Anuj Ranjan
@sfedu.ru
Leading Researcher
Southern federal University
RESEARCH, TEACHING, or OTHER INTERESTS
Multidisciplinary, Environmental Science, Biochemistry, Genetics and Molecular Biology, Structural Biology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Anuj Ranjan, Vishnu D. Rajput, Evgeniya V. Prazdnova, Manisha Gurnani, Shikha Sharma, Pallavi Bhardwaj, Sudhir S. Shende, Saglara S. Mandzhieva, Svetlana Sushkova, Tatiana Minkina,et al.
Elsevier BV
Sarieh Tarigholizadeh, Svetlana Sushkova, Vishnu D. Rajput, Anuj Ranjan, Jayati Arora, Tamara Dudnikova, Andrey Barbashev, Saglara Mandzhieva, Tatiana Minkina, and Ming Hung Wong
American Chemical Society (ACS)
Polycyclic aromatic hydrocarbons (PAHs) are highly toxic, persistent organic pollutants that threaten ecosystems and human health. Consistent monitoring is essential to minimize the entry of PAHs into plants and reduce food chain contamination. PAHs infiltrate plants through multiple pathways, causing detrimental effects and triggering diverse plant responses, ultimately increasing either toxicity or tolerance. Primary plant detoxification processes include enzymatic transformation, conjugation, and accumulation of contaminants in cell walls/vacuoles. Plants also play a crucial role in stimulating microbial PAHs degradation by producing root exudates, enhancing bioavailability, supplying nutrients, and promoting soil microbial diversity and activity. Thus, synergistic plant-microbe interactions efficiently decrease PAHs uptake by plants and, thereby, their accumulation along the food chain. This review highlights PAHs uptake pathways and their overall fate as contaminants of emerging concern (CEC). Understanding plant uptake mechanisms, responses to contaminants, and interactions with rhizosphere microbiota is vital for addressing PAH pollution in soil and ensuring food safety and quality.
Aneesa Batool, Saika Bashir, Jebi Sudan, Momina Nazir, Gulam Nabi Yatoo, Anuj Ranjan, Vishnu D. Rajput, Parvaze A. Sofi, Zahoor Ahmad Bhat, Khurshed Hussain,et al.
CRC Press
Charu Singh, Abhishek Chauhan, Jayati Arora, Anuj Ranjan, Hardeep Singh Tuli, Moyad Shahwan, Vishnu D. Rajput, Tatiana Minkina, Sambasivan Venkat Eswaran, and Tanu Jindal
Journal of Experimental Biology and Agricultural Sciences
Soilless cultivation has emerged as a fundamental alternative for large-scale vegetable production because it generates high-quality yields and uses resources efficiently. While plant growth-promoting bacteria (PGPB) are known to enhance growth and physiological aspects in crops grown in soil, their application in soilless cultivation has been relatively less explored. This study aimed to isolate potential PGPBs from soil samples collected from five locations in and around the Delhi-National Capital Region (NCR), India, which were further screened for significant PGPB attributes. Among these, 51 isolated were selected for assessing the impact on Oryza sativa (rice) growth and yield grown on a hydroponic set. The results indicated that isolates AFSI16 and ACSI02 significantly improved the physiological parameters of the plants. For instance, treatment with AFSI16 showed a 23.27% increase in maximum fresh shoot mass, while ACSI02 resulted in a 46.8% increase in root fresh mass. Additionally, ACSI02 exhibited the highest shoot length (34.07%), whereas AFSI16 exhibited the longest root length (46.08%) in O.sativa. Treatment with AFSI16 also led to significant increases in total protein content (4.94%) and chlorophyll content (23.44%), while ACSI02 treatment showed a 13.48% increase in maximum carotenoid content in the leaves. The potential PGPBs were identified through 16S rRNA sequencing, as the two most effective strains, AFSI16 and ACSI02, belonged to thermo-alkaliphilic Bacillus licheniformis and Burkholderia sp., respectively. This study demonstrated the potential of these identified PGPB strains in enhancing crop performance, specifically in soilless cultivation systems.
Jayati Arora, Abhishek Chauhan, Anuj Ranjan, Vishnu D. Rajput, Tatiana Minkina, Anton Igorevich Zhumbei, Arpna Kumari, Tanu Jindal, and Ram Prasad
Springer Science and Business Media LLC
Sugata Datta, Abhishek Chauhan, Anuj Ranjan, Abul Hasan Sardar, Hardeep Singh Tuli, Seema Ramniwas, Moyad Shahwan, and Tanu Jindal
Journal of Experimental Biology and Agricultural Sciences
The research investigates the escalating consumption of take-out food in India and the associated health risks stemming from the extensive use of plastic packaging. Through a comprehensive nationwide online survey, the study delved into dietary preferences, frequency of take-out food consumption, delivery service timing, and the types of packaging commonly encountered by Indian consumers. To address these concerns, the research team developed an analytical method to detect Bisphenol A (BPA) and Phthalic acid migration from food-contact materials (FCMs) into various food simulants. The investigation revealed that prolonged exposure to elevated temperatures led to increased migration of BPA and Phthalic acid, particularly in polyethylene pouches using 3% acetic acid as a food simulant, with the highest concentrations observed after 45 minutes of exposure. Additionally, a microbial bioassay demonstrated the mutagenic potential of migrated plasticizers, showcasing significant effects in mammalian systems, particularly under metabolic activation. The study underscores the substantial health risks associated with plastic packaging in take-out food, emphasizing potential implications for consumer health and calling for more extensive research and considerations regarding food packaging materials.
Sadiah Shafi, Insha Shafi, Aaqif Zaffar, Sajad Majeed Zargar, Asif B. Shikari, Anuj Ranjan, P.V. Vara Prasad, and Parvaze A. Sofi
Elsevier BV
Jutishna Bora, Ankita Dey, Antonia R. Lyngdoh, Archna Dhasmana, Anuj Ranjan, Shristi Kishore, Sarvesh Rustagi, Hardeep Singh Tuli, Abhishek Chauhan, Prangya Rath,et al.
Springer Science and Business Media LLC
Tatiana Minkina, Svetlana Sushkova, Yanina Delegan, Anzhelika Bren, Maria Mazanko, Yulia Kocharovskaya, Andrey Filonov, Vishnu D. Rajput, Saglara Mandzhieva, Dmitry Rudoy,et al.
Springer Science and Business Media LLC
Vishnu D. Rajput, Arpna Kumari, Tatiana Minkina, Anatoly Barakhov, Shraddha Singh, Saglara S. Mandzhieva, Svetlana Sushkova, Anuj Ranjan, Priyadarshani Rajput, and Manoj Chandra Garg
Springer Science and Business Media LLC
Hemant Joshi, Hardeep Singh Tuli, Anuj Ranjan, Abhishek Chauhan, Shafiul Haque, Seema Ramniwas, Gurpreet Kaur Bhatia, and Divya Kandari
MDPI AG
Flavopiridol is a flavone synthesized from the natural product rohitukine, which is derived from an Indian medicinal plant, namely Dysoxylum binectariferum Hiern. A deeper understanding of the biological mechanisms by which such molecules act may allow scientists to develop effective therapeutic strategies against a variety of life-threatening diseases, such as cancer, viruses, fungal infections, parasites, and neurodegenerative diseases. Mechanistic insight of flavopiridol reveals its potential for kinase inhibitory activity of CDKs (cyclin-dependent kinases) and other kinases, leading to the inhibition of various processes, including cell cycle progression, apoptosis, tumor proliferation, angiogenesis, tumor metastasis, and the inflammation process. The synthetic derivatives of flavopiridol have overcome a few demerits of its parent compound. Moreover, these derivatives have much improved CDK-inhibitory activity and therapeutic abilities for treating severe human diseases. It appears that flavopiridol has potential as a candidate for the formulation of an integrated strategy to combat and alleviate human diseases. This review article aims to unravel the potential therapeutic effectiveness of flavopiridol and its possible mechanism of action.
Sivaraman Somasundaram, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Anuj Ranjan, Qamar Abbas, Navabshan Irfan, Rajeshkumar Shanmugam, and Sanghyuk Park
Elsevier BV
Anuj Ranjan, Vishnu D. Rajput, Evgeniya Valeryevna Prazdnova, Manisha Gurnani, Pallavi Bhardwaj, Shikha Sharma, Svetlana Sushkova, Saglara S. Mandzhieva, Tatiana Minkina, Jebi Sudan,et al.
MDPI AG
Non-ribosomal peptides (NRPs) are a diverse group of bioactive compounds synthesized by microorganisms, and their antimicrobial properties make them ideal candidates for use as biocontrol agents against pathogens. Non-ribosomal peptides produced by Plant-Growth-Promoting Bacteria (PGPB) have gained interest for the biocontrol of plants’ bacterial and fungal pathogens. In this review, the structure and mode of action of NRPs, including their characterization and the characterization of NRP-producing microorganisms, are discussed. The use of NRPs in soilless agriculture and their potential as part of a sustainable plant disease control strategy are also highlighted. In addition, the review debates the commercial aspects of PGPB’s formulations and their potential as a biocontrol agent. Overall, this review emphasizes the importance of NRPs derived from PGPB in the biocontrol of plant pathogens and their potential to be used as an environmentally friendly and sustainable plant disease control strategy.
Jayati Arora, Abhishek Chauhan, Anuj Ranjan, Reetu Singh, Khatib Sayeed Ismail, Amita G. Dimri, Rima Biswas, and Tanu Jindal
Asian Journal of Chemistry
Anionic surfactants in the river, particularly downstream in Delhi, have created massive foam-like conditions which may be harmful to aquatic life and humans that come in contact. The present study focussed on the quantification of anionic surfactants, biological contaminants in terms of total bacterial count, total and faecal coliform bacteria and qualitative analysis of pathogenic bacteria from the samples acquired from different sites of Yamuna river. The concentration of anionic surfactants was observed to be between 0.42-3.89 mg L-1 at Okhla barrage, which was significantly high as compared to Wazirabad barrage and ITO bridge. The total bacterial count of Okhla barrage was observed more as compared to Wazirabad barrage and ITO Bridge ranging between 9.7 × 106 to 9.1 × 108 CFU/mL. The findings of total coliform bacteria were observed to be consistently high at Wazirabad barrage ranging between 1.3 × 103 to 9.0 × 104 MPN/100 mL. Qualitative analysis of pathogenic bacteria showed the presence of P. aeruginosa, Salmonella sp., E. coli and S. aureus. Based on the results obtained in the study, it was inferred that the water quality of Yamuna river at Wazirabad barrage, ITO Bridge and Okhla barrage was poor and thus requires regular monitoring and call for immediate effective mitigation strategies.Anionic surfactants in the river, particularly downstream in Delhi, have created massive foam-like conditions which may be harmful to aquatic life and humans that come in contact. The present study focussed on the quantification of anionic surfactants, biological contaminants in terms of total bacterial count, total and faecal coliform bacteria and qualitative analysis of pathogenic bacteria from the samples acquired from different sites of Yamuna river. The concentration of anionic surfactants was observed to be between 0.42-3.89 mg L-1 at Okhla barrage, which was significantly high as compared to Wazirabad barrage and ITO bridge. The total bacterial count of Okhla barrage was observed more as compared to Wazirabad barrage and ITO Bridge ranging between 9.7 × 106 to 9.1 × 108 CFU/mL. The findings of total coliform bacteria were observed to be consistently high at Wazirabad barrage ranging between 1.3 × 103 to 9.0 × 104 MPN/100 mL. Qualitative analysis of pathogenic bacteria showed the presence of P. aeruginosa, Salmonella sp., E. coli and S. aureus. Based on the results obtained in the study, it was inferred that the water quality of Yamuna river at Wazirabad barrage, ITO Bridge and Okhla barrage was poor and thus requires regular monitoring and call for immediate effective mitigation strategies.
Ritu Chauhan, Ashutosh Tripathi, Abhishek Chauhan, Rupesh Kumar Basniwal, Anuj Ranjan, Arpna Kumari, Vishnu D. Rajput, Evgeniya V. Prazdnova, Tatiana Minkina, Subhash C. Chauhan,et al.
Elsevier BV
Arathi Radhakrishnan, Pandiyan Balaganesh, Mangottiri Vasudevan, Narayanan Natarajan, Abhishek Chauhan, Jayati Arora, Anuj Ranjan, Vishnu D. Rajput, Svetlana Sushkova, Tatiana Minkina,et al.
MDPI AG
The increasing population density and industrialization are adversely affecting the environment globally. The contamination of the soil, agricultural lands, and water bodies with petroleum wastes and other hydrocarbon pollutants has become a serious environmental concern as perceived by the impacts on the aquatic and marine ecosystem. Various investigations have provided novel insights into the significant roles of microbial activities in the cleanup of hydrocarbon contaminants. However, the burden of these pollutants is expected to increase many folds in the next decade. Therefore, it is necessary to investigate and develop low-cost technologies rapidly, focusing on eco-sustainable development. An understanding of the details of biodegradation mechanisms paves the way for enhancing the efficiency of bioremediation technology. The current article reviews the applicability of various bioremediation processes, biodegradation pathways, and treatments, and the role of microbial activities in achieving efficient eco-sustainable bioremediation of hydrocarbon pollutants. It is envisaged that an integrated bioremediation approach, including biostimulation and bioaugmentation is preferably advocated for the cost-effective removal of toxic petroleum hydrocarbons and their derivatives.
Ritu Chauhan, Ashutosh Tripathi, Abhishek Chauhan, Anuj Ranjan, Hardeep Singh Tuli, Hadi Sajid Abdulabbas, Subhash C. Chauhan, and Tanu Jindal
Asian Journal of Chemistry
In recent years, studies on phytochemicals, antioxidants, and antibiotics using blue green algae from harsh environments has become increasingly prevalent. The search for novel bioactive molecules exhibiting diverse biological activity is one of the most important strategies for addressing the issue of rising concerns regarding bacterial antibiotic resistance. In present study, the phytochemicals, antioxidant potentiality and antibacterial assessment of organic solvent extracts of blue-green alga isolated from Naini lake water were characterized. From the mass culture of alga, extracts were prepared in MeOH, EtOH, acetone, AcOEt, hexane and DCM and antioxidant potential and antibacterial properties were studied against multiple antibiotic-resistant E. coli, P. aeruginosa, P. fluorescence, S. enteric, S. typhimurium and Sh. dysenteriae. The 16S rRNA gene sequence analysis and phylogenetic tree revealed that blue-green algal isolate belongs to Nostoc sp. A higher extraction yield (5.3%) was recorded for MeOH extract as compared to other solvent extracts. Alkaloids, flavonoids and phenols were present in all extracts. DPPH free radical scavenging activity was determined using various concentrations of extracts (1 to 2048 μg mL-1). Maximum % inhibition (free radical scavenging activity) was observed in MeOH extract (35.23 ± 0.12). The methanolic extract was found to be inhibitory against P. aeruginosa and P. fluorescence. 2048 μg mL-1 MIC value was recorded against P. aeruginosa. In GC-MS profiling, a total of 8 significant peaks showing various compounds were identified among the 21 peaks. Oxirane hexadecyl was reported as the main components in this compound. The results showed that Nostoc sp. HANL07 is a good source of antioxidant and antibacterial compounds and could be used for further study in the field of drug discovery.
Vishnu D. Rajput, Arpna Kumari, Sudhir K. Upadhyay, Tatiana Minkina, Saglara Mandzhieva, Anuj Ranjan, Svetlana Sushkova, Marina Burachevskaya, Priyadarshani Rajput, Elizaveta Konstantinova,et al.
MDPI AG
Global issues such as soil deterioration, pollution, and soil productivity loss induced by industrialization and intensive agriculture pose a serious danger to agricultural production and sustainability. Numerous technical breakthroughs have been applied to clean up soil or boost the output of damaged soils, but they have failed to restore or improve soil health to desired levels owing to expense, impossibility in a practical setting, or, to a lesser extent, high labor consumption. Recent nanotechnology advancements promise to improve soil quality indicators and crop yields while ensuring environmental sustainability. As previously discovered, the inclusion of nanomaterials (NMs) in soils could manipulate rhizospheric microbes or agriculturally important microbes and improve their functionality, facilitating the availability of nutrients to plants and improving root systems and crop growth in general, opening a new window for soil health improvement. A viewpoint on the difficulties and long-term outcomes of applying NMs to soils is provided, along with detailed statistics on how nanotechnology can improve soil health and crop productivity. Thus, evaluating nanotechnology may be valuable in gaining insights into the practical use of NMs for soil health enhancement.
Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, and Hardeep Singh Tuli
MDPI AG
Due to rising incidence rates of liver cancer and worries about the toxicity of current chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy has escalated. Compared to chemotherapy, quercetin, a flavonoid, is relatively less harmful to normal cells and is regarded as an excellent free-radical scavenger. Apoptotic cell death of cancer cells caused by quercetin has been demonstrated by many prior studies. It is present in many fruits, vegetables, and herbs. Quercetin targets apoptosis, by upregulating Bax, caspase-3, and p21 while downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, and Bcl-2. Additionally, it has been reported to increase STAT3 protein degradation in liver cancer cells while decreasing STAT3 activation. Quercetin has a potential future in chemoprevention, based on substantial research on its anticancer effects. The current review discusses quercetin’s mechanisms of action, nanodelivery strategies, and other potential cellular effects in liver cancer.
Pallavi Bhardwaj, Abhishek Chauhan, Anuj Ranjan, Saglara S. Mandzhieva, Tatiana Minkina, Usha Mina, Vishnu D. Rajput, and Ashutosh Tripathi
MDPI AG
Rapid urbanization and population growth are stressing the present agricultural systems and could threaten food security in the near future. Sustainable development in agriculture is a way out to such enormously growing food demand. Plant growth-promoting bacteria (PGPB) are considered pivotal to providing adequate nutrition and health to plants and maintaining soil microbial dynamics. In the present study, municipal solid waste composts (MSWC) were studied for the presence of PGPB and their growth-promoting characteristics such as ammonium production, siderophores production, phosphorus solubilization and potassium solubilization, IAA (indole acetic acid), and HCN production. Four promising isolates were chosen and identified through 16S rRNA sequencing as Bacillus sp. strain L5-1, Bacillus pumilus strain EE107-P5, Bacillus sp. strain LSRBMoFPIKRGCFTRI6 and Bacillus sp. strain LPOC3. The potential of isolates is validated using Solanum lycopersicum (tomato) and was found to improve its growth significantly. The findings indicated the presence of potential Bacillus strains in MSWCs, and these composts can be utilized as biofertilizers for urban agricultural practices. However, studies concerning their impact on other crops’ growth and health are still underdeveloped. Since MSWCs might carry hazardous metals or chemicals, their evaluation for the safe application on the crops should also be assessed.
Archna Dhasmana, Sumira Malik, Amit Kumar Sharma, Anuj Ranjan, Abhishek Chauhan, Steve Harakeh, Rajaa M. Al-Raddadi, Majed N. Almashjary, Waleed Mohammed S. Bawazir, and Shafiul Haque
Frontiers Media SA
Richa Pahariya, Abhishek Chauhan, Anuj Ranjan, Rupesh Kumar Basniwal, Sumant Upadhyay, S. K. Thakur, and Tanu Jindal
Springer Science and Business Media LLC
Jayati Arora, Anuj Ranjan, Abhishek Chauhan, Vishnu D. Rajput, Svetlana Sushkova, Evgeniya V. Prazdnova, Tatiana Minkina, Rima Biswas, Sanket Joshi, Tanu Jindal,et al.
Springer Science and Business Media LLC
Vishnu D. Rajput, Tatiana Minkina, Anuj Ranjan, Abhishek Joshi, Arpna Kumari, Prabhat K. Chauhan, Sudhir K. Upadhya, Svetlana Sushkova, Saglara Mandzhieva, and Jaya Arora
Elsevier