or OTHER INTERESTS
Medicine, Pediatrics, Perinatology and Child Health, Surgery
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mehmet Serif Arslan, Serkan Arslan, Hikmet Zeytun, Erol Basuguy, Bahattin Aydogdu, Mehmet Hanifi Okur, Ibrahim Uygun, Murat Kemal Cigdem, Abdurrahman Onen, and Selcuk Otcu
Springer Science and Business Media LLC
Mehmet Hanifi Okur, Serkan Arslan, Bahattin Aydogdu, Hikmet Zeytun, Erol Basuguy, Mehmet Serif Arslan, Ibrahim Ibiloglu, and Ibrahim Kaplan
Informa UK Limited
ABSTRACT Objective: To investigate the role of cordycepin in testicular ischemia/reperfusion injury in rats. Materials and methods: Forty Wistar albino rats were randomly divided into four groups, as follows: group one, control (C); group two, torsion and ischemia (I); group three: detorsion with ischemia–reperfusion (IR); and group four, detorsion/cordycepin. The rats were then analyzed macromorphologically and histopathologically, and blood tests were performed. Specifically, the total oxidant status (TOS) and total antioxidant status (TAS) were determined, and malondialdehyde (MDA), tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β levels were analyzed. In addition, pyknotic nuclei, spermatozoa, edema, and hemorrhage were assessed. Results: When the IR and cordycepin groups were compared with the other groups, there was a statistically significant decrease in TNF-α and MDA levels (p < 0.05). Increased TAS levels were observed in the cordycepin group compared with the control group. TOS levels were significantly increased in the I and IR groups, but decreased in the cordycepin group (p < 0.05). Similar effects were observed in tissue biochemistry analysis. Histopathological evaluations revealed that the spermatozoa count was decreased in the I and IR groups. However, there was an increase in the cordycepin group, as well as a statistically significant difference between the IR and cordycepin groups (p < 0.01). Finally, edema and inflammation were increased in the I and IR groups, but decreased in the cordycepin group. Conclusions: Histological and biochemical findings revealed that cordycepin protected against IR-induced testicular injury.
Mehmet Serif Arslan
Kare Publishing
BACKGROUND
Non-operative management (NOM) is a standard treatment method for solid organ injuries worldwide. There is no consensus on the management of gunshot wounds (GSW) because of the higher frequency of hollow viscus injuries (HVI) and the unpredictable depth of tissue damage produced by kinetic energy transfer during retardation of the bullet. Here we aimed to reevaluate indications for surgery and NOM based on our pediatric patients with abdominal GSW.
METHODS
We performed a retrospective analysis of patients evaluated and treated for abdominal GSW at University of Dicle between January 2010 and October 2016. Patients with hemodynamic instability, signs of peritonitis on serial abdominal examination, and free air in the abdomen underwent laparotomy; these were included in group I (n=17). Patients managed non-operatively were included in group II (n=13).
RESULTS
Our statistical analysis showed significantly lower Hb levels and systolic blood pressure levels (p<0.001) and higher pulse rate, higher mean injury severity score, and longer length of stay at intensive care unit in patients in group I than in those in group II (p<0.001). We further detected colon perforation (n=10) and small bowel perforation (n=7) in patients in group I; liver laceration (n=4), splenic injury (n=1), and renal injury (n=3) but no solid organ injury or HVI (n=5) were detected in patients in group II.
CONCLUSION
The major drawback of NOM is the difficulty in diagnosing HVI in abdominal GSW, which may delay treatment. We suggest that patients with solid organ damage who are hemodynamically stable and exhibit no signs of peritonitis upon serial abdominal exam may be treated with NOM.
M. H. Okur, S. Arslan, B. Aydogdu, M. S. Arslan, C. Goya, H. Zeytun, E. Basuguy, I. Uygun, M. K. Çigdem, A. Önen,et al.
Springer Science and Business Media LLC
Serkan Arslan, Mehmet Hanifi Okur, Mehmet Serif Arslan, Bahattin Aydogdu, Hikmet Zeytun, Erol Basuguy, Mustafa Icer, and Cemil Goya
Springer Science and Business Media LLC
Mehmet Serif Arslan, Erol Basuguy, Ibrahim Ibiloglu, Eda Bozdemir, Hikmet Zeytun, Atalay Sahin, Ibrahim Kaplan, Bahattin Aydogdu, and Selcuk Otcu
Informa UK Limited
ABSTRACT Objective: Ecballium elaterium (EE) is a plant from Cucurbitaceae family. Its anti-inflammatory role in sepsis is not well understood. We investigated the effects of EE on serum levels of proinflammatory cytokines and further explored the mechanisms underlying histological changes in liver and ileum following EE administration in a polymicrobial sepsis model. Methods: Thirty rats were divided into three groups of 10 rats each. Rats were subjected to sham laparotomy plus normal saline administration (control group, CG), laparotomy with cecal ligation and puncture (CLP) (sepsis group, SG), and laparotomy with CLP plus 2.5 mg/kg EE administration (experimental group, EG). Twenty-four hours after laparotomy, animals underwent cardiac puncture, and blood was collected for interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) assessment. Whole sections of liver and ileum tissues were collected for histologic examination. Results: The serum level of IL-6 was significantly lower in EG as compared to SG. Although IL-6 levels were shown a statistically significant (p < 0.0001) decline to near control values, no significant changes were observed in serum levels of IL-1 and TNF-α after EE treatment. Histologic examination revealed statistically significant reduction in collagen formation (p = 0.001) on serosal surface of ileum and hepatic venous congestion (p = 0.040) in EG as compared to SG. Conclusion: EE might play a protective role in sepsis prevention and treatment by decreasing IL-6 production and reducing liver damage and may influence bacterial translocation by reinforcing intestinal barrier function.
M.S. Arslan, S. Arslan, H. Zeytun, E. Basuguy, M. Ozkir, B. Aydogdu, M.H. Okur, and I. Uygun
Springer Science and Business Media LLC
Bahattin Aydogdu, Serkan Arslan, Hikmet Zeytun, Mehmet Serif Arslan, Erol Basuguy, Mustafa İçer, Cemil Goya, Mehmet Hanifi Okur, Ibrahim Uygun, Murat Kemal Cıgdem,et al.
Springer Science and Business Media LLC
B. Aydogdu, M. Okur, S. Arslan, M. Arslan, H. Zeytun, E. Basuguy, M. Içer, C. Goya, I. Uygun, M. Çığdem,et al.
PURPOSE
Adrenal gland injury (AGI) caused by trauma may cause bleeding and life-threatening problems in children.The objective of this study was to analyze the prevalence of AGI in final diagnoses of trauma.
MATERIALS AND METHODS
The records of 458 patients with abdominal trauma (out of a total 8,200 pediatric patientswith trauma of any sort), who were referred to our clinic between January 2009 and July 2014, were reviewed retrospectively.The numbers of patients with AGI and their ages, gender, trauma patterns, affected organs, pediatrictrauma scores (PTSs), and injury severity scores (ISSs) were recorded, as well as the associated ultrasound (US)and tomographic scan data, treatments, and complications. Computed tomography (CT) scans obtained after traumawere subjected to both primary and secondary evaluation.
RESULTS
In total, 28 patients with AGI were detected; their average age was 8.54 ± 4.09 (3-17) years. Twenty(71%) patients were male and 8 (29%) were female. Nineteen (68%) patients had fallen from heights; the mostcommonly injured organs were the kidneys, spleen, and lungs. Injuries were right-sided in 26 (92.9%) patients.The mean ISS was 13.2 (range 5-50) and the mean PTS 8.6 (range 0-11). Seven patients had ISS > 16 and ninehad PTS < 8. AGI was diagnosed by CT in 14 (50%) patients and in 3 (9%) by US at primary evaluation. Uponsecondary scan inspection focusing on the possibility of adrenal gland injury, such injury was ultimately detectedin 28 patients. All patients underwent conservative follow-up, and one died.
CONCLUSION
We recommend calculation of the PTS, as well as other trauma scores, when pediatric patients sufferingmultiple or blunt abdominal trauma(s) present to the emergency . In addition, we believe that in children withtrauma involving the liver, spleen or kidneys, careful evaluation using a CT scan would increase the diagnosis ofAGI and reveal a realistic rate of AGI in trauma cases.
Hikmet Zeytun, Mehmet Hanifi Okur, Erol Basuguy, Serkan Arslan, Bahattin Aydogdu, Gul Turkcu, and Mehmet Serif Arslan
Springer Science and Business Media LLC
Mehmet Hanifi Okur, Bahattin Aydogdu, Mehmet Serif Arslan, Ulaş Alabalik, Serkan Arslan, İbrahim Kara, Fethiye Canpolat, Atalay Şahin, and Selçuk Otcu
FapUNIFESP (SciELO)
PURPOSE
To evaluate the effects of Ecballium elaterium (EE), Elaterium officinarum, in postoperative intraperitoneal adhesions in rats.
METHODS
Thirty rats were divided into three groups and underwent midline laparotomy under 35 mg/kg ketamine and 5 mg/kg xylazine anaesthesia. In group 1 (n=10), the sham operation group, the abdominal walls were closed without any process. In group 2 (n=10), the control group, the antimesenteric border of the ceacum and the corresponding parietal peritoneum were abraded with dry sterile gauze. In group 3 (n=10), the EE group, 2.5 mg/kg dose of EE was administered as intraperitoneally to the rats after abrasion. All rats were sacrificed on postoperative day 15. Samples were obtained
RESULTS
The adhesion score was significantly decreased in the EE group (p=0.001) in comparison with the control group. Microscopically, the EE and sham groups were significantly lower than that of the control group (p<0.001 and p=0.000, respectively). Furthermore, the measurement of tissue levels of hydroxyproline was significantly lower in the sham and EE groups compared to the control group (sham group: 47.6 ± 10.6, EE group: 62.9 ± 9.7, CONTROL GROUP: 84.2 ± 22.1 mg /L/g-tissue).
CONCLUSION
The grade and severity of abdominal adhesion could be significantly reduced through administered Ecballium elaterium and therefore be a suitable anti-inflammatory agent for the prevention of postoperative peritoneal adhesion in the future.
Mehmet Arslan, Ahmet Öztürk, Yunus Emre Goger, Erkan Aslan, and Mehmet Kilinc
Springer Science and Business Media LLC
Ibrahim Uygun, Selcuk Otcu, Selver Ozekinci, Mehmet Hanifi Okur, Mehmet Serif Arslan, and Bahattin Aydogdu
Elsevier BV
Mehmet Hanifi Okur, Ibrahim Uygun, Mehmet Serif Arslan, Bahattin Aydogdu, Ahmet Turkoglu, Cemil Goya, Mustafa Icen, Murat Kemal Cigdem, Abdurrahman Onen, and Selcuk Otcu
Elsevier BV
Ibrahim Uygun, Mehmet Serif Arslan, Bahattin Aydogdu, Mehmet Hanifi Okur, and Selcuk Otcu
Elsevier BV
Ibrahim Uygun, Mehmet Hanifi Okur, Bahattin Aydogdu, Mehmet Serif Arslan, Hasan Cimen, and Selcuk Otcu
The Korean Surgical Society
Purpose Single-site laparoscopic surgery has become increasingly common. We herein report an easy and low-cost thoracic trocar technique (TTT) for these types of procedures and recommend the simpler name "transumbilical scarless surgery" (TUSS) to minimize confusion in nomenclature. Methods We retrospectively reviewed patients who underwent TUSS by TTT using a thoracic trocar and surgical glove in our hospital between November 2011 and November 2012. Operating time, postoperative stay, and complications were detailed. Results A total of 101 TUSS by TTT were successfully performed, comprising appendectomy (n = 63), ovarian cyst excision (n = 7), splenectomy (n = 5), nephroureterectomy (n = 5), orchidopexy (n = 4), pyeloplasty (n = 3), nephrolithotomy (n = 2), orchiectomy (n = 2), varicocelectomy (n = 2), lymphangioma excision (n = 2), ureterectomy (n = 1), Morgagni diaphragmatic hernia repair (n = 1), ovarian detorsion (n = 1), antegrade continence enema (n = 1), intestinal resection anastomosis (n = 1), and intestinal duplication excision (n = 1). Kirschner wires were used for some organ traction. Nine patients required an additional port, but no major complications occurred. The postoperative stay (mean ± standard deviation) was 3.2 ± 1.4 days, and operating time was 58.9 ± 38.3 minutes. Conclusion We recommend the simpler name of TUSS to minimize confusion in nomenclature for all transumbilical single-incision laparoendoscopic surgeries. TTT is an easy and low-cost TUSS technique.
Mehmet Şerif Arslan, Ersin Köksal, Turan Yıldız, Leyla Tekşan Özalp, and Cengiz Kaya
Ondokuzmayis University, Faculty of Medicine
The purpose of this study is to demonstrate the efficiency of tubularized incised-plate urethroplasty (TIPU) method and the complication rates with postoperative early periodical urethral dilatations. Hypospadias is one of the most common congenital anomaly in male genital system. Retrospectively 45 case’s records which had distal hypospadias and undergone surgery were studied in Samsun Obstetrics and Gynecology and Children’s Hospital. The ages of the patients, their meatus locations, cordi existence, suture materials, stenting times, complication incidences after surgery, were evaluated. None of the patients had urethrocutoneous fistule, meatal stenosis, or wound place infection. In all cases, the cosmetic results satisfied both the patient’s family and the doctor. TIPU is the most outstanding treatment alternative in distal hypospadias, when its advantages, such as less complication ratios, perfect cosmetic and funtional results are considered.
J. Exp. Clin. Med., 2013; 30:23-25