Arijit Das

@bharattechnology.in

Assistant Professor, Department Of Pharmacology
Bharat Technology

Arijit Das


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https://researchid.co/arijitdasar

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Pharmaceutical Science, Toxicology
9

Scopus Publications

46

Scholar Citations

3

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • A Review on Process Analytical Technology as a Driver of Pharmaceutical Manufacturing for the Improvement of Quality while Reducing Costs
    Ritwik Adak, Arinya Jana, Biplab Debnath, Arijit Das, Reechik Bandyopadhyay
    Current Drug Safety, 2025
    Process analytical technology has emerged as a possible game-changing platform in the pharmaceutical business to improve process knowledge while also improving product quality and lowering production costs. This paper outlines the underlying principles of PAT, its application in pharmaceutical manufacturing processes, and the impact on assurance of quality and reduction of cost. Real-time monitoring, multivariate data analysis, and process control strategies are three modules that are computed and integrated with PAT to develop robust and efficient manufacturing processes. A number of case studies and examples have been used to illustrate this relationship between the implementation of PAT and a reduction in variability with an improvement in process control and consistency of the product, which finally realizes million-dollar savings. It also debates the regulatory perspectives and challenges involved in PAT adoption, focusing on how stakeholders in the industry and agencies can integrate in developing and implementing innovations that will pass the test of compliance criteria. In general, what this paper presents is that PAT will drive pharmaceutical manufacturing into advancement for higher standards of quality with increased efficiency.
  • Fundamentals of Stem Cell Therapy in Disease Prevention
    Rajarshi Nath, Arijit Das, Shambo Panda, Souvik Biswas, Biplab Debnath
    Stem Cell Therapy in Dermatological Disorders, 2025
    Stem cell therapy is a possible method of treating most diseases and restoring damaged tissue. In this review, the history, mechanism, application, problems, and prospects of stem cell therapy are summarized. Self-renewal and differentiation into other cell types are key features of stem cells. There, they can be obtained from embryonic, adult, and induced pluripotent sources. Stem cells can replace damaged cells, modulate the immune system, and secrete factors that facilitate the healing of tissues. Stem cell therapy has been researched for the treatment of neurological diseases, cardiovascular diseases, autoimmune diseases, and other conditions. However, other problems have to be solved, such as tumorigenesis risk. Recent progress in technologies of induced pluripotent stem cells and gene-editing technologies, such as CRISPR-Cas9, has provided new opportunities for personalized and targeted stem cell therapies. In the future, we also need to develop safer, more effective, and more accessible stem cell–derived therapies. Consequently, laws should be created to guarantee the clinical implementation and safe evolution of these medications. Although stem cell treatment presents great possibilities for revolutionizing regenerative medicine and enhancing patient outcomes, its advantages can only be fully appreciated by coordinated efforts among scientists, doctors, and legislators.
  • Simultaneous Estimation of Cal DL-2-Hydroxy,4-methyl thio-butyrate and Ca-2-oxo3-phenyl Propionate in Alpha-Ketoanalogues Tablets by Validated RP-HPLC Method
    Shambo Panda, Anindya Bose, Biplab Debnath, Rajarshi Nath, Arijit Das, Somsubhra Ghosh
    Indian Journal of Pharmaceutical Education and Research, 2024
    Introduction: Alpha-Ketoanalogues is a dietary supplement drug containing Calcium-DL- 2-hydroxy-4-(methylthio) butyrate (CHMTB) and Calcium-2-oxo-3-phenyl propionate (COPP) for the management of chronic renal disease. Objectives: In this study, a simple RP-HPLC method has been developed to simultaneously determine Calcium-DL-2-hydroxy-4-(methylthio) butyrate (CHMTB) and Calcium-2-oxo-3-phenyl propionate (COPP) in Alpha-Ketoanalogues Tablets. Materials and Methods: The compounds were separated in a single run using a Waters XBridge 250 mm x 4.6 mm C18 column with 5μm particle size and 130 Å pore size. Elution was carried out via gradient mode with the UV detector wavelength set at 210 nm. The mobile phase selected was a binary mixture of ammonium hydrogen sulphate buffer (pH 7.0) and acetonitrile at a 1.0 mL/min flow rate. Results: The retention time of CHMB and COPP was found to be about 7 min and 20 min, respectively. The chromatographic method shows detector linearity in 50-150% of the operating range with the square of correlation coefficient at 0.9998 and 0.9999 for these two compounds, respectively. The parentage recovery of both CHMB and COPP was within 98-102% range. The method validation was carried out per the USP (chapter 1225) and ICH guidelines (Q2-R2). The developed method was found to be specific, precise, linear, robust, and accurate. Conclusion: This method could be utilized to assay tablet formulation of CHMB and COPP during the in-process and finished product quality control.
  • Obsessive-Compulsive disorder is a severe threat to society
    Anupam Saha, Drishti Maheshwari, Arijit Das, Souvik Biswas, Puja Saha
    Bionatura, 2022
    To give an overview of Obsessive-Compulsive Disorder (OCD). In this review, the vital information about OCD and the possibility of linking suicide through this mental issue, getting to provide references for cover. OCD is a chronicle real unbalanced form of mental disorder that leads to an unreasonable configuration of obsession and compulsion. Obsessive-compulsive disorder (OCD) is usually believed to follow a persistent, repetitive course. The onset of illness has a bimodal peak – in early adolescence and adulthood. Obsessions are the elevation of thoughts and feelings irrespective of common or genuine sentiments, infuriating and repetitive effects on mental beings. Compulsion is a short part tempo result after the obsession to repeat a particular activity. This anomalous situation helps us understand that it turns out to be critical and last for a short period; it gets back as before when done. Obsessive-compulsive Disorder (OCD) is a psycho-neurological issue that sets out to be impulsive and cause distress and uneasiness in a person's life. OCD has the potential to trigger suicide. An obsessive-compulsive disorder is outlined by the two proximity of continuous impulse and compulsions, and recent studies have also identified neuroimaging and neuropsychological correlations of a natural outcome, but these need further replication. After a comprehensive study, the evidence provided in this article presents that OCD may be a grueling mental issue and a significant threat to society. Keywords. OCD; Obsession; Compulsion; Neuropsychiatric; Treatment; Survey.
  • Developed and validated method for the simultaneous estimation of ferulic acid and chlorogenic acid in four Indian ananas comosus merrill cultivars through HPTLC
    Journal of Medical Pharmaceutical and Allied Sciences, 2022
  • Olanzapine induced bruxism
    Tathagata Roy
    Journal of Medical Pharmaceutical and Allied Sciences, 2021
    Iatrogenic or drug induced disease is of great clinical significance in therapeutics. Treatment with antidepressants like selective serotonin reuptake inhibitors (SSRIs) and antipsychotics reveal Bruxism (excessive grinding and clenching of the teeth) as such type of iatrogenic disease, however it is rarely found with atypical antipsychotic drugs like Olanzapine. A 50-year male patient, suffering from schizophrenia was under regular antipsychotic medication receiving Tab. Olanzapine 5 mg O.D., Tab. Clonazepam 0.5 mg O.D. regularly for past 25 years. Recently he gradually developed excessive grinding and clenching of teeth despite of any dental and ENT clinical complications. Biochemical and hematological tests also showed normal result. On admission with the complication of bruxism, tab. Olanzapine dose was reduced to 2.5 mg OD, however even after dose reduction there was not much improvement in bruxism. On the 4th day of the admission tab. Olanzapine has been substituted with tab. Clozapine 50 mg TDS. After 1 week of withdrawal of Olanzapine there was no complain of bruxism and he was discharged. On follow up after 1month the complication was occasional. Causality assessment revealed a probable relation between Olanzapine and Bruxism. Though among the atypical neuroleptics, extrapyramidal side effects are thought to be less common with olanzapine, but it may cause fatal consequences. Therefore, this case study and proper investigation may be helpful in designing the treatment strategy in more effective way and also aware all the healthcare professionals to monitor the patients on neuroleptics.
  • Antihyperglycemic activity of ficus carica leaves extracts on streptozotocin induced diabetic rats
    Tathagata Roy, Susanta Paul, Victor Roy Chowdhury, Arijit Das, Srikanta Chandra, Avik Das, Abhishek Jana, Muniraj Bhattacharya, Nibir Ghosh
    Research Journal of Pharmacy and Technology, 2021
    Antihyperglycemic activity of leave extracts of Ficus carica was evaluated on STZ induced diabetic rats. Diabetes was induced in albino Wistar rats of either sex by intraperitoneal (60mg/kg b.w.) of STZ, freshly dissolved in citrate buffer (0.01 M, pH 4.5). Ficus carica leave extract in different solution (viz. petroleum ether, ethyloacetate, methanol and aqueous) were administered to diabetic rats for 9 days. The effect of extracts on blood glucose and body weight was studies on day 1st and 9th. The study showed that the ethyl acetate, methanolic and aqueous extract of Ficus sarmentosa leaves reduced blood glucose level and body weight significantly. This may justify the use of ficus species as ethanomedical medicine for treatment of diabetes mellitus.
  • Emergent strategy in management of inflammatory bowel disease: A narrowed in on novel drugs
    Srikanta Chandra, Avik Das, Tathagata Roy, Preeta Bose, Susanta Paul, Lucky Mukherjee, Arijit Das
    Research Journal of Pharmacy and Technology, 2021
    Inflammatory bowel disease is looming large on the modern society which has raised the brows of the medical scientists in both the developed and developing countries. According to American Gastrological Society (AGS) IBD is defined acute or chronic idiopathic ulceroinflammatory condition of the bowel which may or may not have transmural stretch. IBD encompasses two pivotal kinds of pathological condition Ulcerative colitis (UC) and Crohn's disease (CD). Epidemiologically UC has a greater prevalence in the global prospective. So we decided to zero in on UC in our work ahead. Pivotal contours may be featured as toxic megacolon, pseudopolyps and backwash ileitis. The featured encountered in the clinical course of the disease are multiferrous spanning from rectal bleeding, abdominal pain, weight loss and malasei. Coming to the option available for management they include both non pharmacological approach and pharmacological approach. Under the nonpharmacological approach life style changes like monitored dieting, exercise may plays a pivotal role and psychological intervention also deployed to control the functional aspects of the disease. On the other hand Salfasalazine and Mesalamine are still considered as a corner stone of the therapy as per as pharmacological approach.
  • A competitive analysis of top ten pharmaceutical companies in India
    Anupam Saha, Arijit Das, Subhasish Dutta, Suprodip Mandal
    Bionatura, 2021
    Contemplating the activities and conduct of close contenders is fundamental. Competitive analysis is a significant piece of the vital arranging process, and the wellsprings of such Web data are enhanced, and the data are refreshed much of the time. This expansive intrigue has brought about different definitions and conceptualizations of recognizable contender proof just as different ways to deal with considering it, which disables the reconciliation of existing information planned for responding to fundamental inquiries regarding its revenue, procedures, and suggestions. To compete with the opposition organizations are against, it is essential to survey things that are genuinely working in the business. Inquire about rely upon measurable studying, which is limited most definitely and limit. There can be more recommendations, which can show profitability to the association. In this task, the top ten pharmaceutical organizations of India are firmly watched. The absolute positioning gives according to general income, i.e., overall revenue.

RECENT SCHOLAR PUBLICATIONS

  • Flavonoid Based Development of Synthetic Drugs: Chemistry and Biological Activities
    MJA Rajarshi Nath, Swarup Manna, Shambo Panda, Arindam Maity, Krishnalekha ...
    Chemistry & Biodiversity 22 (3), https://onlinelibrary.wiley.com/doi/10.1 , 2024
    2024.0
    Citations: 19
  • Obsessive-Compulsive disorder is a severe threat to society
    A Saha, D Maheshwari, A Das, S Biswas, P Saha
    Bionatura 7 (2) , 2022
    2022.0
    Citations: 1
  • An overview on mouth dissolving tablets
    D Roy, A De, S Biswas, N Pramanick, A Das, S Mondal
    Journal of Huazhong University of Science and Technology 1671, 4512 , 2022
    2022.0
    Citations: 2
  • A Comprehensive Survey Report Regarding Public Perception on COVID-19
    A Saha, SR Chowdhury, AP Mukherjee, T Saha, M Rahaman, DD Roy, ...
    Asian Journal of Pharmacy and Pharmacology 8 (1), 9-17 , 2022
    2022.0
  • Developed and validated method for the simultaneous estimation of ferulic acid and chlorogenic acid in four Indian Ananas comosus merrill cultivars through HPTLC
    S Biswas, A Das, D Roy, T Roy, D Dewan, RK Paul, M Bhowmick, M Nag
    J Med Pharm Allied Sci 11 (1), 4250-4255 , 2022
    2022.0
    Citations: 1
  • Antihyperglycemic activity of ficus carica leaves extracts on streptozotocin induced diabetic rats
    T Roy, S Paul, VR Chowdhury, A Das, S Chandra, A Das, A Jana, ...
    Research Journal of Pharmacy and Technology 14 (8), 4151-4156 , 2021
    2021.0
    Citations: 8
  • Dietetic benefits of yogurt based beverage (Lassi) becoming fact-finding probe in research
    A Saha, M Das, A Das, S Mandal
    Int. J. Pharm. Res. 13, 1150-1156 , 2021
    2021.0
    Citations: 10
  • Emergent Strategy in Management of Inflammatory Bowel Disease: A Narrowed in on Novel Drugs
    S Chandra, A Das, T Roy, P Bose, S Paul, L Mukherjee, A Das
    Research Journal of Pharmacy and Technology 14 (3), 1811-1814 , 2021
    2021.0
    Citations: 1
  • Olanzapine induced bruxism
    A Rakshit, D Mukhopadhyay, M Ray, S Paul, S Chandra, A Das, T Roy
    J Med Pharm Allied Sci 10, 3597-3600 , 2021
    2021.0
    Citations: 2
  • A Competitive Analysis Of Top Ten Pharmaceutical Companies In India
    A Saha, A Das, S Dutta, S Mandal
    RB 6 (2), 1865-1872 , 2021
    2021.0
    Citations: 2
  • Characterization Microorganisms and Identification of Antimicrobial Resistance Pattern in Different Parts of Labeo Rohita: Monitoring and Managing Aquaculture
    T Roy, S Chandra, M Roy, P Bose, S Ghosh, S Paul, A Das
    Annals of RSCB 25 (2), 3449-3468 , 2021
    2021.0
  • A REVIEW ON FANCONI SYNDROME: A WORST ENEMY
    A Das, A Saha, S Biswas, D Roy, P Chattopadhyay, A Dey, R Nath
    Pharmaceutical Research 11 (09) , 2021
    2021.0
  • Obsessive-Compulsive disorder is a severe threat to society. Revis Bionatura 2022; 7 (2) 11
    A Saha, D Maheshwari, A Das, S Biswas, P Saha
    Clin Med Res 9 (12), 1026-1028 , 2017
    2017.0
  • Dipan Roy, Payel Laha, Nabanita Pramanick, Arijit Das, Histomorphological progression of DEN induced hepatocellular carcinoma model in rat.(2022)
    K Mukherjee, S Biswas
    Int. J. Life Sci. Pharma Res 12 (3), P86-96 , 124
    124.0
  • AN OVERVIEW ON BRAIN TARGETED DRUG DELIVERY SYSTEM
    D Roy, A De, P Laha, S Biswas, A Das, R Nath
  • Mrinmoy Nag, Poushali Boral, Poulomi Biswas, Debajit Dewan, Nabanita Pramanick, Utkalika Sarkar, Souvik Chattopadhyay, and Soumya Datta, A Spotlight on Novel Coronavirus (COVID …
    S Biswas, D Roy, B Debnath, A Das, R Nath
    Int. J. Life Sci. Pharma Res 12 (5), L206-220 , 0
  • Evaluation of Antibiotic Activity of Tetracycline on Lactobacillus acidophilus
    S Biswas, H Bit, M Chatterjee, S Datta, A Das

MOST CITED SCHOLAR PUBLICATIONS

  • Flavonoid Based Development of Synthetic Drugs: Chemistry and Biological Activities
    MJA Rajarshi Nath, Swarup Manna, Shambo Panda, Arindam Maity, Krishnalekha ...
    Chemistry & Biodiversity 22 (3), https://onlinelibrary.wiley.com/doi/10.1 , 2024
    2024.0
    Citations: 19
  • Dietetic benefits of yogurt based beverage (Lassi) becoming fact-finding probe in research
    A Saha, M Das, A Das, S Mandal
    Int. J. Pharm. Res. 13, 1150-1156 , 2021
    2021.0
    Citations: 10
  • Antihyperglycemic activity of ficus carica leaves extracts on streptozotocin induced diabetic rats
    T Roy, S Paul, VR Chowdhury, A Das, S Chandra, A Das, A Jana, ...
    Research Journal of Pharmacy and Technology 14 (8), 4151-4156 , 2021
    2021.0
    Citations: 8
  • An overview on mouth dissolving tablets
    D Roy, A De, S Biswas, N Pramanick, A Das, S Mondal
    Journal of Huazhong University of Science and Technology 1671, 4512 , 2022
    2022.0
    Citations: 2
  • Olanzapine induced bruxism
    A Rakshit, D Mukhopadhyay, M Ray, S Paul, S Chandra, A Das, T Roy
    J Med Pharm Allied Sci 10, 3597-3600 , 2021
    2021.0
    Citations: 2
  • A Competitive Analysis Of Top Ten Pharmaceutical Companies In India
    A Saha, A Das, S Dutta, S Mandal
    RB 6 (2), 1865-1872 , 2021
    2021.0
    Citations: 2
  • Obsessive-Compulsive disorder is a severe threat to society
    A Saha, D Maheshwari, A Das, S Biswas, P Saha
    Bionatura 7 (2) , 2022
    2022.0
    Citations: 1
  • Developed and validated method for the simultaneous estimation of ferulic acid and chlorogenic acid in four Indian Ananas comosus merrill cultivars through HPTLC
    S Biswas, A Das, D Roy, T Roy, D Dewan, RK Paul, M Bhowmick, M Nag
    J Med Pharm Allied Sci 11 (1), 4250-4255 , 2022
    2022.0
    Citations: 1
  • Emergent Strategy in Management of Inflammatory Bowel Disease: A Narrowed in on Novel Drugs
    S Chandra, A Das, T Roy, P Bose, S Paul, L Mukherjee, A Das
    Research Journal of Pharmacy and Technology 14 (3), 1811-1814 , 2021
    2021.0
    Citations: 1
  • A Comprehensive Survey Report Regarding Public Perception on COVID-19
    A Saha, SR Chowdhury, AP Mukherjee, T Saha, M Rahaman, DD Roy, ...
    Asian Journal of Pharmacy and Pharmacology 8 (1), 9-17 , 2022
    2022.0
  • Characterization Microorganisms and Identification of Antimicrobial Resistance Pattern in Different Parts of Labeo Rohita: Monitoring and Managing Aquaculture
    T Roy, S Chandra, M Roy, P Bose, S Ghosh, S Paul, A Das
    Annals of RSCB 25 (2), 3449-3468 , 2021
    2021.0
  • A REVIEW ON FANCONI SYNDROME: A WORST ENEMY
    A Das, A Saha, S Biswas, D Roy, P Chattopadhyay, A Dey, R Nath
    Pharmaceutical Research 11 (09) , 2021
    2021.0
  • Obsessive-Compulsive disorder is a severe threat to society. Revis Bionatura 2022; 7 (2) 11
    A Saha, D Maheshwari, A Das, S Biswas, P Saha
    Clin Med Res 9 (12), 1026-1028 , 2017
    2017.0
  • Dipan Roy, Payel Laha, Nabanita Pramanick, Arijit Das, Histomorphological progression of DEN induced hepatocellular carcinoma model in rat.(2022)
    K Mukherjee, S Biswas
    Int. J. Life Sci. Pharma Res 12 (3), P86-96 , 124
    124.0
  • AN OVERVIEW ON BRAIN TARGETED DRUG DELIVERY SYSTEM
    D Roy, A De, P Laha, S Biswas, A Das, R Nath
  • Mrinmoy Nag, Poushali Boral, Poulomi Biswas, Debajit Dewan, Nabanita Pramanick, Utkalika Sarkar, Souvik Chattopadhyay, and Soumya Datta, A Spotlight on Novel Coronavirus (COVID …
    S Biswas, D Roy, B Debnath, A Das, R Nath
    Int. J. Life Sci. Pharma Res 12 (5), L206-220 , 0
  • Evaluation of Antibiotic Activity of Tetracycline on Lactobacillus acidophilus
    S Biswas, H Bit, M Chatterjee, S Datta, A Das