Medical Laboratory Technology, Histology, Anatomy, Cellular and Molecular Neuroscience
16
Scopus Publications
281
Scholar Citations
8
Scholar h-index
7
Scholar i10-index
Scopus Publications
Medicinal Ethnobotanicals in Mitigating Pollution-Induced Oxidative Damage With Mechanisms and Therapeutic Potential: Mechanistic Basis of Plant Antioxidant Defense Temidayo Daniel Adeniyi, Akinpelu Moronkeji, Godwin Olawoyin Adunmo, Gbadebo Maroof Oyeniyi, Emmanuel Tolulope Adegoke, et al. Pharmacology Characterizations Toxicity and Herb Drug Interactions of Herbs in Traditional Medicine, 2026 Environmental pollution remains a global health issue linked to numerous diseases, primarily through the generation of reactive oxygen species (ROS) that induce lipid peroxidation, protein and DNA damage, and cellular dysfunction. This review examines the therapeutic potential of medicinal ethnobotanicals in mitigating pollution-induced oxidative stress, with a focus on their molecular mechanisms and therapeutic potentials. Ethnobotanicals, rich in bioactive phytochemicals such as flavonoids, phenolic acids, alkaloids, and terpenoids, exhibit potent antioxidant and cytoprotective properties. Their protective effects are largely mediated through the enhancement of endogenous antioxidant systems and modulation of redox-sensitive signalling pathways. Evidence from both in vivo and in vitro studies highlights the efficacy of selected ethnobotanicals in reducing oxidative biomarkers and restoring tissue homeostasis, particularly in mammalian systems. This review highlights the potential of ethnobotanicals as promising agents in mitigating the health effects of environmental pollutants.
Ascorbate and alpha-tocopherol attenuate hepatorenal injury and modulate CYP2E1 and Nrf2 expression in rats exposed to herbalised alcoholic beverage Temidayo Daniel Adeniyi, Akinpelu Moronkeji, Godwin Olawoyin Adunmo, Adetokunbo Adedotun Okunnuga, Olayinka Joshua Ajala, et al. Human and Experimental Toxicology, 2026 Background The rising consumption of herbal alcoholic beverages in Nigeria, driven by unverified health claims, poses growing public health risks and adds to the global disease burden. Aim To evaluate the effects of ascorbate and alpha-tocopherol supplementation on hepatorenal biochemical parameters, histopathology, and expression of oxidative stress-related genes (Nrf2 and CYP2E1) in rats exposed to a herbal-based alcoholic beverage. Methods Twenty-eight adult male Wistar rats were randomly assigned into four groups (n=7 per group) using a computer-generated randomisation, with all outcome assessments performed under blinded conditions. Group I consisted of the unexposed control rats. Group II rats received a daily oral dose of alcohol at 0.2 mL/kg/bw. Groups III and IV were also administered alcohol daily at 0.2 mL/kg/bw but were additionally treated with ascorbate (500 mg/kg) and alpha-tocopherol (300 mg/kg), respectively, for 28 days. Hepatorenal biochemical parameters, hepatic and renal Nrf2 and CYP2E1 expression, and histopathological changes were subsequently evaluated. Results Supplementation with ascorbate (500 mg/kg) or α-tocopherol (300 mg/kg) was associated with significantly lower (p < 0.05) ALP, ALT, AST, creatinine, and urea levels compared with alcohol-exposed untreated rats. Vitamin supplementation was associated with the modulation of alcohol-induced overexpression of CYP2E1 and Nrf2, and partially restored the altered biochemical parameters. Histopathological examination further revealed mitigated alcohol-induced architectural disruptions in the liver and kidney, suggestive of the protective effects of antioxidant supplementation. Conclusion Ascorbate and alpha-tocopherol supplementation were associated with attenuation of alcohol-induced hepatorenal biochemical alterations, partial normalisation of liver and kidney function parameters, and modulation of oxidative stress-related gene expression (CYP2E1, Nrf2), findings consistent with a potential adjunctive role of these vitamins in mitigating alcohol-related organ toxicity rather than indicating definitive therapeutic effects. Mechanistic conclusions are limited by the absence of direct oxidative stress marker measurements (lipid peroxidation, glutathione status, antioxidant enzyme activities), and interpretation is limited by the absence of pure ethanol and vitamin-only control groups and the lack of independent chemical verification of the test beverage.
Epidemiological survey and chromatographic profiling of ligands associated with Schistosoma haematobium infection in Oke-Alafia, Ondo State, Nigeria Temidayo Adeniyi, Abdulazeez Abubakar, Lovette Akinoguntuase, Shefiat Bashir Babcock University Medical Journal, 2025 Objective: Nigeria is the world's most endemic country for schistosomiasis, with the disease burden second only to malaria globally. Objective: This study aimed to survey Schistosoma haematobium infection in Oke-Alafia, Ondo State, and identify ligands associated with urinary schistosomiasis. Methods: A cross-sectional survey of 400 participants was conducted in the Oke-Alafia community to assess the distribution of Schistosoma haematobium infection and identify associated ligands. Microscopy and cultural techniques were employed on urine samples from randomly selected subjects to detect S. haematobium and exclude bacterial infections. Statistical analysis used the Chi-square test (p < 0.05). Results: The prevalence of urinary schistosomiasis was 18.75%. The most abundant ligands in infected urine samples included Methyl 4-hydroxybutyl, Trimethyl Silyl, Thiazole, 2-Pyrrolidinone, 1-methyl, and Piperidine. Statistical analysis showed no significant difference in ligand abundance related to urinary schistosomiasis (X2 = 1.7312; P > 0.05). In contrast, normal urine samples (without parasitic or bacterial infections) had five distinct ligands, including Hydrazine carbothioamide, Dihydroartemisinic acid, and Silane, with significant differences in abundance (X2 = 5.242; P < 0.05). Conclusion: Identified ligands may serve as potential biomarkers for rapid diagnostic methods in urinary schistosomiasis.
Modulatory effects of Aframomum melegueta and Rauvolfia vomitoria in cadmium-induced renal toxicity in adult rats Akinpelu Moronkeji, Temidayo Adeniyi, Esan Olubunmi, Immanuel Kayode, Olayinka Joshua Ajala, et al. Journal of Cellular Biotechnology, 2025 Background Cadmium, a nephrotoxic heavy metal, poses significant health risks that may be mitigated by the phytocompounds in ethnobotanicals like Aframomum melegueta and Rauvolfia vomitoria. Objective To evaluate the modulatory potential of Aframomum melegueta and Rauvolfia vomitoria on myeloperoxidase (MPO) and nuclear factor kappa B (NF-Κβ) expression, alongside histomorphological changes in cadmium chloride (CdCl 2 )-induced renal toxicity. Methods Twenty-five adult Wistar rats (200 g) were divided into five groups ( n = 7). Group I was the control, while Groups II–V received CdCl 2 (30 mg/kg BW, weekly). Group II received no treatment; Groups III and IV were administered Aframomum melegueta and Rauvolfia vomitoria extract (200 mg/kg BW daily), respectively. Group V received both extracts (200 mg/kg BW daily). After 28 days, kidneys were excised for histological and mRNA expression of myeloperoxidase and NF-κB. Data were analysed using one-way ANOVA, with p ≤ 0.05 considered significant. Results Aframomum melegueta and Rauvolfia vomitoria extracts significantly repressed MPO and NF-κB expression, with co-treatment exhibiting a stronger downregulatory effect ( p < 0.05). Histological analysis also showed improved renal architecture, as treatments mitigated histoarchitectural abnormalities observed in the cadmium-exposed untreated rats. Conclusion Findings suggest the potential therapeutic effects of Aframomum melegueta and Rauvolfia vomitoria in mitigating cadmium-induced kidney toxicity.
Arsenic and vanadium co-exposure induced cerebellar neurotoxicity: aggravates apoptosis, inflammation, oxidative stress, and locomotor deficits in juvenile BALB/c mice Damilare Adedayo Adekomi, John Olabode Fatoki, Titilayo Deborah Adesipe, Omowumi Oyeronke Adewale, Adesina Oloruntoba Adekeye, et al. Anatomy and Cell Biology, 2025 In this research, we studied the individual and combined effects of arsenic and vanadium on the cerebellum of mice. Mice were subjected to arsenic and vanadium individually and in combination for 21 days. Twenty-four hours after the last administration, the mice were subjected to open field and rotarod tests after which the cerebellar tissues were harvested for biochemical analysis of the levels of malondialdehyde (MDA), catalase (CAT), caspase-3, tumor necrosis factor alpha (TNF-α), nuclear factor erythroid 2-related factor 2 (Nrf2), interleukin-1 beta (IL-1β), dopamine, serotonin, acetylcholine, and acetylcholinesterase. The hematoxylin and eosin stain was employed to explore histopathological event in the cerebellar tissue. The mice were either subjected to arsenic or vanadium or their combination showed significant short fall respectively in the open field and rotarod tests. There was an aggravated shortfall in the mice exposed to arsenic+vanadium combination. Furthermore, our data showed that exposure to the combination of arsenic and vanadium provoked synergistic neurotoxicity in the cerebellum of the mice subjected to arsenic+vanadium resulting into disturbance of locomotor and the production of neurodegenerative characteristics in the cerebellum. Relative to the control group, the levels of MDA, CAT, caspase-3, TNF-α, Nrf2, IL-1β, dopamine, serotonin, acetylcholine, and acetylcholinesterase were adversely modulated in the arsenic-treated, vanadium-treated and in the group exposed to the combination of arsenic+vanadium. The histopathology of the cerebellum showed that exposure to arsenic, vanadium, and their combination produced neurodegenerative effects. The study conclude that exposure to arsenic and vanadium, as well as their combination, had a considerable influence on cerebellar tissue, culminating in a synergistic toxic effect.
Oxidative stress response to gasoline generator exhaust emission in adult male wistar rats Akinpelu Moronkeji, Ayodeji Olayanju, Temidayo Daniel Adeniyi, Atere Adedeji David, Moronkeji Adebimpe Iyanuoluwa, et al. Environmental Analysis Health and Toxicology, 2024 Petroleum-powered generators are commonly used in many developing countries as an alternative to meet utility demands. Generator exhaust emission significantly contributes to air pollution, which remains a constant threat to human health due to the presence of aromatic hydrocarbons and other harmful gases. This study assessed oxidative stress parameters in response to exhaust emission from gasoline generator engine in adult male wistar rats. Forty-eight (48) adult wistar rats weighing between 180-200g were randomly allocated to four (4) groups (A-D) of twelve (12) rats each. After the acclimatization period, the control group (A) were kept unexposed, whereas rats in groups (C-D) were exposed daily at 2, 4, and 8-hour intervals for 4, 8, and 12 weeks, respectively. Tissue samples were obtained at four weeks intervals. Fresh lung tissues weighing 1g were rinsed twice in phosphate-buffered saline (PBS, pH 8.0), homogenized and centrifuged at 3000 revolutions per minute for 20 min at 4°C. Supernatant levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione S-transferase (GST), reduced glutathione (GSH), nitric oxide (NO), hydrogen peroxide (H2O2), catalase (CAT), and total antioxidant status (TAS) were determined using standard protocols. The findings revealed elevated oxidant levels of MDA, NO, and H2O2, whereas SOD, GPX, GST, GSH, CAT, and TAS were significantly reduced across the exposure time points compared to the unexposed control rats (p < 0.05). The research findings revealed that exposure to emissions from gasoline generators induced oxidative stress in the exposed rats, with the extent of disruption to their oxidative balance dependent on the duration and length of exposure time.
Exposure to smoke extract of datura stramonium leaf: Some of its effects on the heart, liver, lungs, kidneys and testes of male sprague dawley rats Journal of Pharmacognosy and Phytotherapy, 2011
RECENT SCHOLAR PUBLICATIONS
Ascorbate and alpha-tocopherol attenuate hepatorenal injury and modulate CYP2E1 and Nrf2 expression in rats exposed to herbalised alcoholic beverage TD Adeniyi, A Moronkeji, GO Adunmo, AA Okunnuga, OJ Ajala, A Oyeleke, ... Human & Experimental Toxicology 45, 09603271261442765 , 2026 2026
Histopathological Consequences A Moronkeji, TD Adeniyi Methane-Innovations for a Sustainable Future: Innovations for a Sustainable … , 2026 2026
Behavioural, Neurochemical, and Neurohistological Effects of Bisphenol A and Vanadium following Chronic Co-administration in Mice DA ADEKOMI, HA AJANI, RY IBIYEYE, AO ADEKEYE, AA ADEGOKE, ... IBRO Neuroscience Reports , 2026 2026
Mechanistic Basis of Plant Antioxidant Defense TD Adeniyi, A Moronkeji, GO Adunmo, GM Oyeniyi, ET Adegoke, ... 2026
Medicinal Ethnobotanicals in Mitigating Pollution-Induced Oxidative Damage With Mechanisms and Therapeutic Potential: Mechanistic Basis of Plant Antioxidant Defense TD Adeniyi, A Moronkeji, GO Adunmo, GM Oyeniyi, ET Adegoke, ... Pharmacology, Characterizations, Toxicity, and Herb-Drug Interactions of … , 2026 2026
Epidemiological survey and chromatographic profiling of ligands associated with Schistosoma haematobium infection in Oke-Alafia, Ondo State, Nigeria: Ligand profiling and … T Adeniyi, A Abubakar, L Akinoguntuase, S Bashir Babcock University Medical Journal 8 (2), 168-175 , 2025 2025
In Vivo anti-Plasmodium Potential of Aloe barbadensis Anthraquinones and its Combination with Amodiaquine. AA Abubakar, JO Arawande, TD Adeniyi, A Moronkeji, O Aina, S Salau Tropical Journal of Natural Product Research 9 (10) , 2025 2025 Citations: 1
Histopathological Perspectives on Toxic Environmental Pollutants: Cellular Damage Pathways and Strategic Interventions in Mammalian Systems A Moronkeji, TD Adeniyi, SA Fasogbon, JO Ajala, ET Adegoke, ... IntechOpen , 2025 2025
Histopathological Consequences of Methane and Associated Air Pollutants: Linking Oxidative Stress to Organ Toxicity and Carcinogenesis A Moronkeji, TD Adeniyi IntechOpen , 2025 2025
Safety Evaluation of Sub-acute and Acute Oral Treatment with Aqueous Extract and Methanol Fraction of Aloe barbadensis (Aloe vera) Leaves in Wistar Rats. AA Abubakar, JO Arawande, TD Adeniyi, A Moronkeji Tropical Journal of Natural Product Research 9 (8) , 2025 2025
Histopathological Evaluation and Immunomodulatory Effects of Methanolic Leaf Extracts of Rauwolfia vomitoria and Aframomum melegueta in Cadmium Chloride Induced Renal Toxicity A Moronkeji, TD Adeniyi, OO Akinlami, I Akogun, AJ Olayinka Journal of Phytomedicine and Therapeutics 24 (1), 1748-1758 , 2025 2025
Arsenic and vanadium co-exposure induced cerebellar neurotoxicity: aggravates apoptosis, inflammation, oxidative stress, and locomotor deficits in juvenile BALB/c mice DA Adekomi, JO Fatoki, TD Adesipe, OO Adewale, AO Adekeye, ... Anatomy & Cell Biology 58 (2), 229-246 , 2025 2025 Citations: 4
Cervical lesion evaluation in females of reproductive age in Ondo town, Nigeria A Moronkeji, T Adeniyi, A Samuel, G Eze, F AKINBO, O Temidayo, ... Nigerian Medical Journal 66 (2), 407-419 , 2025 2025 Citations: 1
Influence of occupational cement exposure on inflammatory markers, hepatorenal function indices and oxidative stress markers among male cement handlers in Ilorin-Metropolis. AG Olawoyin, AT Daniel, OG Maroof, AG Temitope, AE Olutoyin, ... Tanzania Journal of Health Research 26 (3), 1915 , 2025 2025 Citations: 1
Modulatory effects of Aframomum melegueta and Rauvolfia vomitoria in cadmium-induced renal toxicity in adult rats A Moronkeji, T Adeniyi, E Olubunmi, I Kayode, OJ Ajala, AI Moronkeji, ... Journal of Cellular Biotechnology 11 (1), 3-13 , 2025 2025 Citations: 5
A Modification of Staining Technique for Reticular Fibre Using the Aqueous Leaf Extracts of Camellia Sinensis (Green Tea) As an Oxidizing Agent O Olayinka, T Adeniyi, B Hauwa, B Misbaudeen, J Babatunde, ... Otuoke Journal Of Medical Laboratory Science 2 (1), 13-17 , 2025 2025
Tropical Journal of Natural Product Research AA Abubakar, JO Arawande, TD Adeniyi, A Moronkeji, O Aina, S Salau 2025
ISSN2636–5448 https://dx. doi. org/10.4314/jopat. v24i1. 2 A Moronkeji, TD Adeniyi, OO Akinlami, I Akogun, AJ Olayinka Journal of Phytomedicine and Therapeutics 24 (1), 1748 , 2025 2025
Mitigation of Diclofenac-Induced Hepatorenal Toxicity by Methanolic Extract of Cymbopogon citratus TD Adeniyi, A Moronkeji, IO Ajala, A Oyeleke, AI Moronkeji, F Falana, ... Niger. J. Physiol. Sci 39, 241-249 , 2024 2024 Citations: 1
IMMUNO-OXIDATIVE AND HISTOLOGICAL EVALUATION OF VERNONIA AMYGDALINA AND AFRAMOMUM MELEGUETA ETHANOLIC LEAF EXTRACTS IN CADMIUM-INDUCED CARDIOPULMONARY TOXICITY IN RATS AA Oyeleke, A Moronkeji, TD Adeniyi, CP Umeboro, AI Moronkeji, ... FUOYE JOURNAL OF BIOMEDICAL RESEARCH 1 (2) , 2024 2024
MOST CITED SCHOLAR PUBLICATIONS
Histological study of smoke extract of Tobacco nicotiana on the heart, liver, lungs, kidney, and testes of male Sprague-Dawley rats AD Adedayo, AA Tijani, AA Musa, TD Adeniyi Nigerian Medical Journal 52 (4), 217-222 , 2011 2011 Citations: 41
Exposure to smoke extract of Datura stramonium leaf: Some of its effects on the heart, liver, lungs, kidneys and testes of male Sprague Dawley rats A Tijani Journal of pharmacognosy and phytotherapy , 2011 2011 Citations: 26
Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex AD Adedayo, AO Stephen, TA Adekilekun, AT Daniel Anatomy 11 (2), 79-86 , 2017 2017 Citations: 22
Histopathological and Biochemical Effect of Vitamin C and D on Phosphine-Induced Hepatoxicity in Wistar Rats SM GAMDE Asian Journal of Dental and Health Sciences , 2023 2023 Citations: 20
Some of the Effects of Aqueous Leaf Extracts of Cnidoscolus aconitifolius (Euphorbiaceae) on the Morphology and Histology of the Kidney and Liver of Sprague Dawley Rat DA Adekomi, AA Tijani, TD Adeniyi, JO Olajide The Tropical Journal Health Sciences 18, 9-15 , 2011 2011 Citations: 13
Methanolic leaf extract of Vernonia amygdalina mitigates cadmium-induced oxidative stress in the liver and kidney of adult male Wistar rats A Moronkeji, A Temidayo, A Benita, O Latifat Egyptian Journal of Basic and Applied Sciences 11 (1), 469-478 , 2024 2024 Citations: 12
Cyanide-induced hyperthyroidism in male Wistar rats AT Daniel, TA Adekilekun, MAS Adewale, AT Adekemi Nigerian Medical Journal 55 (3), 246-249 , 2014 2014 Citations: 10
Evaluation of the Combined Extract of Rauwolfia vomitoria and Aframomum melegueta on theKidney and Liver of Adult Male WistarRats TD Adeniyi SJMLS 9 (2) , 2024 2024 Citations: 8
Histological evaluation of the liver, kidney, and testes of adult male Wistar rats exposed to heavy metals-contaminated waterways T Adeniyi, A Moronkeji, V Ekundina Medical Laboratory Journal 17 (5), 4-8 , 2023 2023 Citations: 8
Ascorbate and alpha-tocopherol mitigate toxic pathological changes in adult Wistar rats exposed to cypermethrin TD Adeniyi, A Moronkeji, OF Ralph-Okhiria Folia Medica Indonesiana 59 (4), 391-399 , 2023 2023 Citations: 8
Histological and hepatic enzymes response of Oreochromis niloticus and Clarias anguillaris to pollution in Asa River, Ilorin SO Oladipo, T Adeniyi, A Anifowoshe Journal of Life and Bio Sciences Research 1 (01), 16-21 , 2020 2020 Citations: 8
Datura metel is deleterious to the visual cortex of adult wistar rats AA Tijani, DT Adeniyi, DA Adekomi Advances in Applied Science Research 3 (2), 944-949 , 2012 2012 Citations: 8
Histological and biochemical evaluation of the protective potential of ascorbate and alpha-tocopherol against cypermethrin-induced toxicity T Adeniyi, A Moronkeji, A Fikayomi The Journal of Experimental Life Science 14 (1), 33-39 , 2024 2024 Citations: 7
Heavy metals obtained from waterways induced neurodegeneration in the prefrontal cortex of Wistar rats TD Adeniyi, PU Achukwu, AA Abubakar, AD Adekomi European Journal of Anatomy 23 (1), 65-76 , 2019 2019 Citations: 7
Frequency of electronics waste generated heavy metals in urban waterways TD Adeniyi, PU Achukwu, AA Abubakar Int J Hum Cap Urb Manag 2 (2), 89-100 , 2017 2017 Citations: 7
A comparative study of the lateral geniculate body of rat (Rattus norvegicus), bat (Eidolon helvum) and pangolin (Manis tricuspis) T Adeniyi, A Tijani, D Adekomi, T Abayomi Global Journal of Health Science 4 (4), 118 , 2012 2012 Citations: 7
Oxidative stress response to gasoline generator exhaust emission in adult male wistar rats A Moronkeji, A Olayanju, TD Adeniyi, AD Atere, AI Moronkeji, MC Igunbor, ... Environmental Analysis, Health and Toxicology 39, e2024030 , 2024 2024 Citations: 6
Modulatory effects of Aframomum melegueta and Rauvolfia vomitoria in cadmium-induced renal toxicity in adult rats A Moronkeji, T Adeniyi, E Olubunmi, I Kayode, OJ Ajala, AI Moronkeji, ... Journal of Cellular Biotechnology 11 (1), 3-13 , 2025 2025 Citations: 5
D-ribose-L-cysteine exhibits neuroprotective activity through inhibition of oxido-behavioral dysfunctions and modulated activities of neurotransmitters in the cerebellum of … DA Adekomi, OJ Olajide, OO Adewale, AA Okesina, JO Fatoki, BA Falana, ... Drug and Chemical Toxicology 46 (4), 746-756 , 2023 2023 Citations: 5
Arsenic and vanadium co-exposure induced cerebellar neurotoxicity: aggravates apoptosis, inflammation, oxidative stress, and locomotor deficits in juvenile BALB/c mice DA Adekomi, JO Fatoki, TD Adesipe, OO Adewale, AO Adekeye, ... Anatomy & Cell Biology 58 (2), 229-246 , 2025 2025 Citations: 4