Kashintsev Aleksei

@pandica.com

Surgery/oncology
Pandica LTD

Kashintsev Aleksei


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https://researchid.co/alexey.kashintsev
MD, PhD, more than 20 years in surgery

EDUCATION

State Pediatric Medical University

RESEARCH, TEACHING, or OTHER INTERESTS

General Medicine, Oncology, Education

FUTURE PROJECTS

Physiologic Duodenal Aspiration Liquid Biopsy Enables Early Risk Stratification in Pancreatic Cystic Neoplasms

Early identification of high-risk pancreatic cystic neoplasms (PCNs) is critical for prevention of pancreatic ductal adenocarcinoma, yet current diagnostic tools remain limited in sensitivity and specificity. We developed a physiologic and minimally invasive method—Duodenal Aspiration Liquid Biopsy (DALB)—to obtain pancreaticobiliary secretions for cytological and biochemical analysis prior to endoscopic ultrasound (EUS) or biopsy. This study aimed to assess the clinical utility of DALB for early risk stratification in patients with PCNs. Between 2023 and 2025, we prospectively enrolled 35 patients with PCNs detected on MRI or CT. Before performing EUS or other invasive procedures, we used the Pandicath system to isolate the duodenal segment surrounding the major papilla and collect a physiologically stimulated secretion sample after oral liquid intake. The aspirate was analyzed for carcinoembryonic antigen (CEA) and cytological abnormalities.


Applications Invited
Stratification of the patients du to the risk of malignant transformation
13

Scopus Publications

Scopus Publications

  • Duodenal aspiration biopsy for diagnosing pancreatic cystic lesions: a four-case series
    Aleksei Kashintsev, Vitali Proutski
    Annals of Pancreatic Cancer, 2025
  • Early selective enteral feeding in combination with active decompression of duodenum in treatment of moderate and severe acute pancreatitis – A proof-of-concept clinical study
    A.A. Kashintsev, R. Kunda, V. Proutski
    Pancreatology, 2024
  • APPLICATION OF A SPECIAL NASOINTESTINAL TUBE IN THE TREATMENT OF ACUTE PANCREATITIS
    A. A. Kashintsev, N. Yu. Kokhanenko, V. Yu. Proutski, S. V. Anisimov, A. A. Nadeeva, et al.
    Grekov S Bulletin of Surgery, 2024
    Conservative treatment of severe and moderately severe acute pancreatitis (AP) with a focus on reducing suppurative complications poses a challenging task. The early initiation of enteral nutrition plays a crucial role in improving AP treatment outcomes. This case presentation illustrates an original method of duodenal drainage and intestinal tube feeding.A case of a patient with moderately severe acute pancreatitis and a relatively high risk of a fatal outcome is presented. Positive therapeutic effects were achieved through the innovative method of selective feeding with duodenal isolation. Percutaneous drainage of the abdominal cavity under ultrasound control for enzymatic peritonitis, coupled with early artificial feeding, successfully prevented infection and the development of multiorgan failure.The developed method of duodenal content aspiration and early jejunal tube feeding has demonstrated both effectiveness and safety.
  • Prevention of Infectious Complications in Acute Pancreatitis
    A. A. Kashintsev, A. A. Zavrajnov, N. Yu. Kokhanenko, V. Yu. Proutski, I. A. Solovyev, et al.
    Russian Sklifosovsky Journal of Emergency Medical Care, 2024
    AIM OF STUDY. The study was aimed to evaluate the effectiveness of treating acute pancreatitis by early enteral nutrition and selective introduction of nutritional mixtures directly into the initial sections of the jejunum, bypassing the duodenum.MATERIAL AND METHODS. A comprehensive treatment method for acute pancreatitis was developed based on the use of a pancreatoduodenal catheter. The method focuses on preventing intestinal failure syndrome by isolating the duodenum and preventing any liquid from entering it while ensuring the selective introduction of glucose-saline solutions and/or enteral nutritional mixtures directly into the initial sections of the jejunum. Several Russian clinics are currently conducting the research approved by local ethics committees. This article presents preliminary results from the data analysis. The study included moderate to severe forms (according to the 2012 Atlanta classification) of acute biliary pancreatitis without indications for endoscopic retrograde cholangiopancreatography, as well as alimentary-alcoholic pancreatitis. The first group of patients received standard therapy according to the 2020 clinical guidelines of the Russian Society of Surgeons. The second group received standard therapy combined with the new selective enteral nutrition method. The observation period lasted until the end of the hospital treatment, including five mandatory visits and a final visit to the physician. A follow-up survey was conducted three months or more after discharge to identify delayed episodes of acute pancreatitis complications, focusing on the incidence of infectious complications and surgical interventions.RESULTS. A total of 148 patients were treated. Patients were evenly distributed by etiology, gender, age, and body mass index. The analysis revealed that the number of patients with infectious complications decreased from 19.3% in the comparison group to 6.67% in the study group (p=0.041). The number of patients requiring surgical interventions was 5.0% in the study group compared to 19.3% in the comparison group (p=0.017).CONCLUSIONS. The study demonstrated that the use of the new method in the comprehensive treatment of acute pancreatitis, including early enteral feeding at the onset of the disease, may improve the course of the disease by reducing the incidence of infectious complications and the number of necessary surgical interventions.
  • Historical aspects of portal hypertension surgery: evolution of thinking
    T. Sh. Morgoshiia, N. Yu. Kohanenko, A. A. Kashintsev, O. G. Vavilova, Yu. N. Ulyanov, et al.
    Annals of HPB Surgery, 2023
    The paper presents the evolution of views on the surgery of portal hypertension, as well as some historical aspects of its development. The authors considered the main types of surgical interventions to be performed in this pathology. It is noted that in the middle of the 20th century, the direct portacaval anastomosis gained the widest acceptance of all the proposed types of vascular anastomoses. A number of surgeons considered it a classical method of treatment in portal hypertension. Thereafter, the indirect portacaval anastomosis proved to have the best outcomes. The advantage of portacaval anastomoses in comparison with other modifications of surgeries was substantiated by a significant decrease in portal pressure and disappearance of oesophageal varices after developing the anastomosis. Surgical treatment of patients with liver cirrhosis and portal system thrombosis reasonably requires closer attention of doctors in various fields. Such patients should be managed in specialized clinics and well-equipped medical centers.
  • Enhanced recovery after surgery in chronic pancreatitis
    N. Yu. Kokhanenko, O. G. Vavilova, K. V. Pavelets, A. A. Kashintcev, T. Sh. Morgoshiia, et al.
    Annals of HPB Surgery, 2023
  • Isolated metastasis of uterine leiomyosarcoma to the pancreas: clinical observation
    Alina Perminova, Mikhail Khanevich, Nikolai Kokhanenko, Alexey Kashintsev, Anna Glebova
    Voprosy Onkologii, 2021
    The article presents a clinical case of successful surgical treatment of a patient with isolated metastasis of uterine leiomyosarcoma to the head of the pancreas 3 years after the removal of the primary tumor. A pancreatectomy with immunohistochemical examination was performed. The patient was examined 6 months after the operation. There are no signs of a relapse of the disease.
  • Staged surgical treatment of the patient with chronic pancreatitis
    N. Yu. Kokhanenko, A. V. Glebova, O. G. Vavilova, A. A. Kashintsev, S. A. Kaliuzhnyi, et al.
    Annals of HPB Surgery, 2021
    A clinical case of successful surgical treatment of a patient with chronic pancreatitis, complicated by suppuration of a postnecrotic cyst and the formation of a cysto-gastric fistula. As a result of the conservative and minimally invasive treatment, the pseudocyst was drained, and the cystogastric fistula was closed. The staged treatment was completed by resection of the head of the pancreas with the formation of an anastomosis.
  • An experience of the treatment of a patient with chronic pancreatitis with pancreatic pleural fistula complicated by lung abscesses
    N. Yu. Kokhanenko, A. A. Kashintsev, A. A. Bobylkov, R. G. Avanesyan, E. V. Shepichev, et al.
    Grekov S Bulletin of Surgery, 2021
    Pancreatic pleural fistula is one of the rare and difficulty verifying complication of chronic pancreatitis. We present a rare medical case of a patient with chronic pancreatitis complicated by pancreatic pleural fistula with the formationof multiple lung abscesses. At the same time, the success of the treatment of the patient was due to the staged treatment and the participation of a multidisciplinary team of specialists.
  • Staged interventional and surgical treatment of patient with chronic pancreatitis complicated by pancreaticopleural fistula with lung abscesses
    Nikolay Y. Kokhanenko, Alexey A. Kashintsev, Andrey A. Bobylkov, Ruben G. Avanesyan, Evgeniy V. Shepichev, et al.
    American Journal of Case Reports, 2020
  • Surgical treatment of patient with chronic pancreatitis complicated by bleeding
    N. Yu. Kokhanenko, A. V. Glebova, A. A. Kashintsev, V. V. Zelenin, D. V. Merkulov, et al.
    Khirurgiia, 2018
  • Appendectomy and resection of the terminal ileum with secondary severe necrotic changes in acute perforated appendicitis
    Yuri V. Radionov
    American Journal of Case Reports, 2015
  • Esophagectomy and pancreatoduodenectomy in the same patient: Tactical and technical considerations
    Hepato Gastroenterology, 2014

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Pandicath platform for isolation of the part of gastrointestinal tract.