Synthesis of Silver and Copper oxide nanoparticles using Ficus racemosa leaf extract: characterization, anticancer potential, and dye degradation efficacy Akhilesh Kumar Maurya, Shagun Varshney, Vinod Verma, Hifzur R. Siddique, Nidhi Mishra Journal of Umm Al Qura University for Applied Sciences, 2025 Due to their economic and eco-friendly attributes, there has recently been a growing interest in phytochemicals as catalysts for synthesizing nanoparticles (NPs). The present study describes the synthesis of nanoparticles (NPs) via green chemistry by utilizing Ficus racemosa (F. racemosa) leaf extract without using any harsh chemical reagents. Silver (Ag) NPs were synthesized through conventional and microwave-irradiation routes, while the NPs of Copper oxide (CuO) were synthesized through traditional synthetic routes. The average crystallite size was around 26 and 38 nm for Ag and CuO NPs, respectively, with highly crystalline properties. The peak of around 450 nm for Ag and 551 nm for CuO, respectively, provided evidence of their formation. The NPs synthesized via the conventional route had spherical morphology with sizes between 40–80 nm and 95–250 nm for Ag and CuO NPs, respectively. With a size range of 80–300 nm, Ag NPs synthesized via microwave irradiation had triangular, polygonal, and almost spherical shapes. Ag NPs synthesized via microwave irradiation had triangular, polygonal, and nearly spherical morphology with a size range of 80–300 nm. The cytotoxicity of NPs was assessed on the human lung cancer cell line (A549). With an IC50 value of 75 µg/mL, the studies revealed that both NPs displayed comparable activities. The catalytic dye degradation activity of Ag NPs was investigated using Bromophenol blue (BB), Methylene blue (MB), and Methyl orange (MO). Therefore, using green synthesis, the current pathway facilitates the environmentally favorable synthesis of NPs for anti-cancer and dye degradation applications.
Green synthesis of copper oxide nanoparticles using Ficus racemosa leaf extract and investigation of its antibacterial properties Akhilesh Kumar Maurya, Shagun Varshney, Sonal Upadhyay, Akshi Gupta, Ebenezer Jeyakumar, Rubina Lawrence, Nidhi Mishra Advances in Materials and Processing Technologies, 2025 The present work reports a one-pot green synthesis of copper oxide nanoparticles (CuO NPs) using Ficus racemosa leaf extract via a green chemistry approach without using any harsh chemical reagents. The crystalline and single-phase CuO NPs were analysed via XRD. DLS revealed the average particle size distribution, and zeta potential was used for the evaluation of surface charge. Optical properties were determined at 530 nm through UV–Vis spectroscopy with a broad peak in the range from 500 to 590 nm. Different functional groups in the leaf extract containing flavonoids and polyphenols as reducing agents responsible for the synthesis of CuO NPs were verified through FTIR. The FESEM images revealed the average particle size in the range from 30 to 300 nm with a spherical morphology, and EDS was used for the quantitative elemental analysis. The strong bacterial inhibition tendency of CuO NPs against 12 bacterial strains including Bacillus cereus, Campylobacter jejuni, Bacillus subtilis, Clostridium perfringens, Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Vibrio cholerae, Shigella dysenteriae, Listeria monocytogenes, Helicobacter pylori, and Salmonella typhi was observed with MIC values between 60 and 1000 µg/mL. The findings suggest that the synthesis of CuO NPs via green chemistry can serve as a potential substitute for traditional multi-step chemical synthetic routes.
Silica from waste rice husk and its polymeric hydrogel-based composite filler: synthesis, characterisation, and antibacterial activity Shagun Varshney, Akhilesh Kumar Maurya, Akash Kanaujia, Nidhi Mishra Advances in Materials and Processing Technologies, 2024 Researchers are focusing on the development of bio-fillers through different approaches for dental purposes. The present work reports a relatively simple and faster chemical approach for synthesising composites using silica from waste rice husk along with PEGMA, PNIPAm, HEMA, APS, and MBA. The synthesis includes no harmful chemical reagents and focuses on the effective management of waste. The X-ray diffraction revealed the crystalline nature of composite and with an average crystallite size of 35 nm for the silica particles. The average particle size for silica was found in the range 200–230 nm from dynamic light scattering having a stable structure with −18.23 ± 0.5 mV as the zeta potential. The porosity was analysed using scanning electron microscopy and the stoichiometric composition by energy-dispersive spectroscopy with the pore size from 95–350 nm. Fourier transform infrared spectroscopy revealed the presence of different functional groups. The thermal stability of silica was analysed through Thermogravimetric analysis. The antibacterial activity of the composite against E.coli and S. aureus demonstrated its efficacy against bacterial growth inhibition. The porous composite can be effectively used as a filler material in potential biomedical applications including dental composite for sustained drug loading and release.
Myricetin 3-rhamnoside retards the proliferation of hormone-independent breast cancer cells by targeting hyaluronidase Shilpi Singh, Akhilesh Kumar Maurya, Abha Meena, Nidhi Mishra, Suaib Luqman Journal of Biomolecular Structure and Dynamics, 2024 Breast cancer is the second-leading cause of cancer-related death in women and the most often diagnosed malignancy. As the majority of chemotherapeutic medications are associated with recurrence, drug resistance, and side effects, scientists are shifting to beneficial agents for prevention and treatment, such as natural molecules. Myricetin 3-rhamnoside, a natural flavonol glycoside is known for diverse pharmacological activities but fewer reports describe the antiproliferative ability. The study aims to investigate the antiproliferative efficacy and target [hyaluronidase (HYAL) and ornithine decarboxylase (ODC), two poor breast cancer prognostic markers] modulatory potential of myricetin 3-rhamnoside on breast cancer cell lines using cytotoxicity assays and in silico docking, molecular dynamics analysis, cell-free and cell-based test methods. Myricetin 3-rhamnoside significantly retard the growth of MDA-MB-231 cells in SRB (IC50 88.64 ± 7.14 µM) and MTT (56.26 ± 8.50 µM) assay. It suppressed the transition of cells to the S-phase by inducing arrest in the G0/G1 phase with a fold change of 1.10. It shows robust binding interaction with ODC (-7.90 kcal/mol) and HYAL (-9.46 kcal/mol) and inhibits ODC (15.22 ± 2.61 µM) and HYAL (11.92 ± 2.89 µM) activity, but in a cell-based assay, the prominent response was observed against HYAL (21.46 ± 4.03 µM). Besides, it shows a 1.38 fold-down regulation of HYAL and forms a stable complex with HYAL. The binding pocket for myricetin 3-rhamnoside and the simulation pocket during the simulation are identical, indicating that myricetin 3-rhamnoside is actively blocking hyaluronidase. The computational prediction suggests it is a safe molecule. These observations imply that myricetin 3-rhamnoside could be used as a pharmacophore to design and synthesize a novel and safe agent for managing hormone-independent breast cancer.Communicated by Ramaswamy H. Sarma.
Methods in drug repurposing: Emphasis on COVID-19 Akhilesh Kumar Maurya, Nidhi Mishra Covid 19 Origin Impact and Management Part 2, 2023 Coronavirus disease 19 (COVID-19) is a pandemic situation caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), and dedicated medical research finding to cure the disease are rapidly evolving globally. SARS-Co- -2 is a highly mutating virus having various strains, till the reporting of this study, COVID-19 has 5 variants, i.e., Alfa, beta, gamma, delta, and omicron. A potential way for drug development is drug repurposing has got a lot of attention. Drug repurposing is the easiest and safest way to find out the drugs to cure COVID-19. Various new drugs have been discovered and are under clinical trial for the treatment of disease. Combinatorial treatments of COVID-19 patients give a very positive response in the treatment of SARS-CoV-2. The various vaccine already has been developed to produce antibodies against COVID-19. However, a large number of research studies have been done on COVID-19. This study is dedicated to research on COVID-19 therapy by the repurposing of existing drugs and methods used for the drug repurposing.<br>
Green synthesis of copper oxide nanoparticles using Ficus racemosa leaf extract and investigation of its antibacterial properties AK Maurya, S Varshney, S Upadhyay, A Gupta, E Jeyakumar, ... Advances in Materials and Processing Technologies 11 (4), 1937-1957 , 2025 2025 Citations: 9
Synthesis of Silver and Copper oxide nanoparticles using Ficus racemosa leaf extract: characterization, anticancer potential, and dye degradation efficacy AK Maurya, S Varshney, V Verma, HR Siddique, N Mishra Journal of Umm Al-Qura University for Applied Sciences 11 (3), 581-594 , 2025 2025 Citations: 12
Exploring flavonoid derivatives as potential pancreatic lipase inhibitors for obesity management: An in silico and in vitro study S Modanwal, AK Maurya, V Mulpuru, N Mishra Molecular Diversity 29 (3), 2499-2516 , 2025 2025 Citations: 6
Myricetin 3-rhamnoside retards the proliferation of hormone-independent breast cancer cells by targeting hyaluronidase S Singh, AK Maurya, A Meena, N Mishra, S Luqman Journal of Biomolecular Structure and Dynamics 42 (19), 10311-10322 , 2024 2024 Citations: 7
Silica from waste rice husk and its polymeric hydrogel-based composite filler: synthesis, characterisation, and antibacterial activity S Varshney, AK Maurya, A Kanaujia, N Mishra Advances in Materials and Processing Technologies 10 (3), 1485-1500 , 2024 2024 Citations: 7
Development of QSAR model using machine learning and molecular docking study of polyphenol derivatives against obesity as pancreatic lipase inhibitor S Modanwal, AK Maurya, SK Mishra, N Mishra Journal of Biomolecular Structure and Dynamics 41 (14), 6569-6580 , 2023 2023 Citations: 20
Myricitrin from bayberry as a potential inhibitor of cathepsin-D: prospects for squamous lung carcinoma prevention S Singh, AK Maurya, A Meena, N Mishra, S Luqman Food and Chemical Toxicology 179, 113988 , 2023 2023 Citations: 4
Computational Drug Designing, Synthesis, Characterization and Anti-bacterial Activity Evaluation of Some Mixed Ligand–Metal Complexes of 2-hydroxybenzaldehydethiosemicarbazone … T Khan, S Zehra, U Fatima, N Mishra, R Lawrence, A Maurya, S Singh, ... Chemistry Africa 6 (4), 1943-1960 , 2023 2023 Citations: 18
Narirutin downregulates lipoxygenase-5 expression and induces G0/G1 arrest in triple-negative breast carcinoma cells S Singh, AK Maurya, A Meena, N Mishra, S Luqman Biochimica et Biophysica Acta (BBA)-General Subjects 1867 (6), 130340 , 2023 2023 Citations: 9
Methods in Drug Repurposing: Emphasis on COVID-19 AK Maurya, N Mishra COVID-19: Origin, Impact and Management-(Part 2), 111-126 , 2023 2023
Narirutin. A flavonoid found in citrus fruits modulates cell cycle phases and inhibits the proliferation of hormone-refractory prostate cancer cells by targeting hyaluronidase S Singh, AK Maurya, A Meena, N Mishra, S Luqman Food and Chemical Toxicology 174, 113638 , 2023 2023 Citations: 14
Synthesis and characterization of polymeric hydrogel-based nanoporous composite and investigation of its temperaturedependent drug release activity. AK Maurya, S Varshney, N Mishra Materials Physics & Mechanics 50 (2) , 2022 2022
Coumarin-based combined computational study to design novel drugs against Candida albicans AK Maurya, N Mishra Journal of Microbiology 60 (12), 1201-1207 , 2022 2022 Citations: 10
Role of lupeol in chemosensitizing therapy-resistant prostate cancer cells by targeting MYC, β-catenin and c-FLIP: In silico and in vitro studies SK Maurya, H Fatma, AK Maurya, N Mishra, HR Siddique In Silico Pharmacology 10 (1), 16 , 2022 2022 Citations: 26
Smart polymeric biomaterials in tissue engineering AK Maurya, N Mishra Tissue Engineering, 59-88 , 2022 2022 Citations: 2
In silico validation of coumarin derivatives as potential inhibitors against Main Protease, NSP10/NSP16-Methyltransferase, Phosphatase and Endoribonuclease of … AK Maurya, N Mishra Journal of Biomolecular Structure and Dynamics 39 (18), 7306-7321 , 2021 2021 Citations: 40
Identification of Severe Acute Respiratory Syndrome Coronavirus‐2 inhibitors through in silico structure‐based virtual screening and molecular interaction studies I Azad, T Khan, AK Maurya, M Irfan Azad, N Mishra, AM Alanazi Journal of Molecular Recognition 34 (10), e2918 , 2021 2021 Citations: 28
Microwave assisted green synthesis of silver nanoparticles with leaf of Ficus racemosa and its in vitro antibacterial analysis and dye catalytic activity MA Kumar, U Sonal, G Akshi, JK Ebenezer, R Lawrence, M Nidhi Res J Chem Environ 25, 111-119 , 2021 2021 Citations: 7
Discovery of novel coumarin analogs against the α-glucosidase protein target of diabetes mellitus: pharmacophore-based QSAR, docking, and molecular dynamics simulation studies AK Maurya, V Mulpuru, N Mishra ACS omega 5 (50), 32234-32249 , 2020 2020 Citations: 65
Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/NSP16 methyltransferase and main protease … SK Maurya, AK Maurya, N Mishra, HR Siddique Journal of Receptors and Signal Transduction 40 (6), 605-612 , 2020 2020 Citations: 63
MOST CITED SCHOLAR PUBLICATIONS
Discovery of novel coumarin analogs against the α-glucosidase protein target of diabetes mellitus: pharmacophore-based QSAR, docking, and molecular dynamics simulation studies AK Maurya, V Mulpuru, N Mishra ACS omega 5 (50), 32234-32249 , 2020 2020 Citations: 65
Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/NSP16 methyltransferase and main protease … SK Maurya, AK Maurya, N Mishra, HR Siddique Journal of Receptors and Signal Transduction 40 (6), 605-612 , 2020 2020 Citations: 63
In silico validation of coumarin derivatives as potential inhibitors against Main Protease, NSP10/NSP16-Methyltransferase, Phosphatase and Endoribonuclease of … AK Maurya, N Mishra Journal of Biomolecular Structure and Dynamics 39 (18), 7306-7321 , 2021 2021 Citations: 40
Identification of Severe Acute Respiratory Syndrome Coronavirus‐2 inhibitors through in silico structure‐based virtual screening and molecular interaction studies I Azad, T Khan, AK Maurya, M Irfan Azad, N Mishra, AM Alanazi Journal of Molecular Recognition 34 (10), e2918 , 2021 2021 Citations: 28
Role of lupeol in chemosensitizing therapy-resistant prostate cancer cells by targeting MYC, β-catenin and c-FLIP: In silico and in vitro studies SK Maurya, H Fatma, AK Maurya, N Mishra, HR Siddique In Silico Pharmacology 10 (1), 16 , 2022 2022 Citations: 26
Development of QSAR model using machine learning and molecular docking study of polyphenol derivatives against obesity as pancreatic lipase inhibitor S Modanwal, AK Maurya, SK Mishra, N Mishra Journal of Biomolecular Structure and Dynamics 41 (14), 6569-6580 , 2023 2023 Citations: 20
Nanoengineered polymeric biomaterials for drug delivery system AK Maurya, A Mishra, N Mishra Nanoengineered Biomaterials for Advanced Drug Delivery, 109-143 , 2020 2020 Citations: 19
Computational Drug Designing, Synthesis, Characterization and Anti-bacterial Activity Evaluation of Some Mixed Ligand–Metal Complexes of 2-hydroxybenzaldehydethiosemicarbazone … T Khan, S Zehra, U Fatima, N Mishra, R Lawrence, A Maurya, S Singh, ... Chemistry Africa 6 (4), 1943-1960 , 2023 2023 Citations: 18
Narirutin. A flavonoid found in citrus fruits modulates cell cycle phases and inhibits the proliferation of hormone-refractory prostate cancer cells by targeting hyaluronidase S Singh, AK Maurya, A Meena, N Mishra, S Luqman Food and Chemical Toxicology 174, 113638 , 2023 2023 Citations: 14
Synthesis of Silver and Copper oxide nanoparticles using Ficus racemosa leaf extract: characterization, anticancer potential, and dye degradation efficacy AK Maurya, S Varshney, V Verma, HR Siddique, N Mishra Journal of Umm Al-Qura University for Applied Sciences 11 (3), 581-594 , 2025 2025 Citations: 12
Coumarin-based combined computational study to design novel drugs against Candida albicans AK Maurya, N Mishra Journal of Microbiology 60 (12), 1201-1207 , 2022 2022 Citations: 10
Green synthesis of copper oxide nanoparticles using Ficus racemosa leaf extract and investigation of its antibacterial properties AK Maurya, S Varshney, S Upadhyay, A Gupta, E Jeyakumar, ... Advances in Materials and Processing Technologies 11 (4), 1937-1957 , 2025 2025 Citations: 9
Narirutin downregulates lipoxygenase-5 expression and induces G0/G1 arrest in triple-negative breast carcinoma cells S Singh, AK Maurya, A Meena, N Mishra, S Luqman Biochimica et Biophysica Acta (BBA)-General Subjects 1867 (6), 130340 , 2023 2023 Citations: 9
Myricetin 3-rhamnoside retards the proliferation of hormone-independent breast cancer cells by targeting hyaluronidase S Singh, AK Maurya, A Meena, N Mishra, S Luqman Journal of Biomolecular Structure and Dynamics 42 (19), 10311-10322 , 2024 2024 Citations: 7
Silica from waste rice husk and its polymeric hydrogel-based composite filler: synthesis, characterisation, and antibacterial activity S Varshney, AK Maurya, A Kanaujia, N Mishra Advances in Materials and Processing Technologies 10 (3), 1485-1500 , 2024 2024 Citations: 7
Microwave assisted green synthesis of silver nanoparticles with leaf of Ficus racemosa and its in vitro antibacterial analysis and dye catalytic activity MA Kumar, U Sonal, G Akshi, JK Ebenezer, R Lawrence, M Nidhi Res J Chem Environ 25, 111-119 , 2021 2021 Citations: 7
Exploring flavonoid derivatives as potential pancreatic lipase inhibitors for obesity management: An in silico and in vitro study S Modanwal, AK Maurya, V Mulpuru, N Mishra Molecular Diversity 29 (3), 2499-2516 , 2025 2025 Citations: 6
Myricitrin from bayberry as a potential inhibitor of cathepsin-D: prospects for squamous lung carcinoma prevention S Singh, AK Maurya, A Meena, N Mishra, S Luqman Food and Chemical Toxicology 179, 113988 , 2023 2023 Citations: 4
CFD analysis of anticancerous Ag and CuO nanoparticles in tumor angiogenic vessels V Mulpuru, AK Maurya, N Mishra 2019 IEEE 16th India Council International Conference (INDICON), 1-2 , 2019 2019 Citations: 3
Smart polymeric biomaterials in tissue engineering AK Maurya, N Mishra Tissue Engineering, 59-88 , 2022 2022 Citations: 2
