Achmad Fauzi Kamal
@ui.ac.id
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia/Cipto mangunkusumo Hospital, jakarta, Indonesia
Universitas Indonesia
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mohamad Fadhil Ardianov, Yogi Prabowo, Sugeng Supriadi, Pelangi Raihan Mathar, and Achmad Fauzi Kamal
AIP Publishing
Iwan Setyadi, Suryadi, I Nyoman Jujur, Mirza Wibisono, Damisih, Maykel Manawan, Krisna Adhitya, Arif Hidayat, Achmad Fauzi Kamal, Rahyusalim,et al.
Insight Society
Developing biodegradable bone implants using magnesium-based materials has garnered significant attention in research. Magnesium offers favorable properties, such as low density, biocompatibility, elastic modulus like bone, and high toxicity limits. However, improvements are needed in mechanical properties and degradation rate. This study focuses on enhancing these properties by developing a novel composite of magnesium with carbonate apatite (CA) reinforcement, Mg/5CA. Compared to hydroxyapatite (HA), CA offers better absorption and avoids fibrotic tissue formation. However, CA undergoes carbonate decomposition during sintering, leading to composite degradation. To address this, an extrusion process is employed to prevent carbonate decomposition. The advanced sintering and extrusion compaction processes are compared for the Mg/5CA composite, examining density, microstructure, hardness, compressive strength, and biocorrosion. Results demonstrate that extrusion increases relative density while CA slightly reduces it. Microstructural analysis reveals finer and elongated grains, tighter bonding between CA and Mg particles, and reduced microporosity in the extruded composite. Mechanical properties, including hardness distribution and compressive strength, are improved in the extruded composite, and the degradation rate decreases compared to sintering. Overall, the extrusion process effectively enhances Mg/5CA composite properties, positioning it as a promising manufacturing technique for biodegradable implant materials. This research contributes to the development of advanced biodegradable implants, which can have significant applications in the field of medical science. Further investigations in this area can contribute to the ongoing advancements in biodegradable implant technology.
I Wayan Arya Mahendra Karda, Wan Faisham Wan Ismail, and Achmad Fauzi Kamal
Springer Science and Business Media LLC
AbstractIn Indonesia, the challenge of osteosarcoma progression is further worsened by patients' dependence on traditional massage therapy, low socio-economy, and educational status. This study aims to analyze the differences in the characteristics, laboratory findings, surgery techniques, degree of histopathological necrosis, and metastasis between osteosarcoma patients with and without prior massage manipulation therapy. This research is an analytical observational study with a prospective and retrospective cohort design. Patients were treated and followed for one year to evaluate the occurrence of metastasis. Prospective data was collected through interviews, and secondary data was collected from the patient's medical record. Of 84 subjects analyzed, 69% had a history of massage. There was an increase in LDH and ALP in patients with massage manipulation (p = 0.026). The median time to metastasis from baseline in the massage group (4 months) was statistically significant compared to the non-manipulation group (12 months) (p < 0.0001). This research found that massage therapy significantly increases LDH and ALP levels, making amputations more likely to be performed and a higher risk of metastasis that lowered the survival rate. The onset of metastasis was three times faster in patients with prior massage therapy. Therefore, we strongly recommend against massage manipulation therapy in osteosarcoma patients.
Muhammad Rizqi Adhi Primaputra, Sashia Laras, Achmad Fauzi Kamal, and Yogi Prabowo
Elsevier BV
Ludwig Andre Pontoh, Ismail Hadisoebroto Dilogo, Achmad Fauzi Kamal, Wahyu Widodo, Erica Kholinne, Sholahuddin Rhatomy, and Jessica Fiolin
Springer Science and Business Media LLC
Andri Maruli Tua Lubis, Petrus Aprianto, Jeanne Adiwinata Pawitan, Bambang Pontjo Priosoeryanto, Tri Isyani Tungga Dewi, and Achmad Fauzi Kamal
Medical Journals Sweden AB
Background and purpose: Mesenchymal stem cells (MSCs), both endogenous and exogenous, enhance chondrocyte proliferation by stimulating collagen type II. Secretome, an MSC derivate, has shown to also provide this mechanism through a paracrine effect. We aimed to evaluate the use of secretome and MSC in the management of early osteoarthritis (OA).Animals and methods: 19 (1 control) male sheep (Ovies aries), which were operated on with total lateral meniscectomy to induce knee OA, were divided into 3 groups: the secretome group, hyaluronic acid group, and MSC group. Each group was injected with the respective substances and was evaluated macroscopically and microscopically. The Osteoarthritis Research Society International (OARSI) score was calculated for all subjects and a descriptive and comparative statistical analysis was undertaken.Results: The macroscopic analysis of the treated groups revealed better OARSI score in the secretome group compared with the other 2 groups. The secretome group showed a significantly better microscopic score compared with the hyaluronic acid group (mean difference [MD] 6.0, 95% confidence interval [CI] 0.15–12), but no significant difference compared with the MSC group (MD 1.0, CI –4.8 to 6.8).Conclusion: Intra-articular injection of secretome is effective in managing early-stage osteoarthritis in the animal model compared with hyaluronic acid and has similar efficacy to MSC injection.
Fahmi Anshori, Achmad Fauzi Kamal, Yogi Prabowo, Aria Kekalih, Rudi Febrianto, Dyah Purnaning, and Ismail Hadisoebroto Dilogo
Informa UK Limited
Introduction There was a magnitude 7 on the Richter scale earthquake on Lombok Island in 2018, causing more than 500 deaths. In the event of earthquakes, there is often an imbalance between overcrowding in hospitals and inadequate resources. The initial management of earthquake victims with musculoskeletal injuries is controversial, arguing over whether to utilize debridement, external or internal fixation, or conservative or operative treatment in an acute onset disaster situation. This study aims to determine the outcome of initial management after the 2018 Lombok earthquake, between immediate open-reduction and internal fixation (ORIF) and Non-ORIF procedures after one year follow-up. Methods This is a cohort study to evaluate radiological and clinical outcomes one year after orthopedic treatment in the Lombok earthquake 2018. The subjects were recruited from eight public health center and one hospital in Lombok in September 2019. We evaluate radiological outcomes (non/malunion and union) and clinical outcomes (infection and SF-36 score). Results Based on 73 subjects, the ORIF group has a higher union rate than the non-ORIF group (31.1% vs. 68.9%; p = 0.021). Incidence of infection only appeared in the ORIF group (23.5%). Clinical outcome as measured by SF36 showed the ORIF group had a lower mean of general health (p = 0.042) and health change (p = 0.039) clinical outcomes than the non-ORIF group. Discussion The most affected public group is the productive age with significant impact on social-economy. ORIF procedure is a major risk factor of infection in initial treatment after earthquake. Therefore, definitive operation with internal fixation is not recommended in the initial phase of a disaster. Damage Control Orthopedic (DCO) surgery protocol is the treatment of choice in acute disaster setting. Conclusion The ORIF group had better radiological outcomes than the non-ORIF group. However the ORIF group had higher cases of infection and lower SF-36 than the non-ORIF group. Definitive treatment in acute onset disaster setting should be prevented.
Achmad Fauzi Kamal and Fahresa Hilmy
Elsevier BV
Mohamad Fadhil Ardianov, Sugeng Supriadi, Yogi Prabowo, and Achmad Fauzi Kamal
AIP Publishing
Ifran Saleh, Didik Librianto, Achmad Fauzi Kamal, Fachrisal Ipang, Wahyu Widodo, and Dina Aprilya
Elsevier BV
Achmad Fauzi Kamal, Sigit Daru Cahayadi, Reza Abidin Shihab, and Didi Saputra Ramang
Elsevier BV
Ludwig Andre Pontoh, Ismail Hadisoebroto Dilogo, Achmad Fauzi Kamal, Wahyu Widodo, and Jessica Fiolin
Elsevier BV
Achmad Fauzi Kamal and Riko Satriyo Wibowo
Elsevier BV
Iwan Setyadi, Toto Sudiro, Bambang Hermanto, Prima Rizky Oktari, Achmad Fauzi Kamal, Ahmad Jabir Rahyussalim, Bambang Suharno, and Sugeng Supriadi
Penerbit Universiti Kebangsaan Malaysia (UKM Press)
Magnesium-Carbonate Apatite (Mg-xCA) is one of the potential magnesium composites to be developed as an alternative biodegradable implant material. Several attempts were made to optimize its characteristics. In this study, Mg-xCA (x = 0, 5, 10, and 15% wt) was prepared by powder metallurgy through warm compaction (WC) and further densified by 2 sintering process methods, namely conventional sintering (CS) and spark plasma sintering (SPS). The characterization included density test, XRD test, microstructure test (OM and SEM-EDS-Mapping), microhardness test, and electrochemical test. The SPS process improves the characteristics of Mg-xCA better than the CS process. The SPS process can increase the relative density by about 0.7-2.4%, increase the hardness by about 2-13%, and reduce the corrosion rate by about 32-49% compared to the initial condition before sintering (WC). The SPS structure has a lower oxygen elemental content than the CS structure. The sintered process with SPS is considered effective for the fabrication of Mg-xCA powder-based composites compared to the CS process.
Achmad Fauzi Kamal, Prima Rizky Oktari, Aryadi Kurniawan, Evelina Kodrat, and Nadia Asmirtania Mumpuni
Informa UK Limited
Purpose The lack of knowledge regarding osteoarticular tuberculosis (TB) cases in Indonesia leads to delayed and chronic conditions. This study aims to evaluate clinical outcomes of patients with osteoarticular TB. Materials and Methods Thirty osteoarticular cases were retrospectively analyzed, with a focus on non-immunocompromised patients without spine involvement. Chemotherapy length, operative treatment method, and infection recurrence were evaluated. Results The majority (60%) of patients were aged between 19 to 49 years. The most common complaint was painful swelling, particularly during physical activity. Weight-bearing joints, such as the hips, knees, and ankles, were the most affected. Laboratory results showed over half of the patients had anemia, 96% had elevated erythrocyte sedimentation rate (ESR), and 76% had elevated C-reactive protein (CRP) levels. Radiological findings varied, with lytic lesions, abscesses, and joint destruction observed. All patients presented with pathognomonic histological tubercle appearances, with caseous necrosis, lymphocytes, and Langhans giant cells present. Twenty-nine cases were treated with anti-TB drugs for 12 months, while one recurrent case received the drugs for 24 months. All patients underwent surgery to gain local infection control. Conclusion Osteoarticular TB is a common manifestation of extrapulmonary TB and must not be overlooked. Early detection of osteoarticular TB may prevent limb morbidity. Although anti-TB drugs are the primary treatment for osteoarticular TB, in some cases, surgery is required to establish a diagnosis and gain local infection control.
Achmad Fauzi Kamal and Didi Saputra Ramang
Elsevier BV
INTRODUCTION
Osteofibrous dysplasia is a relatively rare disease, exclusively found in children, affecting the tibial diaphysis. Various management approaches are already available, but an internationally approved management guideline is not yet established. There is a major concern in the current management of wide excision technique as it frequently results in massive bone defect.
CASE PRESENTATION
Here we present a case of osteofibrous dysplasia on a 10-year-old girl in Cipto Mangunkusumo Hospital with chief complaint of mild persistent pain of her lower leg since two years before with slight bowing deformity. The radiograph and histopathological examination support the diagnosis of osteofibrous dysplasia. She was managed with en-bloc resection (wide excision) of the tumor, followed with reconstruction using biomaterials substitute; combination between demineralized bone matrix (BonegenerR) and bone substitute "hydroxyapatite and calcium sulphate" and internal fixation using plate and screw.
RESULTS
Clinical and radiological evaluation showed successful improvement and outcome. The patient showed progressive functional outcomes and achieved functional score of 100% LEFS at 3 years follow-up. The plate and screw was removed at 48 weeks after adequate callus formation andradiological union was achieved.
CONCLUSION
Simple reconstruction using biomaterial bone substitute not only created new bone formation with good stability, but also enabled patient to have an improved quality of life. This method is recommended to overcome the massive bone defect after tumor resection in osteofibrous dysplasia patient.
Suprayitno Wardoyo, Achmad Fauzi Kamal, Muhammad Aris Furqon, Jonathan Grantomo, and Witantra Dhamar Hutami
Elsevier BV
Achmad Fauzi Kamal, Irsan Abubakar, and Thariqah Salamah
Elsevier BV
Achmad Fauzi Kamal, Fahmi Anshori, and Evelina Kodrat
Elsevier BV
Highlights • Challenging diagnostic regarding diagnosis of Osteofibrous dysplasia and Osteofibrous dysplasia-like adamantinoma.• There is controversy spectrum disease between adamantinoma and OFD-like adamantinoma and OFD in children.• Histopathology and immunohistochemical staining for diagnostic OFD, OFD-like adamantinoma and adamantinoma.
Didik Librianto, Ismail Hadisoebroto Dilogo, Achmad Fauzi Kamal, Ifran Saleh, Fachrisal Ipang, and Dina Aprilya
Informa UK Limited
Background Kyphosis in spondylitis tuberculosis (STb) is more than just a cosmetic issue. It has a potentially detrimental effect on both spine-associated structures and cardiopulmonary function. It can be corrected in any stage of STb; however, the corrective surgery is challenging, especially in the late case, in which the additional stiffness of the spine can come into consideration. To date, the cantilever technique is still a gold standard for sagittal plane deformity correction. However, no study to date has explored its effectiveness for thoracolumbar kyphotic deformity, especially that caused by spondylitis tuberculosis. Methods This is a retrospective study of 16 consecutive cases of spondylitis tuberculosis with thoracolumbar kyphosis that underwent corrective surgery in our center in the period of 2020–2021. We aim to evaluate the effectiveness of the cantilever technique that we use for kyphotic correction in thoracolumbar STb patients. Results At the 3-months follow-up, the mean Cobb angle was 14.6°±10.27°, with the mean gain of 20.90°±12.00° and positively correlate with the thoracolumbar kyphosis (TLK) correction (68.69%, r = 0.654, p = 0.001). The mean thoracic kyphosis, lumbar lordosis, and sagittal vertebral axis were 30.6°±13.08°, 39.4°±16.02°, and 1.4±4.09 cm, respectively, with sagittal Cobb difference of 12.70±9.85. Conclusion The kyphotic Cobb angle reduction by cantilever technique in the thoracolumbar area significantly improved the thoracolumbar kyphosis and realign the spinal sagittal axis. Thus, the cantilever technique remains the gold standard for sagittal plane deformity correction which can be applied for kyphotic deformity correction in thoracolumbar STb cases.
Achmad Fauzi Kamal, Didi Saputra Ramang, and Marcel Prasetyo
Hindawi Limited
Malignant musculoskeletal tumour may cause considerable burden to general health. The fast growth combined with the tumour characteristics and its invasion capability resulted in the poor prognosis of malignant musculoskeletal tumour. Malignant musculoskeletal tumour may cause significant disability by destroying normal tissue that plays important role in body kinematics. Thromboembolism, including deep vein thrombosis, pulmonary embolism, and other kinds of venous thromboembolism, is one of the most underestimated complications of musculoskeletal tumour. Normally, thrombosis ensues when pathologic factors overcame the body hemostatic regulatory capabilities, which will predispose the body to the formation of thrombus. Venous thromboembolism in musculoskeletal tumour may develop as a result of interaction between the tumour pathologic capabilities and its interaction with normal bodily functions. In this study, we reviewed the burden of musculoskeletal tumour and its complication on global health. Then, the review will focus on the pathologic and clinical aspect of thromboembolism in malignant musculoskeletal tumour, including pathophysiology, diagnosis, and treatment based on recent findings and literature.