Abdulbasit Amin

@unilorin.edu.ng

Lecturer, Faculty of Basic Medical Sciences
University of Ilorin, Nigeria



                       

https://researchid.co/abdulbasit

RESEARCH, TEACHING, or OTHER INTERESTS

Physiology, Endocrinology, Cell Biology

30

Scopus Publications

680

Scholar Citations

13

Scholar h-index

20

Scholar i10-index

Scopus Publications

  • How pathogens drive adipose tissue loss in the host
    Abdulbasit Amin, David V Ferreira, and Luisa M Figueiredo
    Elsevier BV

  • Optimization of Parkinson's disease therapy with plant extracts and nutrition's evolving roles
    Patrick Oluwole Abolarin, Abdulbasit Amin, Abdulrazaq Bidemi Nafiu, Olalekan Michael Ogundele, and Bamidele Victor Owoyele
    Elsevier BV

  • Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis
    Abdulbasit Amin, Marina Badenes, Johanna Tüshaus, Érika de Carvalho, Emma Burbridge, Pedro Faísca, Květa Trávníčková, André Barros, Stefania Carobbio, Pedro M. Domingos,et al.
    Elsevier BV

  • The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
    Marina Badenes, Emma Burbridge, Ioanna Oikonomidi, Abdulbasit Amin, Érika de Carvalho, Lindsay Kosack, Camila Mariano, Pedro Domingos, Pedro Faísca, and Colin Adrain
    Life Science Alliance, LLC
    The metalloprotease ADAM17 is a sheddase of key molecules, including TNF and epidermal growth factor receptor ligands. ADAM17 exists within an assemblage, the “sheddase complex,” containing a rhomboid pseudoprotease (iRhom1 or iRhom2). iRhoms control multiple aspects of ADAM17 biology. The FERM domain–containing protein iTAP/Frmd8 is an iRhom-binding protein that prevents the precocious shunting of ADAM17 and iRhom2 to lysosomes and their consequent degradation. As pathophysiological role(s) of iTAP/Frmd8 have not been addressed, we characterized the impact of iTAP/Frmd8 loss on ADAM17-associated phenotypes in mice. We show that iTAP/Frmd8 KO mice exhibit defects in inflammatory and intestinal epithelial barrier repair functions, but not the collateral defects associated with global ADAM17 loss. Furthermore, we show that iTAP/Frmd8 regulates cancer cell growth in a cell-autonomous manner and by modulating the tumor microenvironment. Our work suggests that pharmacological intervention at the level of iTAP/Frmd8 may be beneficial to target ADAM17 activity in specific compartments during chronic inflammatory diseases or cancer, while avoiding the collateral impact on the vital functions associated with the widespread inhibition of ADAM17.

  • Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms
    Adedamola Bayo-Olugbami, AbdulRazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C. Lee, and Bamidele Victor Owoyele
    Physiological Society of Nigeria
    L-DOPA, the gold standard for managing Parkinson’s disease (PD) is fraught by motor fluctuations termed L-Dopa-Induced Dyskinesia (LID). LID has very few therapeutic options. Hence, the need for preclinical screening of new interventions. Cholecalciferol (VD3) treatment reportedly improves motor deficit in experimental Parkinsonism. Therefore, the novel anti-dyskinetic effect of VD3 and its underlying mechanisms in LID was investigated. Dyskinesia was induced by chronic L-DOPA administration in parkinsonian (6-OHDA- lesioned) mice. The experimental groups: Control, Dyskinesia, Dyskinesia/VD3, and Dyskinesia/Amantadine were challenged with L-DOPA to determine the abnormal involuntary movements (AIMs) score during 14 days of VD3 (30 mg/kg) or Amantadine (40 mg/kg) treatment. Behavioral Axial, Limb & Orolingual (ALO) AIMs were scored for 1 min at every 20 mins interval, over a duration of 100 mins on days 1,3,7,11 and 14. Using western blot, striatum was assessed for expression of dopamine metabolic enzymes: Tyrosine Hydroxylase (TH) and Monoamine Oxidase-B (MAO-B); CD11b, BAX, P47phox, and IL-1β. Cholecalciferol significantly attenuated AIMs only on days 11 & 14 with maximal reduction of 32.7%. Expression of TH and MAO-B was not altered in VD3 compared with dyskinetic mice. VD3 significantly inhibited oxidative stress (P47phox), apoptosis (BAX), inflammation (IL-1β) and microglial activation (CD11b). VD3 showed anti-dyskinetic effects behaviorally by attenuating abnormal involuntary movements, modulation of striatal oxidative stress, microglial responses, inflammation, and apoptotic signaling; without affecting dopamine metabolic enzymes. Its use in the management of dyskinesia is promising. More studies are required to further evaluate these findings. Keywords: Cholecalciferol; L-DOPA-Induced Dyskinesia; Parkinson’s Disease; Microglial; Oxidative stress; Inflammation

  • Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity
    Patrick Oluwole Abolarin, Abdulrazaq Bidemi Nafiu, Aboyeji Lukuman Oyewole, Abdulbasit Amin, Olalekan Michael Ogundele, and Bamidele Victor Owoyele
    Elsevier BV

  • Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice
    Adedamola Bayo-Olugbami, Abdulrazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C. Lee, and Bamidele Victor Owoyele
    Informa UK Limited
    ABSTRACT Background: L-DOPA, the predominant therapy for Parkinson's disease (PD) is associated with motor deficits after prolonged use. The nigrostriatal tract, a primary target of neurodegeneration in PD, contains abundant Vitamin-D receptors, suggesting a potential role for VD in the disease. Therefore, we tested the impact of Vitamin D3 (VD3) in a mouse model of PD. Methods: PD was induced in adult male C57BL6 mice by a single intrastriatal injection of 6-hydroxydopamine. Two weeks post lesion, these mice received injections of a vehicle, VD3, L-DOPA, or a combination of VD3/L-DOPA and compared with sham controls. Treatment lasted three weeks, during which motor-cognitive neurobehaviour was assessed. Five weeks post lesion, brains were collected and striatal levels of the following proteins assessed: tyrosine hydroxylase (TH), dopamine decarboxylase (DDC), monoamine oxidase (MAO-B), Catechol-O-methyl transferase (COMT), dopamine transporter (DAT), brain-derived neurotrophic factor (BDNF), microglia marker (CD11b), inflammation (IL-1β), apoptotic signaling (BAX) and oxidative stress (p47phox). Results: Treatment with VD3 attenuated behavioural deficits induced by 6-OHDA, protein associated with dopamine metabolism and biomarkers of oxidative stress. VD3 significantly increased contralateral wall touches, exploratory motor and cognitive activities. VD3 significantly enhanced the expression of TH, DAT, BDNF, while significantly reducing expression of MAO-B, CD11b, IL-I β and p47phox. Conclusion: VD3 reversed some of the 6-OHDA induced changes in proteins involved in modulating the dopamine system, behavioural deficits and oxidative stress biomarkers. The data suggests that VD3 might be beneficial in reducing L-DOPA dosage, thereby reducing problems associated with dosage and prolonged use of L-DOPA in PD management.

  • Two decades of neuroscience publication trends in Africa
    M. B. Maina, U. Ahmad, H. A. Ibrahim, S. K. Hamidu, F. E. Nasr, A. T. Salihu, A. I. Abushouk, M. Abdurrazak, M. A. Awadelkareem, A. Amin,et al.
    Springer Science and Business Media LLC
    AbstractNeuroscience research in Africa remains sparse. Devising new policies to boost Africa’s neuroscience landscape is imperative, but these must be based on accurate data on research outputs which is largely lacking. Such data must reflect the heterogeneity of research environments across the continent’s 54 countries. Here, we analyse neuroscience publications affiliated with African institutions between 1996 and 2017. Of 12,326 PubMed indexed publications, 5,219 show clear evidence that the work was performed in Africa and led by African-based researchers - on average ~5 per country and year. From here, we extract information on journals and citations, funding, international coauthorships and techniques used. For reference, we also extract the same metrics from 220 randomly selected publications each from the UK, USA, Australia, Japan and Brazil. Our dataset provides insights into the current state of African neuroscience research in a global context.

  • Current status of endoplasmic reticulum stress in type ii diabetes
    Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala,et al.
    MDPI AG
    The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating an adaptive signaling process called the unfolded protein response (UPR). However, the ER initiates death signaling pathways when ER stress persists. ER stress is linked to several diseases, such as cancer, obesity, and diabetes. Thus, its regulation can provide possible therapeutic targets for these. Current evidence suggests that chronic hyperglycemia and hyperlipidemia linked to type II diabetes disrupt ER homeostasis, thereby, resulting in irreversible UPR activation and cell death. Despite progress in understanding the pathophysiology of the UPR and ER stress, to date, the mechanisms of ER stress in relation to type II diabetes remain unclear. This review provides up-to-date information regarding the UPR, ER stress mechanisms, insulin dysfunction, oxidative stress, and the therapeutic potential of targeting specific ER stress pathways.

  • Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers
    Aboyeji Lukuman Oyewole, Kehinde Olumide Oyafemi, Kolade Samson Badmus, Janet Omotola Omoleye, Midrar Folahanmi Abubakar, Omolade Adeniyi-Raheem, Abdul-hameed Amedu, Dolapo Latifah Lawal, Aishat Oluwakemi Ijiyode, Ateeqah Oreoluwa Yussuf,et al.
    Elsevier BV

  • Crosstalk between metabolism and immunity: the 3rd Annual Research Symposium of Instituto Gulbenkian de Ciência
    Abdulbasit Amin, Ana Neves‐Costa, Dora Pedroso, Henrique Colaço, Inês Coelho, Inês Mahú, Marina Badenes, and Nádia Duarte
    Wiley
    The ‘Crosstalks of immunity and metabolism’ Symposium was focused on how the intercommunication between different organs and the immune system affects organismal health. At this meeting, experts in immunology and metabolic research provided novel insights into the growing field of immunometabolism. This report attempts to review and integrate views, ideas, propositions, and conclusions that emanated from the symposium.

  • Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
    Marina Badenes, Abdulbasit Amin, Ismael González-García, Inês Félix, Emma Burbridge, Miguel Cavadas, Francisco José Ortega, Érika de Carvalho, Pedro Faísca, Stefania Carobbio,et al.
    Elsevier BV

  • Using invertebrate model organisms for neuroscience research and training: an opportunity for Africa
    Wasiu Gbolahan Balogun, Ansa Emmanuel Cobham, Abdulbasit Amin, and Azman Seeni
    Springer Science and Business Media LLC

  • Pro-neurogenic and antioxidant efficacy of Nigella sativa oil reduced vulnerability cholinesterase dysfunction and disruption in amygdala-dependent behaviours in chlorpyrifos exposure


  • Neuroscience in Nigeria: the past, the present and the future
    Wasiu Gbolahan Balogun, Ansa Emmanuel Cobham, and Abdulbasit Amin
    Springer Science and Business Media LLC

  • Advancing Neuroscience Research in Africa: Invertebrate Species to the Rescue
    Wasiu Gbolahan Balogun, Ansa Emmanuel Cobham, Abdulbasit Amin, and Azman Seeni
    Elsevier BV

  • Glucocorticoid receptor activation selectively influence performance of Wistar rats in Y-maze
    Amin Abdulbasit, Fii Stephen Michael, Amusa Shukurat Onaopemipo, Alli-Oluwafuyi Abdulmusawwir, Imam Aminu, Asogwa Nnaemeka Tobechukwu, Abdulmajeed Wahab Imam, Adeyanju Oluwaseun Aremu, Olaseinde Folajimi, Abolarinwa Bilikis Aderonke,et al.
    Elsevier BV

  • Oral Ingestion of Cannabis sativa: Risks, Benefits, and Effects on Malaria-Infected Hosts
    Olugbenga Akinola, Elizabeth O. Ogbeche, Hidayah A. Olumoh-Abdul, Abdulmusawwir O. Alli-Oluwafuyi, Aboyeji L. Oyewole, Abdulbasit Amin, Wahab Imam AbdulMajeed, Olayemi Joseph Olajide, Abdurrazaq B. Nafiu, Anoka A. Njan,et al.
    Mary Ann Liebert Inc
    Abstract Background: The emergence of a multidrug-resistant strain of Plasmodium falciparum (Pf Pailin) raises concern about malaria control strategies. Unfortunately, the role(s) of natural plants/remedies in curtailing malaria catastrophe remains uncertain. The claims of potential antimalarial activity of Cannabis sativa in vivo have not been well established nor the consequences defined. This study was, therefore, designed to evaluate the effects of whole cannabis consumption on malaria-infected host. Methods: Thirty mice were inoculated with dose of 1×107 chloroquine-resistant Plasmodium berghei ANKA-infected erythrocyte and divided into six treatment groups. Cannabis diet formulations were prepared based on weighted percentages of dried cannabis and standard mice diet and the study animals were fed ad libitum. Chemosuppression of parasitemia, survival rates, parasite clearance, and recrudescence time were evaluated. Histopathological studies were performed on the prefrontal cortex (PFC) and hippocampus of the animals after 14 days' consumption of cannabis diet formulation by naive mice. Results: There was a significant difference (p<0.05) in the day-4 chemosuppression of parasitemia between the animals that were fed C. sativa and chloroquine relative to the untreated controls. There was also a significant difference in the survival rate (p<0.05) of animals fed C. sativa diet (40%, 20%, 10%, and 1%) in contrast to control animals on standard mice diet. A parasite clearance time of 2.18±0.4 was recorded in the chloroquine treatment group, whereas recrudescence in chloroquine group occurred on day 7. There were slight histomorphological changes in the PFC and cell densities of the dentate gyrus of the hippocampus of animals that were fed C. sativa. Conclusions: C. sativa displayed mild antimalarial activity in vivo. There was evident reduction in symptomatic manifestation of malaria disease, though unrelated to levels of parasitemia. This disease tolerance status may be beneficial, but may also constitute a transmission burden through asymptomatic carriage of parasites by habitual cannabis users.

  • Differential oxidative stress thresholds distinguishes cellular response to vascular occlusion and chemotoxicity in vivo
    Olalekan Michael Ogundele, Balogun Wasiu Gbolahan, Ansa Emmanuel Cobham, Ishola Azeez Olakunle, and Amin Abdulbasit
    Informa UK Limited
    Abstract Background: A major effect of cyanide toxicity (CN) and vascular occlusion (VO) is the production of reactive oxygen species (ROS) linked with a defective energy coupling process in the mitochondria. In CN, oxygen is present but its conversion is blocked in the mitochondria (Complex V). By contrast, in VO, oxidative stress is induced via reduction of oxygen (blood) circulation to the occluded brain region. We hypothesize that differential oxygen concentration in both forms of ischemia affect ROS production rate in the mitochondria; thus distinguishing the cytotoxicity pattern for CN and VO. Method: Male, adult Wistar rats (N = 30) were separated into three groups. A set of n = 12 animals were treated with orally administered potassium ferricyanide. Global vascular occlusion (GVO) was induced in a second set of animals (n = 12) using neck cuffs to occlude the common carotid arteries and brachiocephalic vein. The control group (n = 6) received normal saline for the total duration of the treatment (10 days). Glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and acid phosphatase (ACP) levels were assayed in tissue homogenate using colorimetric assay techniques while Cathepsin D (CAD+) was demonstrated through antigen retrieval immunohistochemistry. Data were analyzed in One Way ANOVA with Tukey’s post-hoc test. Significance was set p < 0.05. Results/Discussion: Cyanide treatment and VO caused a significant rise in SOD; attributed to ROS formation in both forms of ischemia. However, an increase in GSH levels demonstrates mitochondria-ROS production in cyanide treatment while no significant change in GSH was observed in VO versus the control (reduced mitochondria-ROS production). In addition, CN recorded a significant increase in GSH when compared with the control and VO (p < 0.001). The level of ROS was also proportional to the degree of lipid peroxidation (GPx) and autophagic cell response (ACP/CAD+). Ultimately, the lipid peroxidation/ROS effect was more significant in CN than VO. Conclusion: Although CN and VO induced oxidative stress through ROS production, our findings suggest a difference in the threshold of ROS production and cytotoxicity for both forms of ischemia. However, this threshold is dependent on the availability of oxygen to fuel mitochondria-ROS production in oxidative stress. Ultimately, the difference in oxygen availability in vivo determined the significance of lipid peroxidation, calcium-shift and autophagic cell response associated with the ischemia. CN treatment generated more ROS and was associated with prominent cellular changes when compared with VO.

  • Cannabis-induced moto-cognitive dysfunction in Wistar rats: Ameliorative efficacy of Nigella Sativa
    Imam Aminu, , Ajao Moyosore Saliu, Amin Abdulbasit, Abdulmajeed Wahab Imam, Ibrahim Abdulmumin, Olajide Olayemi Joseph, Ajibola Musa Iyiola, Alli-Oluwafuyi Abdulmusawir, Balogun Wasiu Gbolahan,et al.
    Penerbit Universiti Sains Malaysia
    BACKGROUND Cannabis is a widely used illicit drug with various threats of personality syndrome, and Nigella sativa has been widely implicated as having therapeutic efficacy in many neurological diseases. The present study investigates the ameliorative efficacy of Nigella sativa oil (NSO) on cannabis-induced moto-cognitive defects. METHODS Scopolamine (1 mg/kg i.p.) was given to induce dementia as a standard base line for cannabis (20 mg/kg)-induced cognitive impairment, followed by an oral administration of NSO (1 ml/kg) for 14 consecutive days. The Morris water maze (MWM) paradigm was used to assess the memory index, the elevated plus maze was used for anxiety-like behaviour, and the open field test was used for locomotor activities; thereafter, the rats were sacrificed and their brains were removed for histopathologic studies. RESULTS Cannabis-like Scopolamine caused memory impairment, delayed latency in the MWM, and anxiety-like behaviour, coupled with alterations in the cerebello-hippocampal neurons. The post-treatment of rats with NSO mitigated cannabis-induced cognitive dysfunction as with scopolamine and impaired anxiety-like behaviour by increasing open arm entry, line crossing, and histological changes. CONCLUSIONS The observed ameliorative effects of NSO make it a promising agent against moto-cognitive dysfunction and cerebelo-hippocampal alterations induced by cannabis.

  • Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain
    Wahab Imam Abdulmajeed, Ridwan Babatunde Ibrahim, Azeez Olakunle Ishola, Wasiu Gbolahan Balogun, Ansa Emmanuel Cobham, and Abdulbasit Amin
    Walter de Gruyter GmbH
    AbstractPhenytoin and amitriptyline are often reported to attenuate pain in chronic conditions. Information on their ability to ameliorate cognitive impairment associated with neuropathic pain remains unclear due to mixed results from studies. This study investigated the effects of phenytoin and amitriptyline on memory deficit associated with neuropathic pain.Twenty-eight adult male Wistar rats were randomly divided into four groups: A, B, C, and D (n=7). Groups A, B, C, and D served as sham control, sciatic nerve ligated untreated, sciatic nerve ligated receiving amitriptyline (5 mg/kg), and sciatic nerve ligated receiving phenytoin (10 mg/kg) respectively. Treatments lasted for 14 days, after which both ‘Y’ maze and novel object recognition test (NOR) were performed. On the last day of treatment, the animals were anesthetized and their brain excised, and the prefrontal cortices and sciatic nerve were processed histologically using hematoxylin and eosin.There was memory impairment in the sciatic nerve ligated untreated group which was statistically significant (p&lt;0.05) when compared to the phenytoin-treated, amitriptyline-treated, and sham control groups using the ‘Y’ maze and NOR tests. Histological quantification showed that the prefrontal cortices of the ligated animals showed increased neural population in comparison to normal control. These increases were significantly marked in the untreated ligated group. Sciatic nerve of untreated ligated group showed high demyelination and axonal degeneration which was ameliorated in the treated animals.The administration of amitriptyline and phenytoin can ameliorate neuronal injury, demyelination, and memory impairment associated with neuropathic pain in Wistar rats.

  • Repeated acute oral exposure to Cannabis sativa impaired neurocognitive behaviours and cortico-hippocampal architectonics in Wistar rats


  • Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats- a preliminary study
    Wahab Imam Abdulmajeed, Habeeb Bolakale Sulieman, Maymunah Oloruntosin Zubayr, Aminu Imam, Abdulbasit Amin, Sikiru Abayomi Biliaminu, Lukuman Aboyeji Oyewole, and Bamidele Victor Owoyele
    Springer Science and Business Media LLC

  • -NMDA R/+VDR pharmacological phenotype as a novel therapeutic target in relieving motor-cognitive impairments in Parkinsonism
    Olalekan Michael Ogundele, Ednar Tarebi Nanakumo, Azeez Olakunle Ishola, Oluwafemi Michael Obende, Linus Anderson Enye, Wasiu Gbolahan Balogun, Ansa Emmanuel Cobham, and Amin Abdulbasit
    Informa UK Limited
    Abstract Background: Parkinsonism describes Parkinson’s disease and other associated degenerative changes in the brain resulting in movement disorders. The motor cortex, extrapyramidal tracts and nigrostriatal tract are brain regions forming part of the motor neural system and are primary targets for drug or chemotoxins induced Parkinsonism. The cause of Parkinsonism has been described as wide and elusive, however, environmental toxins and drugs accounts for large percentage of spontaneous cases in humans. A common mechanism in the cause and progression of drug/chemotoxin induced Parkinsonism involves calcium signalling in; oxidative stress, autophagy, cytoskeletal instability and excitotoxicity .Aim: This study sets to investigate the effect of targeting calcium controlling receptors, specifically activation of Vitamin D3 receptor (VDR) and inhibition of N-Methyl-D-Aspartate Receptor (NMDAR) in the motor cortex of mice model of drug induced Parkinsonism. Also we demonstrated how these interventions improved neural activity, cytoskeleton, glia/neuron count and motor–cognitive functions in vivo. Methods: Adult mice were separated into six groups of n = 5 animals each. Body weight (5 mg/kg) of haloperidol was administered intraperitoneally for 7 days to block dopaminergic D2 receptors and induce degeneration in the motor cortex following which an intervention of VDR agonist (VDRA), and (or) NMDAR inhibitor was administered for 7 days. A set of control animals received normal saline while a separate group of control animals received the combined intervention of VDRA and NMDAR inhibitor without prior treatment with haloperidol. Behavioral tests for motor and cognitive functions were carried out at the end of the treatment and intervention periods. Subsequently, neural activity in the motor cortex was recorded in vivo using unilateral wire electrodes. We also employed immunohistochemistry to demonstrate neuron, glia, neurofilament and proliferation in the motor cortex after haloperidol treatment and the intervention. Result/Discussion: We observed a decline in motor function and memory index in the haloperidol treatment group when compared with the control. Similarly, there was a decline in neural activity in the motor cortex (a reduced depolarization peak frequency). General cell loss (neuron and glia) and depletion of neurofilament were characteristic anatomical changes seen in the motor cortex of this group. However, Vitamin D3 intervention facilitated an improvement in motor–cognitive function, neural activity, glia/neuron survival and neurofilament expression. NMDAR inhibition and the combined intervention improved motor–cognitive functions but not as significant as values observed in VDRA intervention. Interestingly, animals treated with the combined intervention without prior haloperidol treatment showed a decline in motor function and neural activity. Conclusion: Our findings suggest that calcium mediated toxicity is primary to the cause and progression of Parkinsonism and targeting receptors that primarily modulates calcium reduces the morphological and behavioral deficits in drug induced Parkinsonism. VDR activation was more effective than NMDAR inhibition and a combined intervention. We conclude that targeting VDR is key for controlling calcium toxicity in drug/chemotoxin induced Parkinsonism.

  • Exogenous administration of l-arginine enhances the anti-inflammatory activity of nigella sativa (Blackseed) oil in wistar rats


RECENT SCHOLAR PUBLICATIONS

  • How pathogens drive adipose tissue loss in the host
    A Amin, DV Ferreira, LM Figueiredo
    Current Opinion in Microbiology 85, 102597 2025

  • A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis
    E de Carvalho, A Amin, R LiIttle, KF Silva, C Gaspar, M Badenes, ...
    bioRxiv, 2025.03. 10.642408 2025

  • Optimization of Parkinson's disease therapy with plant extracts and nutrition’s evolving roles
    PO Abolarin, A Amin, AB Nafiu, OM Ogundele, BV Owoyele
    IBRO Neuroscience Reports 2024

  • iRhom2/ADAM17 deletion protects from obesity associated to increased adipocyte thermogenesis and differentiation and reduced adipocyte Semaphorin 4B shedding
    M Badenes, A Amin, I Gonzlez-Garca, J Tshaus, I Flix, E Burbridge, ...
    Revista Lusfona de Cincia e Medicina Veterinria 15, 10-10 2024

  • Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis
    A Amin, M Badenes, J Tshaus, de Carvalho, E Burbridge, P Fasca, ...
    Molecular metabolism 73, 101731 2023

  • The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
    M Badenes, E Burbridge, I Oikonomidi, A Amin, de Carvalho, L Kosack, ...
    Life Science Alliance 6 (4) 2023

  • Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms
    AA Bayo-Olugbami, AB Nafiu, A Amin, OM Ogundele, CC Lee, ...
    Nigerian journal of physiological sciences: official publication of the 2022

  • Semaphorin 4B is an ADAM17-cleaved inhibitor of adipocyte thermogenesis
    A Amin, M Badenes, J Tshaus, de Carvalho, E Burbridge, P Fasca, ...
    bioRxiv, 2022.10. 11.511765 2022

  • Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity
    PO Abolarin, AB Nafiu, AL Oyewole, A Amin, OM Ogundele, BV Owoyele
    IBRO neuroscience reports 12, 1-11 2022

  • The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth
    M Badenes, E Burbridge, I Oikonomidi, A Amin, de Carvalho, L Kosack, ...
    BioRxiv, 2022.04. 11.487842 2022

  • Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice
    A Bayo-Olugbami, AB Nafiu, A Amin, OM Ogundele, CC Lee, BV Owoyele
    Nutritional neuroscience 25 (4), 823-834 2022

  • RESEARCH JOURNAL OF HEALTH SCIENCES
    A JA, O Faokunla, SO Alabi, AKM OA, TO Saka, OA Abayomi, ...
     2022

  • Role of the Metalloprotease Adam17 in Metabolic Regulation
    A Amin
    PQDT-Global 2022

  • Amelioration of L-DOPA-induced dyskinesia with vitamin D3 in Parkinsonian mice model
    AA Bayo-Olugbami, AB Nafiu, A Amin, OM Ogundele, CC Lee, ...
    bioRxiv, 2021.09. 13.459937 2021

  • Current status of endoplasmic reticulum stress in type II diabetes
    S Mustapha, M Mohammed, AK Azemi, AI Jatau, A Shehu, L Mustapha, ...
    Molecules 26 (14), 4362 2021

  • Two decades of neuroscience publication trends in Africa
    MB Maina, U Ahmad, HA Ibrahim, SK Hamidu, FE Nasr, AT Salihu, ...
    Nature communications 12 (1), 3429 2021

  • Proprotein convertase subtilisin kexin-9 level remains unchanged following glucocorticoid-induced dyslipidemia in Wistar rats
    AA Alli-Oluwafuyi, A Amin, N Omeiza, AB Nafiu, LA Oyewole, ...
    Int. J. Biomed. & Hlth. Sci. Volume 17 (1) 2021

  • Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers
    AL Oyewole, KO Oyafemi, KS Badmus, JO Omoleye, MF Abubakar, ...
    Journal of Neuroscience Methods 345, 108890 2020

  • Crosstalk between metabolism and immunity: the 3rd Annual Research Symposium of Instituto Gulbenkian de Cincia
    A Amin, A Neves‐Costa, D Pedroso, H Colao, I Coelho, I Mah, ...
    The FEBS Journal 287 (21), 4602-4606 2020

  • 20 years of African Neuroscience: Waking a sleeping giant
    MB Maina, U Ahmad, HA Ibrahim, SK Hamidu, FE Nasr, AT Salihu, ...
    BioRxiv, 2020.06. 03.131391 2020

MOST CITED SCHOLAR PUBLICATIONS

  • Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats-a preliminary study
    WI Abdulmajeed, HB Sulieman, MO Zubayr, A Imam, A Amin, ...
    Metabolic brain disease 31, 37-44 2016
    Citations: 81

  • Hepatoprotective and pancreatoprotective properties of the ethanolic extract of Nigerian propolis
    IR Babatunde, A Abdulbasit, MI Oladayo, OI Olasile, FR Olamide, ...
    Journal of intercultural ethnopharmacology 4 (2), 102 2015
    Citations: 67

  • Current status of endoplasmic reticulum stress in type II diabetes
    S Mustapha, M Mohammed, AK Azemi, AI Jatau, A Shehu, L Mustapha, ...
    Molecules 26 (14), 4362 2021
    Citations: 46

  • Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice
    A Bayo-Olugbami, AB Nafiu, A Amin, OM Ogundele, CC Lee, BV Owoyele
    Nutritional neuroscience 25 (4), 823-834 2022
    Citations: 42

  • Two decades of neuroscience publication trends in Africa
    MB Maina, U Ahmad, HA Ibrahim, SK Hamidu, FE Nasr, AT Salihu, ...
    Nature communications 12 (1), 3429 2021
    Citations: 36

  • Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
    M Badenes, A Amin, I Gonzlez-Garca, I Flix, E Burbridge, M Cavadas, ...
    Molecular Metabolism 31, 67-84 2020
    Citations: 30

  • Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male Wistar rats
    A Imam, MS Ajao, MI Ajibola, A Amin, WI Abdulmajeed, AZ Lawal, ...
    Bulletin of faculty of pharmacy, cairo university 54 (1), 49-57 2016
    Citations: 27

  • Cannabis-induced moto-cognitive dysfunction in wistar rats: ameliorative efficacy of nigella sativa
    A Imam, MS Ajao, A Amin, WI Abdulmajeed, A Ibrahim, OJ Olajide, ...
    The Malaysian journal of medical sciences: MJMS 23 (5), 17 2016
    Citations: 26

  • Effect of Nigerian propolis on glycemia, lipid profile, and oxidative stress markers in alloxan-induced diabetic rats
    A Abdulbasit, M Oladayo, F Olamide, O Olasile, I Babatunde, B Gbolahan
    PHOL 2, 149-158 2013
    Citations: 22

  • Oral Ingestion of Cannabis sativa: Risks, Benefits, and Effects on Malaria-Infected Hosts
    O Akinola, EO Ogbeche, HA Olumoh-Abdul, AO Alli-Oluwafuyi, ...
    Cannabis and cannabinoid research 3 (1), 219-227 2018
    Citations: 21

  • Glucocorticoid receptor activation selectively influence performance of Wistar rats in Y-maze
    A Abdulbasit, FS Michael, AS Onaopemipo, AO Abdulmusawwir, I Aminu, ...
    Pathophysiology 25 (1), 41-50 2018
    Citations: 19

  • − NMDA R/+ VDR pharmacological phenotype as a novel therapeutic target in relieving motor–cognitive impairments in Parkinsonism
    OM Ogundele, ET Nanakumo, AO Ishola, OM Obende, LA Enye, ...
    Drug and chemical toxicology 38 (4), 415-427 2015
    Citations: 18

  • Pro-Neurogenic and Antioxidant Efficacy of Nigella sativa Oil Reduced Vulnerability Cholinesterase Dysfunction and Disruption in Amygdala-Dependent Behaviours in Chlorpyrifos
    A Imam, NA Sulaiman, AL Oyewole, A Amin, STT Shittu, MS Ajao
    Journal of Krishna Institute of Medical Sciences (JKIMSU) 7 (3) 2018
    Citations: 16

  • Neuroscience in Nigeria: the past, the present and the future
    WG Balogun, AE Cobham, A Amin
    Metabolic brain disease 33, 359-368 2018
    Citations: 13

  • Role of ginger as anti-inflammatory and anti-apoptotic in protection of liver damage induced by metalaxyl fungicide in male albino rats
    MF Hassa, S Hussein, MM Senosi YEl, A Amin
    J Clin Exp Pathol 8 (346), 2161-0681.1000346 2018
    Citations: 13

  • Black seed oil reversed scopolamine-induced Alzheimer and cortico-hippocampal neural alterations in male Wistar rats
    A Imam, MS Ajao, MI Ajibola, A Amin, AI Abdulmajeed, AZ Lawal, ...
    Bulletin–Faculty of Pharmacy, Cairo University 54 (1), 49-57 2016
    Citations: 13

  • Black seed oil improves motor and anxiety-like behaviors and cerebellar cyto-architectonic in adult male wistar rats
    MS Ajao, A Imam, A Amin, WI Abdulmajeed, MI Ajibola, A Alli-Oluwafuyi, ...
    Nigerian journal of Neuroscience 8 (1-2), 8-14 2016
    Citations: 12

  • Repeated acute oral exposure to Cannabis sativa impaired neurocognitive behaviours and cortico-hippocampal architectonics in Wistar rats
    A Imam, MS Ajao, OB Akinola, MI Ajibola, A Ibrahim, A Amin, ...
    Nigerian Journal of Physiological Sciences 31 (2), 153-159 2016
    Citations: 11

  • Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances
    AB Nafiu, S Alimi, A Babalola, AT Ogunlade, FD Muhammad, A Abioye, ...
    J Complement Med Res 10 (4), 186-199 2019
    Citations: 10

  • Vitamin D3 receptor activation rescued corticostriatal neural activity and improved motor-cognitive function in− D2R Parkinsonian mice model
    AO Ishola, BJ Laoye, DE Oyeleke, OO Bankole, MU Sirjao, AE Cobham, ...
    J. Biomedical Science and Engineering, 1-15 2015
    Citations: 10