Jose Alfonso Apesteguia Infantes

@unmsm.edu.pe

Professor of Pharmacology, Bromatologya and Toxicology Academic Department/ Faculty of Pharmacy and Biochemistry
UNMSM

Jose Alfonso Apesteguia Infantes


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https://researchid.co/apesteguia
I am a Licensed in Education ( Spanish - English) . I am a Pharmaceutical Chemist too. I work at UNMSM. I am a Researcher and a Prefessor.

EDUCATION

Licensed in Education ( Spanish - English)
Pharmaceutical Chemist

RESEARCH, TEACHING, or OTHER INTERESTS

Health, Toxicology and Mutagenesis, Pharmacology, Toxicology and Pharmaceutics, Toxicology, Food Science
8

Scopus Publications

80

Scholar Citations

5

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Volatile Components, Antioxidant and Phytotoxic Activity of the Essential Oil of Piper acutifolium Ruiz & Pav. from Peru
    Carmela Fiorella Cuadros-Siguas, Oscar Herrera-Calderon, Gaber El-Saber Batiha, Najlaa Hamed Almohmadi, Nada H. Aljarba, et al.
    Molecules, 2023
    Piper acutifolium Ruiz & Pav is known as “matico” and belongs to the Piperaceae family, and in Peru it is traditionally used as an infusion or decoction to ameliorate wound healings or ulcers. In this study, the aim was to investigate the volatile components, the antioxidant profile, and the phytotoxic activity of the essential oil (EO) of P. acutifolium from Peru. To identify the phytoconstituents, the EO was injected into a Gas Chromatography-Mass Spectrometry (GC-MS) to obtain the chemical profile of the volatile components, followed by the antioxidant activity carried out by the reaction with three organic radicals (2,2-diphenyl-1-picrylhydrazyl (DPPH); 2,2′-azinobis-(3-ethylbenzothiazoline)-6- sulfonic acid (ABTS); ferric reducing/antioxidant power (FRAP)). Finally, the phytotoxic capabilities of the EO were tested on two model plants, Lactuca sativa seeds and Allium cepa bulbs. As a result, the analysis identified α-phellandrene as its main volatile chemical at 38.18%, followed by β-myrcene (29.48%) and β-phellandrene (21.88%). Regarding the antioxidant profile, the half inhibitory concentration (IC50) in DPPH was 160.12 ± 0.30 µg/mL, for ABTS it was 138.10 ± 0.06 µg/mL and finally in FRAP it was 450.10 ± 0.05 µg/mL. The phytotoxic activity demonstrated that the EO had high activity at 5% and 10% against L. sativa seed germination, the inhibition of root length, and hypocotyl length. Additionally, in A. cepa bulbs, the inhibition root length was obtained at 10%, both comparable to glyphosate, which was used as a positive control. The molecular docking on 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) revealed that α-phellandrene had −5.8 kcal/mol, being near to glyphosate at −6.3 kcal/mol. The conclusion shows that the EO of P. acutifolium presented antioxidant and phytotoxic activity and might be useful as a bioherbicide in the future.
  • Globalization and Pharmaceutical Industry: The Ethical Dimension of Health Care
    Encuentros Maracaibo, 2023
  • Solar photovoltaic technology in isolated rural communities in Latin America and the Caribbean
    Bárbara Liz Miravet-Sánchez, Alberto E. García-Rivero, Ricardo A. Yuli-Posadas, Luis Alberto Inostroza-Ruiz, Victor Fernández-Guzmán, et al.
    Energy Reports, 2022
  • Sustainable Human Development: The Challenges of Ethics, Science and Education in the 21st Century
    Revista De Filosofia Venezuela, 2022
  • Environmental Strategies for Sustainability: Challenges in the Face of the Global Crisis
    Revista De Filosofia Venezuela, 2022
  • Vaccination against COVID-19 in Pregnant Women: Bioethical Dilemmas about its Implementation
    Revista De Filosofia Venezuela, 2022
  • Patents as Business Strategies: Human Rights in the Pharmaceutical Market
    Revista De Filosofia Venezuela, 2022
  • Perceptions of self-medication of the population, during the covid-19 pandemic in Peru
    Luis Alberto Inostroza-Ruiz, Paul Ivan Gutiérrez-Elescano, Nelson Bautista-Cruz, Jose Alfonso Apesteguia-Infantes, José Fidel Jáuregui-Maldonado, et al.
    Revista Del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo, 2021
    Background: Describe characteristics of self-medication of the population, in the context of the COVID 19 pandemic. Material and Methods: We carried out a cross-sectional survey with students in a major public Peruvian university. We measured perception of self-medication of the population, as well as characteristics, consequences, and associated factors. Results: A total of 274 students of Pharmacy and biochemistry filled in the questionnaire, 80.3% of which reported to know someone that self-medicated during the COVID-19 pandemic. 98.9 % of surveyed participants considered that the current pandemic increased self-medication practices in the population and that it occurred more frequently when people have symptoms associated with COVID-19 (65.4%). The medicines most frequently used were ivermectin (79.2%), azithromycin (71.2%) and hydroxychloroquine (38.7%). Conclusion: According to the surveyed participants, self-medication has increased in the general population during the COVID-19 pandemic. Strategies to prevent these practices are needed, as they could delay adequate medical care.

RECENT SCHOLAR PUBLICATIONS

  • Volatile Components, Antioxidant and Phytotoxic Activity of the Essential Oil of Piper acutifolium Ruiz & Pav. from Peru
    CF Cuadros-Siguas, O Herrera-Calderon, GES Batiha, NH Almohmadi, ...
    Molecules 28 (8), 3348 , 2023
    2023
    Citations: 13
  • Globalización e industria farmacéutica: la dimensión ética del cuidado de la salud.
    LA Inostroza-Ruiz, JA Apesteguia-Infantes, ER Tapia-Manrique, ...
    Encuentros. Revista de Ciencias Humanas, Teoría Social y Pensamiento Crítico … , 2023
    2023
    Citations: 5
  • Solar photovoltaic technology in isolated rural communities in Latin America and the Caribbean
    BL Miravet-Sánchez, AE García-Rivero, RA Yuli-Posadas, ...
    Energy Reports 8, 1238-1248 , 2022
    2022
    Citations: 39
  • La vacunación contra el COVID-19 en mujeres embarazadas: Dilemas bioéticos sobre su implementación
    MI Meza
    2022
  • Desarrollo humano sostenible: Los avatares de la ética, la ciencia y la educación en el siglo XXI
    JMR Marín, JAA Infantes, LAI Ruiz
    Revista de filosofía 39 (1), 366-374 , 2022
    2022
    Citations: 6
  • Las patentes como estrategias comerciales: Los derechos humanos frente al mercado farmacéutico.
    JAA Infantes, PIG Elescano, JFJ Maldonado
    Revista de Filosofia (Venezuela), 472-488 , 2022
    2022
    Citations: 1
  • Estrategias medioambientales para la sustentabilidad: Desafíos ante la crisis global.
    JM Rutti Marín, HO Chávez-Angulo, JA Apesteguia-Infantes
    Universidad del Zulia , 2022
    2022
    Citations: 3
  • Solar photovoltaic technology in isolated rural communities in Latin America and the Caribbean. Energy Reports, 8, 1238-1248
    BL Miravet-Sánchez, AE García-Rivero, RA Yuli-Posadas, ...
    2022
    Citations: 4
  • Aprendizaje colaborativo y estrategias de aprendizaje en estudiantes de farmacia y bioquímica de una universidad nacional de Lima, 2021
    JA Apesteguia Infantes
    2022
  • Perceptions of self-medication of the population, during the covid-19 pandemic in Peru
    LA Inostroza-Ruiz, PI Gutiérrez-Elescano, N Bautista-Cruz, ...
    Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo 14 (4 … , 2021
    2021
    Citations: 5
  • Percepciones de automedicación de la población durante la pandemia covid-19 en Perú
    LA Inostroza-Ruiz, PI Gutiérrez-Elescano, N Bautista-Cruz, ...
    Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo 14 (4 … , 2021
    2021
    Citations: 2
  • Determinación del contenido de antimonio en agua de consumo humano en envases de polietileno tereftalato y expendidas en forma ambulatoria en Lima Metropolitana
    JA Apesteguia Infantes
    2017
    Citations: 1
  • Efecto diurético del zumo del fruto del limón (Citrus limón L.) en ratas de experimentación
    JA Apesteguía Infantes
    2009
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • Solar photovoltaic technology in isolated rural communities in Latin America and the Caribbean
    BL Miravet-Sánchez, AE García-Rivero, RA Yuli-Posadas, ...
    Energy Reports 8, 1238-1248 , 2022
    2022
    Citations: 39
  • Volatile Components, Antioxidant and Phytotoxic Activity of the Essential Oil of Piper acutifolium Ruiz & Pav. from Peru
    CF Cuadros-Siguas, O Herrera-Calderon, GES Batiha, NH Almohmadi, ...
    Molecules 28 (8), 3348 , 2023
    2023
    Citations: 13
  • Desarrollo humano sostenible: Los avatares de la ética, la ciencia y la educación en el siglo XXI
    JMR Marín, JAA Infantes, LAI Ruiz
    Revista de filosofía 39 (1), 366-374 , 2022
    2022
    Citations: 6
  • Globalización e industria farmacéutica: la dimensión ética del cuidado de la salud.
    LA Inostroza-Ruiz, JA Apesteguia-Infantes, ER Tapia-Manrique, ...
    Encuentros. Revista de Ciencias Humanas, Teoría Social y Pensamiento Crítico … , 2023
    2023
    Citations: 5
  • Perceptions of self-medication of the population, during the covid-19 pandemic in Peru
    LA Inostroza-Ruiz, PI Gutiérrez-Elescano, N Bautista-Cruz, ...
    Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo 14 (4 … , 2021
    2021
    Citations: 5
  • Solar photovoltaic technology in isolated rural communities in Latin America and the Caribbean. Energy Reports, 8, 1238-1248
    BL Miravet-Sánchez, AE García-Rivero, RA Yuli-Posadas, ...
    2022
    Citations: 4
  • Estrategias medioambientales para la sustentabilidad: Desafíos ante la crisis global.
    JM Rutti Marín, HO Chávez-Angulo, JA Apesteguia-Infantes
    Universidad del Zulia , 2022
    2022
    Citations: 3
  • Percepciones de automedicación de la población durante la pandemia covid-19 en Perú
    LA Inostroza-Ruiz, PI Gutiérrez-Elescano, N Bautista-Cruz, ...
    Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo 14 (4 … , 2021
    2021
    Citations: 2
  • Las patentes como estrategias comerciales: Los derechos humanos frente al mercado farmacéutico.
    JAA Infantes, PIG Elescano, JFJ Maldonado
    Revista de Filosofia (Venezuela), 472-488 , 2022
    2022
    Citations: 1
  • Determinación del contenido de antimonio en agua de consumo humano en envases de polietileno tereftalato y expendidas en forma ambulatoria en Lima Metropolitana
    JA Apesteguia Infantes
    2017
    Citations: 1
  • Efecto diurético del zumo del fruto del limón (Citrus limón L.) en ratas de experimentación
    JA Apesteguía Infantes
    2009
    Citations: 1
  • La vacunación contra el COVID-19 en mujeres embarazadas: Dilemas bioéticos sobre su implementación
    MI Meza
    2022
  • Aprendizaje colaborativo y estrategias de aprendizaje en estudiantes de farmacia y bioquímica de una universidad nacional de Lima, 2021
    JA Apesteguia Infantes
    2022