Andreea SOARE

@campusbiomedicohospital.com

Department of Medicine Campus Bio-Medico University Hospital Prevention and Check-up Medicine
Campus Bio-Medico University Hospital

Andreea SOARE


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https://researchid.co/andreeasoare

RESEARCH INTERESTS

cardio metabolic
preventive medicine
14

Scopus Publications

Scopus Publications

  • An extra virgin olive oil-enriched chocolate spread positively modulates insulin-resistance markers compared with a palm oil-enriched one in healthy young adults: A double-blind, cross-over, randomised controlled trial
    Dario Tuccinardi, Antonio Di Mauro, Greta Lattanzi, Giovanni Rossini, Lavinia Monte, et al.
    Diabetes Metabolism Research and Reviews, 2022
    To investigate if extra virgin olive oil (EVOO) or palm oil enriched chocolate spreads consumption leads to different results in terms of plasma ceramides concentration, glucose and lipid metabolism, inflammatory markers and appetite regulation in young healthy subjects.
  • The Mediterranean diet increases glucagon-like peptide 1 and oxyntomodulin compared with a vegetarian diet in patients with type 2 diabetes: A randomized controlled cross-over trial
    Antonio Di Mauro, Dario Tuccinardi, Mikiko Watanabe, Rossella Del Toro, Lavinia Monte, et al.
    Diabetes Metabolism Research and Reviews, 2021
    To compare a Mediterranean diet (MED) with a high‐fibre vegetarian diet (HFV) in terms of hunger‐satiety perception through post‐prandial assessment of appetite‐related hormones glucagon‐like peptide 1 (GLP‐1) and oxyntomodulin, as well as self‐rated visual analogue scale (VAS) quantification, in overweight/obese subjects with type 2 diabetes (T2D).
  • Increased sclerostin and bone turnover after diet-induced weight loss in type 2 diabetes: a post hoc analysis of the MADIAB trial
    R. Strollo, A. Soare, Yeganeh Manon Khazrai, A. Di Mauro, A. Palermo, et al.
    Endocrine, 2017
  • Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial
    Andreea Soare, Yeganeh Manon Khazrai, Lucia Fontana, Rossella Del Toro, Maria Concetta Lazzaro, et al.
    Metabolism Clinical and Experimental, 2017
  • A 6-month follow-up study of the randomized controlled Ma-Pi macrobiotic dietary intervention (MADIAB trial) in type 2 diabetes
    A Soare, R Del Toro, Y M Khazrai, A Di Mauro, S Fallucca, et al.
    Nutrition and Diabetes, 2016
  • The effect of macrobiotic Ma-Pi 2 diet on systemic inflammation in patients with type 2 diabetes: A post hoc analysis of the MADIAB trial
    Andreea Soare, Rossella Del Toro, Elena Roncella, Yeganeh Manon Khazrai, Silvia Angeletti, et al.
    BMJ Open Diabetes Research and Care, 2015
    Introduction Current guidelines for the management of type 2 diabetes (T2D) emphasize diet as essential therapy. However, the effect of diet on systemic inflammation remains unclear. We investigated the effects of consuming a macrobiotic Ma-Pi 2 diet versus a standard recommended diet (control diet) on markers of inflammation in patients with T2D. Methods This was a post hoc analysis of the MADIAB trial, a 21-day randomized controlled trial conducted in 51 patients (25 males and 26 females) with T2D. Patients were randomized 1:1 to the Ma-Pi 2 macrobiotic diet or a control diet based on dietary guidelines for T2D. Biological antioxidant potential of plasma and circulating levels of high-sensitivity C reactive protein, interleukin-6, tumor necrosis factor-α, and insulin-like growth factor-1 were assessed. Results After 21 days on the Ma-Pi 2 or control diet, markers of inflammation were reduced in both groups. The antioxidant potential of plasma improved significantly in the Ma-Pi group. A significant reduction in insulin growth factor-1 was observed in the Ma-Pi group versus control group (p<0.001). Conclusions Findings of this post hoc analysis demonstrated that the Ma-Pi 2 diet is a safe dietary strategy to reduce levels of the markers of insulin resistance and inflammation, compared with baseline values, in the short term. Furthermore, the Ma-Pi 2 diet was superior to the control diet in reducing insulin growth factor-1 and may be beneficial for patients with T2D. Trial registration number Current Controlled Trials ISRCTN10467793.
  • Benefits of caloric restriction for cardiometabolic health, including type 2 diabetes mellitus risk
    A. Soare, E. Weiss, P. Pozzilli
    Diabetes Metabolism Research and Reviews, 2014
    In the United States, life expectancy has markedly increased during the past century, and population ageing is expected to double within the next 25 years. The process of ageing in a population is associated with the development of chronic diseases, such as type 2 diabetes mellitus, that can be prevented, and even reversed, with the implementation of healthy lifestyle interventions. The evidence to date, consolidated by the numerous epidemiological studies and clinical trials conducted, suggests that caloric restriction is an effective nutritional intervention for preventing most of these age‐related conditions. At a metabolic level, caloric restriction with adequate nutrition has been shown to improve insulin sensitivity, reduce fasting glucose and insulin concentration and prevent obesity, type 2 diabetes, hypertension and chronic inflammation. The purpose of this article is to review current knowledge of the metabolic and clinical implications of caloric restriction with adequate nutrition for the prevention of type 2 diabetes and cardiovascular disease. Copyright © 2013 John Wiley & Sons, Ltd.
  • Multiple dietary supplements do not affect metabolic and cardiovascular health
    Andreea Soare, Edward P. Weiss, John O. Holloszy, Luigi Fontana
    Aging, 2014
    Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. This study was a 6-month randomized, single-blind controlled trial, in which 56 non-obese (BMI 21.0-29.9 kg/m2) men and women, aged 38 to 55 yr, were assigned to a dietary supplement (SUP) group or control (CON) group, with a 6-month follow-up. The SUP group took 10 dietary supplements each day (100 mg of resveratrol, a complex of 800 mg each of green, black, and white tea extract, 250 mg of pomegranate extract, 650 mg of quercetin, 500 mg of acetyl-l-carnitine, 600 mg of lipoic acid, 900 mg of curcumin, 1 g of sesamin, 1.7 g of cinnamon bark extract, and 1.0 g fish oil). Both the SUP and CON groups took a daily multivitamin/mineral supplement. The main outcome measures were arterial stiffness, endothelial function, biomarkers of inflammation and oxidative stress, and cardiometabolic risk factors. Twenty-four weeks of daily supplementation with 10 dietary supplements did not affect arterial stiffness or endothelial function in nonobese individuals. These compounds also did not alter body fat measured by DEXA, blood pressure, plasma lipids, glucose, insulin, IGF-1, and markers of inflammation and oxidative stress. In summary, supplementation with a combination of popular dietary supplements has no cardiovascular or metabolic effects in non-obese relatively healthy individuals.
  • The effect of the macrobiotic Ma-Pi 2 diet vs. The recommended diet in the management of type 2 diabetes: The randomized controlled MADIAB trial
    Andreea Soare, Yeganeh M Khazrai, Rossella Del Toro, Elena Roncella, Lucia Fontana, et al.
    Nutrition and Metabolism, 2014
  • Wrist circumference: An independent predictor of both insulin resistance and chronic kidney disease in an elderly population
    Adina Mitrea, Andreea Soare, Simona Georgiana Popa, Mirela Nicoleta Tudor, Maria Mota, et al.
    Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 2013
    Background and aim: It was recently reported that wrist circumference is associated with insulin resistance (IR) both in children and adults. We aimed to evaluate whether wrist circumference is a useful anthropometrical parameter for the evaluation of IR in an elderly population. Material and method: We performed a study on 40 subjects, 20 with type 2 diabetes (T2D) and 20 control subjects. IR was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). We measured the following anthropometrical parameters: weight, height, waist circumference (WC), hip circumference, wrist circumference, waist to hip ratio (WHR), waist to height ratio (WHtR), body mass index (BMI) and body adiposity index (BAI). Results: We found statistically significant differences between the subjects with T2D and the control group for all the analyzed parameters. Statistically significant correlations between all the anthropometrical parameters and HOMA-IR were observed. However, only WC was an independent predictor of IR. Wrist circumference was the only parameter negatively correlated with the estimated glomerular filtration rate (eGFR). Furthermore, this measurement was an independent predictor of chronic kidney disease (CKD) in the studied subjects. Conclusion: Wrist circumference can be used in the general practice as a surrogate marker of IR in the elderly, being both easily determined and a cost-free method
  • Buccal spray insulin in subjects with impaired glucose tolerance: Improvement in HbA1c is lost after 6 months washout therapy
    Satish K. Garg
    Diabetes Technology and Therapeutics, 2013
  • Searching the missing link between alzheimer's disease and diabetes
    Adina Mitrea, Simona Georgiana Popa, Cristina Muntean, Andreea Soare, Laura Trotta, et al.
    Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 2013
  • Caloric restriction may reverse age-related autonomic decline in humans
    Phyllis K. Stein, Andreea Soare, Timothy E. Meyer, Roberto Cangemi, John O. Holloszy, et al.
    Aging Cell, 2012
  • Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
    Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
    Aging, 2011