Ali Zamlout

@tishreen.edu.sy

Department of Pediatric Surgery - Tishreen University Hospital
Faculty of Medicine - Tishreen University

Ali Zamlout


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https://researchid.co/ali_zamlout

EDUCATION

Doctor of Medicine (MD) - Faculty of Medicine, Tishreen University

RESEARCH, TEACHING, or OTHER INTERESTS

Surgery, Pediatrics, Perinatology and Child Health
6

Scopus Publications

87

Scholar Citations

3

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Spinnaker-sail sign in full-term neonates with spontaneous pneumomediastinum: a case study and scoping literature review
    Ali Zamlout, Bushra Jamahiri, Elisar Jabbour
    BMC Pediatrics, 2025
    Background Pneumomediastinum is a condition that is occasionally observed in preterm neonates, characterized by the presence of free air within the mediastinal spaces. Spontaneous Pneumomediastinum (SPM) in full-term neonates is a rare form. The clinical spectrum ranges from asymptomatic cases to severe respiratory distress. Objective To highlight the diagnostic challenges posed by the “spinnaker-sail sign”, and to create a stepwise framework for clinicians encountering similar cases. Methods We present two cases of SPM in a full-term neonate. Case-1: a 2-day-old boy with respiratory distress exhibited on CXR a crescentic radiolucent configuration elevating the thymus from the pericardium (“spinnaker-sail” sign). CT demonstrated an extrapulmonary multiseptated cystic mass within the anterior mediastinum. The neonate was treated with supplemental oxygen and antibiotics, showing improvement by day 11. Case-2: a 6-hour-old boy presented with respiratory distress shortly after birth. CXR showed the spinnaker-sail sign, alongside a band of air overlying the left hemidiaphragm (“Extrapleural air” sign). Lateral projection revealed mediastinal air collection lifting the thymus from the pericardium and great vessels. He was managed with oxygen moisture and antibiotics, showing significant improvement by day 4. Discussion The pathophysiology stems from uneven inflation and minute ruptures of immature alveoli, allowing air to leak through peribronchial and perivascular fasciae into the mediastinum. A fetal-remnant fascia entraps this air behind the thymus, constituting the “spinnaker-sail” appearance. The clinical course is typically benign. The management mainly involves supplemental oxygen and close monitoring. In severe cases, interventions such as needle decompression or chest tube insertion may be warranted. Conclusion Unfamiliar radiographic patterns of PM in neonates pose diagnostic challenges and interventional hazards. Understanding the unique anatomy of the mediastinum in neonates is essential to formulate a proper diagnosis and management strategy. Clinical trial number Not applicable.
  • Uncharted surgical therapy for acquired perforating dermatoses
    Mohammad Bashar Izzat, Ali Kahila, Ahmad Walid Izzat, Ali Zamlout, Sami Alashi
    Asian Cardiovascular and Thoracic Annals, 2023
    Acquired perforating dermatoses represent an uncommon group of chronic papulonodular dermatoses of unknown aetiology, characterized clinically by intense itching; and histopathologically by transepidermal elimination of dermal components. Definitive targeted pharmacological approaches are lacking, and the disease is usually refractory to therapy. We report here a case of rapid remission of acquired perforating dermatosis following simple thymectomy. If a role for the thymus in the pathogenesis of acquired perforating dermatoses was to be established, this could pave the way for a yet uncharted surgical therapy for these debilitating conditions.
  • Syrian national growth references for children and adolescents aged 2–20 years
    Ali Zamlout, Kamal Alwannous, Ali Kahila, Majd Yaseen, Raneem Albadish, et al.
    BMC Pediatrics, 2022
    Background During the past three decades, growth charts have become one of the principal tools for monitoring anthropometric development in individuals and populations as well. Growth references by the CDC and other countries have been widely used in our hospitals and healthcare units for clinical assessment of children’s development. The apparent overestimation and underestimation of many children's anthropometrics indicated the need to construct our own references. The objective of this study is to establish the national growth references for the Syrian population 2–20-year-old. Methods A multicenter cross-sectional sample of 13,548 subjects, aged 2–20 years, were recruited from various kindergartens, schools, and universities across the Syrian Arab Republic between February and May-2019. Response variables (stature, weight, and BMI) were fitted against age using P-splines and three empirical distributions: Box-Cox T, Box-Cox Power Exponential, and Box-Cox Cole and Green. Residuals diagnostic Q-tests and worm plots were used to check the validity of fitted models. Results Box-Cox T provided the best fit for stature-for-age, whereas Box-Cox Power Exponential provided the best fit for weight-for-age and BMI-for-age. Residuals diagnostics revealed adequate models fitting. BMI cutoffs revealed an increased prevalence of obesity (4.5% and 3.66%) and overweight (20.1% and 19.54%), for boys and girls respectively, in our population. Conclusions Growth charts are available for use now in our hospitals and healthcare units. For 0–2-year-old children, we recommend using the World Health Organization’s standards.
  • Factors associated with the intention of Syrian adult population to accept COVID19 vaccination: a cross-sectional study
    Okbah Mohamad, Ali Zamlout, Naseem AlKhoury, Abd Aljawad Mazloum, Marah Alsalkini, et al.
    BMC Public Health, 2021
    Background and objectives With global efforts to develop and deliver a COVID-19 vaccine rapidly, vaccine hesitancy stands as a barrier to these efforts. We aimed to estimate the proportion of Syrian adult population intending to be vaccinated against COVID-19 and, principally, to assess the demographic and attitudinal factors associated with it in order to approach suitable solutions. Methods An anonymous online questionnaire was conducted between 23rd December 2020 and 5th January 2021 in various provinces in Syria. A total of 3402 adults were sampled to reflect the population demographic factors. Attitudinal factors included Covid-19 fears, risks, and beliefs on the origin. Vaccination hesitancy and knowledge were also measured. The intention to get vaccinated against COVID-19 was the primary endpoint. Results According to their statements, 1222 participants (35.92%) will consent to get vaccinated against COVID-19. Our findings indicate that male gender, younger age, rural residence, not having children, smoking, fear about COVID-19, individual perceived severity, believing in the natural origin of the coronavirus, and high vaccination knowledge were positive predictors of embracing COVID-19 vaccine when it is available. Conclusion COVID-19 vaccine acceptance rate is considerably poor across Syrian population compared to populations in developed countries. Vaccine hesitancy is closely bound to the fear of side effects and doubts about vaccine efficacy. Factors such as conspiracy beliefs and myths about the vaccine lower vaccine uptake. Thus, interventional educational campaigns are increasingly required to overcome misinformation and avert low vaccination acceptance rates.
  • Congenital erythropoietic porphyria (Gunther disease): A case report
    Ali Kahila, Ali Zamlout, Abdaljawad Mazloum, Omar Laila, Ayham Badran
    Oxford Medical Case Reports, 2020
    Congenital erythropoietic porphyria (CEP or Gunther disease) is a very rare subtype of porphyria with a prevalence of <0.9 per 1 000 000. A 13-year-old female patient came to our hospital complaining of a severe cutaneous ulceration and scarring. The symptoms began in her first year of life as urine discoloration and skin blistering in sun-exposed areas. The family had been trapped in a high-risk conflict zone in Syria for many years, which precipitated the aggravation of symptoms. Based on clinical examination and laboratory tests, we diagnosed the patient with CEP and treated her with vitamin D supplementation alongside chronic blood transfusions, strict photoprotection and psychotherapy. After 7 months, there were no longer active ulcers or novel complications. Psychotherapy and patient education were important for her psychological development at this age. This treatment limited the deterioration of the symptoms and made the patient more committed to the periodic examinations.
  • Adenolipoma of the thyroid gland:A case report from Syria
    Asil Esper, Ali Zamlout, Rana Issa, Samir Kanaan, Zuheir Alshehabi
    Journal of Clinical and Translational Endocrinology Case Reports, 2020

RECENT SCHOLAR PUBLICATIONS

  • Spinnaker-sail sign in full-term neonates with spontaneous pneumomediastinum: a case study and scoping literature review
    A Zamlout, B Jamahiri, E Jabbour
    BMC pediatrics 25 (1), 293 , 2025
    2025
    Citations: 1
  • Uncharted surgical therapy for acquired perforating dermatoses
    MB Izzat, A Kahila, AW Izzat, A Zamlout, S Alashi
    Asian Cardiovascular and Thoracic Annals 31 (2), 148-150 , 2023
    2023
    Citations: 1
  • Syrian national growth references for children and adolescents aged 2–20 years
    A Zamlout, K Alwannous, A Kahila, M Yaseen, R Albadish, M Aleid, ...
    BMC pediatrics 22 (1), 282 , 2022
    2022
    Citations: 14
  • Factors associated with the intention of Syrian adult population to accept COVID19 vaccination: a cross-sectional study
    O Mohamad, A Zamlout, N AlKhoury, AA Mazloum, M Alsalkini, ...
    BMC Public Health 21 (1), 1310 , 2021
    2021
    Citations: 60
  • Congenital erythropoietic porphyria (Gunther disease): a case report
    A Kahila, A Zamlout, A Mazloum, O Laila, A Badran
    Oxford Medical Case Reports 2020 (7), omaa051 , 2020
    2020
    Citations: 11
  • Adenolipoma of the thyroid gland: A case report from Syria
    A Esper, A Zamlout, R Issa, S Kanaan, Z Alshehabi
    Journal of Clinical and Translational Endocrinology: Case Reports 16, 100060 , 2020
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Factors associated with the intention of Syrian adult population to accept COVID19 vaccination: a cross-sectional study
    O Mohamad, A Zamlout, N AlKhoury, AA Mazloum, M Alsalkini, ...
    BMC Public Health 21 (1), 1310 , 2021
    2021
    Citations: 60
  • Syrian national growth references for children and adolescents aged 2–20 years
    A Zamlout, K Alwannous, A Kahila, M Yaseen, R Albadish, M Aleid, ...
    BMC pediatrics 22 (1), 282 , 2022
    2022
    Citations: 14
  • Congenital erythropoietic porphyria (Gunther disease): a case report
    A Kahila, A Zamlout, A Mazloum, O Laila, A Badran
    Oxford Medical Case Reports 2020 (7), omaa051 , 2020
    2020
    Citations: 11
  • Spinnaker-sail sign in full-term neonates with spontaneous pneumomediastinum: a case study and scoping literature review
    A Zamlout, B Jamahiri, E Jabbour
    BMC pediatrics 25 (1), 293 , 2025
    2025
    Citations: 1
  • Uncharted surgical therapy for acquired perforating dermatoses
    MB Izzat, A Kahila, AW Izzat, A Zamlout, S Alashi
    Asian Cardiovascular and Thoracic Annals 31 (2), 148-150 , 2023
    2023
    Citations: 1
  • Adenolipoma of the thyroid gland: A case report from Syria
    A Esper, A Zamlout, R Issa, S Kanaan, Z Alshehabi
    Journal of Clinical and Translational Endocrinology: Case Reports 16, 100060 , 2020
    2020