Dr.A.Anton Smith

@annamalaiuniversity.ac.in

Department of Pharmacy
Annamalai University



                 

https://researchid.co/auantonsmith

EDUCATION

M.Pharm., PhD., PGDCA., DIH., DQCM., MISTE., FICS.,

RESEARCH INTERESTS

Pharmaceutical Analysis, Phyto Chemistry, Medicinal Chemistry, Nano Formulation

45

Scopus Publications

1177

Scholar Citations

19

Scholar h-index

34

Scholar i10-index

Scopus Publications

  • Stability Indicating Method Development and Validation for the Simultaneous Estimation of Azilsartan and Chlorthalidone in their Bulk and Pharmaceutical Dosage Forms by RP-UPLC
    Upender Rao Eslawath, Kannappan Kannappan N, Venkateshwarlu Venkateshwarlu L, and Anton Smith A
    EManuscript Technologies

  • Phytochemical analysis, in-vitro antioxidant and cytotoxicity activities of Flaveria trinervia ethanolic extract
    Anju A. Varghese, Anton Smith A., and Sreejith M.
    Indian Association of Biomedical Scientists
    Introduction and Aim: Crude herbal drugs and commercial extracts obtained from plant sources continue to play a significant role in healthcare, particularly in developing countries where traditional medicine practices are deeply rooted. The aim of the study was to estimate the antioxidant (DPPH) and cytotoxic effects of the ethanolic extract of Flaveria trinervia on raw 246.7 cells.   Materials and Methods: In the Indian town of Thoothukudi's Kovilpatti village, F. trinervia was isolated. The entire plant was air-dried before being crushed, and 1 kg of the powdered ethanolic extract was employed in the Soxhlet apparatus for continuous extraction. By utilizing GC-MS analysis, F. trinervia ethanolic extract phytochemical assessment was studied. The antioxidant potential of F. trinervia was examined using the DPPH test. Raw 246.7 cell lines were used to test the ethanolic extract of F. trinervia for cytotoxic activity.   Results: F. trinervia extracts were found to contain a variety of biologically active phytoconstituents, including ergosterol, octadecanoic acid, propanoic acid, and isopropyl palmitate, according to phytochemical analysis. Compared to the negative control, the ethanolic extract of F. trinervia considerably showed antioxidant activity and cytotoxicity. Ascorbic acid antioxidant activity with DPPH was 98.12%, whereas F.trinervia ethanolic extract's antioxidant activity was 78.91%. The anticancer efficacy of F. trinervia ethanolic extract against uncultured 246.7 cells was evaluated using the MTT assay. By charting cell viability vs extract concentration, the IC50 value was determined. The MTT assay identified raw cells IC50 at 24 hrs as 200 µg/mL of ethanolic F. trinervia extract.   Conclusion: Active phytoconstituents are present in the F. trinervia whole plant ethanolic extract. Because of the presence of phytoconstituents, the extracts have excellent antioxidant activity and good cytotoxicity activity against raw 246.7 cell lines. The study recommended using whole plant extract from F. trinervia to treat several metabolic diseases.



  • Artificial ripening of banana-an overview
    M. Mouli Chandar and A. Anton Smith
    Diva Enterprises Private Limited
    Ripening of banana fruits was carried out by different methodologies like naturally, stressed by fumes, placing in hot condition, using calcium carbide, calcium chloride, potash, ethylene, ethereal, ethylene glycol, methyl jasmonate, etc. The objective of the study is aimed to review on artificial ripening of banana and its physicochemical changes, benefits and harmful effect caused by ripening methods. Artificial ripening of banana is experimented by fumigation and its results on morphological and physiological changes like colour, sweetness, firmness, acceptability have been observed. Various harmful effects or toxicity which is caused by artificial ripening agents are also studied. This purpose of this article is to showcase the most toxic to least or nil toxic agents and to portray the best acceptable methods of artificial ripening of banana. It was found evidence that natural method of artificial ripening gives beneficial effects without toxicity whereas stress induced or chemically induced artificial ripening leads to changes in active components that may lead to physiological malfunctioning of human beings. It was found that the order of beneficial effect is declined by natural > ethylene > ethrel with sodium hydroxide > methyl jasmonate > ethephon > calcium chloride > ethylene glycol > calcium carbide.

  • Development of analytical method and validation for nadolol in pure and pharmaceutical formulations using UV-spectrophotometry and spectrofluorimetry using hydrochloric acid


  • In vitro antioxidant activity of ethanolic extract of leaves of cnidoscolus chayamansa Mc Vaugh (Euphorbiaceae)


  • Case study of adverse event following immunization of diphtheria, pertussis (whooping cough), and tetanus vaccineinduced encephalopathy in an infant


  • Phytochemical investigation and antioxidant activities of albizia saman flowers


  • In-Silico design, synthesis and in vitro antitubercular activity of novel 1, 2, 4 - Triazole derivatives


  • Effect of an active fraction isolated from the leaf extract of Leptadenia reticulata on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats
    Natarajan VENKATESAN and Arul Gnana Dhas ANTON SMITH
    Elsevier BV
    AIM To evaluate the effect of an active fraction from Leptadenia reticulata leaves on serum glucose and lipid profile in normal and diabetic rats. METHOD Diabetes was induced by streptozotocin in Wistar rats. Petroleum ether, ethyl acetate, and ethanol extracts of Leptadenia reticulata leaves were administered orally at a dose of 200 mg·kg(-1), p.o. Metformin was used as standard anti diabetic drug (50 mg·kg(-1), p.o). The extract showing higher antidiabetic activity was subjected to column chromatography and led to the isolation of an active fraction, which was given trivial name Lr-1. Lr-1 (100 mg·kg(-1), p.o.) was studied for its hypoglycemic and hypolipidemic potential. RESULTS The ethanol extract was found to lower the FBG level significantly (P < 0.05) in diabetic rats. Lr-1 caused a significant (P < 0.05) reduction in FBG level, and additionally it caused reduction in cholesterol, triglyceride levels, and an improvement in the HDL level in diabetic rats. CONCLUSION Reduction in the FBG, cholesterol, triglyceride levels, and an improvement in the HDL by Lr-1 indicates that Lr-1 has antidiabetic activity, along with cardioprotective potential, and provides a scientific rationale for the use as an antidiabetic agent.

  • Stability study of chitosan nanoparticles containing some antiretroviral drugs


  • Colloidal dispersions as a potential nasal drug delivery system for ondansetron hydrochloride - In Vitro and In Vivo properties


  • Insilico design of pyrazole derivatives as DPP IV inhibitors


  • Formulation development and evaluation of Ondansetron hydrochloride nasal spray


  • Development and validation of analytical method for zidovudine, lamivudine and nevirapine by HPLC


  • Anti cancer activity of n-butanol extract of marine sediment fungi Aspergillus protuberus sp1 against dalton's ascitic lymphoma in mice


  • Estimation of age using aspartic acid racemisation in human dentin in Indian population
    S. Rajkumari, Madhavan Nirmal, P.M. Sunil, and A. Anton Smith
    Elsevier BV
    AIM The quest to identify an accurate method of age estimation, had lead to the evaluation of aspartic acid racemisation in hard tissues of the human remains using high performance liquid chromatography (HPLC). Our study is aimed at the applicability of the racemisation technique to use dentin as the sample to estimate the age in South Indian sub-population. MATERIALS AND METHODS Thirty-six non-carious teeth from living individuals distributed among 6 age groups (6 each), sexes (18 each) and jaws (18 each) were analysed for dextro (d) and levo (l) forms of aspartic acid using high performance liquid chromatography (HPLC) technique and their racemisation ratio were calculated for each tooth sample. RESULTS High correlation was obtained between the aspartic acid racemisation rates in dentin and age of the individual with an error limited to ±3 years. Racemisation rates in teeth did not significantly differ between the sexes or jaws. CONCLUSION The d-aspartic acid accumulation in dentin is synchronous with the aging of an individual and can be used as an accurate method of age estimation in our population.

  • Development and validation of analytical method for lopinavir and ritonavir by HPLC


  • Formulation of tigecycline injection by lyophilization technique


  • Modeling assisted in silico design of ligand molecule for DPP IV in Type II diabetes Mellitus
    S. Amuthalakshmi, A. Anton Smith, and R. Manavalan
    Bentham Science Publishers Ltd.

  • Development and validation of analytical method for ritonavir by HPLC


  • Comparative hepatoprotective activity of Liv-52 and Silymarine against hepatotoxicity induced by antiandrogen -Bicalutamide in rats


  • Preparation and evaluation of chitosan nanoparticles containing zidovudine


  • Determination of adulterants in food: A review


RECENT SCHOLAR PUBLICATIONS

  • NUTRACEUTICALS FOR THE MANAGEMENT OF OSTEOPOROSIS: A REVIEW.
    RR Murali, AA Smith
    Degrs 9 (4) 2024

  • Stability Indicating Method Development and Validation for the Simultaneous Estimation of Azilsartan and Chlorthalidone in their Bulk and Pharmaceutical Dosage Forms by RP-UPLC
    MUR Eslawath
    Ind. J. Pharm. Edu. Res 58 (1), 297-304 2024

  • STABILITY INDICATING RP-UPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TELMISARTAN AND AZELNIDIPINE IN THEIR BULK AND SOLID DOSAGE FORMS.
    UR Eslawath, N Kannappan, L Venkateshwarlu, AA Smith
    Biochemical & Cellular Archives 23 (2) 2023

  • Patient-related factors and their impact on surgical site infections and recovery rates for diverse surgeries in a tertiary care teaching hospital: A comprehensive study
    R Asha, A Rajasri, J Sundresh N, A Anton Smith
    Journal of Xi'an University of Architecture & Technology 15 (8), 229-236 2023

  • Phytochemical analysis, in-vitro antioxidant and cytotoxicity activities of Flaveria trinervia ethanolic extract
    AA Varghese, AA Smith, M Sreejith
    Biomedicine 43 (3), 867-872 2023

  • Phytochemical Investigation In vitro Antioxidant Activity & Anti Diabetic Activity of Euphorbia Nivulia.
    JJ Wesley, AA Smith, N Balakrishnan
    Journal of Pharmaceutical Negative Results 13 2022

  • The regional whole blood program in San Antonio, TX: A 3‐year update on prehospital and in‐hospital transfusion practices for traumatic and n on‐traumatic hemorrhage
    MA Braverman, AA Smith, AV Ciaraglia, JS Radowsky, SG Schauer, ...
    Transfusion 62, S80-S89 2022

  • The scavenging patterns of feral cats on human remains in an outdoor setting
    S Garcia, A Smith, C Baigent, M Connor
    Journal of Forensic Sciences 65 (3), 948-952 2020

  • Antidiabetic activity of phenolic compounds from Dregea volubilis [Benth] leaves in streptozotocin induced diabetic rats
    V Natarajan, AA Smith, BA Vishwanath
    Global J. Pharmacol 14 (1), 1-7 2020

  • In-vitro anti-diabetic activity of ethanolic extract of the medicinal plants Desmodium triflorum, Allmonia nodiflora and Digeria muricata
    K Ramkumar, AA Smith, BA Vishwanath, V Natarajan
    International Journal of Sciences 9 (10), 12-16 2020

  • Development of analytical method for imatinib mesylate by ultraviolet spectroscopy
    P Ajithkumar, A SMITH
    Development 13 (1) 2020

  • Artificial Ripening of Banana-An Overview
    MM Chandar, AA Smith
    Research Journal of Pharmacy and Technology 12 (10), 5101-5106 2019

  • In-Silico Design, Synthesis and In-Vitro Anti-Tubercular and Anti-Microbial Screening of Novel Benzimidazole Derivatives
    PT Manju, AA Smith, V Padmaja
    International Journal of Pharmaceutical Sciences and Research 9 (9), 3705-3711 2018

  • Evaluation of In vitro anticancer activity of ethanol and ethyl acetate extracts of Albizia saman flowers.
    R Murali, AA Smith, S Parimalakrishnan, G Jaralda, N Vinothini
    International Journal of Pharmaceutical, Chemical & Biological Sciences 8 (2) 2018

  • Development and validation of analytical method for quantitation of Emtricitabine, Tenofovir, Efavirenz based on HPLC
    A Ramaswamy, ASAG Dhas
    Arabian Journal of Chemistry 11 (2), 275-281 2018

  • Cost Effective Analysis Of Pharmaceutical Care In Management Of Patients With Stage Iii Hypertension: An Indian Pharmacists Experience
    S Parimalakrishnan, RJ Nachiya, AA Smith, GP Mohanta, PK Manna
    Value in Health 20 (9), A916 2017

  • Development of Analytical Method for Oxybutynin Hydrochloride by Spectrofluorimetry.
    L Arthy, S Subha, R Arun, AA Smith
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES 8 (3 2017

  • In vitro antioxidant activity of ethanolic extract of leaves of cnidoscolus chayamansa Mc Vaugh (Euphorbiaceae)
    KK Pillai
    International Journal of Green Pharmacy (IJGP) 11 (01) 2017

  • In-silico design, synthesis and in vivo antiinflammatory evaluation of novel 1, 2, 4-triazole derivatives
    K Arul, AA Smith
    Int J Pharm Sci Rev Res 47 (1), 95-9 2017

  • Phytochemical investigation and antioxidant activities of Albizia saman flowers
    M Sundar, A Anton Smith, J Amutha Iswarya Devi, A Kottai Muthu, ...
    Journal of Chemical and Pharmaceutical Sciences 9 (4), 2952-2955 2016

MOST CITED SCHOLAR PUBLICATIONS

  • Studies of anticancer and antipyretic activity of Bidens pilosa whole plant
    P Sundararajan, A Dey, A Smith, AG Doss, M Rajappan, S Natarajan
    African health sciences 6 (1), 27-30 2006
    Citations: 119

  • Determination of adulterants in food: a review
    M Kartheek, AA Smith, AK Muthu, R Manavalan
    Journal of Chemical and Pharmaceutical Research 3 (2), 629-636 2011
    Citations: 96

  • Preservatives in food products-review
    K Seetaramaiah, AA Smith, R Murali, R Manavalan
    Int J Pharm Biol Arch 2 (2), 583-99 2011
    Citations: 95

  • Preparation and evaluation of chitosan nanoparticles containing zidovudine
    JAJ Nesalin, AA Smith
    Asian J Pharm Sci 7 (1), 80-4 2012
    Citations: 64

  • Development and validation of analytical method for quantitation of Emtricitabine, Tenofovir, Efavirenz based on HPLC
    A Ramaswamy, ASAG Dhas
    Arabian Journal of Chemistry 11 (2), 275-281 2018
    Citations: 62

  • In vitro antioxidant activity of various extracts of whole plant of Mucuna pruriens (Linn).
    DS Kumar, AK Muthu, AA Smith, R Manavalan
     2010
    Citations: 47

  • Anticancer and antimicrobial activity of Aspergillus protuberus SP1 isolated from marine sediments of South Indian coast
    S Mathan, AA Smith, J Kumaran, S Prakash
    Chinese Journal of Natural Medicines 9 (4), 286-292 2011
    Citations: 41

  • Simultaneous HPLC-UV method for the estimation of artemether and lumefantrine in tablet dosage form
    R Arun, AA Smith
    Int J Pharm Biomed Res 2 (3), 201-205 2011
    Citations: 38

  • Development and validation of a reversed phase HPLC method for simultaneous determination of amlodipine and telmisartan in pharmaceutical dosage form
    MA KOTTAI, R Sankhla, S Gupta, AA Smith, R Manavalan
    JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR) 12 (4), 43-52 2010
    Citations: 37

  • Estimation of age using aspartic acid racemisation in human dentin in Indian population
    S Rajkumari, M Nirmal, PM Sunil, AA Smith
    Forensic science international 228 (1-3), 38-41 2013
    Citations: 32

  • Development of analytical method for lumefantrine by UV spectrophotometry
    R Arun, A Smith
    Int. J. Res. Pharm. Sci 1 (3), 321-4 2010
    Citations: 29

  • Spectrofluorimetric determination of flutamide in pharmaceutical preaparations
    AA Smith, R Manavalan, K Kannan, N Rajendiran
    Oriental Journal of Chemistry 24 (1), 189 2008
    Citations: 26

  • The regional whole blood program in San Antonio, TX: A 3‐year update on prehospital and in‐hospital transfusion practices for traumatic and n on‐traumatic hemorrhage
    MA Braverman, AA Smith, AV Ciaraglia, JS Radowsky, SG Schauer, ...
    Transfusion 62, S80-S89 2022
    Citations: 25

  • The scavenging patterns of feral cats on human remains in an outdoor setting
    S Garcia, A Smith, C Baigent, M Connor
    Journal of Forensic Sciences 65 (3), 948-952 2020
    Citations: 25

  • Preparation and evaluation of stavudine loaded chitosan nanoparticles
    JAJ Nesalin, AA Smith
    Journal of Pharmacy Research 6 (2), 268-274 2013
    Citations: 25

  • Formulation development and evaluation of ondansetron hydrochloride sustained release matrix tablets
    AA Smith, AK Muthu, R Manavalan
    Journal of Pharmaceutical Science & Research 1 (4), 48-54 2009
    Citations: 23

  • Spectrophotometric estimation of terbutaline sulphate in pharmaceutical dosage forms
    AA Smith, R Manavalan, K Sridhar
    Int Res J Pharm 1, 213-9 2010
    Citations: 21

  • Analytical method development and validation of secnidazole tablets by RP-HPLC
    NA Farooqui, AA Smith, HK Sharma, R Manavalan
    Journal of Pharmaceutical Sciences and Research 2 (7), 412-416 2010
    Citations: 20

  • Evaluation of anti-inflammatory, antinociceptive and antipyretic effects of methanol extract of Cleome chelidonii
    S Parimalakrishnan, A Dey, AA Smith, R Manavalan
    International Journal of Biological and Chemical Sciences 1 (3), 223-228 2007
    Citations: 20

  • Nanoparticles–a review
    G Maruthi, AA Smith, R Manavalan
    Journal of Advanced Scientific Research 2 (04), 12-19 2011
    Citations: 19