BHEEMREDDY ANUSHA

@sjgckurnool.edu.in

ASSISTANT PROFESSOR OF CHEMISTRY
SILVER JUBILEE GOVERNMENT COLLEGE(A), CLUSTER UNIVERSITY, KURNOOL, ANDHRA PRADESH, INDIA

https://researchid.co/anushabheemreddy

EDUCATION

M.Sc, Ph.D

RESEARCH INTERESTS

TOTAL SYNTHESIS OF BIO-ACTIVE MOLECULES AND DEVELOPMENT OF NOVEL METHODOLOGIES

Scopus Publications

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Deracemization of Benzoin and its Derivatives via Kinetic, Dynamic Kinetic, Aerobic Oxidative Kinetic, and Reagent-mediated resolution
Venkata Subba Reddy Ummareddy, Raveendra Babu Kothapalli, Anusha Bheemreddy, Naveen Kumar Marri, Sundar Singh P, and Ramakrishna S
Wiley
The production of enantiomerically pure compounds remains a vital and valuable objective in modern organic chemistry due to their broad applications in fields such as biosensing, optics, electronics, photonics, catalysis, nanotechnology, and drug or DNA delivery. Optically pure α‐hydroxy ketones, in particular, are key structural components in many drugs and natural products with significant biological activity. Among these, benzoin type α‐hydroxy ketones, which possess two adjacent functional groups, a carbonyl and a hydroxy group, are especially important. These functional groups can be easily transformed into the significant organic compounds such as 1,2 amino alcohols and 1,2 diols etc, which are important intermediates for synthesis of high profile biological active natural products. Deracemization of racemic compounds remains one of the most effective strategies for producing optically pure compounds, despite recent advances in asymmetric synthesis. Many research groups have developed various methods for resolving racemic benzoins, including kinetic resolution, dynamic kinetic resolution, metal‐catalyzed aerobic oxidative kinetic resolution, and reagent‐mediated resolution. In this context, we aim to provide a comprehensive review of the various resolution methods applied specifically to racemic benzoins. To the best of our knowledge, no comprehensive review on the resolution of racemic benzoins has been published to date.

Catalytic efficiency of primary β-amino alcohols and primary α-amino amides in enantioselective reactions of isatins
Ummareddy Venkata Subba Reddy, Bheemreddy Anusha, Marri Naveen Kumar, Raveendra Babu Kothapalli, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita,et al.
Elsevier BV

Concise review on isolation, biological activity, structure elucidation, and total synthetic approaches of 16-membered C2-symmetric macrolide pyrenophorol
Bheemreddy Anusha, Raveendra Babu Kothapalli, Miriyala Victor Prem Sagar, Bairla Surendra, and Ummareddy Venkata Subba Reddy
Informa UK Limited

Catalytic Efficiency of Primary α-Amino Amides as Multifunctional Organocatalysts in Recent Asymmetric Organic Transformations
Ummareddy Venkata Subba Reddy, Bheemreddy Anusha, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, and Hiroto Nakano
MDPI AG
Chiral primary α-amino amides, consisting of an adjacent enamine bonding site (Bronsted base site), a hydrogen bonding site (Bronsted acid site), and flexible bulky substituent groups to modify the steric factor, are proving to be extremely valuable bifunctional organocatalysts for a wide range of asymmetric organic transformations. Primary α-amino amides are less expensive alternatives to other primary amino organocatalysts, such as chiral diamines and cinchona-alkaloid-derived primary amines, as they are easy to synthesize, air-stable, and allow for the incorporation of a variety of functional groups. In recent years, we have demonstrated the catalytic use of simple primary α-amino amides and their derivatives as organocatalysts for the aldol reaction, Strecker reaction, Michael tandem reaction, allylation of aldehydes, reduction of N-Aryl mines, opening of epoxides, hydrosilylation, asymmetric hydrogen transfer, and N-specific nitrosobenzene reaction with aldehydes.

A Diamino Alcohol Catalyzed Enantioselective Crossed Aldol Reaction of Acetaldehyde with Isatins – A Concise Total Synthesis of Antitumor Agents
Ummareddy Venkata Subba Reddy, Madhu Chennapuram, Kento Seki, Chigusa Seki, Bheemreddy Anusha, Eunsang Kwon, Yuko Okuyama, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita,et al.
Wiley
Enantioselective crossed aldol reactions of isatin derivatives and acetaldehyde have been developed with a series of simple diamino alcohol catalysts to afford 3-substituted 3-hydroxyindolin-2-ones in high chemical yields (up to 95 %) and optical purities (up to 92 % ee). The synthetic potential of the present protocol has been demonstrated by concise, enantioselective, protecting-group-free, and transition metal-free total syntheses of antitumor and antiviral agents with the tryptanthrin architecture, that is, phaitanthrin B and cephalanthrin A, along with the biologically active indolidine alkaloids chimonamidine and donaxaridine as well as the formal synthesis of CPC-1. The highly enantioselective outcome of this catalytic crossed aldol reaction was evaluated by calculating the Gibbs free energies of the possible transition states.

Diastereoselective synthesis of (+)-pseudohygroline via proline-catalyzed α-hydroxylation
Bheemreddy Anusha, Ummareddy V. Subba Reddy, Basireddy V. Subba Reddy, and Cirandur Suresh Reddy
SAGE Publications
A highly diastereoselective total synthesis of (+)-pseudohygroline (1) starting from D-proline is described using Wittig olefination and MacMillan-α-hydroxylation as key reactions. (+)-Pseudohygroline is an important molecule in alkaloid chemistry as it was prepared as part of the first chemical proof of the absolute stereochemistry of biosynthetically important (+)-hygroline (2) and (+)-hygrine (3).

A concise and convergent total synthesis of two novel cytotoxic hydroquinones, lanneaquinol and (R)-2′-hydroxylanneaquinol
Basireddy V. Subba Reddy, Bheemreddy Anusha, Ummareddy V. Subba Reddy, Jhillu S. Yadav, and Cirandur Suresh Reddy
Wiley
A short and efficient approach for the total synthesis of two novel cytotoxic hydroquinones, lanneaquinol (1) and (R)-2′-hydroxylanneaquinol (2) isolated from the organic extract of the plant Lannea welwitschii, has been developed. Enantioselective organocatalytic McMillan hydroxylation has been successfully utilized for the creation of the stereogenic center bearing the OH group of (R)-2′-hydroxylanneaquinol (2). The hydroquinone core was constructed through the alkylation of cyclohexane-1,4-dione with a corresponding aldehyde. Both hydroquinone natural products can be synthesized by a mere change in the synthetic strategy.

The stereoselective total synthesis of (+)-garvensintriol
J.S. Yadav, U.V. Subba Reddy, B. Anusha, and B.V. Subba Reddy
Elsevier BV

HBF<inf>4</inf>·OEt<inf>2</inf> as a versatile reagent for the Hosomi-Sakurai allylation and Prins cyclization: one-pot synthesis of symmetrical 4-fluorotetrahydropyrans
J.S. Yadav, B.V. Subba Reddy, B. Anusha, U.V. Subba Reddy, and V.V. Bhadra Reddy
Elsevier BV

RECENT SCHOLAR PUBLICATIONS

Catalytic efficiency of primary β-amino alcohols and primary α-amino amides in enantioselective reactions of isatins
UVS Reddy, B Anusha, MN Kumar, RB Kothapalli, C Seki, Y Okuyama, ...
Tetrahedron, 134124 2024

Concise review on isolation, biological activity, structure elucidation, and total synthetic approaches of 16-membered C2-symmetric macrolide pyrenophorol
B Anusha, RB Kothapalli, M Victor Prem Sagar, B Surendra, ...
Synthetic Communications 54 (5), 323-347 2024

Catalytic Efficiency of Primary α-Amino Amides as Multifunctional Organocatalysts in Recent Asymmetric Organic Transformations
UVS Reddy, B Anusha, Z Begum, C Seki, Y Okuyama, M Tokiwa, ...
Catalysts 12 (12), 1674 2022

A Diamino Alcohol Catalyzed Enantioselective Crossed Aldol Reaction of Acetaldehyde with Isatins–A Concise Total Synthesis of Antitumor Agents
UV Subba Reddy, M Chennapuram, K Seki, C Seki, B Anusha, E Kwon, ...
European Journal of Organic Chemistry 2017 (26), 3874-3885 2017

Diastereoselective Synthesis of (+)-Pseudohygroline via Proline-catalyzed α-Hydroxylation
B Anusha, UVS Reddy, BVS Reddy, CS Reddy
Natural Product Communications 9 (5), 1934578X1400900510 2014

A Concise and Convergent Total Synthesis of Two Novel Cytotoxic Hydroquinones, Lanneaquinol and (R)‐2′‐Hydroxylanneaquinol
BV Subba Reddy, B Anusha, UV Subba Reddy, JS Yadav, ...
Helvetica Chimica Acta 96 (10), 1983-1990 2013

The stereoselective total synthesis of (+)-garvensintriol
JS Yadav, UVS Reddy, B Anusha, BVS Reddy
Tetrahedron Letters 51 (42), 5529-5531 2010

HBF4 OEt2 as a versatile reagent for the Hosomi–Sakurai allylation and Prins cyclization: one-pot synthesis of symmetrical 4-fluorotetrahydropyrans
JS Yadav, BVS Reddy, B Anusha, UVS Reddy, VVB Reddy
Tetrahedron Letters 51 (21), 2872-2874 2010

Deracemization of Benzoin and its Derivatives via Kinetic, Dynamic Kinetic, Aerobic Oxidative Kinetic, and Reagent‐mediated resolution
R Babu Kothapalli, B Anusha, M Naveen Kumar, PS Singh, ...
Chemistry–An Asian Journal, e202401693

MOST CITED SCHOLAR PUBLICATIONS

The stereoselective total synthesis of (+)-garvensintriol
JS Yadav, UVS Reddy, B Anusha, BVS Reddy
Tetrahedron Letters 51 (42), 5529-5531 2010
Citations: 12

Diastereoselective Synthesis of (+)-Pseudohygroline via Proline-catalyzed α-Hydroxylation
B Anusha, UVS Reddy, BVS Reddy, CS Reddy
Natural Product Communications 9 (5), 1934578X1400900510 2014
Citations: 2