Dentistry, Microbiology, Atomic and Molecular Physics, and Optics
70
Scopus Publications
Scopus Publications
Targeting pain and inflammation: A comparative study of photobiomodulation with 532 and 660 nm lasers in rats Andréa Ribeiro Mattoso‐Câmara, Juliana Zampoli Boava Papini, Marcos Aurélio Teixeira, Denise Nami Fujii, Giovana Radomille Tofoli, et al. Photochemistry and Photobiology, 2026 This study evaluated the analgesic and anti‐inflammatory effects of photobiomodulation (PBM) using 532 nm (green) and 660 nm (red) low‐power lasers in an animal model of acute postoperative pain. Forty‐five Wistar rats underwent a 1 cm surgical incision on the right hind paw and were randomly assigned to three groups: red laser (RL, 660 nm, 100 mW, 5 J, 167 J/cm 2 ), green laser (GL, 532 nm, 70 mW, 4.97 J, 166 J/cm 2 ), and control (LO, no irradiation). PBM was applied immediately and at 1‐, 3‐, 6‐, and 24‐h postsurgery, and pain levels were assessed using von Frey's electronic analgesimeter. Inflammatory cytokines (TNF‐α, IL‐1β, CGRP, and Substance P) were measured by ELISA. Results showed that both RL and GL were significantly more effective than the control group in reducing pain and inflammation. RL provided superior analgesia, increasing pain tolerance to 690.54 ± 50.20 g at 24 h, reaching levels comparable to the non‐incised paw ( p < 0.001). GL demonstrated greater anti‐inflammatory effects, significantly reducing TNF‐α levels at 1 h ( p < 0.05) and 24 h and maintaining lower IL‐1β and CGRP levels. RL also modulated Substance P levels, correlating with its stronger analgesic effect. These findings suggest that RL is preferable for direct pain relief, while GL is more effective in modulating inflammatory responses. Given the statistically significant improvement in pain control and inflammatory marker modulation, PBM using these wavelengths could be a valuable adjunct therapy for postoperative pain management and enhanced healing in surgical patients. Future studies should explore synergistic PBM protocols combining both wavelengths to optimize clinical outcomes.
Enhancing bone remodeling and accelerating tooth movement with photobiomodulation in middle-aged adults Selly S. Suzuki, Amanda M. Ribeiro, Marcella U. R. Fernandes, Chooryung Chung, Aguinaldo S. Garcez Photochemistry and Photobiology, 2025 Although age is not a contraindication for orthodontic treatment, it can be considered more challenging in mature adult patients, mainly due to a less responsive bone metabolism and reduced osteoblastic activity compared to young patients. In orthodontics, photobiomodulation (PBM) has shown positive results in bone remodeling during tooth movement. This study seeks to assess the effect of PBM can have a positive effect on bone remodeling, stimulating bone formation in middle‐aged individuals and allowing for a better periodontal condition. Bone structure and the length of the roots were evaluated using cone beam computed tomography images before and after tooth movement and PBM in patients aged between 40 and 60 years. In addition, we aimed to evaluate the expression of the markers receptor activator of NFκB (RANK), osteoprotegerin (OPG), and osteopontin (OPN) presented in the crevicular fluid using the enzyme‐linked immunosorbent assay test. Tooth movement was performed by intruding upper molars with two mini‐implants as anchorage bilaterally. One side received PBM with light‐emitting diode (LED) light and the contralateral side was used as control (no irradiation). The PBM equipment specially designed for this study consisted of six LEDs of 5 mW each, for 7 minutes, totaling 2 J, 3 times a week, for 5 months. The PMB group showed greater tooth movement (p < 0.05), an increase of 74% on average for bone height. PBM induced a significant increase in RANK expression at month 3 (p < 0.05), and the expression of OPG and OPN showed a significant increase in the fifth month of movement (p < 0.05) in the PBM group. PBM may represent an adjunct therapeutic approach during tooth movement in more mature patients, leading to a more responsive bone metabolism and favoring more comprehensive orthodontic treatment.
Effects of transcranial photobiomodulation on fine motor skills in boccia para-athletes Edna de Morais Garcez, Alessandra Baptista, Michael R. Hamblin, Selly S. Suzuki, Aguinaldo Garcez, et al. Photochemistry and Photobiology, 2025 This study investigated the effects of transcranial photobiomodulation (t‐PBM) on para‐athletes' manual dexterity and intralimbal coordination. Six para‐athletes from a Boccia Team participated. t‐PBM was administered using a LED helmet with 204 LEDs (660 and 850 nm) emitting 10 mW each, delivering 9 J/cm2 per LED during 15‐min sessions three times a week. The trial lasted 2 weeks, with baseline, placebo treatment, and post‐treatment assessments. Manual dexterity was measured by Box and Ball Test (BBLT), and intralimbal coordination by discrete and continuous horizontal and vertical touch tests. Results showed significant improvements in manual dexterity for the t‐PBM group compared to the placebo. Discrete vertical touch tests showed reduced time to perform movements, and continuous vertical touch tests showed increased movement frequency in the t‐PBM group. No significant improvements were observed in the placebo group. t‐PBM was shown to be a potentially effective treatment, with significant benefits in fine motor skills.
Photobiomodulation increases uprighting tooth movement and modulates IL-1β expression during orthodontically bone remodeling Felipe Murakami‐Malaquias‐Silva, Ellen Perim Rosa, Tainá Caroline Santos Malavazzi, Tamiris Silva, Dmitry José de Santana Sarmento, et al. Journal of Biophotonics, 2023 This study investigated the effects of photobiomodulation (PBM) in acceleration of orthodontic movement of inferior molar uprighting movement. Thirty‐four individuals, with indication of molar uprighting movement for oral rehabilitation, were randomly divided in two groups: verticalization + PBM (808 nm, 100 mW, 1 J per point, 10 points and 25 J/cm2) or verticalization + PBM simulation. Elastomeric chain ligatures were changed every 30 days for 3 months. FBM was performed immediately, 24 h, 72 h, 1 and 2 months after activation. The primary outcome was the amount of uprighting movement. Secondary outcomes were pain, amount of medication, OHIP‐14 questionnaire, and cytokine IL‐1β. PBM group increase uprighting movement when compared to control after 3 months and modulate IL‐1β expression. For pain control, the amount of medication and OHIP‐14 no difference were found. This study suggests that PBM accelerates tooth movement during molar uprighting, due to modulation of IL‐1β during bone remodeling.
Effect of low-level laser therapy on bone metabolism and root resorption during tooth movement in rats 11th World Congress of the World Association of Laser Therapy 2016 Walt 2016, 2016
Methylene blue aggregation in the presence of human saliva Silvia Cristina Núñez, Aguinaldo Silva Garcez, Laércio Gomes, Maurício S. Baptista, Martha Simões Ribeiro Progress in Biomedical Optics and Imaging Proceedings of SPIE, 2008
