Dr Atul Pratap Singh
@iimtu.edu.in
Principal, school of Pharmaceutical Sciences
IIMT University Meerut
1
Scopus Publications
Scopus Publications
- Mixed Solvency Concept to Replace Harmful Organic Solvent: Recent Trends and Future Challenges in Formulation Development
Pranjal Kumar Singh, Nidhi Singh, Atul Pratap Singh, Poonam Bhardwaj, Kapil Sachan, and Smita Singh
Bentham Science Publishers Ltd.
Organic solvents are hazardous and should be replaced with less harmful alternatives. When developing a new formulation for a medicine with low aqueous solubility, improving its solubility might be a significant difficulty. According to the mixed solvency concept, a novel concept of solubilization, the solubility of poorly soluble drugs can be increased by dissolving them in a concentrated solution comprising various substances. Methods commonly used to improve solubility include complexation, pH modification, salt formation, hydrotropy, cosolvency, and micelle solubilization. By reducing the concentration of specific solubilizers, this method can be used to reduce the toxicity of solubilizers in various formulations of poorly soluble medicines. This review aims to provide scientists with a fresh concept for enhancing medication solubility. The benefits and drawbacks of currently available green solvents have been analyzed as potential replacements for traditional solvents. Some examples of these solvents are bio-based solvents like ethanol, methanol, and cyrene; d-limonene; deep eutectic solvents such as ionic liquids and natural deep eutectic solvents; supercritical fluids; subcritical water; surfactant-based solutions like hydrotopes and supramolecular solvents; and deep eutectic solvents like cyrene. - Development and In-Vitro Characterization of Gentamycin Sulphate Nanoemulgel for Ophthalmic Applications
Mandal S and Singh . AP
Dr. Yashwant Research Labs Pvt. Ltd.
This work investigates the optimization of nanoemulgel by analyzing their viscosity and spreadability properties. The findings demonstrate a negative association between the concentration of the polymer and the spreadability, while the viscosity rises with an increase in the polymer content. As an example, formulation F1 exhibited a viscosity of 62,035 ± 10 mPa•S and a notable spreadability value of 38 ± 1. In contrast, formulations F3 and F4, which had viscosities of 92,345 ± 9 and 97,654 ± 10 mPa•S, respectively, showed insufficient capacity to spread. The improved formulation, F2, had an ideal viscosity of 66,098 ± 6 mPa•S and outstanding spreadability of 37 ± 1. Carbopol 974 and other gelling agents have a substantial impact on the physical properties of nanoemulgels, such as their texture, ability to stick to surfaces, ability to expand, and how they release drugs. The compatibility between the essential oils and the formulation was confirmed using FTIR analysis, which maintained the individual peaks of the components without any interactions. The drug content study showed that cinnamon oil had a high incorporation efficiency of 95.20 ± 1.5%, whereas olive oil had an incorporation efficiency of 93.32 ± 2.6%. The entrapment efficiencies were remarkable, averaging 96.23% for cinnamaldehyde and 97.78% for olive oil. In in vitro release tests, Franz diffusion cells demonstrated sustained release characteristics for both oils over a 24-hour period. The nanoemulgel's mucoadhesive strength, quantified at 41.3 N/cm², ensures prolonged adherence to mucosal surfaces, facilitating the efficient administration of medications. The stability trials done over a three-month period at varied temperatures and humidity levels proved the formulation's durability. These experiments did not lead to any significant alterations in the drug release patterns or physical attributes. These results highlight the capability of nanoemulgel that have been tuned for the administration of topical medications. - Development and Characterization of Cinnamon Oil-Salicylic Acid Blended Nanoemulsion (CSN) for topical Application
Atul Pratap Singh and TS Easwari
EManuscript Technologies
Background: This study aimed to develop and describe a Cinnamon Oil-Salicylic Acid Blended Nanoemulsion (CSN) for topical use. Different ratios of oil, surfactants, and water were used to create the base for the nanoemulsions. Methods: To determine the nanoemulsion (NE) base regions, pseudo ternary phase diagrams were created. In addition, nine formulations containing mixes of Tween 80 and ethanol were examined for their droplet size, zeta potential, viscosity, pH, microscopy and spectroscopic technique. Results: As a result of the experiments, it was discovered that the nanoemulsion comprising cinnamon oil and salicylic acid had an average size of 103.55 ± 1.83 and excellent rheological properties. Results revealed that the nanoemulsion bases, including ethanol as a co-surfactant, produced a larger emulsion area in the phase diagram than the other nanoemulsion bases. The formulation exhibited homogeneity, stability, and viscosity. Spherical NE was observed in transmission electron microscopy photos of CSN, and the size distribution was very narrow. The results of the in vitro release investigation showed that the medicine was released at a 95.87% effective rate in 24 hr. At a temperature of 25°C, the results of the short-term stability research, which was carried out for six months, revealed that CSN is stable. When applied to the skin of animals, CSN showed no signs of skin toxicity or irritation. Conclusion: As a result, CSN is an excellent natural-based preparation that may be utilized topically against different kinds of skin conditions. - Recent advances in psoriasis therapy: Trends and future prospects
Atul Singh and T.S. Easwari
Bentham Science Publishers Ltd.
Background: Psoriasis is a challenging skin disorder due to its chronicity, high rate of prevalence, disability, comorbidity and disfiguration. It is a multi-system disorder that includes joints and metabolic syndromes. Psoriasis is a condition of pathologic interaction among immune cells, biological signaling molecules and skin cells. Several contributing factors are responsible for the exacerbation and onset of psoriasis, i.e. genetic factors and environmental factors such as medications, infectious diseases and lifestyle. Objectives: To study the new insights in the treatment of psoriasis and future prospects. Methods: This review article gives an insight on the current concepts of psoriasis and deals with discussing the initiation and development of the diseases. We described the pathogenetic pathway for psoriasis. The article focuses on the treatment approaches for psoriasis that have arisen from the dissection of the inflammatory psoriatic pathways. Results: We aimed to highlight the novel therapies and drugs used in the treatment of psoriasis, including food and drug administration (FDA) approved drugs and drugs under clinical trials. The treatment can be initiated for mild to the moderate diseased condition employing vitamin D3 analogues, corticosteroids and a combination of products as first-line therapy. Conclusion: Psoriasis can be managed by a proper understanding of the immune function. We have also discussed medicinal herbs used for psoriasis based on their ethnopharmacological knowledge and reported work of researchers.