dr arvind shetti

Scopus Publications

Accuracy of sex estimation by morphometric evaluation of foramen magnum using computed tomography – a systematic review and meta-analysis
Anabelle Louise Veiga Coutinho Fernandes, Arvind Shetti, Vasanti Lagali-Jirge, Vaishali Keluskar
Forensic Science Medicine and Pathology, 2024
Assessment and comparison of salivary survivin biomarker in oral leukoplakia, oral lichen planus, and oral cancer: A comparative study
Ruchika Garg, Arvind V Shetti, Anjana S Bagewadi
World Journal of Dentistry, 2017
Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.
Assessment of serum enzymatic antioxidant levels in patients with recurrent aphthous stomatitis: A case control study
Ishita Gupta, Arvind Shetti, Vaishali Keluskar, Anjana Bagewadi
Enzyme Research, 2014
Background and Aim. Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae. Despite extensive research, the exact etiology of RAS remains elusive. Recently oxidant-antioxidant imbalance of the body has been implicated in the pathogenesis of recurrent aphthous stomatitis. Thus, the aim of the study was to evaluate the enzymatic antioxidant levels in patients with recurrent aphthous stomatitis. Materials and Methods. The serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured in 30 patients with recurrent aphthous stomatitis and compared to the control group, which included 30 healthy subjects. Student’s t-test was performed for statistical evaluation. Results. The mean levels of superoxide dismutase (130.2 ± 15.94 U/mL) and glutathione peroxidase (3527.93 ± 488.32 U/L) were found to be significantly lower in study group as compared to control group (211.9 ± 20.93 U/mL, 8860.93 ± 1105.31 U/L, resp.) (P=0.000) while level of catalase in study group was significantly higher when compared to control group (10981.00 ± 1018.07 U/mL versus 9764.00 ± 1621.19 U/mL) (P=0.000). Conclusion. Enzymatic antioxidant system is impaired in recurrent aphthous stomatitis patients and seems to play a crucial role in its pathogenesis.
Estimation of serum beta carotene levels in patients with oral submucous fibrosis in India.
Ashish Aggarwal, Arvind Shetti, Vaishali Keluskar, Anjana Bagewadi
Journal of Oral Science, 2011
Oral submucous fibrosis (OSMF) is a chronic, insidious and disabling condition affecting the oral cavity, being especially prevalent in India and South East Asia. However, considering its high prevalence and potential to undergo malignant transformation, OSMF has not been widely investigated with respect to levels of antioxidants, especially beta carotene. In the present study, an attempt was made to analyze serum levels of beta carotene in 45 patients with oral submucous fibrosis and 45 age- and sex-matched controls. The serum beta carotene level was estimated using the Bradley and Hornbeck method. The serum beta carotene level was significantly lower in the patients with oral submucous fibrosis than in the controls. When the values were compared between different disease stages, the maximum reduction of beta carotene was evident for Grade III OSMF, as compared with Grade I and II. From the present results, it is evident that beta carotene plays an important role in the pathogenesis of OSMF, and that its level decreases with disease progression. OSMF patients should be treated with a diet rich in beta carotene to reduce disease severity and progression towards malignancy.
The microbial flora associated with oral carcinomas
Quintessence International, 2011
Evaluating and comparing phagocytic functions of salivary and blood neutrophils in patients with recurrent aphthous ulcers and controls
Quintessence International, 2010
Comparison of palatal rugae pattern in two populations of India
International Journal of Medical Toxicology and Legal Medicine, 2008