Alankar Shrivastava
@kiet.edu
Associate Professor
KIET Group of Institutions, KIET School of Pharmacy
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Alankar SHRİVASTAVA and Ashu MITTAL
Hacettepe University
The Benign Prostatic Hyperplasia is one of the common old age problem and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was under taken to establish the compatibility of Tamsulosin with a number of commonly used excipients by using thermo analytical technique viz Thermogravimetry (TG) and differential scanning calorimetry (DSC) used in formulation. The TG and DSC both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.
Alankar Shrivastava
Bentham Science Publishers Ltd.
Abstract: Cell phones are like a notepad PC with their own working framework, processor, interior memory, and top-notch camera focal points. Cell phones are more open and less expensive than versatile analytical devices. The quantity of cell phone users overall outperformed 2 billion in 2016 and it addresses more than a fourth of the worldwide population. There have been numerous new articles on the utilization of cell phones as versatile detectors, bioanalytical equipment, and instrument interfaces. The utilization of cell phones has opened doors for prognostic, diagnostic, detection, observing, quantification, control, or making versatile applications, since it can be very well utilized to run routine tests. Moreover it does not require a trained personnel and it is convenient and considered a minimal-expense gadget. The development of analytical methods is crucial in drug development. Improvement of existing and execution of new methodologies are essential for the present-day analytical chemistry of drugs. Recently published studies focussed on some of the applications of smartphone-based analytical methodologies in the last few years for the determination of drugs in different matrices. The aim of the presented review was to enhance the visibility of one of the fast and novel applications of smartphone technology. This will help scientists and researchers to understand the recent developments and explore new possibilities in this field.
AKANKSHA DWIVEDI, RAKHI KHABIYA, ALANKAR SHRIVASTAVA, SIDDHARTH TYAGI, KANDASAMY NAGARAJAN, and G. N. DARWHEKAR
Innovare Academic Sciences Pvt Ltd
Globally, the burden of cancer is substantial and growing. The impact of the burden of such diseases over society is unpredictable in terms of health lost and cost. Unfortunately, the estimates shown the burden may be increasing in the upcoming decades. Cabozantinib (CBZ) is a newly developed tyrosin kinase inhibitor (TKI) for Differentiated thyroid cancer (DTC), Hepatic Cellular Carcinoma (HCC), Medullary thyroid cancer (MTC) and Renal Cell Carcinoma (RCC). The objective of the presented review is to provide updated knowledge of drugs especially covering analytical methodologies. The review covered the introduction, mechanism of action, pharmacokinetics, synthesis and developed analytical methods by various researchers. The review covered one spectrophotometry and about twenty chromatography methods. The review will be helpful for the scientist working in this area and especially helpful for analytical scientists exploring new analytical methodologies for CBZ.
ALANKAR SHRIVASTAVA, RADHIKA AGGARWAL, RISHI PRATAP SINGH, and RAKHI KHABIYA
Innovare Academic Sciences Pvt Ltd
Cariprazine (CPZ) being a “D2/D3 receptor partial agonist” is used for schizophrenia treatment. CPZ illustrate different functional study at “dopamine receptors depending on the assay system”. This study elaborate review summarizes the structure–activity relationship (SAR), Mechanism of action (MOA), pharmacokinetics, pharmacodynamics and analytical methods published. CPZ was found to be more effective than risperidone. It was analogus with a remarkably longer time to deteriorate than inactive drug in a long-term, phase III,-deteriorate prevention study. This study elaborate the activating and solemn or sedative properties of first-line oral second generation antipsychotics by explore the rates of adverse effect in product labelling for the indications of schizophrenia and ancillary treatment of major depressive disorder (MDD). The common adverse events reported were extrapyramidal disorder, insomnia, dizziness, solemn, anxiety, vomiting and constipation in “fixed dose study of tested 1.5, 3.0, and 4.5 mg/day”. The presented review explains about biological properties, pharmacokinetics, pharmacodynamics, and analytical methods of CPZ.
Mukul Sharma, Mukesh Chandra Sharma, Rakhi Khabiya, Akanksha Dwivedi, Alankar Shrivastava, G.P. Choudhary, Shivani Dubey, and Sanjay Jain
Elsevier BV
Pankaj Bhatt, Vipin Kumar, Richa Goel, Somesh Kumar Sharma, Shikha Kaushik, Shivani Sharma, Alankar Shrivastava, and Mulugeta Tesema
Hindawi Limited
Pharmaceutical excipients are compounds or substances other than API which are added to a dosage form, these excipients basically act as carriers, binders, bulk forming agents, colorants, and flavouring agents, and few excipients are even used to enhance the activity of active pharmaceutical ingredient (API) and various more properties. However, despite of these properties, there are problems with the synthetic excipients such as the possibility of causing toxicity, inflammation, autoimmune responses, lack of intrinsic bioactivity and biocompatibility, expensive procedures for synthesis, and water solubility. However, starch as an excipient can overcome all these problems in one go. It is inexpensive, there is no toxicity or immune response, and it is biocompatible in nature. It is very less used as an excipient because of its high digestibility and swelling index, high glycemic index, paste clarity, film-forming property, crystalline properties, etc. All these properties of starch can be altered by a few modification processes such as physical modification, genetic modification, and chemical modification, which can be used to reduce its digestibility and glycemic index of starch, improve its film-forming properties, and increase its paste clarity. Changes in some of the molecular bonds which improve its properties such as binding, crystalline structure, and retrogradation make starch perfect to be used as a pharmaceutical excipient. This research work provides the structural modifications of native starch which can be applicable in advanced drug delivery. The major contributions of the paper are advances in the modification of native starch molecules such as physically, chemically, enzymatically, and genetically traditional crop modification to yield a novel molecule with significant potential for use in the pharmaceutical industry for targeted drug delivery systems.
Alankar SHRİVASTAVA
Hacettepe University
Alankar Shrivastava, Ashu Mittal, Rakhi Khabiya, GP Choudhary, and Gajanan N. Darwhekar
Bentham Science Publishers Ltd.
Background: Brexpiprazole (BRZ) is a "third-generation" antipsychotic dopaminergic (D2) and 5HT1A (serotonin) partial agonist, approved in July 2015 by the US Food and Drug Administration for the treatment of the major depressive disorder (MDD) other than schizophrenia in adults. Antipsychotics are known to produce extrapyramidal effects as side effects. The recent development in this segment is of piperazine-based antipsychotic BRZ, which is more specific towards indented indications (depression) and has fewer side effects. Objective: To critically review the different analytical methods available in the literature. Methods: Eight spectrophotometry-based studies, nineteen chromatography-based studies, and two other method-based studies were found in the literature search. A brief discussion on pharmacokinetics and the mechanism of action is also included. Conclutions: This review can be used for the development of more robust and suitable analytical methods for the determination of drugs in different matrices. A brief discussion concerning the approach towards the advancement of green analytical methods is likewise one of the points of this review.
Alankar Shrivastava and Ashu Mittal
Informa UK Limited
Irritable bowel syndrome (IBS) is a world-wide disease prevalently in Western nations. It influences about 15% of the western populace, with a negative effect on the quality of life and furthermore on medical services costs. Anticholinergic antispasmodics are first line of treatment for discomfort or abdominal pain, particularly if unrelieved after alleviation of stoppage or antidiarrheal treatment. Otilonium bromide (OTB) is quaternary ammonium compound with action on distal GI tract as antispasmodic. It is utilized in the treatment of patients influenced by Irritable inside disorder (IBS) because of its particular pharmacokinetic and pharmacodynamic properties. OTB is poorly absorbed systematically was viable in contrast with different medications used for same purpose, for example, pinaverium bromide and mebeverine, with a good tolerability profile. The effects are long lasting, even after stopping the dosage regime for reduction of abdominal pain. In this review, an overview of mechanism of action, pharmacologic action, synthesis and particularly various analytical and bioanalytical methods are discussed. The analytical methods discussed are spectrophotometry including Near Infrared Spectroscopy (NIRS), chromatography and capillary electrophoresis methods are described with the range, limit of detection and quantification. The paper also provides details of scope of further extension of analytical methods. It was found that most of the analytical methods involves usage of toxic solvents e.g., methanol, acetonitrile, chloroform etc. posing risk to the analyst as well as environment.
ALANKAR SHRIVASTAVA, SANJAY SHARMA, MONIKA KAURAV, and ABHISHEK SHARMA
Innovare Academic Sciences Pvt Ltd
Mannitol is an organic compound, a widely distributed natural sugar alcohol in nature. It is found in various plant species and produced by many microorganisms. Mannitol is about 50% as sweet as sucrose, has a low glycaemic index and inert nature, making it suitable to be used in many food products. Mannitol is an osmotic diuretic administering through the iv route and having many clinical usages and is one of the well-known excipients in many different types of formulations. This is also used to increase the dissolution of drugs having solubility problems. Mannitol can be used as a drug and excipient. The goal of this work was to summarize the important physicochemical properties, mechanism of action, production, applications, incompatibilities, polymorphism, and particularly the analytical methodologies published in the last five decades for quantification. Relevant articles related to analytical methods were identified through a search of the English-language literature indexed in Medline, PubMed, ScienceDirect and google scholar from 1970 to till date. The search terms were benign estimation of mannitol, determination of mannitol, methods for determination of mannitol, HPLC and Spectrophotometry method for estimation of mannitol. The methods described in USP, IP, and BP are also described. The presented review also outlines the further scope of research in the field of development of analytical methods.
AMAL A. AMMAR, HODA A. SALEM, SHEREEN A. ELADAWY, ZINAB I. ABD ELSAMAD, and NEVEEN A. KOHAF
Innovare Academic Sciences Pvt Ltd
Objective: The goal of the present study was to develop niosomal gel as a nanocarrier for improved depigmentation effect of hydroquinone (HQ). As well as to evaluate the prepared niosomes for entrapment efficiency, transmission electron microscopy (TEM), zeta potential, and in vitro release study. As an ultimate point of the objectives was to evaluate the best-prepared niosomal gel formula clinically in well-diagnosed patients of melasma and the results were compared with a commercial product.
 Methods: The effect of incorporation of co-surfactant such as Tween 20, Tween 40, and Tween 60 with Span 80, was studied to determine the highest entrapment efficiency and the desired release rate. Niosomes showed the highest entrapment efficiency was incorporated in different gelling agents like Carbopol 934 and Carboxymethylcellulose sodium (CMC Na) with different concentrations. Accelerated stability testing of HQ from niosomal gel formulations; the expiry date t90 was estimated. The best-prepared niosomal gel formula was studied clinically in patients of melasma and the results were compared with the commercial product (Clearique 2%)®Delta Pharma Company. 
 Results: There was a significant increase in the clinical efficacy of the niosomal therapy and a highly significant decrease regarding to modified melasma area and severity index (MASI), duration to achieve improvement, side effects, and the recurrence of melasma in patients treated with niosomal gel compared to the commercial product.
 Conclusion: The incorporation of hydroquinone in niosomal gel improves its therapeutic effect regarding clinical effect, duration of treatment, side effects, recurrence and patient compliance.
A. Shukla, B. Sharda, S. Sharma, S. Bhardwaj, U. Kailash, R. Kalani, L. Satyanarayana, and A. Shrivastava
Springer Science and Business Media LLC
Alankar Shrivastava, Jitendra Sharma, KanhaiyaLal Aggrawal, and Saurabh Jain
BRNSS Publication Hub
Pranav Kumar Gutch, Sharma Jitendra, Shrivastava Alankar, Jain Anurekha, and K. Ganesan
Springer Science and Business Media LLC
Pralidoxime chloride known as 2-PAM chloride is used as antidote for nerve agent’s poisoning. This study was undertaken to establish the compatibility of 2-PAM chloride with a number of commonly used excipients by using thermoanalytical technique viz., differential scanning calorimetry (DSC) and thermogravimetry/differential thermogravimetry (TG/DTG) used in pharmaceutical formulation. The TG and DSC both results demonstrated that polyvinyl alcohol, polyacrylamide, microcrestline cellulose, hydroxypropyl cellulose, cellulose acetate, ethyl cellulose found to be compatible with 2-PAM chloride and chosen for the preparation of antidote against chemical warfare agents.
Alankar Shrivastava
MDPI AG
The current study was carried out with an attempt to separate similarly structured title drugs by liquid chromatography. Spectrophotometric techniques were generally insufficient under these conditions because of the spectral overlapping of drugs with similar functional groups. The pharmaceutical drugs prazosin, terazosin, and doxazosin contain the same parent quinazoline nucleus, thus making it especially difficult to separate the former two drugs because of their very similar structures. A simple and sensitive method for the routine determination of these drugs in pharmaceutical formulations was attempted. We found that the mobile phase consisting of A: ACN–diethylamine (0.05 ml), B: methanol, and C: 10 mM Ammonium acetate separated these drugs effectively. Separations were carried out on a new Kromasil C18 column (250 × 4.6 mm, 5.0 μm) at 254 nm wavelength. The calibration curve was found to be linear in the range of 2–500 μg/ml. The stated method was then validated in terms of specificity, linearity, precision, and accuracy. Additionally, the proposed method reduced the duration of the analysis.
Alankar Shrivastava, Jitendra Sharma, and Pranav K. Gutch
Bentham Science Publishers Ltd.
Purpose: Incompatibility between drugs and excipients can alter stability and bioavailability of drugs thereby affecting an active’s safety and/or efficacy. The purpose of this investigation was to study the compatibility of � , � ’-xylene-� -bis3,3’(hydroxyiminomethyl) pyridinium dibromide, (3 PApxy) with a number of commonly used excipients. Methods: Solid dosage forms typically contain diluents, disintegrants, polymers, glidants and lubricants and therefore the compatibility of 3 PApxy with selected excipients from each group was investigated. TGA of Perkin Elmer equipped with Pyris Manager TM software and Mettler Toledo Differential Scanning Calorimeter (DSC). Excipients used were Sodium Laurel Sulphate (SLS), Methyl Cellulose (MC), Hydroxy Propyl methyl cellulose (HPMC), Cellulose acetate (CA), Hydroxy Propyl Cellulose (HPC), Carboxy methyl cellulose (CMC), Ethyl Cellulose (EC), Poly Acryl Amide (PAA), Poly Vinyl Alcohol (PVA), Methyl Paraben (MP), Micro Crystalline Cellulose (MCC), Cetyl trimethyl Ammonium Bromide (CTAB) and Acacia were purchased from Sigma-Aldrich and Alfa-Aesar (USA) and used as such. Results: TGA analysis shows seven out of fourteen excipients, SLS, Betain CMC, MCC, EC, PAA and acacia are found to decrease the thermal stability of drug. The DSC thermogram of 3 PApxy showed a sharp endothermic peak at 267 °C corresponding to its melting point. The DSC thermograms of 3 PApxy and each of the investigated excipients with 1:1 mixtures of 3 PApxy and excipients were compared. On the basis of DSC results, 3 PApxy was found to be compatible with all excipients except SLS. Conclusion: Based on TGA and DSC studies, 3 PApxy was found to be compatible with most commonly used excipients except for SLS. These studies may be relevant when formulating novel dosage form systems for 3 PApxy.
Alankar Shrivastava
SynthesisHub Advance Scientific Research
There may be significant variation in stereoisomers related to distribution, bioavailability, metabolism, and excretion. Venlafaxine is a bicyclic phenylethylamine derivative, a unique anti-depressant,which structurally differs from other currently available anti-depressants. Its mechanism of action is believed to be associated with triggering neurotransmitter activity in the CNS. This drug is a racemic mixture of the (−)-R-enantiomer and (+)-S-enantiomer. O-desmethylvenlaflaxine is the major metabolite formed after first pass metabolism with similar potency as parent drug. Two less potent minor metabolites are N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. Thus, summarization of all of the analytical methods for the determination of venlaflaxine alone, in combination, or in the presence of other metabolites, is summarized. The keywords used for search were "Analytical methods on Venlaflaxine," "Determination of venlaflaxine," "Determination of venlaflaxine and metabolites," and "Venlaflaxine plasma determinations." Eight spectrophotometry, 26 chromatography, and seven electroanalytical methods were found for the determination of venlaflaxine alone, in formulations, biological matrices, and simultaneous determinations with metabolites and other anti-depressants. Short review of pharmacological activity of venlaflaxine and its metabolites are also presented.
Alankar Shrivastava and VipinBihari Gupta
Siree Journals
Background: Although initially introduced for the management of hypertension, al-adrenergic-receptor antagonists (a 1 blockers) have become the standard of care for the medical management of benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS). Alpha-blockers (alfuzosin, tamsulosin, doxazosin, prazosin, and terazosin) relax the smooth muscles in the prostate and are indicated for the symptomatic treatment of BPH, due to evidence of their positive and rapid effect on LUTS. Objective: Our objective was to develop and validate a method for simultaneous estimation of these drugs. Our aim was to develop a UV spectrophotometric method because of the simplicity and economical advantage of this technique. Materials and Methods: All these drugs were dissolved in the same solvent (methanol) and scanned under a ShimadzuUV spectrophotomer, under full UV (ultraviolet) range (200 - 400 nm). Result: After some experiments we found that this is impossible. This was evident from our study that UV spectra were overlapping each other, except in the case of tamsulosin. Conclusion: Same class of drugs may have almost the same functional groups, and gradient Reverse-Phase Liquid Chromatography(RPLC) will be more useful to separate such complicated mixtures. Therefore, we propose to develop a gradient High-Performance Liquid Chromatography(HPLC) method as it may be a more suitable method for the simultaneous estimation of these drugs.
Alankar Shrivastava and Vipin B. Gupta
Bentham Science Publishers Ltd.
Background: Although initially introduced for the management of hypertension, � l-adrenergic-receptor antagonists (� l- blockers) have become the standard of care for the medical management of benign prostatic hyperplasia (BPH) related lower urinary tract symptoms (LUTS). Alpha-blockers (alfuzosin, tamsulosin, doxazosin, prazosin and terazosin) relax the smooth muscles in the prostate and are indicated for the symptomatic treatment of BPH due to evidence of their positive and rapid effect on LUTS. However, these agents have the potential to produce orthostatic hypotension and other blood pressure-related adverse effects in normotensive patients and in those receiving concurrent treatment with other antihyper- tensive agents. As a result, more "uroselective," less vasoactivel-blockers have been developed such as tamsulosin and alfuzosin. Objective: The presented review provides information about the various analytical methods available in the literature to the scientists and health professionals engaged in research relating these drugs such as clinical trials or developing new formulations. Various analytical methods for the estimation of these drugs in bulk or in various matrices like blood, se- rum, plasma, alone or in combination with other drugs is discussed. Methods: Relevant articles were identified through a search of the English-language literature indexed in MEDLINE, PubMed, Sciencedirect and the proceedings of scientific meetings from 1977 to 2010. The search terms were benign esti- mation of alpha one blockers, determination of prazosin, terazosin, tamsulosin, doxazosin, alfuzosin. Similarly HPLC and Spectroscopy methods for estimation of prazosin, terazosin, tamsulosin, doxazosin, alfuzosin. Results: Total 57 analytical methods were found. 11 spectrophotometry, 39 chromatographic methods including 2 ESI MS/MS, 1 ESI MS, 2 HPTLC, 3 TLC, 17 HPLC with UV, 9 with fluorescence, 1 with electrochemical detection, 4 with MS detector. Other than this 3 voltametry, 1 method each for radioreceptor assay, polarography, capillary electrophoresis and potentiometry titrations were found. Conclusion: Radioreceptor assay, LC-MS, UPLC-MS methods were found to be the most sensitive for prazosin, terazosin and doxazosin respectively. Likewise, HPLC-MS-MS methods was found as most sensitive method for estimation of tam- sulosin and alfuzosin.
A. Shrivastava, R. Issarani, and B.P. Nagori
EManuscript Technologies
A new simple, sensitive, precise, and accurate high-performance liquid chromatography (HPLC) method of analysis for artemether both as a bulk drug and in capsule formulations was developed and validated. The method employed mobile phase acetonitrile (ACN) and buffer in the ratio 65:35 of pH 6.5 adjusted with tryethylamine. The linear regression analysis data for the calibration plots showed good linear relationship with r2 = 0.9996 in the concentration range 250-750 μg/ml. The mean value slope and intercept were 9355.5 and −93.5, respectively. The method was validated for precision, accuracy, and recovery studies. Limit of detection (LOD) and Limit of quantitation (LOQ) for artemether were found to be 21.83-750 μg/ml, respectively. The method has been successfully applied in the analysis of marketed capsule formulations. The presented method was found to be reliable to separate all the degradents from all the stress conditions with resolution of more than 1.5 showing that it is a stability indicating method.