Pharmaceutical Science, Analytical Chemistry, Pharmacology, Toxicology and Pharmaceutics
32
Scopus Publications
5092
Scholar Citations
19
Scholar h-index
31
Scholar i10-index
Scopus Publications
DEVELOPMENT AND PHARMACOLOGICAL EVALUATION OF A VETIVERIA ZIZANIOIDES HYDROGEL WITH ANTI-INFLAMMATORY ACTIVITY IN WISTAR RATS , Subarnarekha Maitra, Arun Kumar Maurya, Satish Kumar Sharma, Km. Saiphali, , Raghav Dixit, Alankar, Alankar Shrivastava, Sreemoy Kanti Das, , , , and Journal of Experimental Zoology India, 2026 Lorazepam is a potent anxiolytic agent, but its conventional oral dosage forms are often associated with delayed onset of action due to gastrointestinal transit and first-pass metabolism. The present study aimed to develop and evaluate a lorazepam-loaded mouth dissolving film (MDF) to achieve rapid onset of anxiolytic activity and improved patient compliance. Lorazepam MDFs were prepared using the solvent casting technique employing HPMC E5 and PVP K30 as film-forming polymers. The films were characterized for physicochemical properties, mechanical strength, disintegration time, drug content uniformity, and in-vitro drug release. In vivo anxiolytic activity was assessed using the elevated plus maze model in rodents, and histopathological examination of paw tissue was performed to evaluate tissue safety. Stability studies were conducted under accelerated and long-term conditions. The optimized MDF formulation exhibited uniform thickness, satisfactory mechanical properties, rapid disintegration, and consistent drug content. In-vitro release studies demonstrated faster drug release compared to the conventional oral tablet. In vivo evaluation showed a significantly earlier and enhanced anxiolytic effect of the MDF at initial time points when compared with the standard oral tablet. Histopathological analysis confirmed normal tissue architecture with minimal inflammatory changes, indicating good biocompatibility. Stability studies revealed no significant changes in physical, chemical, or performance parameters. The findings demonstrate that lorazepam mouth dissolving films provide a rapid onset of action and superior pharmacological performance compared to conventional oral tablets. The developed MDF system represents a promising alternative for effective and patient-friendly anxiolytic therapy
DEVELOPMENT OF A DELAYED-RELEASE TABLET FOR CYSTINURIA: IN VITRO CHARACTERIZATION AND PRECLINICAL ASSESSMENT IN ALBINO SWISS RAT MODEL , Satish Kumar Sharma, Shikha Kaushik, Arpita Gupta, Varsha Deva, Km. Saiphali, Alankar Shrivastava, Raghav Dixit, Suruchi Singh, , , , , , , and Journal of Experimental Zoology India, 2026 Cystinuria, a genetic disorder causing recurrent nephrolithiasis, requires strict maintenance of urinary cystine below its solubility threshold. Current therapies involving frequent dosing of thiol drugs like tiopronin are hampered by poor patient compliance and side effects, necessitating advanced drug delivery solutions. A novel delayed-release tablet was developed by press-coating a tiopronin core with a polymeric blend of hydroxypropyl methylcellulose (HPMC K4M) and ethyl cellulose (EC) to create a time-lagged barrier, followed by an enteric coating of cellulose acetate phthalate (CAP). The formulation was characterized for physicochemical properties and in vitro drug release in sequential pH media. Its pharmacokinetic and pharmacodynamic efficacy was evaluated in an Albino Swiss rat model of induced hypercystinuria, comparing it against a standard tiopronin suspension. The optimized tablet exhibited excellent acid resistance (<5% release in 2 h at pH 1.2) and a defined lag time of 120±8 minutes in intestinal pH, followed by complete drug release. In vivo, it demonstrated equivalent bioavailability to the standard suspension but with a significantly delayed Tmax (6.0 vs. 1.5 h) and lower Cmax. The formulation was superior in reducing 24-hour urinary cystine excretion (67.5% vs. 41.2%) and in maintaining sub-saturation levels for a prolonged duration, which correlated with markedly less renal crystal deposition and tissue damage on histopathology. The developed delayed-release tablet successfully provides a chronotherapeutic drug delivery profile for tiopronin. By ensuring targeted intestinal release and sustaining therapeutic drug levels, it offers a promising strategy to enhance efficacy, improve patient adherence and potentially reduce renal pathology in cystinuria management.
Spectrophotometry Method for Determination of Mannitol in Injectable Formulation Alankar Shrivastava, Abhishek Sharma Research Journal of Pharmacy and Technology, 2024 Mannitol, an osmotic diuretic derived from naturally occurring alcohols in plants and fruits, is one such substance. Mannitol was discovered in 1806 by Joseph Louis Proust. Because of its ability to promote dehydration, mannitol is also used in neurosurgery and neurology. Ocular pressure should be reduced by using Mannitol. Because it is eliminated unaltered via the kidneys, impaired renal function results in cellular dehydration. Mannitol is well known excipient used in preparation of solid dosage forms. The development of suitable analytical method is essential part of drug development. Various methods for the determination of Mannitol in different matrices are available in literature. Most of them particularly chromatography methods are tedious and expensive. Because of the linear structure of structure of molecule and absence of suitable chromophore, it is difficult to develop any direct spectrophotometry method. Thus, the aim of presented study is to develop simple, economical, sensitive, and accurate method for determination of Mannitol in injectable formulations. The developed method after validation as per ICH guidelines, successfully utilized for analysis of marketed formulation.
Incompatibility Studies of Tamsulosin HCl using TGA, DSC and IR Alankar SHRİVASTAVA, Ashu MITTAL Hacettepe University Journal of the Faculty of Pharmacy, 2023 The Benign Prostatic Hyperplasia is one of the common old age problem and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was under taken to establish the compatibility of Tamsulosin with a number of commonly used excipients by using thermo analytical technique viz Thermogravimetry (TG) and differential scanning calorimetry (DSC) used in formulation. The TG and DSC both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.
A Critical Review on Smartphone Based Determinations of Drugs Alankar Shrivastava Current Pharmaceutical Analysis, 2023 Cell phones are like a notepad PC with their own working framework, processor, interior memory, and top-notch camera focal points. Cell phones are more open and less expensive than versatile analytical devices. The quantity of cell phone users overall outperformed 2 billion in 2016 and it addresses more than a fourth of the worldwide population. There have been numerous new articles on the utilization of cell phones as versatile detectors, bioanalytical equipment, and instrument interfaces. The utilization of cell phones has opened doors for prognostic, diagnostic, detection, observing, quantification, control, or making versatile applications, since it can be very well utilized to run routine tests. Moreover it does not require a trained personnel and it is convenient and considered a minimal-expense gadget. The development of analytical methods is crucial in drug development. Improvement of existing and execution of new methodologies are essential for the present-day analytical chemistry of drugs. Recently published studies focussed on some of the applications of smartphone-based analytical methodologies in the last few years for the determination of drugs in different matrices. The aim of the presented review was to enhance the visibility of one of the fast and novel applications of smartphone technology. This will help scientists and researchers to understand the recent developments and explore new possibilities in this field.
A MINI REVIEW ON PROPERTIES, MECHANISM OF ACTION, PHARMACOKINETIC AND PHARMACODYNAMICS AND ANALYTICAL METHODS OF CARIPRAZINE ALANKAR SHRIVASTAVA, RADHIKA AGGARWAL, RISHI PRATAP SINGH, RAKHI KHABIYA International Journal of Applied Pharmaceutics, 2023 Cariprazine (CPZ) being a “D2/D3 receptor partial agonist” is used for schizophrenia treatment. CPZ illustrate different functional study at “dopamine receptors depending on the assay system”. This study elaborate review summarizes the structure–activity relationship (SAR), Mechanism of action (MOA), pharmacokinetics, pharmacodynamics and analytical methods published. CPZ was found to be more effective than risperidone. It was analogus with a remarkably longer time to deteriorate than inactive drug in a long-term, phase III,-deteriorate prevention study. This study elaborate the activating and solemn or sedative properties of first-line oral second generation antipsychotics by explore the rates of adverse effect in product labelling for the indications of schizophrenia and ancillary treatment of major depressive disorder (MDD). The common adverse events reported were extrapyramidal disorder, insomnia, dizziness, solemn, anxiety, vomiting and constipation in “fixed dose study of tested 1.5, 3.0, and 4.5 mg/day”. The presented review explains about biological properties, pharmacokinetics, pharmacodynamics, and analytical methods of CPZ.
Simultaneous determination of two alphaone adrenoreceptor blockers terazosin and prazosin using tamsulosin as internal standard International Journal of Pharmacy and Pharmaceutical Sciences, 2012
Isocratic RP-HPLC-UV method development and validation for the simultaneous estmation of ramipril and telmisartan in tablet dosage form Asian Journal of Pharmaceutical and Clinical Research, 2009
A review on peppermint oil Asian Journal of Pharmaceutical and Clinical Research, 2009
RECENT SCHOLAR PUBLICATIONS
DEVELOPMENT OF A DELAYED-RELEASE TABLET FOR CYSTINURIA: IN VITRO CHARACTERIZATION AND PRECLINICAL ASSESSMENT IN ALBINO SWISS RAT MODEL. SK Sharma, S Kaushik, A Gupta, V Deva, K Saiphali, A Shrivastava, ... Journal of Experimental Zoology India 29 (1) , 2026 2026
DEVELOPMENT AND PHARMACOLOGICAL EVALUATION OF A VETIVERIA ZIZANIOIDES HYDROGEL WITH ANTI-INFLAMMATORY ACTIVITY IN WISTAR RATS. S Maitra, AK Maurya, SK Sharma, K Saiphali, R Dixit, A Shrivastava, ... Journal of Experimental Zoology India 29 (1) , 2026 2026
Chromatography and Artificial Intelligence A Shrivastava International Journal of Newgen Research in Pharmacy & Healthcare, 98-103 , 2025 2025 Citations: 1
Animal Model Replacement Using AI Simulation: An Expanding Frontier in Biomedical Research A Verma, A Shrivastava International Journal of Newgen Research in Pharmacy & Healthcare, 158-163 , 2025 2025 Citations: 1
Role of Probiotics and Prebiotics in Ischemic Stroke in Connection with the Gut–Brain Axis A Gupta, A Shrivastava Biotics and the Gut–Brain Axis in Neurological Disorders, 163-170 , 2025 2025
ADVANCED STRATEGIES FOR TARGETED MODULATION OF PLANT-DERIVED BIOACTIVES: COMPUTATIONAL CHEMISTRY, RECEPTOR PROFILING AND POLYMERIC NANOPLATFORMS SK Natesan, N Singh, A Dutta, P Soni, A Shrivastava, S Parmar, S Jailani, ... Biochemical & Cellular Archives 25 (2) , 2025 2025
Imaging techniques for probiotic tracking and localization A Gupta, P Kumar, A Shrivastava Advances in Probiotic Delivery Systems, 545-566 , 2025 2025
Spectrophotometry Method for Determination of Mannitol in Injectable Formulation AS Alankar Shrivastava Research Journal of Pharmacy and Technology 17 (7), 3177 , 2024 2024
IMMUNOTHERAPEUTIC APPROACHES FOR AUTOIMMUNE DISEASES: RECENT ADVANCES AND FUTURE PERSPECTIVES. K Gupta, T Gupta, S Pamu, RB Tripathi, A Shrivastava, R Shukla, ... Biochemical & Cellular Archives 24 (1) , 2024 2024 Citations: 1
An approach towards green analytical chemistry: spectrophotometric method for the determination of celecoxib in capsule formulations K Saiphali, A Shrivastava, JG Neha, A Kumar Afr. J. Bio. Sc 6 (9), 1198-1212 , 2024 2024 Citations: 4
Steam Distillation: Principle and Applications for the Extraction of Essential Oils from Plants A Shrivastava Bioprospecting of Tropical Medicinal Plants, 893-903 , 2023 2023 Citations: 18
Nanotechnological Modus Operandi for the Delivery of Cytotoxic Phytochemicals T Alex, A Shrivastava, DK Lang, R Khabiya, SS Koka, Y Sultana Bioprospecting of Tropical Medicinal Plants, 1365-1385 , 2023 2023
A critical review on smartphone based determinations of drugs A Shrivastava Current Pharmaceutical Analysis 19 (3), 177-183 , 2023 2023 Citations: 4
MECHANISM OF ACTION, SYNTHESIS, PROPERTIES AND ANALYTICAL METHODS OF CABOZANTINIB GND AKANKSHA DWIVEDI, RAKHI KHABIYA, ALANKAR SHRIVASTAVA, SIDDHARTH TYAGI ... International Journal of Applied Pharmaceutics 15 (1), 57–65 , 2023 2023 Citations: 4
Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR A Shrivastava, A Mıttal Hacettepe University Journal of the Faculty of Pharmacy 43 (1), 22-31 , 2023 2023 Citations: 1
A mini review on properties, mechanism of action, pharmacokinetic and pharmacodynamics and analytical methods of cariprazine A SHRIVASTAVA, R AGGARWAL, RP SINGH, R KHABIYA International Journal of Applied Pharmaceutics 15 (1), 31-5 , 2023 2023 Citations: 1
Designing of novel nanoemulsions of retinol using box Behnken design for psoriasis M Sharma, MC Sharma, R Khabiya, A Dwivedi, A Shrivastava, ... Materials Today: Proceedings 80, 420-426 , 2023 2023 Citations: 7
Recent advances in nanotechnology for combating against corona virus infection V Raghuwanshi1a, R Khabiya1a, A Derashri, A Dwivedi, GN Darwhekar, ... 2022 Citations: 44
A mini review on characteristics and analytical methods of otilonium bromide A Shrivastava, A Mittal Critical Reviews in Analytical Chemistry 52 (7), 1717-1725 , 2022 2022 Citations: 11
Characteristics, biological activities, synthesis, and methods for the determination of brexpiprazole in different matrices A Shrivastava, A Mittal, R Khabiya, GP Choudhary, GN Darwhekar Current Pharmaceutical Analysis 18 (8), 765-776 , 2022 2022 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Methods for the determination of limit of detection and limit of quantitation of the analytical methods A Shrivastava, VB Gupta Chronicles of Young Scientists 2 (1), 21 , 2011 2011 Citations: 3984
A review on peppermint oil S Alankar Asian Journal of Pharmaceutical and Clinical Research 2 (2), 27-33 , 2009 2009 Citations: 164
Various treatment options for benign prostatic hyperplasia: A current update VBG Alankar Shrivastava Journal of Midlife health 3 (1), 10 , 2012 2012 Citations: 130
Structural Modifications and Strategies for Native Starch for Applications in Advanced Drug Delivery MT Pankaj Bhatt, Vipin Kumar, Richa Goel, Somesh Kumar Sharma, Shikha ... BioMed Research International 2022, 1-14 , 2022 2022 Citations: 72
HPLC: Isocratic or Gradient Elution and Assessment of Linearity In Analytical Methods VBG Alankar Shrivastava Journal of Advanced Scientific Research 3 (2), 12-20 , 2012 2012 Citations: 66
Various electroanalytical methods for the determination of uranium in different matrices VS Alankar Shrivastava, Jitendra Sharma Bulletin of Faculty of Pharmacy, Cairo University , 2013 2013 Citations: 60
Stability-indicating RP-HPLC method for the simultaneous determination of prazosin, terazosin, and doxazosin in pharmaceutical formulations A Shrivastava, VB Gupta Scientia pharmaceutica 80 (3), 619 , 2012 2012 Citations: 46
Recent advances in nanotechnology for combating against corona virus infection V Raghuwanshi1a, R Khabiya1a, A Derashri, A Dwivedi, GN Darwhekar, ... 2022 Citations: 44
A new RP-HPLC method for simultaneous estimation of nebivolol hydrochloride and hydrochlorthiazide in dosage forms Y Gupta, A Shrivastava, D Duggal, A Patel, S Agrawal Journal of young Pharmacists 1 (3), 264 , 2009 2009 Citations: 30
Spectrophotometric estimation of tamsulosin hydrochloride by acid-dye method A Shrivastava, P Saxena, VB Gupta Pharmaceutical methods 2 (1), 53-60 , 2011 2011 Citations: 29
Analytical methods for the determination of hydroxychloroquine in various matrices A Shrivastava Int. J. Appl. Pharm 4, 55-61 , 2020 2020 Citations: 23
New simple and economical spectrophotometric method for estimation of artemether in pharmaceutical dosage forms A Shrivastava, BP Nagori, P Saini, R Issarani, SS Gaur Asian j. research chem 1 (1), 19-21 , 2008 2008 Citations: 23
Clinical trial of herbal drugs and products in India: Past and current status and critical issues A Shrivastava, R Jain, RK Agrawal, D Ahirwar Research Journal of Pharmacy and Technology 1 (2), 69-74 , 2008 2008 Citations: 22
Various Analytical Methodologies for Determination of Selective α1A Receptor Blocker Tamsulosin Hydrochloride and Its Combinations in Different Matrices PA Alankar Shrivastava World Journal of Analytical Chemistry 1 (3), 37-48 , 2013 2013 Citations: 21
A review on various analytical methods on some alpha adrenergic antagonists A Shrivastava, V B Gupta Current Pharmaceutical Analysis 7 (1), 27-41 , 2011 2011 Citations: 21
Stability indicating reverse phase high performance liquid chromatography method for the estimation of capsaicin P Shrivastava, A. & Saxena Pharm. Meth. 2, 135–142 , 2011 2011 Citations: 21
Characteristics and analytical methods of Mannitol: An update A Shrivastava, S Sharma, M Kaurav, A Sharma International Journal of Applied Pharmaceutics 13 (5), 20-32 , 2021 2021 Citations: 20
Stability indicating high-performance liquid chromatography method for the estimation of artemether in capsule dosage forms A Shrivastava, R Issarani, BP Nagori Journal of Young Pharmacists 2 (1), 79-84 , 2010 2010 Citations: 20
Isocratic RP-HPLC-UV method development and validation for the simultaneous estimation of ramipril and telmisartan in tablet dosage form Y Gupta, A Shrivastava Asian J Pharm Clin Res 2 (4), 104-11 , 2009 2009 Citations: 19
Steam Distillation: Principle and Applications for the Extraction of Essential Oils from Plants A Shrivastava Bioprospecting of Tropical Medicinal Plants, 893-903 , 2023 2023 Citations: 18