Analysis of Consensus Molecular Subtypes of Colorectal Cancer in Oman with Clinicopathologic Correlation Shaista Rehman, Asem Shalaby, Said Al-Busafi, Moon Chan, Shaima Al Khabouri, et al. International Journal of Molecular Sciences, 2026 Colorectal cancer (CRC) is a major public health challenge in Oman and a leading cause of cancer-related mortality. The rising incidence has been associated with lifestyle changes, urbanization, and genetic factors. The CRC Subtyping Consortium has defined four consensus molecular subtypes (CMS1–CMS4); however, data on their distribution in the Gulf region, including Oman, remain limited. This study aimed to characterize the distribution of CMS subtypes in Omani CRC patients and assess their clinicopathologic correlations using a practical immunohistochemistry (IHC) panel supplemented by a limited targeted molecular approach. This study included 273 CRC patients diagnosed between 2023 and 2024 at two major referral hospitals in Muscat. Initially, the mismatch repair (MMR)-deficient tumors (dMMR) were assigned as CMS1, while the MMR-proficient (pMMR) tumors were further evaluated for β-catenin, P53, KRAS, and TGF-β expression. Mutations in BRAF, TP53, and KRAS were analyzed by sequencing. The cohort comprised 51.6% males, with a mean age of 59.1 years. Most tumors were left-sided (70.7%). dMMR (CMS1) comprised 31 cases (11.35%). Out of the pMMR tumors, 111 cases (40.65%) showed positive expression of β-catenin and P53 (CMS2), 63 cases (23.0%) showed KRAS mutations (CMS3), and 68 cases (24.9%) showed TGF-β-positive expression (CMS4). The cases were predominantly concentrated in Muscat (41%). This study demonstrated the feasibility and clinical relevance of CMS-based classification in Oman and its potential role in precision oncology and healthcare planning.
A retrospective study of clinico-pathological characteristics of colonic polyps in adults seen at a tertiary care centre Journal of the Pakistan Medical Association, 2017
Vascular endothelial growth factor serum level as a diagnostic and prognostic marker for colorectal carcinoma Life Science Journal, 2013
Agreement of histopathological findings of preoperative uterine curettage and hysterectomy specimens: Impact of time factor and hormonal therapy Journal of Experimental Therapeutics and Oncology, 2013
Evaluation of Chitosan–Pimelate Buccal Film Loaded with Duloxetine-Modified Sage Lipid Carriers Nanoformulation for Effective Antidepressant Activity in a Rat Model WA El-Dakroury, YA Nomier, AR Said, MG Taura, A Soliman Doghish, ... International Journal of Nanomedicine, 1-30 , 2026 2026 Citations: 2
Correlation of the expression of mismatch repair proteins, CDX2, and SATB2 with the clinicopathological parameters of patients with colorectal carcinoma A Shalaby, H Hany, AM Ramez, IH Metwally, SS Elbalka, AM Fareed, ... Clinical and Translational Oncology, 1-11 , 2026 2026
Correction: Rehman et al. Analysis of Consensus Molecular Subtypes of Colorectal Cancer in Oman with Clinicopathologic Correlation. Int. J. Mol. Sci. 2026, 27, 2038 S Rehman, A Shalaby, SA Al-Busafi, MF Chan, S Al Khabouri, M Al Hinai, ... International Journal of Molecular Sciences 27 (6), 2578 , 2026 2026
Assessing telomerase and Ki-67 protein expression in pre-invasive lesions and invasive cervical neoplasia with correlation to clinico-pathological parameters MMM Al Awfi, ASIS Al Wahaibi, M Arafa, H Al Badi, R Al Shamsi, ... Clinical and Translational Oncology, 1-17 , 2026 2026
Primary Mucoepidermoid Carcinoma of the Thyroid with Lymph Node Metastases: A Case Report of a Rare Entity and Review of Literature A Shalaby, AT Al-Senani, H Al Shukaili, E Al-Ajmi, A Qureshi, ... Indian Journal of Otolaryngology and Head & Neck Surgery, 1-6 , 2026 2026
Analysis of Consensus Molecular Subtypes of Colorectal Cancer in Oman with Clinicopathologic Correlation S Rehman, A Shalaby, SA Al-Busafi, MF Chan, S Al Khabouri, M Al Hinai, ... International Journal of Molecular Sciences 27 (4), 2038 , 2026 2026 Citations: 2
The effects of sacubitril/valsartan compared to valsartan in experimentally induced chronic kidney disease R Al Maskari, AM Abdelrahman, A Shalaby, P Manoj, YM Al Suleimani Naunyn-Schmiedeberg's Archives of Pharmacology, 1-12 , 2026 2026
Incensole enhances anti-tumor immunity and inhibits melanoma progression by modulating macrophage polarization and suppressing metastasis F Jamshidi-Adegani, J Al-Kindi, S Vakilian, F Al-Fahdi, R Rezaei, ... Naunyn-Schmiedeberg's Archives of Pharmacology, 1-17 , 2025 2025
Correction to: Assessment of telomerase expression in melanoma and cutaneous squamous cell carcinoma: correlation with clinical parameters (Clinical and Translational Oncology … TN Alsurhi, A Shalaby, S Al-Sinawi, M Mabruk Clinical and Translational Oncology 27 (9), 3836 , 2025 2025
Pseudoendocrine sarcoma: a case report of a newly described soft tissue tumour A Shalaby, S Al Jahdhami, H Al Farii, Y Mahfouz, M Al Riyami, A Qureshi VIRCHOWS ARCHIV 487, S416-S416 , 2025 2025
Consensus molecular subtypes of colorectal cancer in various regions of Oman S Rehman, S Al Busaifi, MF Chan, A Shalaby, A Al Zaabi, M Al Masqari, ... VIRCHOWS ARCHIV 487, S429-S429 , 2025 2025
Comparative analysis of molecular testing and immunohistochemistry for KRAS mutation detection in colorectal carcinoma S Rehman, S Al Khabouri, S Al Sinawi, A Al Shauibi, A Shalaby, ... VIRCHOWS ARCHIV 487, S429-S429 , 2025 2025
Expression of some stem cell markers in hepatocellular carcinomas in correlation with clinco-pathological parameters and prognosis A Shalaby, H Hany, M Mohammed VIRCHOWS ARCHIV 487, S322-S322 , 2025 2025
Long-standing Pseudopapillary Neoplasm of the Pancreas and G6PD Deficiency IH Musa, AA Al-Zadjali, B Rehmani, A Shalaby, FH Al Hajri, S Younas, ... Pancreatology: official journal of the International Association of … , 2025 2025
Assessment of telomerase expression in melanoma and cutaneous squamous cell carcinoma: correlation with clinical parameters TN Alsurhi, A Shalaby, S Al-Sinawi, M Mabruk Clinical and Translational Oncology 27 (9), 3763-3769 , 2025 2025 Citations: 1
Correlation of HER2 Expression in Gastric Carcinoma with Clinicopathological Parameters in the Omani Population A Qureshi, H Al Julandana, S Al Barkhati, A Al Ghaithi, A Shalaby Age 40, 40-60 , 2025 2025
Cytomegalovirus Colitis in 2 Patients With Kindler Syndrome A Al-Hinai, LAL Yazidi, A Al Jamei, A Shalaby, K Al-Said, Y Al Rawahi The Pediatric Infectious Disease Journal 44 (7), e270 , 2025 2025
Extrameduallary hematopoesis of the endometrium in a successfully treated case with acute myeloid leukemia M Arafa, A Shalaby Indian Journal of Pathology and Microbiology 68 (2), 445-446 , 2025 2025
Synovial sarcoma of the hand: a case report and literature review on a significant challenge in treatment SS Tajammul, K Mohammed, H Al Farii, A Shalaby, J Munir, I Al-Amri, ... Cureus 17 (3) , 2025 2025 Citations: 1
Correlation of PD-L1 expression with different clinico-pathological and immunohistochemical features of ovarian surface epithelial tumors A Shalaby, O Shalaby, H Abdullah, MR Boulassel, M Arafa Clinical and Translational Oncology 27 (2), 699-705 , 2025 2025 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional‐based study N Presneau, A Shalaby, H Ye, N Pillay, D Halai, B Idowu, R Tirabosco, ... The Journal of pathology 223 (3), 327-335 , 2011 2011 Citations: 247
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target A Shalaby, N Presneau, H Ye, D Halai, F Berisha, B Idowu, A Leithner, ... The Journal of pathology 223 (3), 336-346 , 2011 2011 Citations: 149
Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway N Presneau, A Shalaby, B Idowu, P Gikas, SR Cannon, I Gout, T Diss, ... British journal of cancer 100 (9), 1406-1414 , 2009 2009 Citations: 140
Effect of diesel exhaust particles on renal vascular responses in rats with chronic kidney disease YM Al Suleimani, AS Al Mahruqi, M Al Za'abi, A Shalaby, M Ashique, ... Environmental toxicology 32 (2), 541-549 , 2017 2017 Citations: 75
Protective effects of methyl palmitate against silica-induced pulmonary fibrosis in rats MH Sharawy, DS El-Agamy, AA Shalaby, ESM Ammar International Immunopharmacology 16 (2), 191-198 , 2013 2013 Citations: 58
Effect of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on cisplatin-induced nephrotoxicity in mice AM Abdelrahman, Y Al Suleimani, A Shalaby, M Ashique, P Manoj, ... Naunyn-Schmiedeberg's archives of pharmacology 392 (1), 45-53 , 2019 2019 Citations: 56
The effect of thymoquinone treatment on the combined renal and pulmonary toxicity of cisplatin and diesel exhaust particles BH Ali, M Al Za'abi, A Shalaby, P Manoj, MI Waly, J Yasin, M Fahim, ... Experimental Biology and Medicine 240 (12), 1698-1707 , 2015 2015 Citations: 49
Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas AAE Shalaby, N Presneau, BD Idowu, L Thompson, TRW Briggs, ... Modern Pathology 22 (8), 996-1005 , 2009 2009 Citations: 48
A competitive nature-derived multilayered scaffold based on chitosan and alginate, for full-thickness wound healing S Vakilian, F Jamshidi-Adegani, A Al Yahmadi, M Al-Broumi, NU Rehman, ... Carbohydrate polymers 262, 117921 , 2021 2021 Citations: 45
Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease MA Nader, MS El-Awady, AA Shalaby, DS El-Agamy Naunyn-Schmiedeberg's archives of pharmacology 385 (9), 909-919 , 2012 2012 Citations: 44
Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma W Zedan, MI Mourad, SMA El-Aziz, NM Salamaa, AA Shalaby Diagnostic pathology 10 (1), 2 , 2015 2015 Citations: 34
Chronic water-pipe smoke exposure induces injurious effects to reproductive system in male mice BH Ali, KA Al Balushi, M Ashique, A Shalaby, MA Al Kindi, SA Adham, ... Frontiers in Physiology 8, 158 , 2017 2017 Citations: 32
Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats AM Abdelrahman, Y Al Suleimani, A Shalaby, M Ashique, P Manoj, ... Toxicology reports 6, 232-238 , 2019 2019 Citations: 31
Effect of tocilizumab, an interleukin-6 inhibitor, on early stage streptozotocin-induced diabetic nephropathy in rats AM Abdelrahman, Y Al Suleimani, A Shalaby, M Ashique, P Manoj, BH Ali Naunyn-Schmiedeberg's archives of pharmacology 392 (8), 1005-1013 , 2019 2019 Citations: 26
Calpain‐1 expression in triple‐negative breast cancer: A potential prognostic factor independent of the proliferative/apoptotic index SM Al-Bahlani, RM Al-Rashdi, S Kumar, SS Al-Sinawi, MA Al-Bahri, ... BioMed research international 2017 (1), 9290425 , 2017 2017 Citations: 24
Development of a Tacrolimus-loaded carboxymethyl chitosan scaffold as an effective 3D-printed wound dressing S Al-Hashmi, S Vakilian, F Jamshidi-adegani, J Al-Kindi, F Al-Fahdi, ... Journal of Drug Delivery Science and Technology 86, 104707 , 2023 2023 Citations: 19
The in vivo effects of adenine-induced chronic kidney disease on some renal and hepatic function and CYP450 metabolizing enzymes M Al Za’abi, A Shalaby, P Manoj, BH Ali Physiol Res 66 (2), 263-271 , 2017 2017 Citations: 19
A systematic review of diagnostic performance of circulating microRNAs in colorectal cancer detection with a focus on early-onset colorectal cancer A AlZaabi, A Shalaby International Journal of Molecular Sciences 25 (17), 9565 , 2024 2024 Citations: 18
Reproductive toxicity to male mice of nose only exposure to water-pipe smoke BH Ali, SA Adham, KA Al Balushi, A Shalaby, MI Waly, P Manoj, ... Cellular Physiology and Biochemistry 35 (1), 29-37 , 2015 2015 Citations: 16
Agreement of histopathological findings of preoperative uterine curettage and hysterectomy specimens: impact of time factor and hormonal therapy. RA Hemida, AE Zayed, A Shalaby, H Goda, M Fawzy, AA El Refaeey Journal of Experimental Therapeutics & Oncology 10 (3) , 2013 2013 Citations: 14
