Psychiatry and Mental health, Biological Psychiatry, Multidisciplinary
125
Scopus Publications
7966
Scholar Citations
44
Scholar h-index
95
Scholar i10-index
Scopus Publications
Translation and cross-cultural adaptation of the eating disorder examination questionnaire short (EDE-QS) into Brazilian portuguese Maria Amália Accari Pedrosa, Carlos Eduardo Ferreira de Moraes, Rob Saunders, Lucy Serpell, Henry Delamain, José Carlos Appolinário, Maria Carmen Viana, Thiago Dias Sarti Journal of Human Growth and Development, 2026 Introduction: eating disorders (EDs) are frequently underdiagnosed in primary and community health settings, despite their high prevalence, complexity, and clinical severity. The Eating Disorder Examination Questionnaire Short (EDE-QS) is a brief self-administered instrument designed to screen for ED symptoms and monitor clinical progression. Objective: this study aimed to translate and culturally adapt the EDE-QS for Brazilian Portuguese, enabling its use as a practical tool in health services. Method: following Task Force for Translation and Cultural Adaptation guidelines for translation and cross-cultural adaptation, the process included forward translation, synthesis, back-translation, expert committee review, and pretesting with the target population. Semantic, idiomatic, experiential, and conceptual equivalences were assessed, along with comprehension and clarity. Results: the Brazilian version of the EDE-QS showed strong content validity, high comprehension rates, and minor cultural adjustments. It was considered easy to use, with an average completion time of 10 minutes. The adapted instrument preserves the psychopathological constructs of the original version and is suitable for use in primary and community health services by nonspecialist providers. Conclusions: the EDE-QS was translated and cross-culturally adapted into Brazilian Portuguese following internationally accepted guidelines. The adapted EDE-QS for Brazilian Portuguese is brief, self-administered, and accessible, making it suitable for use in primary and community health settings.
Exploring associations between suicidal ideation and binge spectrum eating disorders: A general population-based survey Walter Santos Gonçalves, Carlos Eduardo F Moraes, Cassia de Carvalho Moulin, Cynthia M Bulik, Rosely Sichieri, Phillipa Hay, Jose Carlos Appolinario Australasian Psychiatry, 2026 Introduction People with eating disorders (ED) are at a high risk for suicidal ideation (SI), and evidence suggests that psychiatric comorbidities play an important role in this association. The objective of this study was to investigate the relationships between SI in binge-eating spectrum conditions (BESC includes binge-eating disorder (BED), bulimia nervosa (BN), and recurrent binge-eating behavior (RBE)) in a representative sample from Rio de Janeiro, Brazil. Methods In-house interviews were conducted with 2297 adults. SI was assessed by the PHQ-9. BESC were screened using the QEWP-5 and confirmed at a clinical interview. Valid instruments evaluated psychiatric comorbidities, and logistic regression was used to estimate associations between SI and BESC. Results Individuals with BESC had higher rates of SI (BED (39.6%), BN (40.8%), RBE (26.5%)) compared to those in the general population (7.5%) ( p < .0001). There was a higher odds ratio for SI in BED (OR 7.1, 95% CI 2.3–21.7), BN (OR 7.3, 95% CI 1.9–27.0), and RBE (OR 4.0, 95% CI 2.1–7.7). However, when adjusted for depressive symptoms, the observed differences were no longer statistically significant. Conclusion A high prevalence of SI was found in individuals with BESC. Furthermore, this maybe an indirect effect of comorbid depressive symptoms.
Food addiction and its associations with mental and physical health comorbidities and with quality of life in the general population Valeria Lima da Cruz, Jose Carlos Appolinario, Rosely Sichieri, Phillipa Hay, Claudia de Souza Lopes Journal of Eating Disorders, 2025 There is limited information on the prevalence and characteristics of Food Addiction (FA) in representative samples of the general population, and particularly in low- and middle-income countries. This study aimed to estimate the prevalence of FA and its associations with mental and physical health comorbidities, and with quality of life in Brazil. A population-based household survey of 2297 individuals aged 18 to 60 years with 3-staged sampling was conducted in the city of Rio de Janeiro, Brazil from 2019 to 2020. FA was assessed with the modified Yale Food Addiction Scale 2.0 (mYFAS 2.0). Psychiatric comorbidity was evaluated with validated instruments and physical health conditions with close-ended questions. The prevalence of FA and all analyses were adjusted with sample weights. Multivariate logistic regression was used to assess associations between psychiatric and physical comorbidities and FA. The prevalence of FA was 2.78% (95% CI: 1.40 to 4.17) and was significantly higher in women than men [4.08% vs. 1.39% respectively, p < .001] and in younger compared to older individuals. Individuals with FA were significantly more likely to have depression (75.4%), anxiety (77.0%), attention deficit hyperactivity disorder (32.7%) and alcohol use disorder (19.7.%) symptoms compared to those without FA. Eating disorders (binge eating disorder and bulimia nervosa) were more than 10 more likely to occur in individuals with FA compared to those without FA. Furthermore, FA was significantly associated with all eating disorder, mental and physical health comorbidities, such as diabetes, stroke, asthma, chronic asthma, headaches, muscle problems, and gastroesophageal reflux, adjusting for Body Mass Index (BMI), sex and race, and poorer quality of life. The prevalence of FA in the general population of a metropolitan city of Brazil lower than reported in other populations. However, FA was associated with notable mental and physical health comorbidity and a lower quality of life. There is limited information on the prevalence and characteristics of Food Addiction (FA) in representative samples of the general population, especially in low- and middle-income countries. Therefore, this study aimed to assess the occurrence of FA and its associations with mental and physical health conditions, and quality of life in a representative sample of the city of Rio de Janeiro/ Brazil. From 2297 respondents the rate of occurrence of food addiction was 2.78%. The associations between FA and various mental/physical comorbidities and higher body weight denote the importance of studying this topic and evaluating the impact on quality of life. The results provide valuable public health information regarding the prevalence and associations of FA with eating and general mental and physical health problems providing new insights into this phenomenon in a major urban center in a developing country.
MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs Larissa Junkes, Laiana A. Quagliato, Jose C. Appolinario, Richard I. Shader, Antonio E. Nardi Pharmacological Research, 2025 In the 1950s, monoamine oxidase inhibitors transformed the pharmacological treatment of mental disorders as the first class of antidepressant drugs. Currently considered third-line medications for treatment-resistant depression, they are markedly underutilized. Despite the benefits of these drugs, controversies exist due to their potential for serious adverse effects. These now have well-recognized mechanisms of action, making them much less common and potentially preventable. It is important to study and teach the pharmacology of monoamine oxidase inhibitors again in order to revive their use in severely depressed patients, as well as in those who have experienced multiple treatment failures.
Virtual Reality in the Treatment of Panic Disorder in the Last Decade: A Systematic Review Lucio Gonçalves, Rafael Garcia, Laiana Quagliato, Jose Carlos Appolinario, Antonio Nardi Clinical Practice and Epidemiology in Mental Health, 2025 Introduction Virtual Reality (VR) is an interactive, three-dimensional computing environment that enables individuals to experience a sense of presence as if they are immersed in a real-world setting. VR is currently being implemented in therapeutic interventions for individuals with certain mental disorders. Objective To illustrate the implementation and evolution of VR in the treatment of panic disorder, agoraphobia, and panic disorder with or without agoraphobia over the past decade. Method A systematic literature review was conducted based on articles retrieved from PubMed, Cochrane, and Web of Science, covering the period from 2013 to 2023. A total of 21 studies were selected after analyzing the titles, abstracts, and content in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results A total of 153 articles were initially selected and included in the study. The results demonstrated the evolution and increasing use of VR-based technologies for the treatment of mental disorders, including panic disorder and PDA. Discussion The utilization of VR exposure therapy (VRET) for patients with panic disorder, agoraphobia, or PDA yielded measurable outcomes, including the evolution of VRET applications, an increase in the number of scientific articles and patients in recent years, as well as advancements in hardware devices, software, and other application methods, such as self-guided applications. Conclusions The implementation of VRET is increasing in several regions worldwide, and its evolution is indisputable for the treatment of panic disorder, agarophobia, and PDA. Comparisons with traditional in vivo methods revealed that VRET yields satisfactory and promising outcomes. The continued evolution of VR technology is expected to expand its potential application in patients with these disorders.
Virtual reality: an emerging tool for mental health Sergio Machado, Rafael Ferreira-Garcia, Lucio Lage Gonçalves, José Carlos Appolinario, Mauro Giovanni Carta, Antonio E. Nardi Trends in Psychiatry and Psychotherapy, 2025
Medication non-adherence in depression: a systematic review and metanalysis Roseane Dorte Halkjaer-Lassen, Walter S. Gonçalves, Bruno R. Gherman, Evandro S. F. Coutinho, Antonio E. Nardi, Maria A. A. Peres, José Carlos Appolinario Trends in Psychiatry and Psychotherapy, 2025 OBJECTIVE: Medication non-adherence is frequently reported in patients with major depressive disorder (MDD). The objective of this review is to consolidate data on the prevalence of non-adherence to antidepressant in MDD. METHODS: A systematic review with meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and the protocol was registered in International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42021199987. Studies assessing medication adherence in MDD were searched in PubMed/MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO. The data extraction was performed by two independents authors. Meta-analysis used random effects model and performed a subgroup analysis. RESULTS: From the articles retrieved, 11 studies were considered eligible for the final analysis. Most of them assessed non-adherence by self-report scales, followed by Pharmacy Dispensation Records, Monitoring Events Medication System (MEMS), and blood tests. The pooled proportion of non-adherence was 42% (95% confidence interval [95%CI] 30-54), but heterogeneity was very large (I² = 99%). CONCLUSION: Data from the selected studies suggests that a high number of individuals with MDD do not adequately take their medication as prescribed. The high heterogenicity of measures used for the assessment of adherence may have impacted the great variability of the results. The results suggest it is necessary that health care professionals should address this issue in order to achieve a better treatment outcome in major depression.
Translation and cross-cultural adaptation of a portuguese version of the eating disorder assessment for DSM-5 (EDA-5) for Brazil and Portugal Cassia de C. Moulin, Rita Ramos, Carlos Eduardo Ferreira de Moraes, B. Timothy Walsh, José Carlos Appolinário, Paulo P.P. Machado Methodsx, 2024 The EDA-5 was translated from English to Portuguese, followed by a cross-cultural adaptation for use in Brazil and Portugal. Two independent translators worked on the Brazilian and European Portuguese versions, which were then reviewed to create a harmonized version. This version was back-translated into English and approved by the original author. Twenty specialists (ten from each country) evaluated the interview's comprehensibility, and items that more than 20% of experts found unclear were revised. Despite sharing a common language, cultural and linguistic differences between the two Portuguese variants were observed. Discrepancies were addressed in the final version, and only 5.8% of the items in Brazil and 11.6% in Portugal were deemed unclear. The harmonized Portuguese version of the EDA-5 was well-received and is now available for healthcare professionals in both countries.•The final harmonized Portuguese version of the EDA-5 is available online and was well-understood by eating disorder specialists in both Brazil and Portugal.
Sexual function and dysfunction: A systematic review Walter dos Santos Gonçalves, Bruno Rabinovici Gherman, Carmita Helena Najjar Abdo, Antonio Egidio Nardi, Jose Carlos Borges Appolinário Jornal Brasileiro De Psiquiatria, 2019
Depression, glycemic control and type 2 diabetes Marcelo Papelbaum, Rodrigo O Moreira, Walmir Coutinho, Rosane Kupfer, Leão Zagury, Silvia Freitas, José C Appolinário Diabetology and Metabolic Syndrome, 2011
Depression in the menopause: A specific entity? Informacao Psiquiatrica, 1999
The preliminary open trial on the efficacy and safety of citalopram Jornal Brasileiro De Psiquiatria, 1996
Hormonal therapy and the psychiatric symptoms in menopause. Part 2 - Double-blind study on the effects of natural progesterone on the affective symptoms in menopause Jornal Brasileiro De Psiquiatria, 1995
Hormonal therapy and the psychiatric symptoms in menopause. Part 1 - Review of the literature Jornal Brasileiro De Psiquiatria, 1995
Psychiatric manifestations of hyperthyroidism. Review of the literature and case reports Jornal Brasileiro De Psiquiatria, 1994
RECENT SCHOLAR PUBLICATIONS
Exploring associations between suicidal ideation and binge spectrum eating disorders: A general population-based survey WS Gonçalves, CEF Moraes, CC Moulin, CM Bulik, R Sichieri, P Hay, ... Australasian Psychiatry 34 (1), 47-54 , 2026 2026
Tradução e adaptação transcultural do questionário abreviado de exame de transtornos alimentares (EDE-QS) para o português brasileiro. MAA Pedrosa, CEF de Moraes, R Saunders, L Serpell, H Delamain, ... Journal of Human Growth and Development 36 (1), 133 , 2026 2026
Reviewer Summary for International Journal of Eating Disorders G Abbate-Daga, S Abber, E Accurso, A Ahern, M Algars, K Ali, S Ali, ... International Journal Of Eating Disorders 59, 615-620 , 2026 2026
Translation and cross-cultural adaptation of the eating disorder examination questionnaire short (ede-qs) into Brazilian portuguese MAA Pedrosa, CEF de Moraes, R Saunders, L Serpell, H Delamain, ... Journal of Human Growth and Development 36 (1), 133-143 , 2026 2026 Citations: 2
Association of depression and anxiety symptoms with exercise in Brazil: a cross-sectional study D Gadelha, CE de Moraes, WS Goncalves, FB Schuch, R Sichieri, P Hay, ... Trends in Psychiatry and Psychotherapy, 0-0 , 2025 2025
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Virtual reality: an emerging tool for mental health S Machado, R Ferreira-Garcia, LL Gonçalves, JC Appolinario, MG Carta, ... Trends in Psychiatry and Psychotherapy 47, e20240973 , 2025 2025 Citations: 2
Food addiction and its associations with mental and physical health comorbidities and with quality of life in the general population VL da Cruz, JC Appolinario, R Sichieri, P Hay, C de Souza Lopes Journal of Eating Disorders 13 (1), 205 , 2025 2025 Citations: 2
MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs L Junkes, LA Quagliato, JC Appolinario, RI Shader, AE Nardi Pharmacological Research, 107876 , 2025 2025 Citations: 8
Medication non-adherence in depression: a systematic review and metanalysis RD Halkjaer-Lassen, WS Gonçalves, BR Gherman, ESF Coutinho, ... Trends in Psychiatry and Psychotherapy 47, e20230680 , 2025 2025 Citations: 19
Suicidal ideation and medical comorbidity: a hidden problem WS Gonçalves, CEF Moraes, R Sichieri, P Hay, JC Appolinario Brazilian Journal of Psychiatry 47, e20254188 , 2025 2025
Virtual Reality in the Treatment of Panic Disorder in the Last Decade: A Systematic Review L Gonçalves, R Garcia, L Quagliato, JC Appolinario, A Nardi Clinical Practice and Epidemiology in Mental Health: CP & EMH 21 … , 2025 2025 Citations: 1
Relationship between psychopathology and binge size in binge eating spectrum disorders CL Mourilhe Silva, GV da Veiga, CE de Moraes, RR Luiz, P Hay, ... Trends in Psychiatry and Psychotherapy 46, e20230644 , 2024 2024 Citations: 3
Associations of adult ADHD symptoms with binge eating spectrum conditions, psychiatric and somatic comorbidity, and healthcare utilization JC Appolinario, CEF de Moraes, R Sichieri, P Hay, SV Faraone, P Mattos Brazilian Journal of Psychiatry 46, e20243728 , 2024 2024 Citations: 6
Translation and cross-cultural adaptation of a portuguese version of the eating disorder assessment for DSM-5 (EDA-5) for Brazil and Portugal CC Moulin, R Ramos, CEF de Moraes, BT Walsh, JC Appolinário, ... MethodsX 13, 103049 , 2024 2024
Can we effectively manage binge eating disorder with pharmacotherapy? P Hay, CEF de Moraes, JC Appolinario Expert Opinion on Pharmacotherapy 25 (17), 2235-2241 , 2024 2024 Citations: 9
Brazilian psychiatrists’ knowledge of and perceived confidence in eating disorder diagnosis and treatment recommendations MC Almeida, A Segal, C Almeida, JC Hiluy, MA Pedrosa, MA Nunes, ... Brazilian Journal of Psychiatry 46, e20233516 , 2024 2024 Citations: 7
Bridging the gap: psychiatry’s role in the new era of obesity treatment JC Appolinario, P Hay, W Coutinho Brazilian Journal of Psychiatry 46, e20243604 , 2024 2024
Mental health and weight regain after bariatric surgery: associations between weight regain and psychiatric and eating-related comorbidities MFFP Mauro, M Papelbaum, MAA Brasil, JRI Carneiro, RR Luiz, JC Hiluy, ... Archives of Endocrinology and Metabolism 68, e230208 , 2024 2024 Citations: 17
MOST CITED SCHOLAR PUBLICATIONS
Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects RCL James WP, Caterson ID, Coutinho W, Finer N, Van Gaal LF, Maggioni AP ... N Engl J Med 363 (10), 905-917 , 2010 2010 Citations: 1339
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A randomized, double-blind, placebo-controlled study of sibutramine in the treatment of binge-eating disorder JC Appolinario, J Bacaltchuk, R Sichieri, AM Claudino, A Godoy-Matos, ... Archives of General Psychiatry 60 (11), 1109-1116 , 2003 2003 Citations: 309
Cirurgia bariátrica: aspectos clínico-cirúrgicos e psiquiátricos J Fandiño, AK Benchimol, WF Coutinho, JC Appolinário Revista de psiquiatria do Rio Grande do Sul 26, 47-51 , 2004 2004 Citations: 305
Transtornos alimentares e obesidade MA Nunes, JC Appolinario, AL Galvão, W Coutinho Artmed Editora , 2009 2009 Citations: 272
Treatment of obese adolescents with sibutramine: a randomized, double-blind, controlled study A Godoy-Matos, L Carraro, A Vieira, J Oliveira, EP Guedes, L Mattos, ... The Journal of Clinical Endocrinology & Metabolism 90 (3), 1460-1465 , 2005 2005 Citations: 260
Transtornos alimentares JC Appolinário, AM Claudino Brazilian Journal of Psychiatry 22, 28-31 , 2000 2000 Citations: 257
Double-blind, randomized, placebo-controlled trial of topiramate plus cognitive-behavior therapy in binge-eating disorder. AM Claudino, IR Oliveira, JC Appolinario, TA Cordás, M Duchesne, ... Journal of Clinical Psychiatry 68 (9), 1324-1332 , 2007 2007 Citations: 227
Assessment of executive functions in obese individuals with binge eating disorder D Monica, M Paulo, JC Appolinário, SR Freitas, G Coutinho, C Santos, ... Brazilian Journal of Psychiatry 32 (4), 381-388 , 2010 2010 Citations: 214
Instrumentos para a avaliação dos transtornos alimentares S Freitas, C Gorenstein, JC Appolinario Brazilian Journal of Psychiatry 24, 34-38 , 2002 2002 Citations: 192
The assessment of binge eating disorder in obese women: A comparison of the binge eating scale with the structured clinical interview for the DSM-IV SR Freitas, CS Lopes, JC Appolinario, W Coutinho Eating behaviors 7 (3), 282-289 , 2006 2006 Citations: 181
Neuropsychology of eating disorders: a systematic review of the literature M Duchesne, P Mattos, LF Fontenelle, H Veiga, L Rizo, JC Appolinario Brazilian Journal of Psychiatry 26, 107-117 , 2004 2004 Citations: 167
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Diabetes mellitus e depressão: uma revisão sistemática RO Moreira, M Papelbaum, JC Appolinario, AG Matos, WF Coutinho, ... Arquivos Brasileiros de Endocrinologia & Metabologia 47, 19-29 , 2003 2003 Citations: 131
Prevalence of eating disorders and psychiatric comorbidity in a clinical sample of type 2 diabetes mellitus patients M Papelbaum, JC Appolinário, RO Moreira, VCM Ellinger, R Kupfer, ... Brazilian Journal of Psychiatry 27, 135-138 , 2005 2005 Citations: 124
Antidepressants in short-term treatment of binge eating disorder: systematic review and meta-analysis SC Stefano, J Bacaltchuk, SL Blay, JC Appolinário Eating behaviors 9 (2), 129-136 , 2008 2008 Citations: 115
Topiramate use in obese patients with binge eating disorder: an open study JC Appolinario, LF Fontenelle, M Papelbaum, JR Bueno, W Coutinho The Canadian Journal of Psychiatry 47 (3), 271-273 , 2002 2002 Citations: 111
Impact of binge eating disorder in the psychopathological profile of obese women J Fandiño, RO Moreira, C Preissler, CW Gaya, M Papelbaum, ... Comprehensive Psychiatry 51 (2), 110-114 , 2010 2010 Citations: 107
Correlates and impact of DSM-5 binge eating disorder, bulimia nervosa and recurrent binge eating: a representative population survey in a middle-income country JC Appolinario, R Sichieri, CS Lopes, CE Moraes, GV da Veiga, S Freitas, ... Social Psychiatry and Psychiatric Epidemiology 57 (7), 1491-1503 , 2022 2022 Citations: 103