Ali Kalantari-Hesari
@basu.ac.ir
Department of Pathobiology, Faculty of Veterinary Sciences
Bu-Ali Sina University, Hamedan, Iran.
EDUCATION
Ph.D of Comparative Histology, University of Tehran
RESEARCH INTERESTS
Cell Culture
Image Analysis
Histochemistry
Semen Analysis
Sperm Fertility
Fertilization
Immunochemistry
Sperm Count
Scopus Publications
Scopus Publications
Soroush Bijani, Fatemeh Sadat Kashfi, Sadaf Zahedi-Vanjani, Keivan Nedaei, Ali Sharafi, Ali Kalantari-Hesari, and Mir-Jamal Hosseini
Elsevier BV
Asma Ghasemi, Firouzeh Nazari, Ali Kalantari-Hesari, Mehran Mohseni, and Mir-Jamal Hosseini
Informa UK Limited
Vajihe Alinezhad, Reza Ghodsi, Hadi Bagheri, Farzaneh Mahmoudi Beram, Habib Zeighami, Ali Kalantari-Hesari, Laleh Salarilak, Ebrahim Mostafavi, Zainab Ahmadian, Mohammad-Ali Shahbazi,et al.
Royal Society of Chemistry (RSC)
Developing injectable hydrogel dressings with multifunctional properties, including antibacterial and antioxidant ability, and good mechanical properties to treat infected full-thickness skin wounds is of particular importance in clinical applications.
Shayesteh Bochani, Atefeh Zarepour, Ali Kalantari-Hesari, Fakhri Haghi, Mohammad-Ali Shahbazi, Ali Zarrabi, Sophia Taheri, and Aziz Maleki
Royal Society of Chemistry (RSC)
This study introduces a novel antibacterial multifunctional hydrogel with synergistic chemodynamic and photothermal features for wound healing applications.
Vajihe Alinezhad, Kimia Esmaeilzadeh, Hadi Bagheri, Habib Zeighami, Ali Kalantari-Hesari, Rahim Jafari, Pooyan Makvandi, Yi Xu, Hamidreza Mohammadi, Mohammad-Ali Shahbazi,et al.
Royal Society of Chemistry (RSC)
This study presents a novel photothermally active hydrogel that contains platelet-rich plasma for infected wound healing. The hydrogel showed antibacterial, antioxidant, and hemostatic properties, as well as sustained growth factor release.
Leili Hosseinpoor, Bahman Navidshad, Mohammad Faseleh Jahromi, Sadegh Karimzadeh, Ali Kalantari Hesari, Farzad Mirzaei Aghjehgheshlagh, Houshang Lotfollahian, Ehsan Oskoueian, and Amir Heydari
Springer Science and Business Media LLC
Sina Montazeri, Soroush Bijani, Mahdieh Anoush, Ali Sharafi, Ali Kalantari-Hesari, and Mir-Jamal Hosseini
Hindawi Limited
Depression is one of the main factors affecting our daily performance. Among many putative compounds with effect on behavioral and pathophysiological alterations in depression, edaravone (EDV) demonstrates antioxidant and free radical scavenging properties. To investigate possible antidepressive and anxiolytic-like effects of EDV, Wistar rats were randomly divided into six groups: (1) control; (2) EDV (6 mg/kg); (3) post weaning social isolation (PWSI); (4) PWSI+EDV (1.5 mg/kg); (5) PWSI+EDV (3 mg/kg); and (6) PWSI+EDV (6 mg/kg). After the series of behavioral tests, animals were sacrificed, and their hippocampi were dissected for further biochemical and gene expression assays. Our results showed that treatment with 3 and 6 mg/kg EDV after social isolation would improve anxiety, depressive and anhedonic-like behavior in OFT, EPM, FST, and splash tests. In addition, treatment at the aforementioned doses achieved to recover total cellular antioxidant and GSH level. These effects were accompanied with the suppressive effect of EDV on MDA and PCO levels. EDV treatment also modulated the expression of AMPK, Tlr-4, BDNF, nNOS, and iNOS genes. The treatment with 3 and 6 mg/kg EDV would lead to the recovery of behavioral impairments, cellular free radical surge that could be in correlation with the effect of this substance on immune system response, improved energy production system, and more efficacy in the recovery of neural tissue. In conclusion, EDV ameliorates depressive-like disorder by modulating neuroinflammation, energy production, and neural tissue recovery.
Mahdieh Anoush, Soroush Bijani, Fatemeh Moslemifar, Fatemeh Jahanpour, Ali Kalantari-Hesari, and Mir-Jamal Hosseini
Hindawi Limited
Alzheimer’s disease (AD), as the main cause of dementia, has a progressive and neurodegenerative pattern with number of cases increasing over the next decades. Therefore, discovering an effective treatment with the ability to invert memory impairment and pathophysiological events of AD seems to be required. The present study performed to investigate the probable effects of Edaravone (EDV) in AD-like disorder induced by intracerebroventricular streptozotocin (ICV-STZ) administration in mice. This study also compares the two different methods of ICV-STZ in the memory impairment induction. NMRI male mice were administrated with 3 mg/kg of STZ for two times during 48 hours span, and after 24 hours, animals were treated with EDV (5 and 10 mg/kg), Donepezil, and Memantine for 14 days. After behavioral tests regarding memory and cognitive function, animals were sacrificed, and the hippocampi were utilized for further analyses. Our results demonstrated that administration of STZ induced memory impairment in the Morris water maze (MWM) test and decreased the discriminative factor in novel object recognition (NOR). The biochemical output shows a significant decrease in ferric reducing antioxidant power (FRAP) and glutathione (GSH) levels followed by increase in malondialdehyde (MDA) and protein carbonylation (PCO) levels. The output showed no difference between the patterns of AD-like disorder induction. Following our treatment groups, administration of EDV (5 and 10 mg/kg), Donepezil, and Memantine significantly improved memory performance and discriminatory behavior. Aforementioned treatments managed to improve FRAP and GSH content of hippocampus, while significantly attenuating MDA, PCO, and nitric oxide overproduction. In addition, no significant difference has been observed between the effect of 5 and 10 mg/kg EDV application. It was supposed that EDV managed to ameliorate memory dysfunction, discriminatory behavior, oxidative stress, and cellular antioxidant power in a dose-independent pattern in mice.
Faezeh Mozafari, Hamid Rashidzadeh, Soroush Bijani, Faezeh Zare-Molaei, Ziba Islambulchilar, Hossein Danafar, Ali Kalantari-Hesari, Ali Ramazani, and Mir-Jamal Hosseini
Hindawi Limited
Ischemic stroke is the most common among various stroke types and the second leading cause of death, worldwide. Edaravone (EDV) is one of the cardinal antioxidants that is capable of scavenging reactive oxygen species, especially hydroxyl molecules, and has been already used for ischemic stroke treatment. However, poor water solubility, low stability, and bioavailability in aqueous media are major EDV drawbacks. Thus, to overcome the aforementioned drawbacks, nanogel was exploited as a drug carrier of EDV. Furthermore, decorating the nanogel surface with glutathione as targeting ligands would potentiate the therapeutic efficacy. Nanovehicle characterization was assessed with various analytical techniques. Size (199 nm, hydrodynamic diameter) and zeta potential (-25 mV) of optimum formulation were assessed. The outcome demonstrated a diameter of around 100 nm, sphere shape, and homogenous morphology. Encapsulation efficiency and drug loading were determined to be 99.9% and 37.5%, respectively. In vitro drug release profile depicted a sustained release process. EDV and glutathione presence in one vehicle simultaneously made the possibility of antioxidant effects on the brain in specific doses, which resulted in elevated spatial memory and learning along with cognitive function in Wistar rats. In addition, significantly lower MDA and PCO and higher levels of neural GSH and antioxidant levels were observed, while histopathological improvement was approved. The developed nanogel can be a suited vehicle for drug delivery of EDV to the brain and improve ischemia-induced oxidative stress cell damage.
Fatemeh Khomari, Bahar Kiani, Shahin Alizadeh-Fanalou, Mohammad Babaei, Ali Kalantari-Hesari, Iraj Alipourfard, Fatemeh Mirzaei, Sahar Yarahmadi, and Elham Bahreini
Hindawi Limited
Background. Available data suggest inhibition of the pancreatic local-renin-angiotensin system (RAS) reduces tissue complications of diabetes. The purpose of the present study was to investigate the effect of hydroalcoholic seed extract of Securigera securidaca (S. securidaca) (HESS) on the pancreatic local-RAS and its alternative pathway. Methods. Three doses of HESS were orally administered to three groups of diabetic male Wistar rats, and the results were compared with both diabetic and healthy control groups. After 35 days of treatment, the groups were assessed for the levels of pancreatic local-RAS components, including renin, angiotensinogen, ACE, and Ang II, as well as ACE2 and Ang-(1-7) in the alternative pathway. The effect of herbal medicine treatment on tissue damage status was investigated by evaluating tissue levels of oxidative stress, proinflammatory and anti-inflammatory cytokines, and through histopathological examination of the pancreas. Results. HESS showed a dose-dependent palliative effect on the tissue oxidative stress profile ( P < 0.05 ) as well as the levels of pancreatic local-RAS components ( P < 0.05 ), compared to diabetic control group. Considering the interrelationship between tissue oxidative stress and local-RAS activity, the moderating effect of HESS on this relationship could be attributed to the increase in total tissue antioxidant capacity (TAC) and pancreatic Ang-(1-7) concentration. Decrease in local-RAS activity was associated with decrease in the tissue levels of inflammatory cytokines (IL1, IL6, and TNFα) ( P < 0.05 ) and increase in the levels of anti-inflammatory cytokine of IL-10 ( P < 0.05 ). In addition, histological results were consistent with tissue biochemical results. Conclusions. Due to the reduction of local pancreatic RAS activity as well as oxidative stress and proinflammatory cytokines following treatment with HESS, S. securidaca seed can be proposed as a suitable herbal supplement in the drug-treatment of diabetes.
Tayebeh Beigi, Amir Safi, Mahdi Satvati, Ali Kalantari-Hesari, Reza Ahmadi, and Mohammad-Hassan Meshkibaf
Elsevier BV
Manijeh Dogani, Nayere Askari, Ali Kalantari-Hesari, and Fatemeh Hosseini Rahbar
Elsevier BV
Mehdi Asadi, Mohammad Rahmani, Ali Samadi, and Ali Kalantari Hesari
Wiley
The present study investigated the effect of a 5-week ASA treatment on male reproductive parameters in Wistar rats; moreover, the potential benefits of a 4-week sprint interval training (SIT) on these measures following ASA treatment were investigated. A total of 25 male rats were obtained and randomly assigned to the control group (C, n = 10) and the ASA treatment group (EP, n = 15). After 5 weeks, five rats from each group were killed and the effect of ASA treatment on the reproductive parameters was assessed. Then, the ASA treatment terminated and the remaining 10 ASA-treated rats were divided into the non-treatment group (NT, n = 5) and the exercise training group (ET, n = 5), which performed SIT 3 sessions/week for 4 weeks. Five weeks of ASA treatment resulted in a statistically significant decrease in serum testosterone level, Leydig cell number, sperm count, sperm motility, sperm viability, TDI, SI and RI, and it resulted in a significant increase in sperm nucleus maturity and sperm DNA fragmentation (p ˂ 0.05). Furthermore, 4 weeks of SIT reversed all the ASA-induced changes in male reproductive parameters (p < 0.05), but not the number of seminiferous tubules and the sperm motility (p > 0.05). A subchronic dose of ASA could lead to adverse alterations in male reproductive parameters and SIT is beneficial in reversing those alterations.
Aziz Maleki, Shayesteh Bochani, Mehraneh Kermanian, Pooyan Makvandi, Mir-Jamal Hosseini, Mehrdad Hamidi, Ali Kalantari-Hesari, Hamid Reza Kheiri, Mohammad Reza Eskandari, Maryam Rosta,et al.
Springer Science and Business Media LLC
Shayesteh Bochani, Ali Kalantari-Hesari, Fakhri Haghi, Vajihe Alinezhad, Hadi Bagheri, Pooyan Makvandi, Mohammad-Ali Shahbazi, Abdollah Salimi, Ikue Hirata, Virgilio Mattoli,et al.
American Chemical Society (ACS)
The design and development of multifunctional injectable hydrogels with high photothermal antibacterial activity and shape adaptability to accelerate bacteria-infected wound healing is of critical importance in clinical applications. In this study, a hybrid hydrogel composed of gelatin, iron, and MnO2 nanosheets was prepared by multiple interactions, including coordinative and hydrogen bonding as well as electrostatic attraction. The introduced MnO2 and Fe components made the hydrogels photothermally and chemodynamically active, thereby endowing them with potent antibacterial capabilities against both Gram-negative and Gram-positive bacteria. Because of the Fenton activity of the hydrogels, they could produce abandoned oxygen, which is highly crucial in the healing process of wounds. They also showed good cytocompatibility and hemocompatibility as well as high hemostatic properties. Moreover, the injectable hydrogels could fill irregular wounds and significantly accelerate bacteria-infected wound healing through decreasing the inflammatory response and increasing blood vessels. These features indicated the promising potential of the multifunctional hydrogel for healing infected full-thickness wounds.
M. Nourani, A. Kalantari Hesari, R. Shahrooz and M. Asadi
The present study aimed to assess the effect of tissue hypoxia induced by sodium cyanide (NaCN) on male mice fertility and the protective role of ethyl pyruvate (EP). A number of 30 adult mice were assigned to three groups: 1) a control group, 2) a treatment group treated with 2 mg/kg of NaCN, and 3) a treatment group treated with 2 mg/kg of NaCN, along with 40 mg/kg EP (NaCN+EP). After 35 days, animals were anesthetized and serum, sperm, and tissue samples were taken. The results demonstrated a significant decrease in sperm quality, reproduction potency, and anti-oxidant potential, as well as an increase in lipid peroxidation in the NaCN group (p <0.05). Moreover, the use of EP effectively restrained the disastrous effects of tissue hypoxia. It can be concluded that EP can moderate the complications resulting from tissue-hypoxia that is related to testes parameters.
Abdolamir Allameh, Maryam Khanian, Mohammad-Amir Karimi-Torshizi, and Ali Kalantari-Hesari
Informa UK Limited
The aim of this study was to examine the impact of intake of a lactic acid bacterium; Lactobacillus plantarum 299v (Lp299v) on aflatoxin-induced hepatotoxicity in broilers. For this, broilers were intoxicated with dietary aflatoxins and simultaneously treated with live Lp299v in drinking water. One-day-old male broilers were divided into 8 groups (n=10/group) as follows; aflatoxin-groups fed basal diet contaminated with aflatoxins (200 or 2000 ppb). The probiotic groups received drinking water enriched with live Lp299v (108 cfu/ml). A group of birds was given a commercial mycotoxin binder (2.5 g/Kg feed). Control groups received basal diet without probiotic or aflatoxin binder. The growth performance was calculated for the entire period (0-42 days), and blood and liver specimens were processed for histology and determination of liver damage markers. Results showed extensive damage including bile duct hyperplasia, hepatocellular ballooning, and necrosis in chickens fed aflatoxin alone. However, liver lesions were limited to lobular inflammation and pyknosis in broilers treated with aflatoxins along with Lp299v. The histology of the liver tissues from the birds on aflatoxin-free diet + probiotic appeared to be normal when compared to the respective controls. Histopathological indices in different experimental groups were corroborated with the liver damage markers namely; serum ALT, AST, LD, and γ-GT. It is concluded that the improvement in the growth performance and prevention of aflatoxin-related liver lesions could be mainly assigned to the probiotic therapy for the entire period of breeding, although the aflatoxin binding ability of the Lp299v in inactivation of aflatoxins cannot be ruled out.
مسعود ادیب مرادی, علی کلانتری حصاری, رسول شهروز and محمدرضا اسدی
زمینه مطالعه: کمخونی و کاهش اکسیژن رسانی ناشی از آن در بدن میتواند موجب اختلال در عملکرد اکثر بافتها گردد. از سویی آهن آزاد شده از لیز گلبولهای قرمز و افزایش آهن بافتی ناشی از آن ایجاد استرس اکسیداتیو مینماید. هدف: هدف این مطالعه، بررسی اثر آنمی همولیتیک ایجاد شده توسط فنیل هیدرازین بر ساختار بافت شناسی قشر کلیه موش سوری و نقش محافظتی کروسین بر آسیب ناشی از فنیل هیدرازین بود. روشکار: از این رو در تحقیق حاضر تعداد 49 سر موش سوری نر بالغ 20 تا 25 گرمی در 7 گروه بهطور تصادفی تقسیم شدند. گروه اول کنترل، دریافت کننده سرم فیزیولوژی و سه گروه دریافت کننده فنیل هیدرازین با دوزهای mg/100g 2، 4 و 6 هر 48 ساعت یک بار و سه گروه دیگر فنیل هیدرازین به همراه کروسین را با دوز mg/100g 20 هر 24 ساعت یک بار به مدت 35 روز دریافت نمودند. پس از دوره درمان از طریق قلب خونگیری انجام و نمونههای سرمی جهت آزمایشات سرمی، و نمونههای بافتی نیز پس از جدا سازی در داخل فرمالین فیکس شده و پس از انجام برشهای پارافینی در نهایت با رنگ آمیزی هماتوکسیلین- ائوزین مورد بررسی قرار گرفتند. نتایج: نتایج مورفومتری نشان دهنده تغییرات در لوله پیچیده نزدیک کلیه درگروههای دریافت کننده فنیل هیدرازین بود. نتایج آزمایشات سرمی نیز نشانگر تغییرات پروکسیداسیون چربیها و ظرفیت آنتی اکسیدانتی سرم بود. نتایج حاصل بیانگر این است که کم خونی همولیتیک ناشی از فنیل هیدرازین بطور معنیدار بر قسمت لوله پیچیده نزدیک کلیه اثر داشته (05/0>P) ولی در سایر ساختارها تغییر معنی داری را ایجاد نکرد. همچنین بررسی گروههای دریافت کننده کروسین به عنوان یک آنتی اکسیدان نشان دهنده به حداقل رسیدن این آسیبها بود. نتیجهگیری نهایی: بنابراین میتوان نتیجه گرفت که کروسین به عنوان یک آنتی اکسیدان تا حدودی قادر به خنثی نمودن عوارض ناشی از آنمی همولیتیک در رابطه با عملکرد لوله پیچیده نزدیک کلیه می-باشد.
Rasoul Shahrooz, Naser Agh, Nasim Jafari, Ali Kalantari, Reza Jalili, and Ali Karimi
Central Fisheries Research Institute