Abdur Rauf
@uoswabi.edu.pk
Assistant Professor, Department of Chemistry, University of Swabi, KPK, Pakistan
University of Swabi
Abdur Rauf, Ph.D., works at the Department of Chemistry, University of Swabi, KP, Pakistan. He completed his Ph.D. at the Institute of Chemical Sciences, University of Peshawar, Pakistan in 2015. My research work focuses on Phytochemistry and Pharmacology, dealing particularly with bio-guided isolation of new compounds for drug discovery. His research interest includes isolation and structure elucidation of bioactive compounds using several innovative techniques followed by in vitro and in vivo biological screening. Dr. Abdur Rauf is the author and co-author of more than 340 research papers published in peer-reviewed journals (impact factor = 1410.94), with 7600 citations as per a Google scholar report. In addition, he has an H-index of 38 and an i10 index of 117 (Google scholar). He has also written one book as Editor, 10 book chapters for international Book publishers, and two national and two international patents for the discovery of novel antidiabetic drugs.
EDUCATION
PhD (Chemistry)
RESEARCH INTERESTS
My research work focuses on Phytochemistry and Pharmacology, dealing particularly with bio-guided isolation of new compounds for drug discovery. His research interest includes isolation and structure elucidation of bioactive compounds using several innovative techniques.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Tomi Lois Adetunji, Chijioke Olisah, Ahmed Olatunde, Habibu Tijjani, Mohammad S. Mubarak, Abdur Rauf, and Adeyemi Oladapo Aremu
Elsevier BV
Fatima Saleem, Muhammad Zeeshan Abid, Khezina Rafiq, Abdul Rauf, Khalil Ahmad, Shahid Iqbal, Rongchao Jin, and Ejaz Hussain
Elsevier BV
Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Sadiya Islam Trisha, Akram Hossain Nasim, Muniya Akter, Puja Sutro Dhar, Hanan A. Ogaly, Hassan A. Hemeg, Polrat Wilairatana,et al.
Elsevier BV
Samia Khanum, Abdel Rahman Mohammad Al-Tawaha, Abdel Razzaq Al-Tawaha, Hiba Alatrash, Abdur Rauf, Arun Karnwal, Abhijit Dey, Nujoud Alimad, Devarajan Thangadurai, Jeyabalan Sangeetha,et al.
Apple Academic Press
Samia Khanum, Abdel Rahman Mohammad Al-Tawaha, Abdel Razzaq Al-Tawaha, Hiba Alatrash, Abdur Rauf, Arun Karnwal, Abhijit Dey, Nujoud Alimad, Devarajan Thangadurai, Jeyabalan Sangeetha,et al.
Apple Academic Press
Samia Khanum, Abdel Rahman Mohammad Al-Tawaha, Yousef Abu-Zaitoon, Abdel Razzaq Al-Tawaha, Hiba Alatrash, Abdur Rauf, Arun Karnwal, Abhijit Dey, Mohamad Shatnawi, Devarajan Thangadurai,et al.
Apple Academic Press
Samia Khanum, Abdel Rahman Mohammad Al-Tawaha, Abdel Razzaq Al-Tawaha, Hiba Alatrash, Abdur Rauf, Arun Karnwal, Abhijit Dey, Nujoud Alimad, Devarajan Thangadurai, Jeyabalan Sangeetha,et al.
Apple Academic Press
Samia Khanum, Abdel Rahman Mohammad Al-Tawaha, Yousef Abu-Zaitoon, Abdel Razzaq Al-Tawaha, Hiba Alatrash, Abdur Rauf, Arun Karnwal, Abhijit Dey, Mohamad Shatnawi, Devarajan Thangadurai,et al.
Apple Academic Press
Samia Khanum, Abdel Rahman Mohammad Al-Tawaha, Abdel Razzaq Al-Tawaha, Hiba Alatrash, Abdur Rauf, Arun Karnwal, Abhijit Dey, Nujoud Alimad, Devarajan Thangadurai, Jeyabalan Sangeetha,et al.
Apple Academic Press
Samia Khanum, Abdel Rahman Mohammad Al-Tawaha, Abdel Razzaq Al-Tawaha, Hiba Alatrash, Abdur Rauf, Arun Karnwal, Abhijit Dey, Nujoud Alimad, Devarajan Thangadurai, Jeyabalan Sangeetha,et al.
Apple Academic Press
Adnan Khurshid, Khalid Khan, Abdur Rauf, and Javier Cifuentes-Faura
Elsevier BV
M. Kamil, I. Khan, A. Rauf, S. Bawazeer, S. Bawazeer, A. Rauf, and M. Irfan
FapUNIFESP (SciELO)
Abstract Juglans regia L. are nutritious fruit bearing plants mostly found in Northern areas of Pakistan. The population of walnuts was explored from district Dir and Swat Khyber Pakhtunkhwa, Pakistan for their geographical, climatic and chemical divergence. The geographical differences such as altitude, latitude and longitude whereas climatic differences viz. soil EC, soil pH, precipitations, intensity of light, temperature and soil temperature. In both districts TPC ranged from 211.2±0.6 to 227.8±0.4 mg/100g, RSA ranged from 43.32±1.5% to 52.18±0.4%, conductivity ranged from 296.43±0.6 to 312.22±0.3 S/m and elemental composition such as iron, copper, calcium, zinc and magnesium in Dir differs from 0.312±0.032, 0.209±0.13, 20.0±0.313, 0.406±0.10 and 10.2±0.030 mg/L to 0.543±0.65, 0.698±0.82, 28.7±0.234, 0.685±0.15 and 17.6±0.015 mg/L respectively. Altitude and temperature showed a correlation with total phenolics contents and radical scavenging activity while soil pH, precipitations, soil temperature, soil Ec and light intensity indicated a weak correlation with chemical traits of walnuts. Further studies of walnuts are needed to explore their therapeutically important phytochemicals to succeed naturally pharmaceutical nutrients of the maximum significance for the health of human beings.
A. Sharif, N. A. Shah, A. Rauf, N. Hadayat, A. Gul, G. Nawaz, S. Sakhi, M. Iqbal, M. R. Khan, A. A. Shah,et al.
FapUNIFESP (SciELO)
Abstract This study aims at reporting the indigenous knowledge of the medicinal flora from the inhabitants of surroundings of the World’s largest artificial planted forest “Changa Manga”, Pakistan. Data were collected by direct interviews and group meetings from 81 inhabitants including 32 local healers having information regarding the use of indigenous medicinal plants over a period of one year. Different statistical tools were applied to analyze the data including Frequency citation (FC), Relative frequency citation (RFC), Use Value, Factor of informants consensus and fidelity level. This study reported 73 plant species belonging to 37 plant families and 46 genera. The majority of plant species belong to compositae family. The most commonly used medicinal plants were P. hysterophorus L., P. dactylifera L., S. indicum L, P. harmala L., P. emblica L., and A. indica A.Juss. The greatest number of species was used to cure gastrointestinal disorders. The highest fidelity level (68.18%) was of E. helioscopia to cure gastrointestinal disorders. Maximum fresh uses (17) were reported by C. dactylon (L.) Pars. While the highest number of species reporting fresh uses in similar number was 13. In this study, five novel plants are being reported for the first time in Pakistan for their ethnomedicinal worth. Our data reflect unique usage of the medicinal plants in the study area. The statistical tools used in the study proved useful in pointing the most important and disease category specific plants. High use value plant and the new reported medicinal plants might prove an important source of the isolation of pharmacologically active compounds.
Z. Khan, M. S. Khan, S. Bawazeer, N. Bawazeer, Suleman, M. Irfan, A. Rauf, X.-H. Su, and L.-X. Xing
FapUNIFESP (SciELO)
Abstract Termites are known as social insects worldwide. Presently in China 473 species, 44 genera and 4 families of termites have been reported. Of them, 111 Reticulitermes species are widely spread in different zones of China. The dispersion flight season of these Chinese Reticulitermes species are usually started from February to June, but in some regions different species are distributed, sharing their boundaries and having overlapping flight seasons. These reasons become important sources of hybridization between two different heterospecific populations of termites. It was confirmed that the fertilized eggs and unfertilized eggs of some Reticulitermes termites have the capacity of cleavage. While the unfertilized eggs of R. aculabialis, R. chinensis and R. labralis cleaved normally and the only R. aculabialis unfertilized eggs develop in embryos. While, the R. flaviceps and R. chinensis were observed with their abnormal embryonic development, and not hatching of eggs parthenogenetically. They were reported more threatening to Chinese resources as they propagate with parthenogenesis, hybridization and sexual reproduction. Eggshell and macrophiles of eggs play important roles in species identification and control. Although, they are severe pests and cause a wide range of damages to wooden structures and products in homes, buildings, building materials, trees, crops, and forests in China’s Mainland.
M. Ilyas, A. Rahman, N. H. Khan, M. Haroon, H. Hussain, L. Rehman, M. Alam, A. Rauf, D. S. Waggas, and S. Bawazeer
FapUNIFESP (SciELO)
Abstract Germin-like proteins (GLPs) play an important role against various stresses. Vitis vinifera L. genome contains 7 GLPs; many of them are functionally unexplored. However, the computational analysis may provide important new insight into their function. Currently, physicochemical properties, subcellular localization, domain architectures, 3D structures, N-glycosylation & phosphorylation sites, and phylogeney of the VvGLPs were investigated using the latest computational tools. Their functions were predicted using the Search tool for the retrieval of interacting genes/proteins (STRING) and Blast2Go servers. Most of the VvGLPs were extracellular (43%) in nature but also showed periplasmic (29%), plasma membrane (14%), and mitochondrial- or chloroplast-specific (14%) expression. The functional analysis predicted unique enzymatic activities for these proteins including terpene synthase, isoprenoid synthase, lipoxygenase, phosphate permease, receptor kinase, and hydrolases generally mediated by Mn+ cation. VvGLPs showed similarity in the overall structure, shape, and position of the cupin domain. Functionally, VvGLPs control and regulate the production of secondary metabolites to cope with various stresses. Phylogenetically VvGLP1, -3, -4, -5, and VvGLP7 showed greater similarity due to duplication while VvGLP2 and VvGLP6 revealed a distant relationship. Promoter analysis revealed the presence of diverse cis-regulatory elements among which CAAT box, MYB, MYC, unnamed-4 were common to all of them. The analysis will help to utilize VvGLPs and their promoters in future food programs by developing resistant cultivars against various biotic (Erysiphe necator and in Powdery Mildew etc.) and abiotic (Salt, drought, heat, dehydration, etc.) stresses.
M. Irfan, G. Jan, W. Murad, F. G. Jan, A. Rauf, A. Alsayari, Z. M. Almarhoon, and Y. N. Mabkhot
FapUNIFESP (SciELO)
Abstract Ferns are often used by indigenous people in Khyber Pakhtunkhwa, Pakistan. This study was designed to collect the ethnomedicinal and traditional knowledge of these locals about this group of vascular plants. Forty taxa belong to nineteen genera and ten families are used in the treatment of different diseases. The Pteridaceae was the most representative family with twelve taxa (30%), followed by Athyriaceae and Dryopteridaceae with six taxa each (30%), and Thelypteridaceae with five taxa (12.5%). Regarding the genera, Adiantum, Asplenium and Dryopteris ranked first with four taxa each (30%), followed by Aleuritopteris, Diplazium, Pteris and Equisetum with three taxa each (30%), followed by Athyrium, Oeosporangium, Polystichum and Pseudophegopteris with two taxa each (20%). These taxa were commonly used in the treatment of respiratory disorders i.e. asthma, bronchitis, emphysema, pneumonia; intestinal ulcer, stomach, urinary ailments and skin disorders by the methods of decoction and infusion. Traditional knowledge about ethnomedicinal plants is a valuable and essential source for the discovery of allopathic, herbal and homeopathic medicines.
Abdur Rauf, Zuneera Akram, Muhammad Naveed, Najla AlMasoud, Taghrid S. Alomar, Muhammad Saleem, Abdul Waheed, and Giovanni Ribaudo
MDPI AG
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) regulates skeletal and soft tissue mineralization by hydrolyzing nucleotide triphosphates and cyclic nucleotides, and is involved in the modulation of immune system. In fact, ENPP1 degrades 2′,3′-cyclic GMP-AMP dinucleotide (2′,3′-cGAMP), which is an agonist of surface receptor stimulator of interferon genes (STING), thus downregulating immune response. Consequently, ENPP1 inhibitors are being studied as adjuvant agents in infections and cancer. Pistacia chinensis is a medicinal plant endowed with several biological activities and traditional uses. In the current study, we report the isolation of transilitin (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxychromen-4-one) from the methanolic extract of P. chinensis barks and the investigation of its activity as ENPP1 inhibitor. The compound was tested in vitro against snake venom phosphodiesterase, which is structurally related to ENPP1, and dose-dependently inhibited the enzyme. Moreover, molecular modeling studies were employed to assess the binding motif of the transilitin with the macromolecular target. Our findings support the traditional medical application of P. chinensis and its extracts by shedding new light on the mechanisms underlying their biological action.
Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Ajoy Kumer, Md Sadique Hussain, Smrity Akter, Jeetendra Kumar Gupta, L.H. Thameemul Ansari, Mir Md. Mahfoj Islam Raj, Talha Bin Emran,et al.
Elsevier BV
Abdur Rauf, Taghrid S. AlOmar, Sehrish Sarfaraz, Khurshid Ayub, Fahad Hussain, Umer Rashid, Najla Almasoud, Abdulaziz S. AlOmar, Gauhar Rehman, Zubair Ahmad,et al.
Elsevier BV
Abdur Rauf, Bassam Oudh Aljohny, Umer Rashid, Yasir Anwar, Zafar Ali Shah, Naveed Muhammad, Anees Ahmed Khalil, Ahood Khalid, and Gauhar Rehman
Elsevier BV
Md. Rezaul Islam, Puja Sutro Dhar, Shopnil Akash, Sabeena Hussain Syed, Jeetendra Kumar Gupta, Kumaraswamy Gandla, Muniya Akter, Abdur Rauf, Hassan A. Hemeg, Yasir Anwar,et al.
Springer Science and Business Media LLC
AbstractHypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing interest in complementary and alternative therapeutic approaches. This review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating HTN, with an emphasis on the molecular mechanisms of action found in substances found in plants, herbs, and seafood. Bioactive molecules have been a significant source of novel therapeutics and are crucial in developing and testing new HTN remedies. Recent advances in science have made it possible to understand the complex molecular mechanisms underlying blood pressure (BP)-regulating effects of these natural substances better. Polyphenols, flavonoids, alkaloids, and peptides are examples of bioactive compounds that have demonstrated promise in influencing several pathways involved in regulating vascular tone, reducing oxidative stress (OS), reducing inflammation, and improving endothelial function. The article explains the vasodilatory, diuretic, and renin–angiotensin–aldosterone system (RAAS) modifying properties of vital plants such as garlic and olive leaf. Phytochemicals from plants are the primary in traditional drug development as models for novel antihypertensive drugs, providing diverse strategies to combat HTN due to their biological actions. The review also discusses the functions of calcium channel blockers originating from natural sources, angiotensin-converting enzyme (ACE) inhibitors, and nitric oxide (NO) donors. Including seafood components in this study demonstrates the increased interest in using bioactive chemicals originating from marine sources to treat HTN. Omega-3 fatty acids, peptides, and minerals obtained from seafood sources have anti-inflammatory, vasodilatory, and antioxidant properties that improve vascular health and control BP. Overall, we discussed the multiple functions of bioactive molecules and seafood components in the treatment of HTN.
Aftab Alam, Gowhar Ali, Asif Nawaz, Taghrid S. AlOmar, Abdur Rauf, Muhammad Ayaz, Sajjad Ahmad, Najla Almasoud, Abdulaziz S. AlOmar, Anees Ahmed Khalil,et al.
Elsevier BV
Babar Ali, Sabir Ali Siddique, Muhammad Bilal Ahmed Siddique, Sami Ullah, Muhammad Arif Ali, Abdul Rauf, Muhammad Arshad Kamran, and Muhammad Arshad
Elsevier BV
Mamoona Sabir, Khezina Rafiq, Muhammad Zeeshan Abid, Ujala Quyyum, Syed Shoaib Ahmad Shah, Muhammad Faizan, Abdul Rauf, Shahid Iqbal, and Ejaz Hussain
Elsevier BV
Prabhakar Semwal, Abdur Rauf, Ahmed Olatunde, Pooja Singh, Mohamed Y. Zaky, Md. Mozahidul Islam, Anees Ahmed Khalil, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, and Giovanni Ribaudo
Springer Science and Business Media LLC
AbstractUrtica dioica is a perennial herb from the family of Urticaceae that is commonly known as stinging nettle. This plant is widespread in Europe, Africa, America, and a part of Asia, as it adapts to different environments and climatic conditions. The leaves, stalk, and bark of U. dioica found applications in the field of nutrition, cosmetics, textile, pest control and pharmacology. In this connection, bioactive chemical constituents such as flavonoids, phenolic acids, amino acids, carotenoids, and fatty acids have been isolated from the plant. With this review, we aim at providing an updated and comprehensive overview of the contributions in literature reporting computational, in vitro, pre-clinical and clinical data supporting the therapeutic applications of U. dioica. Experimental evidence shows that U. dioica constituents and extracts can provide neuroprotective effects by acting through a combination of different molecular mechanisms, that are discussed in the review. These findings could lay the basis for the identification and design of more effective tools against neurodegenerative diseases. Graphical Abstract