Adel Ali amran
@tu.edu.ye
Physiology department faculty of medicine
Lecture
EDUCATION
PhD in human science physiology
RESEARCH, TEACHING, or OTHER INTERESTS
Physiology, Complementary and alternative medicine, Hematology, Medical Laboratory Technology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Abdullatif D Ali, Amat Al-Khaleq Mehrass, Abdulelah Al-Adhroey, Abdulqawi Al-Shammakh, and Adel Amran
Informa UK Limited
Purpose Gestational diabetes mellitus (GDM) continues to be a significant health disorder triggering harmful complications in pregnant women and fetuses. Our knowledge of GDM epidemiology in Yemen is largely based on very limited data. The aim of this study was, therefore, to determine the prevalence and risk factors of GDM among pregnant women in Dhamar governorate, Yemen. Patients and methods A total of 311 subjects were randomly selected for this cross sectional survey. Health history data and blood samples were collected using a pretested questionnaire. To determine the prevalence of GDM, the fasting and random blood glucose techniques were applied according to the recommendations of the American Diabetes Association, using alternative methods that are more convenient to the targeted population. Poisson’s regression model incorporating robust sandwich variance was utilized to assess the association of potential risk factors in developing GDM. Results The prevalence of GDM was found to be 5.1% among the study population. Multivariate analysis confirmed age ≥30 years, previous GDM, family history of diabetes, and history of polycystic ovary syndrome as independent risk factors for GDM prevalence. However, body mass index ≥30 kg/m2 and previous macrosomic baby were found to be dependent risk factors. Conclusion This study reports new epidemiological information about the prevalence and risk factors of GDM in Yemen. Introduction of proper maternal and neonatal medical care and health education are important in order to save the mother and the baby.
Hesham M. Al-Mekhlafi, Mohammed A. Mahdy, Atiya A. Sallam, W. A. Ariffin, Abdulsalam M. Al-Mekhlafi, Adel A. Amran, and Johari Surin
Cambridge University Press (CUP)
A community-based cross-sectional study was carried out among Aboriginal schoolchildren aged 7–12 years living in remote areas in Pos Betau, Pahang, Malaysia to investigate the potential determinants influencing the cognitive function and educational achievement of these children. Cognitive function was measured by intelligence quotient (IQ), while examination scores of selected school subjects were used in assessing educational achievement. Blood samples were collected to assess serum Fe status. All children were screened for soil-transmitted helminthes. Demographic and socio-economic data were collected using pre-tested questionnaires. Almost two-thirds (67·6 %) of the subjects had poor IQ and most of them (72·6 %) had insufficient educational achievement. Output of the stepwise multiple regression model showed that poor IQ was significantly associated with low household income which contributed the most to the regression variance (r2 0·059; P = 0·020). Low maternal education was also identified as a significant predictor of low IQ scores (r2 0·042; P = 0·043). With educational achievement, Fe-deficiency anaemia (IDA) was the only variable to show significant association (r2 0·025; P = 0·015). In conclusion, the cognitive function and educational achievement of Aboriginal schoolchildren are poor and influenced by household income, maternal education and IDA. Thus, effective and integrated measures to improve the nutritional and socio-economic status of rural children would have a pronounced positive effect on their education.
Abdulelah H. Al-Adhroey, Zurainee M. Nor, Hesham M. Al-Mekhlafi, Adel A. Amran, and Rohela Mahmud
Elsevier BV
Adel A Amran, Zaiton Zakaria, Faizah Othman, Srijit Das, Hesham M Al-Mekhlafi, and Nor-Anita MM Nordin
Springer Science and Business Media LLC
Abstract Background Inflammation process plays an important role in the development of atherosclerosis. Hypercholesterolemia is one of the major risk factors for atherosclerosis. The present study aimed to evaluate the effect of aqueous extract of Piper sarmentosum (P.s) on inflammatory markers like vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and C-reactive protein (CRP). Methods Forty two male New Zealand white rabbits were divided equally into seven groups; (i) C- control group fed normal rabbit chow (ii) CH- cholesterol diet (1%cholesterol) (iii) X1- 1% cholesterol with water extract of P.s (62.5 mg/kg) (iv) X2- 1% cholesterol with water extract of P.s (125 mg/kg (v) X3- 1% cholesterol with water extract of P.s (250 mg/kg) (vi) X4- 1% cholesterol with water extract of P.s (500 mg/kg) and (vii) SMV group fed with 1% cholesterol supplemented with simvistatin drug (1.2 mg/kg). All animals were treated for 10 weeks. Blood serum was taken for observing the inflammatory markers at the beginning and end of the experiment. Results Rabbits fed with 1% cholesterol diet (CH) showed significant increase in the level of VCAM-1, ICAM-1 and CRP compared to the C group. The levels of VCAM-1, ICAM-1 and CRP in the 1% cholesterol group and supplemented with P.s (500 mg/kg) were significantly reduced compared to the cholesterol group. Similar results were also reported with simvistatin group. Conclusion These results suggest that the supplementation of Piper sarmentosum extract could inhibit inflammatory markers which in turn could prevent atherosclerosis.
Abdulelah H. Al-Adhroey, Zurainee M. Nor, Hesham M. Al-Mekhlafi, Adel A. Amran, and Rohela Mahmud
MDPI AG
The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50–400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei(NK65) during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05) schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis.
Adel.A. Amran, Zaiton Zakaria, Faizah Othman, and Paden Morat
Science Publications
Problem statement: Oxidative stress plays a major role in hypercholesterolemia induced
atherosclerosis. Garcinia atroviridis has been shown to exhibit antioxidant properties. Approach: The
present study aimed to investigate the effect of Garcinia atroviridis on the oxidative stress in guinea
pigs fed with high cholesterol diet. Twenty-four male Guinea pigs were divided into four groups.
Group I served as control while group II, III, IV were fed with 1% cholesterol diet in rabbit chow
pellet, fed with both 1% cholesterol diet plus 50 mg body-1 weight of Garcinia atroviridis, fed with
Garcinia atroviridis only (50 mg mL-1 water body-1 weight), respectively. All animals were sacrificed
by cardiac puncture and the blood was collected for the determination of malonaldialdehyde and DNA
damage using comet assay and histology of the aorta was performed. Results: The results showed a
significant increase in the percentage of DNA damage in the tail and in the tail moment (comet assay)
in the group II compared to the group I. Group III showed pattern of reduction in the percentage of
DNA damage by 42% and tail moment by 50% compared to the group II. There were no significant
changes in the MDA levels in serum, liver and heart in all groups. Histological studies in group III
showed a tendency in the reduction of the fat deposition in the aorta and number of foam cells
compared to the group II. Conclusion: The supplementation with Garcinia atroviridis reduced the
DNA damage and deposition of lipids in the wall of the aorta in hypercholesteromic guinea pigs.
Adel A Amran, Zaiton Zakaria, Faizah Othman, Srijit Das, Santhana Raj, and Nor-Anita M M Nordin
Springer Science and Business Media LLC
Abstract Background Piper sarmentosum (P.s) has flavonoid component in its leaves which has antioxidative effect. To date, its effect on atherosclerosis has not been studied histologically. Aim The study aimed to investigate the effect of P.s on atherosclerotic changes in hypercholesterolemic rabbits. Methods Forty two male New Zealand white rabbits were divided into seven groups. C - control group fed normal rabbit chow, CH - cholesterol diet (1% cholesterol), W1 - 1% cholesterol with water extract of P.s (62.5 mg/kg), W2 - 1% cholesterol with water extract of P.s (125 mg/kg), W3 - 1% cholesterol with water extract of P.s (250 mg/kg), W4 - 1% cholesterol with water extract of P.s (500 mg/kg) and Smv - 1% cholesterol supplemented with simvistatin drug (1.2 mg/kg). All rabbits were treated for 10 weeks. Following 10 weeks of supplementation, the animals were sacrificed and the aortic tissue was taken for histological study. Results Rabbits fed only with high cholesterol diet 1% cholesterol (CH) showed focal fatty streak lesions compared to the C group and 1% cholesterol supplemented with simvistatin drug (Smv) group. Atherosclerotic lesions in the 1% cholesterol group supplemented with P.s (500 mg/kg) i.e. W4 group showed significant reduction (30 ± 6.0%, p < 0.05) in fatty streak compared to the high cholesterol group (85.6 ± 4.1%) under Sudan IV stain. The atherosclerotic lesions under transmission electron microscope showed reduction in foam cells in the treatment groups compared to the CH groups. Conclusion Administration of P.s extract has protective effect against atheroscleros