Aysar Ashour Khalaf

@uokerbala.edu.iq

University of Kerbala Biology department/Faculty of Education for Pure Science
University of Kerbala

Aysar Ashour Khalaf


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https://researchid.co/aysar_ashour

RESEARCH, TEACHING, or OTHER INTERESTS

Immunology and Microbiology, Molecular Biology
15

Scopus Publications

44

Scholar Citations

3

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • LncRNAs in inflammasome regulation: Orchestrating cancer signaling and chemoresistance
    Mahmood Yaseen Mukhlif, Shahad Hisham Mahmood, Aysar Ashour Khalaf, Gaurav Sanghvi, Suhas Ballal, et al.
    Seminars in Oncology, 2026
  • A comprehensive insight into NETosis-extracellular vesicle crosstalk in autoimmune diseases
    Mohammed Hashim Mohammed, Sumaya Ayad Abdulrazzaq, Aysar Ashour Khalaf, Ashok Kumar Bishoyi, Roopashree R, et al.
    Naunyn Schmiedeberg S Archives of Pharmacology, 2026
  • A signature serum biomarker for non-invasive diagnosis of preeclampsia patients
    Teeba Ammar Rashid, Shahd Rajab Farhan, Aysar Ashour Khalaf, Gaurav Sanghvi, Subasini Uthirapathy, et al.
    Journal of Assisted Reproduction and Genetics, 2025
  • Navigating Cellular Stress: Endoplasmic Reticulum Stress and the Unfolded Protein Response in the Molecular Pathogenesis of Preeclampsia
    Teeba Ammar Rashid, Shahd Rajab Farhan, Aysar Ashour Khalaf, Gaurav Sanghvi, Subasini Uthirapathy, et al.
    Cell Biochemistry and Biophysics, 2025
  • Breaking barriers: Deciphering the mechanisms of Olaparib resistance in prostate cancer
    Amr Ali Mohammed Abdelgawwad Wl-Sehrawy, Mahmood Yaseen Mukhlif, Aysar Ashour Khalaf, Subasini Uthirapathy, Suhas Ballal, et al.
    Seminars in Oncology, 2025
  • Immunological Biomarkers IL-34, MCP-1, and MIP-1α: Age and Sex Associations in Periodontitis Patients
    A.A. Khalaf, K.A.M. Hussain, R.H. Saleh, S.A. Jasim
    Acta Microbiologica Bulgarica, 2024
    Periodontitis is a common osteolytic disease and the leading cause of adult tooth loss. The disease's susceptibility can be influenced by systemic factors, with age and sex being significant factors. The current study assessed the correlations between interleukins and age and sex in periodontitis patients. A total of 85 periodontitis patients and 40 healthy individuals aged between 18 and 67 years were included to examine statistical correlations between interleukins and age/sex in periodontitis. Using ELISA techniques, levels of IL-34, MCP-1, and MIP-1α in serum and gingival crevicular fluid (GCF) were assessed. Statistical analyses, including the Kruskal-Wallis Test, Mann-Whitney Test, and Chi-square Test, were conducted to ascertain relationships among immunological markers, age, and sex, with significance set at P≤0.05. The results revealed significant age correlations with IL-34 concentrations in serum and GCF, notably increasing in patients aged 40-54. Conversely, no substantial age-based variances were observed in MCP-1 or MIP-1α levels within the patient group. Sex effect on IL-34 production, demonstrating higher levels in patients compared to healthy individuals. Conversely, MCP-1 and MIP-1α levels showed no significant sex-related variations within patients. In conclusion, this study underscores a positive association between age and IL-34 levels in serum and GCF among periodontitis patients. Additionally, it underscores the sex impact on IL-34 production. These findings contribute to comprehending the immunological mechanisms of periodontitis and the role of age and sex in disease susceptibility. Further exploration is needed to assess these findings' implications in tailoring personalized treatment approaches for periodontitis.
  • The Correlation of IL-34 Polymorphisms With Periodontitis in Both Patients and Healthy Babylonians in Iraq
    Ayser A.Khalaf, Siham J. M. AL-Kaabi, Manar M. Hizam
    Aip Conference Proceedings, 2023
  • The antimicrobial activity of nanochitosan and nano-CaCO3against some bacteria
    Rasha Saleh, Aysar Khalaf
    Medical Journal of Babylon, 2023
    Background: The growing threat of infections and drug-resistant microorganisms is a crucial challenge; hence, finding novel antimicrobial medicines is urgently needed. Nanotechnology has garnered interest in many disciplines, especially for therapeutic applications. Chitosan nanoparticles (CS-NPs) and calcium carbonate nanoparticle (CaCO3-NP) are recognized as antimicrobial agents because of their antimicrobial features and minimal risk of toxicity to humans. Objectives: The goal of this investigation was to detect the antibacterial efficacy of CS-NPs and CaCO3-NP at various concentrations toward different bacteria. Materials and Methods: This investigation collected a total of 128 different clinical specimens. Every bacterial isolate was examined using the cultural, microscopic, and biochemical procedures. Antibiotic sensitivity was performed by using disk diffusion methods. The antibacterial activity of different CS-NP and CaCO3-NP concentrations (20, 40, 60, and 80 mg/L) was estimated on medical bacteria, Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, and by well diffusion method. Results: A total of 80 bacterial isolates were collected from various clinical samples. The majority of isolates were P. aeruginosa, E. coli, S. aureus, S. pyogenes, and K. pneumoniae. Most isolates exhibited resistance against tested antibiotics, in which P. aeruginosa exhibited relatively elevated resistance to mainly used antibiotics. Nanoparticle compounds exhibited antimicrobial activity at different concentrations against all bacteria, and it is affected in different degrees. As nanoparticle concentrations increase, antibacterial activity increase as well. Conclusions: CS-NPs and CaCO3-NP showed promising antimicrobial activity against medically relevant microorganisms. It is indicated as an option the manufacturing of antimicrobial medications utilized in medicine.
  • Association between XRCC-1 Arg194Trp Polymorphism with Lung Cancer in Iraqi Patients
    Susan Al-Rawi, Aysar Khalaf, Ashwaq M. S. Al-Jbouri, Saade Jasim, A. Mutar
    Medical Journal of Babylon, 2023
    Background: Preface, DNA repair is the most efficient protective approach against DNA damage. Because the integrity of the genome is vital and crucial, the process of repairing DNA induced by carcinogens is critical. The ability to repair DNA damage may be impacted by specific genetic variants in DNA-repair genes, which may also be a risk factor for the development of cancer. The X-ray repair cross complementing-1 (XRCC-1) gene product has been linked to base-excision and single-strand repair mechanisms. Objective: The goal of this study was to examine the relation of the XRCC-1 gene with lung cancer patients. Materials and Methods: polymarease chain reaction- restriction fragment length polymorphism (PCR-RFLP) analysis was used to compare 40 lung cancer patients along with 40 sample controls. Samples were collected at Al-Amal National Hospital for cancer management, ages ranging from 40 to 70 years. Statistics were carried out by using the SPSS Software program Version 20.0. Results: The results show that the XRCC-1 (Arg194Trp) gene carried seven exons, which were shown to have different frequencies in patients and controls based on three genotypes (Arg/Trp, Arg/Arg, and Trp/Trp). Hardy–Weinberg equilibrium with chi-square for the patient (7.949) and control group (8.236). Also, the Arg/Trp genotype was present at a significantly high frequency in patients (77.5%), and the odds ratio was (14.94, confidence interval [CI] = 4.99–44.76 to CI = 0.642), whereas the Trp/Trp genotype frequency increased in the control group (72.5%). And the odds ratio for this relationship was (0.3, P = 0.001, and CI = 0.01–0.11). Conclusion: This study’s findings also suggest that the Arg/Trp genotype may be linked to lung cancer in this particular group.
  • Survey of Anaerobic Bacteria Isolated from Gingival Crevicular Fluid with Periodontitis Patients
    Ayser A. Khalaf, Siham J. M. AL-Kaabi
    Aip Conference Proceedings, 2023
  • Oral microbiota relationship with and without gingivitis in Iraqi patients
    Aysar Ashour Khalaf, Kaiser Abdulsajjad Mohammed Hussain, Rasha Hadi Saleh
    Journal of Applied and Natural Science, 2023
  • Activity evaluation of ginger (Zingiber officinale) alcoholic extract against Candida albicans
    A. A. Khalaf, A. J. M. Al-Aedany, S. F. Hussein
    Aip Conference Proceedings, 2020
  • Preparation, diagnosis and study of the inhibitory effect of copper nanoparticles before and after Erythromycin loading on Pseudomonas aeruginosa
    K A M Hussein, A A Khalaf
    Iop Conference Series Materials Science and Engineering, 2020
  • Preparation and diagnosis of xerogel nanocomposites and studying their effect on tnf-α level before and after loading dexamethason in male white rats induced rheumatoid arthritis
    K. A. M. Hussain, A. A. Khalaf, Batool A. Hussien
    Indian Journal of Forensic Medicine and Toxicology, 2020
  • Phylogenetic tree of some nosocomial bacteria isolated from Ramadi Teaching Hospital
    International Journal of Pharmaceutical Research, 2020

RECENT SCHOLAR PUBLICATIONS

  • A comprehensive insight into NETosis-extracellular vesicle crosstalk in autoimmune diseases
    MH Mohammed, SA Abdulrazzaq, AA Khalaf, AK Bishoyi, R R, A Kashyap, ...
    Naunyn-Schmiedeberg's Archives of Pharmacology 399 (2), 1871-1895 , 2026
    2026
  • LncRNAs in inflammasome regulation: Orchestrating cancer signaling and chemoresistance
    MY Mukhlif, SH Mahmood, AA Khalaf, G Sanghvi, S Ballal, A Singh, ...
    Seminars in Oncology, 152455 , 2025
    2025
  • A signature serum biomarker for non-invasive diagnosis of preeclampsia patients
    TA Rashid, SR Farhan, AA Khalaf, G Sanghvi, S Uthirapathy, R Jyothi, ...
    Journal of Assisted Reproduction and Genetics 42 (12), 4253-4266 , 2025
    2025
  • Navigating Cellular Stress: Endoplasmic Reticulum Stress and the Unfolded Protein Response in the Molecular Pathogenesis of Preeclampsia
    TA Rashid, SR Farhan, AA Khalaf, G Sanghvi, S Uthirapathy, R Jyothi, ...
    Cell Biochemistry and Biophysics, 1-19 , 2025
    2025
    Citations: 3
  • Breaking barriers: Deciphering the mechanisms of Olaparib resistance in prostate cancer
    AAMA El-Sehrawy, MY Mukhlif, AA Khalaf, S Uthirapathy, S Ballal, ...
    Seminars in Oncology 52 (4), 152375 , 2025
    2025
    Citations: 1
  • التنمية المستدامة في السياقات التعليميةواالكاديمية: المفاهيم والتحديات ‎
    ايسر عاشور خلف ‎
    2024
  • Oral microbiota relationship with and without gingivitis in Iraqi patients.
    AA Khalaf, KAM Hussain, RH Saleh
    Journal of Applied & Natural Science 15 (4) , 2023
    2023
    Citations: 2
  • The correlation of IL-34 polymorphisms with periodontitis in both patients and healthy babylonians in Iraq
    A A. Khalaf, SJM AL-Kaabi, MM Hizam
    AIP Conference Proceedings 2845 (1), 020005 , 2023
    2023
  • The antimicrobial activity of nanochitosan and nano-CaCO3 against some bacteria
    RH Saleh, AA Khalaf
    Medical Journal of Babylon 20 (3), 540-546 , 2023
    2023
    Citations: 8
  • Association between XRCC-1 Arg194Trp polymorphism with lung cancer in Iraqi patients
    SSM Al-Rawi, AA Khalaf, AMS Al-Jbouri, SA Jasim, AA Mutar
    Medical Journal of Babylon 20 (3), 638-641 , 2023
    2023
    Citations: 3
  • Empowering women and entrepreneurship in project management in Iraq
    SH AI-Rubaye, AA Khalaf
    Iraqi Academics Syndicate 3rd International Conference on Arts and … , 2023
    2023
    Citations: 2
  • Survey of anaerobic bacteria isolated from gingival crevicular fluid with periodontitis patients
    AA Khalaf, SJM AL-Kaabi
    AIP Conference Proceedings 2414 (1), 020034 , 2023
    2023
    Citations: 1
  • Association of Gram Negative Anaerobic Bacteria and Some Immunological Parameters in Patients with Periodontitis
    K Ayser ,Ashour
    university of kufa , 2022
    2022
  • ANTIMICROBIAL ACTIVITY OF ENDOPHYTIC FUNGI ISOLATED FROM VINCA ROSA LEAVES
    BM Hassan, AJ Mohammad, SF Hussein, A Ashour
    Ann. For. Res 65 (1), 8981-8992 , 2022
    2022
  • Activity evaluation of ginger (Zingiber officinale) alcoholic extract against Candida albicans
    AA Khalaf, AJM Al-Aedany, SF Hussein
    AIP Conference Proceedings 2290 (1), 020018 , 2020
    2020
    Citations: 13
  • Preparation, diagnosis and study of the inhibitory effect of copper nanoparticles before and after Erythromycin loading on Pseudomonas aeruginosa
    KAM Hussein, AA Khalaf
    IOP Conference Series: Materials Science and Engineering 928 (6), 062003 , 2020
    2020
    Citations: 8
  • Phylogenetic Tree of Some Nosocomial Bacteria Isolated from Ramadi Teaching Hospital
    SAJ YASAMEEN HASAN ALI1 , AYSER ASHOUR KHALAF2 , FARAH JIHAD QANBAR3
    International Journal of Pharmaceutical Research | 12 (4) , 2020
    2020
    Citations: 3
  • SARS-COV2: Genome, Animal Reservoir, Laboratory Diagnosis and Treatment
    ASJALBZJJ Ayser Ashour Khalaf 1
    SCIENTIFIC JOURNAL OF MEDICAL RESEARCH 4 (15), 102-110 , 2020
    2020
  • COMPARATIVE STUDY BETWEEN CONVENTIONAL AND MOLECULAR ASSAYS FOR DETECTION SHIGA TOXIN-PRODUCING ESCHERICHIA COLI IN CHILDREN WITH BLOODY DIARRHEA IN KERBALA CITY
    K Ayser ,Ashour
    2018
  • The effect of alcoholic extract of Punica granatum peels on the gene expression of the gene ALS₁ of the yeast Candida albicans which forming biofilm and isolated from mouth area
    A ashour
    جامعة كربلاء , 2016 ‎
    2016

MOST CITED SCHOLAR PUBLICATIONS

  • Activity evaluation of ginger (Zingiber officinale) alcoholic extract against Candida albicans
    AA Khalaf, AJM Al-Aedany, SF Hussein
    AIP Conference Proceedings 2290 (1), 020018 , 2020
    2020
    Citations: 13
  • The antimicrobial activity of nanochitosan and nano-CaCO3 against some bacteria
    RH Saleh, AA Khalaf
    Medical Journal of Babylon 20 (3), 540-546 , 2023
    2023
    Citations: 8
  • Preparation, diagnosis and study of the inhibitory effect of copper nanoparticles before and after Erythromycin loading on Pseudomonas aeruginosa
    KAM Hussein, AA Khalaf
    IOP Conference Series: Materials Science and Engineering 928 (6), 062003 , 2020
    2020
    Citations: 8
  • Navigating Cellular Stress: Endoplasmic Reticulum Stress and the Unfolded Protein Response in the Molecular Pathogenesis of Preeclampsia
    TA Rashid, SR Farhan, AA Khalaf, G Sanghvi, S Uthirapathy, R Jyothi, ...
    Cell Biochemistry and Biophysics, 1-19 , 2025
    2025
    Citations: 3
  • Association between XRCC-1 Arg194Trp polymorphism with lung cancer in Iraqi patients
    SSM Al-Rawi, AA Khalaf, AMS Al-Jbouri, SA Jasim, AA Mutar
    Medical Journal of Babylon 20 (3), 638-641 , 2023
    2023
    Citations: 3
  • Phylogenetic Tree of Some Nosocomial Bacteria Isolated from Ramadi Teaching Hospital
    SAJ YASAMEEN HASAN ALI1 , AYSER ASHOUR KHALAF2 , FARAH JIHAD QANBAR3
    International Journal of Pharmaceutical Research | 12 (4) , 2020
    2020
    Citations: 3
  • Oral microbiota relationship with and without gingivitis in Iraqi patients.
    AA Khalaf, KAM Hussain, RH Saleh
    Journal of Applied & Natural Science 15 (4) , 2023
    2023
    Citations: 2
  • Empowering women and entrepreneurship in project management in Iraq
    SH AI-Rubaye, AA Khalaf
    Iraqi Academics Syndicate 3rd International Conference on Arts and … , 2023
    2023
    Citations: 2
  • Breaking barriers: Deciphering the mechanisms of Olaparib resistance in prostate cancer
    AAMA El-Sehrawy, MY Mukhlif, AA Khalaf, S Uthirapathy, S Ballal, ...
    Seminars in Oncology 52 (4), 152375 , 2025
    2025
    Citations: 1
  • Survey of anaerobic bacteria isolated from gingival crevicular fluid with periodontitis patients
    AA Khalaf, SJM AL-Kaabi
    AIP Conference Proceedings 2414 (1), 020034 , 2023
    2023
    Citations: 1
  • A comprehensive insight into NETosis-extracellular vesicle crosstalk in autoimmune diseases
    MH Mohammed, SA Abdulrazzaq, AA Khalaf, AK Bishoyi, R R, A Kashyap, ...
    Naunyn-Schmiedeberg's Archives of Pharmacology 399 (2), 1871-1895 , 2026
    2026
  • LncRNAs in inflammasome regulation: Orchestrating cancer signaling and chemoresistance
    MY Mukhlif, SH Mahmood, AA Khalaf, G Sanghvi, S Ballal, A Singh, ...
    Seminars in Oncology, 152455 , 2025
    2025
  • A signature serum biomarker for non-invasive diagnosis of preeclampsia patients
    TA Rashid, SR Farhan, AA Khalaf, G Sanghvi, S Uthirapathy, R Jyothi, ...
    Journal of Assisted Reproduction and Genetics 42 (12), 4253-4266 , 2025
    2025
  • التنمية المستدامة في السياقات التعليميةواالكاديمية: المفاهيم والتحديات ‎
    ايسر عاشور خلف ‎
    2024
  • The correlation of IL-34 polymorphisms with periodontitis in both patients and healthy babylonians in Iraq
    A A. Khalaf, SJM AL-Kaabi, MM Hizam
    AIP Conference Proceedings 2845 (1), 020005 , 2023
    2023
  • Association of Gram Negative Anaerobic Bacteria and Some Immunological Parameters in Patients with Periodontitis
    K Ayser ,Ashour
    university of kufa , 2022
    2022
  • ANTIMICROBIAL ACTIVITY OF ENDOPHYTIC FUNGI ISOLATED FROM VINCA ROSA LEAVES
    BM Hassan, AJ Mohammad, SF Hussein, A Ashour
    Ann. For. Res 65 (1), 8981-8992 , 2022
    2022
  • SARS-COV2: Genome, Animal Reservoir, Laboratory Diagnosis and Treatment
    ASJALBZJJ Ayser Ashour Khalaf 1
    SCIENTIFIC JOURNAL OF MEDICAL RESEARCH 4 (15), 102-110 , 2020
    2020
  • COMPARATIVE STUDY BETWEEN CONVENTIONAL AND MOLECULAR ASSAYS FOR DETECTION SHIGA TOXIN-PRODUCING ESCHERICHIA COLI IN CHILDREN WITH BLOODY DIARRHEA IN KERBALA CITY
    K Ayser ,Ashour
    2018
  • The effect of alcoholic extract of Punica granatum peels on the gene expression of the gene ALS₁ of the yeast Candida albicans which forming biofilm and isolated from mouth area
    A ashour
    جامعة كربلاء , 2016 ‎
    2016