Dr. C. Anjugam

EDUCATION

Dr. C. Anjugam M.Sc, M.Phil, Ph.D.,

RESEARCH INTERESTS

Molecular biology, Cancer and Environmental science

Scopus Publications

Overview of epigenetic changes in cancer-related to gastrointestinal systems
Saranya Arumugam, C. Anjugam, R. Muthuvel, Gowtham Kumar Subbaraj
Epigenetic Regulations in Gastrointestinal Cancers, 2026
Challenges and opportunities for analyzing protein-ligand interactions
Saranya Arumugam, R. Muthuvel, C. Anjugam, Langeswaran Kulanthaivel, Gowtham Kumar Subbaraj
Biochemical Techniques for Analyzing Protein Lipid Interactions, 2024
Structure-based docking studies toward exploring the potential anticancer activity of morin against non-melanoma skin cancer therapeutic drug targets
Anjugam C, Sridevi M, Gnanendra Ts
Asian Journal of Pharmaceutical and Clinical Research, 2018
Objective: The purpose of this study is to explore the anticancer activity of morin compound against human cyclooxygenase-2 (COX-2) and peroxisome-proliferator-activated receptors (PPARs) isotypes (PPARα and PPARγ) through in silico molecular docking studies.Methods: The 3D structures of human COX-2 complexed with ibuprofen (PDB ID: 4PH9), PPARα complexed with a synthetic agonist (2S)-2-(4- methoxy-3-{[(pyren-1-yl carbonyl) amino] methyl} benzyl) butanoic acid (PDB ID: 3VI8) and PPARγ complexed indomethacin (PDB ID: 3ADX) were retrieved from protein databank. The cocrystallized sites were considered as binding sites, and the docking with morin compound was performed along with their respective cocrystals for each target and compared their interactions and binding affinities.Results: It is observed that the morin compound exhibited better binding energy of -32.9528 kJ/mol against PPARα followed by COX-2 (binding energy: −18.4311 kJ/mol) and PPARγ (binding energy: −17.4228 kJ/mol) when compared to their cocrystallized ligands.Conclusion: The present study suggests that morin compound might serve as potential alternatives in the prevention of skin cancers by showing better activity against PPARα.
Morin prevents ultraviolet-b radiation-induced photocarcinogenesis through activating thrombospondin-1 in the mouse skin
Asian Journal of Pharmaceutical and Clinical Research, 2018