Aldo Sena de Oliveira

@ufsc.br

Department of Exact Sciences and Education
Federal University of Santa Catarina

Aldo Sena de Oliveira


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https://researchid.co/aldosena
Has experience in the field of Organic Chemistry working in Medicinal Chemistry. It develops research with search of new active molecules in plant species used in folk medicine, synthesis and semi-synthesis of active molecules from natural models, application of bench bioassays, exploitation of the natural resources of the South Atlantic Forest with a view to obtaining new substances with therapeutic properties. At present he has been dedicated to the planning, synthesis and biological evaluation of new chemotherapeutic agents for the Treatment of Chagas Disease, Cancer and Alzheimer Disease, by in vitro, in vivo and in silico assays.

RESEARCH INTERESTS

Medicinal chemistry
45

Scopus Publications

3037

Scholar Citations

22

Scholar h-index

48

Scholar i10-index

Scopus Publications

  • Multifunctional Carvacrol-based Organoselenium hybrids as anticholinesterase and antioxidant candidates for Alzheimer's therapy
    Luana S. Gomes, Majory C.G.M. Schüler, Gabriela B. Giannini, Eduardo Zapp, Aldo S. de Oliveira, et al.
    Bioorganic and Medicinal Chemistry, 2026
  • In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease
    Lidiane Meier, Milena F. C. V. de Melo, Heitor R. Abreu, Isabella M. e Oliveira, Larissa Sens, et al.
    Pharmaceutics, 2026
    Background/Objectives: Chagas disease remains a major unmet medical need due to the limited efficacy and safety of current therapies. Here, we investigated sixteen thiosemicarbazone (TSC) derivatives as cruzain inhibitors using an integrated in silico/in vitro workflow. Methods: Docking against cruzain (PDB 3KKU) guided hit prioritization and correlated with enzyme inhibition; validation by redocking supported the protocol’s reliability. Results: The top compounds—H7, H10 and H11—showed potent cruzain inhibition (IC50 = 0.306, 0.512 and 0.412 µM, respectively) and low-micromolar trypanocidal activity, with negligible cytotoxicity in human fibroblasts (CC50 > 64 µM) and favorable selectivity. Structure–activity insights highlighted the role of expanded aromatic systems and electron-donating groups in enhancing binding within S2/S1′ subsites, while nitro substituents were associated with higher cytotoxicity. In silico ADMET parameters supported oral drug-likeness and acceptable metabolic liabilities. Conclusions: Overall, these data position TSCs as promising anti-T. cruzi leads and underscore the value of rational design against cruzain.
  • Bridging traditional and contemporary approaches in computational medicinal chemistry: opportunities for innovation in drug discovery
    Aldo Sena de Oliveira
    Rsc Medicinal Chemistry, 2025
    This review bridges traditional and AI-driven approaches in computational medicinal chemistry, showing how hybrid models, federated learning, and explainable generative AI are reshaping modern drug discovery workflows.
  • MEDICINAL CHEMISTRY IN POPULAR CULTURE: AN ANALYSIS OF THE REPRESENTATION OF BIOACTIVE SUBSTANCES IN CARTOONS AND GAMES
    Aldo S. de Oliveira, Angelica Justino, Thiago H. Doring, Vanessa Nascimento
    Quimica Nova, 2025
    This study investigates the representation of bioactive substances in popular culture, with a special focus on cartoons and games, through the lens of Medicinal Chemistry. We explore how these substances, often complex in their composition and effects, are reinterpreted and simplified to fit into fictional narratives, influencing the public perception of science. Taking iconic examples such as “Alice in Wonderland”, “Mario Bros”, “Popeye”, and “Asterix and Obelix”, we analyze not only how science is interpreted but also how it is transformed into narrative elements, fueling imagination and shaping cultural perceptions. Furthermore, this research aims to fill a gap in the literature by introducing a multidisciplinary approach that integrates concepts of Medicinal Chemistry with media analysis and molecular modeling. The inclusion of these novel data and analyses not only enriches our understanding of representations of psychoactive substances in popular culture but also provides valuable insights for research in Medicinal Chemistry and the development of future pharmacological therapies. By highlighting the importance of public science communication and media literacy, this study contributes to promoting critical thinking and a broader appreciation of the intersection between science, popular culture, and entertainment.
  • Sulfur/selenium-functionalized benzotriazoles as multifunctional antivirals targeting Zika & Chikungunya
    Luana S Gomes, C. Cirne-Santos, Caroline de S Barros, Rafael R Batista, Matheus R de P Ignacio, et al.
    Future Medicinal Chemistry, 2025
    AIMS Emerging arboviruses such as Zika virus (ZIKV) and Chikungunya virus (CHIKV) remain significant public health threats. This study aimed to evaluate the antiviral potential of six organochalcogen compounds against ZIKV and CHIKV. MATERIALS & METHODS Compounds were assessed for cytotoxicity and antiviral activity in Vero cells. Antiviral effects were determined using plaque reduction assays, time-of-addition studies, viral adsorption, and virucidal assays. Molecular docking and density functional theory (DFT) calculations were performed to investigate interactions with viral targets and electronic properties. RESULTS Compounds 4, 7, 8, and 9 exhibited potent antiviral activity with low cytotoxicity, demonstrating effective inhibition of viral replication with half-maximal effective concentration (EC₅₀) values in the micromolar range and favorable selectivity indices. Mechanistic assays revealed that the compounds interfered with viral adsorption, exhibited virucidal effects, and inhibited multiple stages of the replication cycle. Docking studies confirmed strong binding to key viral enzymes, supported by HOMO (half-maximal effective concentration) - LUMO (lowest unoccupied molecular orbital) analysis. CONCLUSIONS These findings highlight organochalcogen compounds as promising dual-action antiviral candidates with broad-spectrum activity against ZIKV and CHIKV. Further preclinical investigations are warranted to explore their therapeutic potential.
  • New Tacrine Dimers Alleviate the Intracellular Amyloid-β-induced Cognitive Disturbance and Oxidative Stress in Mice
    ANA ELISA GONÇALVES, OTTO SPIGARIOL, LUÍSA M. DA SILVA, YURI F. REGO, CLARA HERRERA-AROZAMENA, et al.
    Anais Da Academia Brasileira De Ciencias, 2025
    This study aimed to investigate <italic>in vivo</italic> and <italic>ex-vivo</italic> the effects of tacrine dimers (TD1, TD2, TD3 and TD4) in mice with Alzheimer’s disease (AD) induced by amyloid peptide (A<italic>β</italic>42) and, respectively, evaluated in behavioral tests of cognition, oxidative stress and neuroinflammation. All dimers reduced the cognitive deficit caused by A<italic>β</italic>42, oxidative stress and neuroinflammation, especially the compound TD4. By ADMET analysis (SwissADME and pkCSM 2.10 platforms), TD4 exhibited favorable pharmacokinetic properties with the control drug. The results suggest a therapeutic potential for AD for these compounds, given their distinct cognitive and neuroprotective effects in AD models induced by A<italic>β</italic>42.
  • Real-time and video-recorded pain assessment in beef cattle: clinical application and reliability in young, adult bulls undergoing surgical castration
    Rubia Mitalli Tomacheuski, Alice Rodrigues de Oliveira, Pedro Henrique Esteves Trindade, Magdiel Lopez-Soriano, Victoria Rocha Merenda, et al.
    Scientific Reports, 2024
    Bovine pain assessment relies on validated behavioral scales related to normal and pain-related behaviors. This study investigated the reliability and applicability of real-time and video-recorded pain assessment, and their agreement, in young, adult bulls undergoing surgical castration. Ten Nelore and nine Angus bulls underwent general anesthesia and surgical castration. Three-minute real-time observations and simultaneous videos were recorded at − 48 h (M0), before sedation, under fasting (M1), after surgery, 3 h after sternal recumbency (M2), after rescue analgesia (M3) and at 24 h (M4). Animals received morphine (after M2), dipyrone (after M3), and flunixin meglumine after surgical castration (M4). Two trained evaluators assessed real-time (n = 95) and video-recorded time-points (n = 95) using the Unesp-Botucatu Cattle Pain Scale (UCAPS). Both assessment methods inferred ‘very good’ reliability (≥ 0.81) with minimal bias, however, video-recorded assessment (4.33 ± 2.84) demonstrated slightly higher scores compared to real-time (3.08 ± 2.84). The results from this study suggest that UCAPS can be used in real-time or video-recorded to assess pain and guide analgesic therapy in cattle.
  • AI is a viable alternative to high throughput screening: a 318-target study
    Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho, Adrian Morrison, et al.
    Scientific Reports, 2024
    High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery.
  • Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
    Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho, Adrian Morrison, et al.
    Scientific Reports, 2024
  • New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma
    Luana da Silva Gomes, Érica de Oliveira Costa, Thuany G. Duarte, Thiago S. Charret, Raquel C. Castiglione, et al.
    ACS Omega, 2024
    Due to the growth in the number of patients and the complexity involved in anticancer therapies, new therapeutic approaches are urgent and necessary. In this context, compounds containing the selenium atom can be employed in developing new medicines due to their potential therapeutic efficacy and unique modes of action. Furthermore, tellurium, a previously unknown element, has emerged as a promising possibility in chalcogen-containing compounds. In this study, 13 target compounds (9a–i, 10a–c, and 11) were effectively synthesized as potential anticancer agents, employing a CuI-catalyzed Csp-chalcogen bond formation procedure. The developed methodology yielded excellent results, ranging from 30 to 85%, and the compounds were carefully characterized. Eight of these compounds showed promise as potential therapeutic drugs due to their high yields and remarkable selectivity against SCC-9 cells (squamous cell carcinoma). Compound 10a, in particular, demonstrated exceptional selectivity, making it an excellent choice for cancer cell targeting while sparing healthy cells. Furthermore, complementing in silico and molecular docking studies shed light on their physical features and putative modes of action. This research highlights the potential of these compounds in anticancer treatments and lays the way for future drug development efforts.
  • Structure–activity relationships of novel N-imidazoylpiperazines with potent anti-Trypanosoma cruzi activity
    Rocío Marisol Espinoza-Chávez, Celso de Oliveira Rezende Júnior, Mariana Laureano de Souza, Ivani Pauli, Marilia Valli, et al.
    Future Medicinal Chemistry, 2024
  • Chalcone Derivatives as Antibacterial Agents: An Updated Overview
    Aldo Oliveira, Arthur Cenci, Lucas Gonçalves, Maria Eduarda Thedy, Angelica Justino, et al.
    Current Medicinal Chemistry, 2024
  • Treatment of Alzheimer's Disease: Contemporary Perspectives in Medicinal Chemistry
    Aldo Sena de Oliveira
    Current Medicinal Chemistry, 2023
  • The Science Developed by Young Researchers in Brazil – Part 2
    Vanessa Nascimento, Helena Mannochio-Russo, Alan Cesar Pilon, Aldo Sena de Oliveira
    Revista Virtual De Quimica, 2023
  • The Science Developed by Young Researchers in Brazil - Part 1
    Vanessa Nascimento, Helena Mannochio-Russo, Alan Cesar Pilon, Aldo Sena de Oliveira
    Revista Virtual De Quimica, 2023
  • Selenium-Derivative Compounds: A Review of New Perspectives in the Treatment of Alzheimer’s Disease
    Aldo S. de Oliveira, Antonio L. Braga, Flavio A.R. Barbosa, Rômulo F.S. Canto, Kerolain F. Teixeira, et al.
    Current Medicinal Chemistry, 2023
  • DYRK1A Inhibitors and Perspectives for the Treatment of Alzheimer's Disease
    Adriano Defini Andricopulo, Márcia Maria de Souza, Arthur Ribeiro Cenci, Kerolain Faoro Teixeira, Valkiria Machado, et al.
    Current Medicinal Chemistry, 2023
  • Synthesis and investigation of the trypanocidal potential of novel 1,2,3-triazole-selenide hybrids
    Ingrid C. Chipoline, Beatrice F.A.B. Brasil, José S.S. Neto, Marilia Valli, Renata Krogh, et al.
    European Journal of Medicinal Chemistry, 2022
  • Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies
    Valkiria Machado, Arthur R. Cenci, Kerolain F. Teixeira, Larissa Sens, Tiago Tizziani, et al.
    Rsc Medicinal Chemistry, 2022
  • Phomoxanthone A, Compound of Endophytic Fungi Paecilomyces sp. and Its Potential Antimicrobial and Antiparasitic
    Gisele da Costa Ramos, João Victor Silva-Silva, Luciano Almeida Watanabe, José Edson de Sousa Siqueira, Fernando Almeida-Souza, et al.
    Antibiotics, 2022
  • Monomethylsulochrin isolated from biomass extract of Aspergillus sp. against Leishmania amazonensis: In vitro biological evaluation and molecular docking
    João Victor Silva-Silva, Rosiane Fernandes Moreira, Luciano Almeida Watanabe, Celeste da Silva Freitas de Souza, Daiana de Jesus Hardoim, et al.
    Frontiers in Cellular and Infection Microbiology, 2022
  • Novel trypanocidal thiophen-chalcone cruzain inhibitors: structure-and ligand-based studies
    Aldo S de Oliveira, Marilia Valli, Leonardo LG Ferreira, Julia M Souza, Renata Krogh, et al.
    Future Medicinal Chemistry, 2022
  • Witches, potions, and metabolites: an overview from a medicinal perspective
    Luana Canzian Llanes, Nathalia Biazotto Sa, Arthur Ribeiro Cenci, Kerolain Faoro Teixeira, Igor Vinícius de França, et al.
    Rsc Medicinal Chemistry, 2022
  • Carajurin Induces Apoptosis in Leishmania amazonensis Promastigotes through Reactive Oxygen Species Production and Mitochondrial Dysfunction
    João Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, et al.
    Pharmaceuticals, 2022
  • Diaminomaleonitrile derivatives as new potential antichagasic compounds: A study of structure-activity relationships
    Aldo S de Oliveira, Lucas dos S Mello, Camila H Ogihara, Thiago H Döring, David L Palomino-Salcedo, et al.
    Future Medicinal Chemistry, 2021

RECENT SCHOLAR PUBLICATIONS

  • A meta-analysis and meta-regression to compare the production performance, feed efficiency, and milk N efficiency in Jersey versus Holstein cows
    KV Almeida, JP Sacramento, DC Reyes, AS Oliveira, R Martineau, ...
    Journal of Dairy Science , 2026
    2026
  • Evaluating the Efficacy and Safety of Tonic Motor Activation in Restless Legs Syndrome: A Systematic Review with Meta-Analysis
    JVP Gonzalez, L Falcão, J Tekchandani, G Nunes, K Ogasawara, ...
    Sleep Medicine 138, 107897 , 2026
    2026
  • Neurological approaches to restless legs syndrome: a systematic review of non-pharmacological interventions
    JVP Gonzalez, C Fingergut, L Falcão, A Oliveira, G Garrido, L Lopes, ...
    Sleep Medicine 138, 107901 , 2026
    2026
  • In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease
    L Meier, MFCV de Melo, HR Abreu, IM Oliveira, L Sens, TH Doring, ...
    Pharmaceutics 18 (1), 65 , 2026
    2026
  • Multifunctional Carvacrol-based Organoselenium hybrids as anticholinesterase and antioxidant candidates for Alzheimer's therapy
    LS Gomes, MCGM Schülerb, GB Giannini, E Zapp, AS De Oliveira, ...
    Bioorganic & Medicinal Chemistry, 118447 , 2025
    2025
    Citations: 3
  • 654-HOW FOOD INSECURITY CAN PROSPECTIVELY INFLUENCE APPETITE IN ADOLESCENTS FROM THE GENERATION XXI COHORT?
    A Costa, MM Hetherington, A Oliveira
    Gac Sanit 39 (S2), 290 , 2025
    2025
  • Indole amide derivatives in Alzheimer’s disease: advancing from synthesis to drug discovery
    A Justino, TH Doring, JW da Cruz Jr, AL Braga, AS de Oliveira
    Discover Chemistry 2 (1), 175 , 2025
    2025
    Citations: 2
  • Evaluation of Double Acid Attack (Dae) on Deformed and Aged Ti-xNb-ySn Alloys for Application in Implants
    MV Silva, ECS Barboza, AS Oliveira, MA Rocha, LL Santos, AS Oliveira, ...
    Materials Research 28 (Suppl 1), e20250251 , 2025
    2025
  • New Tacrine Dimers Alleviate the Intracellular Amyloid-β-induced Cognitive Disturbance and Oxidative Stress in Mice
    AE Gonçalves, O Spigariol, LMDA Silva, YF Rego, C Herrera-Arozamena, ...
    Anais da Academia Brasileira de Ciências 97 (Suppl. 2), e20241163 , 2025
    2025
  • Diffuse Alveolar Hemorrhage in ANCA-Associated Vasculitis
    IS Lee
    New England Journal of Medicine 393 (1), 72-72 , 2025
    2025
    Citations: 1
  • Sulfur/selenium-functionalized benzotriazoles as multifunctional antivirals targeting Zika & Chikungunya
    LS Gomes, CC Cirne-Santos, C de S. Barros, RR Batista, ...
    Future Medicinal Chemistry 17 (12), 1363-1375 , 2025
    2025
    Citations: 2
  • Surface Analysis of Anodized Ti-45Nb Alloy
    AS Oliveira, ECS Barboza, MA Rocha, MV Silva, DF Rocha, IS Santos, ...
    Materials Research 28 (Suppl 1), e20250226 , 2025
    2025
    Citations: 1
  • Design, Synthesis, and In Vitro Evaluation of 4-(Arylchalcogenyl)methyl)-1H-1,2,3-triazol-1-yl-menadione: Exploring Their Potential Against Tuberculosis
    NLB Santos, LS Gomes, RCB Ribeiro, AS Carvalho, MCS Lourenço, ...
    Pharmaceuticals 18 (6), 797 , 2025
    2025
    Citations: 1
  • DA FUNDAÇÃO DA CASA POPULAR AO PROGRAMA MINHA CASA, MINHA VIDA: RESSIGNIFICAÇÕES DA CATEGORIA “POPULAR” NA POLÍTICA HABITACIONAL BRASILEIRA
    D FERREIRA, A OLIVEIRA
    CONTRIBUCIONES A LAS CIENCIAS SOCIALES 18 (1), e14400 , 2025
    2025
  • SUBDESENVOLVIMENTO E DEPENDÊNCIA: APONTAMENTOS SOBRE O AVANÇO DO AGRONEGÓCIO
    A OLIVEIRA, D FERREIRA
    CONTRIBUCIONES A LAS CIENCIAS SOCIALES 18 (1), e14697 , 2025
    2025
  • Bridging traditional and contemporary approaches in computational medicinal chemistry: opportunities for innovation in drug discovery
    AS de Oliveira
    RSC Medicinal Chemistry 16 (12), 5953-5963 , 2025
    2025
    Citations: 4
  • ABORDAGENS TEÓRICAS SOBRE A CIDADE: ROBERT ERZA PARK E HENRI LEFEBVRE EM DEBATE
    D FERREIRA, A OLIVEIRA
    POLÍTICAS PÚBLICAS & CIDADES Учредители: South Florida Publishing LLC eISSN … , 2025
    2025
  • MEDICINAL CHEMISTRY IN POPULAR CULTURE: AN ANALYSIS OF THE REPRESENTATION OF BIOACTIVE SUBSTANCES IN CARTOONS AND GAMES
    AS Oliveira, A Justino, TH Doring, V Nascimento
    Química Nova 48, e-20250088 , 2025
    2025
  • Structure‐Metabolism Relationships of Benzimidazole Derivatives with anti‐ Trypanosoma cruzi Activity for Chagas Disease
    RM Espinoza‐Chávez, C de Oliveira Rezende Júnior, ...
    ChemMedChem 19 (20), e202400293 , 2024
    2024
    Citations: 3
  • Energy requirement for primiparous Holstein× Gyr crossbred dairy cows
    JP Sacramento, AS Oliveira, AE Leao, AP Fonseca, SG Coelho, ...
    Journal of Dairy Science 107 (9), 6686-6695 , 2024
    2024
    Citations: 3

MOST CITED SCHOLAR PUBLICATIONS

  • Prevalence study of signs and symptoms of temporomandibular disorders in university students
    CR Pedroni, AS De Oliveira, MI Guaratini
    Journal of oral rehabilitation 30 (3), 283-289 , 2003
    2003
    Citations: 482
  • Use of the Fonseca's questionnaire to assess the prevalence and severity of temporomandibular disorders in Brazilian dental undergraduates
    K Nomura, M Vitti, AS Oliveira, TC Chaves, M Semprini, S Siéssere, ...
    Brazilian dental journal 18, 163-167 , 2007
    2007
    Citations: 341
  • The Southern Photometric Local Universe Survey (S-PLUS): improved SEDs, morphologies, and redshifts with 12 optical filters
    C Mendes de Oliveira, T Ribeiro, W Schoenell, A Kanaan, RA Overzier, ...
    Monthly Notices of the Royal Astronomical Society 489 (1), 241-267 , 2019
    2019
    Citations: 295
  • Prevalence study of signs and symptoms of temporomandibular disorder in Brazilian college students
    AS Oliveira, EM Dias, RG Contato, F Berzin
    Brazilian oral research 20, 3-7 , 2006
    2006
    Citations: 264
  • Prospective scenarios: A literature review on the Scopus database
    AS Oliveira, MD de Barros, F de Carvalho Pereira, CFS Gomes, ...
    Futures 100, 20-33 , 2018
    2018
    Citations: 136
  • Heart transplantation in 107 cases of Chagas' disease
    AI Fiorelli, RHB Santos, JL Oliveira Jr, DD Lourenço-Filho, RR Dias, ...
    Transplantation proceedings 43 (1), 220-224 , 2011
    2011
    Citations: 121
  • de.(2009)
    AS Oliveira, I Freire
    Desvendando a religião e as religiões mundiais em Max Weber. Horizonte 7 (14 … , 2008
    2008
    Citations: 85
  • Multiple criteria decision making and prospective scenarios model for selection of companies to be incubated
    AS Oliveira, CFS Gomes, CT Clarkson, AM Sanseverino, MRS Barcelos, ...
    Algorithms 14 (4), 111 , 2021
    2021
    Citations: 69
  • Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease
    RFS Canto, FAR Barbosa, V Nascimento, AS de Oliveira, IMC Brighente, ...
    Organic & biomolecular chemistry 12 (21), 3470-3477 , 2014
    2014
    Citations: 60
  • Periodontal disease and oral health‐related behavior as factors associated with preterm birth: a case–control study in s outh‐eastern B razil
    JF Macedo, RA Ribeiro, FC Machado, N Assis, RT Alves, AS Oliveira, ...
    Journal of periodontal research 49 (4), 458-464 , 2014
    2014
    Citations: 57
  • Reliability of fleximetry and goniometry for assessing cervical range of motion among children
    TC Chaves, HM Nagamine, JFC Belli, MCT de Hannai, ...
    Brazilian Journal of Physical Therapy 12, 283-289 , 2008
    2008
    Citations: 54
  • Carajurin Induces Apoptosis in Leishmania amazonensis Promastigotes through Reactive Oxygen Species Production and Mitochondrial Dysfunction
    JV Silva-Silva, CJ Moragas-Tellis, MSS Chagas, PVR Souza, DL Moreira, ...
    Pharmaceuticals 15 (3), 331 , 2022
    2022
    Citations: 36
  • Chalcone derivatives as antibacterial agents: An updated overview
    AS de Oliveira, AR Cenci, L Gonçalves, MEC Thedy, A Justino, AL Braga, ...
    Current Medicinal Chemistry 31 (17), 2314-2329 , 2024
    2024
    Citations: 33
  • Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action
    C Nucci-Martins, DF Martins, LF Nascimento, D Venzke, AS Oliveira, ...
    Journal of Ethnopharmacology 175, 273-286 , 2015
    2015
    Citations: 33
  • Antioxidant and antifungal activity of naphthoquinones dimeric derived from lawsone
    AS de Oliveira, IMC Brighente, RG Lund, LC Llanes, RJ Nunes, ...
    J. Biosci. Med 5 (2), 39-48 , 2017
    2017
    Citations: 32
  • Synthesis, antioxidant activity, acetylcholinesterase inhibition and quantum studies of thiosemicarbazones
    L Sens, AS Oliveira, A Mascarello, I Brighente, RA Yunes, RJ Nunes
    Journal of the Brazilian Chemical Society 29, 343-352 , 2018
    2018
    Citations: 30
  • Selenium-derivative compounds: A review of new perspectives in the treatment of Alzheimer’s disease
    FAR Barbosa, RFS Canto, KF Teixeira, AS de Souza, AS de Oliveira, ...
    Current Medicinal Chemistry 30 (6), 689-700 , 2023
    2023
    Citations: 28
  • Phomoxanthone A, Compound of Endophytic Fungi Paecilomyces sp. and Its Potential Antimicrobial and Antiparasitic
    GC Ramos, JV Silva-Silva, LA Watanabe, JES Siqueira, F Almeida-Souza, ...
    Antibiotics 11 (10), 1332 , 2022
    2022
    Citations: 27
  • Carajurin: A anthocyanidin from Arrabidaea chica as a potential biological marker of antileishmanial activity
    JV Silva-Silva, CJ Moragas-Tellis, MSS Chagas, PVR Souza, DL Moreira, ...
    Biomedicine & Pharmacotherapy 141, 111910 , 2021
    2021
    Citations: 27
  • Preparation, characterization, cytotoxicity and antioxidant activity of DOPA melanin modified by amino acids: melanin-like oligomeric aggregates
    TG Costa, MJ Feldhaus, FS Vilhena, M Heller, GA Micke, AS Oliveira, ...
    Journal of the Brazilian Chemical Society 26 (2), 273-281 , 2015
    2015
    Citations: 25