Anson S. Maroky

@damcop.com

Professor, Pharmacology/Pharmacy
Devaki Amma Memorial College of Pharmacy

Anson S. Maroky


                  Download Compact PDF  
https://researchid.co/ansonmaroky

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Molecular Biology, Cognitive Neuroscience, Pharmacy
6

Scopus Publications

240

Scholar Citations

4

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • INTEGRATIVE SYSTEMS BIOLOGY AND MULTI-OMICS APPROACHES IN ALZHEIMER'S DISEASE: BRIDGING BIOMARKERS, NEUROINFLAMMATION, AND PRECISION MEDICINE
    JITHIN MATHEW, ANSON SUNNY MAROKY, SIVARANJINI SINDURAJ, ANCHU CHANDRABABU
    International Journal of Applied Pharmaceutics, 2025
    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in cognitive function, driven by synaptic dysfunction and neuronal loss, particularly in the hippocampus a region critical for memory and learning. A hallmark of AD pathogenesis is the aggregation of amyloid-beta (Aβ) peptides into toxic oligomers, which initiate a cascade of events leading to amyloid plaque formation, activation of reactive microglia and astrocytes and subsequent neuronal damage. Neuroinflammation and oxidative stress plays pivotal roles in AD progression, with the interplay between these processes exacerbating the pathological features of the disease. Pro-inflammatory signaling pathways activated by reactive immune cells and the excessive production of reactive oxygen species (ROS) disrupt cellular homeostasis, further accelerating neurodegeneration. This review delves into the intricate mechanisms linking Aβ pathology with inflammatory and oxidative stress responses and highlights how multi-omics and neuroimaging enable precision medicine through molecular and structural brain correlation. Recent advances in understanding the molecular pathways have unveiled potential biomarkers that hold promise for improving diagnostic precision and monitoring disease progression. Furthermore, this review highlights novel therapeutic strategies identified through systems biology approaches, emphasizing their potential to target the multifaceted nature of AD pathophysiology. By exploring the nexus of amyloid pathology, neuroinflammation and oxidative stress, this work aims to provide a comprehensive framework for developing targeted interventions that may mitigate the burden of this devastating disease. This review critically evaluates network-based analyses and case studies in genomics, proteomics and metabolomics that have identified candidate biomarkers and therapeutic targets in AD.
  • Therapeutic potential of free fatty acid receptor 4 (FFAR4/GPR120) in diabetes mellitus: Insights into molecular mechanisms and future directions
    Receptor Targeted Therapies in Diabetes Mellitus from Pathophysiology to Innovative Treatments, 2025
  • Potential bactericidal activity of S. nux-vomica–ZnO nanocomposite against multidrug-resistant bacterial pathogens and wound-healing properties
    Katherin Steffy, G. Shanthi, Anson. S. Maroky, S. Selvakumar
    Journal of Trace Elements in Medicine and Biology, 2018
  • Enhanced antibacterial effects of green synthesized ZnO NPs using Aristolochia indica against Multi-drug resistant bacterial pathogens from Diabetic Foot Ulcer
    Katherin Steffy, Ganesan Shanthi, Anson S. Maroky, Sachidanandan Selvakumar
    Journal of Infection and Public Health, 2018
    BACKGROUND: Increased incidence of Multi-drug resistance in microorganisms has become the greatest challenge in the treatment of Diabetic Foot Ulcer (DFU) and urges the need of a new antimicrobial agent. In this study, we determined the bactericidal effects of ZnO nanoparticles (ZnO NPs) green synthesized from Aristolochia indica against Multi-drug Resistant Organisms (MDROs) isolated from pus samples of DFU patients attending in a tertiary care hospital in South India. METHODS: ZnO NPs were characterized by UV-vis-DRS spectroscopy, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and for its zeta potential value. MIC/MBC assays were performed to determine bactericidal or bacteriostatic effects. Time-kill assays, Protein leakage and Flow cytometric analysis evaluated bacterial cell death at 1x MIC and 2x MIC concentrations of ZnO NPs. RESULTS: ZnO NPs of size 22.5nm with a zeta potential of -21.9±1mV exhibited remarkable bactericidal activity with MIC/MBC ranging from 25 to 400μg/ml with a significant reduction in viable count from 2h onwards. Protein leakage and Flow cytometric analysis confirmed bacterial cell death due to ZnO NPs. CONCLUSION: This study concluded that green synthesis protocol offers reliable, eco-friendly approach towards the development of antimicrobial ZnO NPs to combat antibiotic drug resistance.
  • Synthesis and characterization of ZnO phytonanocomposite using Strychnos nux-vomica L. (Loganiaceae) and antimicrobial activity against multidrug-resistant bacterial strains from diabetic foot ulcer
    Katherin Steffy, G. Shanthi, Anson S. Maroky, S. Selvakumar
    Journal of Advanced Research, 2018
    Nanobiotechnology has been emerged as an efficient technology for the development of antimicrobial nanoparticles through an eco-friendly approach. In this study, green synthesized phytonanocomposite of ZnO from Strychnos nux-vomica leaf aqueous extract was characterized by X-ray diffraction analysis (XRD), UV–visible-spectroscopy, Photoluminescence spectroscopy (PL), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), High-resolution Transmission Electron Microscopy (HR-TEM), and Energy dispersive X-ray analysis (EDX). Antibacterial activity was investigated against multidrug-resistant bacteria (MDR) isolated from diabetic foot ulcers (DFUs), such as MDR–methicillin resistant Staphylococcus aureus (MRSA), MDR–Escherichia coli, MDR–Pseudomonas aeruginosa, MDR–Acinetobacter baumannii, as well as against standard bacterial strains, S. aureus ATCC 29213, E. coli ATCC 25922, P. aeruginosa ATCC 27853, and E. faecalis ATCC 29212 through disc diffusion assays on Muller Hinton Agar. The characterization studies revealed a size-controlled synthesis of quasi-spherical hexagonal wurtzite structured ZnO phytonanocomposite with an average size of 15.52 nm. Additionally, remarkable bactericidal activities against MDR clinical as well as ATCC bacterial strains were exhibited, with a maximum zone of inhibition of 22.33 ± 1.53 mm (against S. aureus ATCC 29213) and 22.33 ± 1.16 mm (MDR–MRSA) at a concentration of 400 µg/mL. This study thus established the possibility of developing antimicrobial ZnO nanocomposite of Strychnos nux-vomica leaf extract to combat developing drug resistance currently being experienced in health care facilities.
  • Preliminary phytochemical analysis of the ethanolic extract of brown seaweed Sargassum wightii
    International Journal of Research in Pharmaceutical Sciences, 2016

RECENT SCHOLAR PUBLICATIONS

  • INTEGRATIVE SYSTEMS BIOLOGY AND MULTI-OMICS APPROACHES IN ALZHEIMER'S DISEASE: BRIDGING BIOMARKERS, NEUROINFLAMMATION, AND PRECISION MEDICINE
    J MATHEW, AS MAROKY, S SINDURAJ, A CHANDRABABU
    Int J App Pharm 17 (5), 107-121 , 2025
    2025.0
    Citations: 1
  • Method development and validation for the estimation of Empagliflozin in bulk form and marketed tablet dosage form by RP-HPLC
    AS Maroky, SA Sreenivas, K Lohitha, EV Kumar, P Roja, K Sreeja
    International Journal of Multidisciplinary Research and Growth Evaluation 3 … , 2022
    2022.0
  • Comparative Efficacies of Antimigraine Drugs Using Nitroglycerin Induced Migraine Rats Model
    AS Maroky, V Parthasarathy
    Journal of Pharmaceutical Research International 32 (43), 34-42 , 2021
    2021.0
    Citations: 1
  • Effect of BIBN4096 in Neurobehavioural Changes of Nitroglycerin-induced Migraineous Rat Model
    AS Maroky, V Parthasarathy
    Journal of Young Pharmacists 12 (4), 327 , 2020
    2020.0
    Citations: 1
  • Potential bactericidal activity of S. nux-vomica–ZnO nanocomposite against multidrug-resistant bacterial pathogens and wound-healing properties
    K Steffy, G Shanthi, AS Maroky, S Selvakumar
    Journal of Trace Elements in Medicine and Biology 50, 229-239 , 2018
    2018.0
    Citations: 34
  • Anson. S. Maroky, S. Selvakumar, Potential bactericidal activity of S. nux-vomica–ZnO nanocomposite against Multidrug-resistant bacterial pathogens and wound-healing properties, J
    K Steffy, G Shanthi
    Trace Elements in Medicine 50, 229-239 , 2018
    2018.0
    Citations: 2
  • Enhanced antibacterial effects of green synthesized ZnO NPs using Aristolochia indica against Multi-drug resistant bacterial pathogens from Diabetic Foot Ulcer
    K Steffy, G Shanthi, AS Maroky, S Selvakumar
    Journal of infection and public health 11 (4), 463-471 , 2018
    2018.0
    Citations: 99
  • Synthesis and characterization of ZnO phytonanocomposite using Strychnos nux-vomica L. (Loganiaceae) and antimicrobial activity against multidrug-resistant bacterial strains …
    K Steffy, G Shanthi, AS Maroky, S Selvakumar
    Journal of advanced research 9, 69-77 , 2018
    2018.0
    Citations: 94
  • Preliminary phytochemical analysis of the ethanolic extract of brown seaweed sargassum wiightii
    Balachandran P, Anson S Maroky, Ajay Kumar T V, Parthasarathy V*
    International Journal of Research in Pharmaceutical Sciences 7 (2), 154-156 , 2016
    2016.0
    Citations: 8
  • Molecular Insights Into Herbal Therapeutics For Hepatocellular Carcinoma: Targeting Oxidative Stress, Inflammation, And Apoptotic Pathways.
    J Mathew, AS Maroky, S Parappurath, AH Thayyil

MOST CITED SCHOLAR PUBLICATIONS

  • Enhanced antibacterial effects of green synthesized ZnO NPs using Aristolochia indica against Multi-drug resistant bacterial pathogens from Diabetic Foot Ulcer
    K Steffy, G Shanthi, AS Maroky, S Selvakumar
    Journal of infection and public health 11 (4), 463-471 , 2018
    2018.0
    Citations: 99
  • Synthesis and characterization of ZnO phytonanocomposite using Strychnos nux-vomica L. (Loganiaceae) and antimicrobial activity against multidrug-resistant bacterial strains …
    K Steffy, G Shanthi, AS Maroky, S Selvakumar
    Journal of advanced research 9, 69-77 , 2018
    2018.0
    Citations: 94
  • Potential bactericidal activity of S. nux-vomica–ZnO nanocomposite against multidrug-resistant bacterial pathogens and wound-healing properties
    K Steffy, G Shanthi, AS Maroky, S Selvakumar
    Journal of Trace Elements in Medicine and Biology 50, 229-239 , 2018
    2018.0
    Citations: 34
  • Preliminary phytochemical analysis of the ethanolic extract of brown seaweed sargassum wiightii
    Balachandran P, Anson S Maroky, Ajay Kumar T V, Parthasarathy V*
    International Journal of Research in Pharmaceutical Sciences 7 (2), 154-156 , 2016
    2016.0
    Citations: 8
  • Anson. S. Maroky, S. Selvakumar, Potential bactericidal activity of S. nux-vomica–ZnO nanocomposite against Multidrug-resistant bacterial pathogens and wound-healing properties, J
    K Steffy, G Shanthi
    Trace Elements in Medicine 50, 229-239 , 2018
    2018.0
    Citations: 2
  • INTEGRATIVE SYSTEMS BIOLOGY AND MULTI-OMICS APPROACHES IN ALZHEIMER'S DISEASE: BRIDGING BIOMARKERS, NEUROINFLAMMATION, AND PRECISION MEDICINE
    J MATHEW, AS MAROKY, S SINDURAJ, A CHANDRABABU
    Int J App Pharm 17 (5), 107-121 , 2025
    2025.0
    Citations: 1
  • Comparative Efficacies of Antimigraine Drugs Using Nitroglycerin Induced Migraine Rats Model
    AS Maroky, V Parthasarathy
    Journal of Pharmaceutical Research International 32 (43), 34-42 , 2021
    2021.0
    Citations: 1
  • Effect of BIBN4096 in Neurobehavioural Changes of Nitroglycerin-induced Migraineous Rat Model
    AS Maroky, V Parthasarathy
    Journal of Young Pharmacists 12 (4), 327 , 2020
    2020.0
    Citations: 1
  • Method development and validation for the estimation of Empagliflozin in bulk form and marketed tablet dosage form by RP-HPLC
    AS Maroky, SA Sreenivas, K Lohitha, EV Kumar, P Roja, K Sreeja
    International Journal of Multidisciplinary Research and Growth Evaluation 3 … , 2022
    2022.0
  • Molecular Insights Into Herbal Therapeutics For Hepatocellular Carcinoma: Targeting Oxidative Stress, Inflammation, And Apoptotic Pathways.
    J Mathew, AS Maroky, S Parappurath, AH Thayyil