Balasubramanian Murugesan

@viaasrtt.ac.in

Assistant Professor and Biotechnology
Vivekanandha Arts and Science College for Women

Balasubramanian Murugesan


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https://researchid.co/balasubramanian1984

RESEARCH, TEACHING, or OTHER INTERESTS

Cancer Research, Biochemistry, Genetics and Molecular Biology, Ecology, Evolution, Behavior and Systematics, Biotechnology
2

Scopus Publications

82

Scholar Citations

4

Scholar h-index

4

Scholar i10-index

Scopus Publications

  • Atranorin from lichens act as potential inhibitor for cervical tumor proteins TGFbeta and kinase enzyme CDK4/CyclinD3: An anti-cancer intervention therapy
    Balasubramanian Murugesan, Thirumalaisamy Rathinavel, R. Selva Kumar, M. Gomathi, Shanmugavel Uma Maheswari, et al.
    International Journal of Biological Macromolecules, 2025
  • Molecular insights of anticancer potential of usnic acid towards cervical cancer target proteins: An in silico validation for novel anti-cancer compound from lichens
    Balasubramanian Murugesan, Anandhi Subramanian, Subha Bakthavachalam, Kavitha Rajendran, Sowndarya Raju, Subha Gabriel
    Journal of Biomolecular Structure and Dynamics, 2024
    Usnic acid is a marker compound produced from numerous lichens (symbiotic association of mycobiont and phycobiont) possessing higher bioavailability, potent and selective against cancer cells. Usnic acid is an underutilized and well-documented anti-cancer compound from lichens and its activity is not yet documented against cervical cancer. The main aim of the present research is to screen the anti-cancer potential of usnic acid against cervical cancer target proteins. The drug-likeness validation of usnic acid shows nil violations against all drug-likeness rules when compared with all three screened anti-cancer standard drugs and shows some violation in drug likeness prediction. Further, ADMET screening reveals usnic acids shows effective pharmacokinetic profiles with good bioactivity scores, essential for drug delivery and metabolism. DFT analysis of usnic acid reveals less energy gap (-0.1184), hardness (0.0592 eV), and high softness (16.8918 eV) scores against three anti-cancer drug DFT scores. Molecular docking study shows usnic acid possesses excellent binding affinity with all the nine screened cervical cancer target proteins with docking scores ranging from -6.9 to -9.1 kcal/mol. Three anti-cancer drugs showed docking scores with a range of -5.2 to -8.4 kcal/mol. Further, four top-scored complexes were taken for molecular dynamic simulation study reveal that usnic acid complexes (1KTZ-usnic acid and 2BIM-usnic acid) possess good simulation trajectories with cervical cancer target proteins than the selected anti-cancer drugs.Communicated by Ramaswamy H. Sarma.

RECENT SCHOLAR PUBLICATIONS

  • Exploring lichen-derived compounds as potential anti-cervical cancer agents an DFT and MD simulation analysis
    VB Balasubramanian Murugesan, Bharath Somasundram, Gopinath Samykannu ...
    In Silico Pharmacology 13 (114) , 2025
    2025
    Citations: 1
  • Atranorin from lichens act as potential inhibitor for cervical tumorrow proteins TGF beta and kinase enzyme CDK4/CyclinD3: An anti-cancer intervention therapy
    TS Balasubramanian Murugesan, Thirumalaisamy Rathinavel, R.Selva kumar, M ...
    International Journal of Biological Macromolecules 320 (3), 145896 , 2025
    2025
  • Remote sensing & sensor for treatment of crops based on Nanofertilizer.
    AS Murugesan Balasubramanian, Apurva Dilip Fuladi, Arpit Srivastava, Piyush ...
    2024
  • A Text Book of Fundamentals of Biochemistry and Cell Biology
    DMB Dr.K.Gopi
    2024
  • A Text Book of Plant Biochemical Therapeutics and Research Methodology for Biologists
    DMB Dr.K.Gopi
    2024
  • Molecular Insights of Anticancer Potential of Usnic Acid Towards Cervical Cancer Target Proteins: An In Silico Validation for Novel Anti-cancer Compound from Lichens
    SG Balasubramanian Murugesan, Anandhi.S, Subha.B, Kavitha.R, Sowndharya.R
    Journal of Biomolecular Structure and Dynamics 42 (18), 9475-9493 , 2024
    2024
    Citations: 10
  • Studies on Genetic Diversity and Polymorphism of Acacia constricta and Acacia farnesiana
    M Balasubramanian
    Research Advances in Microbiology and Biotechnology , 2023
    2023
  • In Vitro Assessment of Free Radicals and Trace Metal Species in Salivary Secretions: A rapid Detection Method for the Prognosis of Oral Precancerous Cancerous Conditions
    B M
    Cutting Edge Research in Biology , 2023
    2023
  • A Textbook of Nanobiotechnology - Concepts, Techniques and its Applications
    KS S.Anandhi, M.Balasubramanian, S.G.Prabhakaran
    2023
  • Biosensors and its applications
    DM Kavitha K, Baskar M, Balasubramanian M
    Innovative trends in biologicalscience , 2023
    2023
  • Screening and characterization of antibacterial compounds from some marine sponge species.
    SK M. Duraipandian, Turibius Simon, M. Balasubramanian
    Scope 13 (2), 137-145 , 2023
    2023
  • Correlation between phytochemicals and antioxidant activities of different leaf extracts of Entada rheedii.
    LRNM Balasubramanian
    Journal of Plant Science Research 39 (1), 199-208 , 2023
    2023
    Citations: 3
  • Green synthesis and characterization of silver nanoparticles using Heliotropium indicum L. leaves extract and antimicrobial activity
    BM Gopinathan Mini
    Journal of Advanced Scientific Research 13 (1), 365-373 , 2022
    2022
    Citations: 4
  • Qualitative phytochemical analysis and antioxidant studies of marine algae Sargassum natans from Rameshwaram, Tamil Nadu.
    BM Subha Priya.B
    Journal of Emerging Technologies and Innovative Research 8 (3), 2438-2448 , 2021
    2021
  • Optimization of biofuel production by the effect of growth parameter by Sargassum natans isolated from Rameshwaram district, Tamil Nadu.
    BM Subha Priya B
    International Journal of All Research Education and Scientific Methods 9 (12 … , 2021
    2021
  • Correlation analysis of phytochemicals and antioxidant activities of Heliotropium indicum leaves extracts.
    BM Gopinathan Mini
    International Journal of Pharmaceutical Science and Research 12 (8), 4386-4393 , 2021
    2021
    Citations: 4
  • A review on the pharmaceutical potential of the Genus Heliotropium (Boraginaceae).
    BM Gopinathan Mini
    European Journal of Pharmaceutical and Medical Research 7 (7), 462-471 , 2020
    2020
    Citations: 3
  • Qualitative and quantitative analysis of secondary metabolites, antimicrobial and anticancer property of Azadirachta indica.
    ASPK Balasubramanian M, Gopinath LR, Nivetha S
    Journal of Applied science and Computers 6 (1), 4696-4710 , 2019
    2019
  • Pharmacological evaluation of Parmelioid lichen FlavoparmeliaCaperata (L) Hale with special reference to analgesic and anti-inflammatory properties
    LR Krishnaveni B, Balasubramanian M, Gopinath
    IOSR Journal of Pharmacy 8 (10), 22-29 , 2018
    2018
    Citations: 2
  • Evaluation of anti-oxidant properties of Foliose lichens.
    M Balasubramanian, P Nirmala
    Journal of Chemical and Pharmaceutical Research 6 (9), 177-184 , 2014
    2014
    Citations: 10

MOST CITED SCHOLAR PUBLICATIONS

  • Effect of α - tocopherol on salivary reactive oxygen species and trace elements in oral submucous fibrosis
    JH Chitra S, Balasubramaniam M
    Annals of Clinical Biochemistry 49 (3), 262-265 , 2012
    2012
    Citations: 22
  • Antimycobacterial activity of foliose lichens on plant and animal pathogens
    NP Balasubramanian M
    International Journal of Pharmaceutical Science and Research 5 (11), 4825-4831 , 2014
    2014
    Citations: 19
  • Molecular Insights of Anticancer Potential of Usnic Acid Towards Cervical Cancer Target Proteins: An In Silico Validation for Novel Anti-cancer Compound from Lichens
    SG Balasubramanian Murugesan, Anandhi.S, Subha.B, Kavitha.R, Sowndharya.R
    Journal of Biomolecular Structure and Dynamics 42 (18), 9475-9493 , 2024
    2024
    Citations: 10
  • Evaluation of anti-oxidant properties of Foliose lichens.
    M Balasubramanian, P Nirmala
    Journal of Chemical and Pharmaceutical Research 6 (9), 177-184 , 2014
    2014
    Citations: 10
  • Green synthesis and characterization of silver nanoparticles using Heliotropium indicum L. leaves extract and antimicrobial activity
    BM Gopinathan Mini
    Journal of Advanced Scientific Research 13 (1), 365-373 , 2022
    2022
    Citations: 4
  • Correlation analysis of phytochemicals and antioxidant activities of Heliotropium indicum leaves extracts.
    BM Gopinathan Mini
    International Journal of Pharmaceutical Science and Research 12 (8), 4386-4393 , 2021
    2021
    Citations: 4
  • Correlation between phytochemicals and antioxidant activities of different leaf extracts of Entada rheedii.
    LRNM Balasubramanian
    Journal of Plant Science Research 39 (1), 199-208 , 2023
    2023
    Citations: 3
  • A review on the pharmaceutical potential of the Genus Heliotropium (Boraginaceae).
    BM Gopinathan Mini
    European Journal of Pharmaceutical and Medical Research 7 (7), 462-471 , 2020
    2020
    Citations: 3
  • Pharmacological evaluation of Parmelioid lichen FlavoparmeliaCaperata (L) Hale with special reference to analgesic and anti-inflammatory properties
    LR Krishnaveni B, Balasubramanian M, Gopinath
    IOSR Journal of Pharmacy 8 (10), 22-29 , 2018
    2018
    Citations: 2
  • Genetic diversity and polymorphism of Acacia constrictaandAcacia farnesiana
    3. Balasubramanian M
    International Journal of Medicobiological Research 1 (5), 267-277 , 2012
    2012
    Citations: 2
  • Salivary analysis of reactive oxygen species in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma patients
    CS 1. Balasubramanian M
    International Journal of Biosciences 2 (2), 36-44 , 2012
    2012
    Citations: 2
  • Exploring lichen-derived compounds as potential anti-cervical cancer agents an DFT and MD simulation analysis
    VB Balasubramanian Murugesan, Bharath Somasundram, Gopinath Samykannu ...
    In Silico Pharmacology 13 (114) , 2025
    2025
    Citations: 1
  • Atranorin from lichens act as potential inhibitor for cervical tumorrow proteins TGF beta and kinase enzyme CDK4/CyclinD3: An anti-cancer intervention therapy
    TS Balasubramanian Murugesan, Thirumalaisamy Rathinavel, R.Selva kumar, M ...
    International Journal of Biological Macromolecules 320 (3), 145896 , 2025
    2025
  • Remote sensing & sensor for treatment of crops based on Nanofertilizer.
    AS Murugesan Balasubramanian, Apurva Dilip Fuladi, Arpit Srivastava, Piyush ...
    2024
  • A Text Book of Fundamentals of Biochemistry and Cell Biology
    DMB Dr.K.Gopi
    2024
  • A Text Book of Plant Biochemical Therapeutics and Research Methodology for Biologists
    DMB Dr.K.Gopi
    2024
  • Studies on Genetic Diversity and Polymorphism of Acacia constricta and Acacia farnesiana
    M Balasubramanian
    Research Advances in Microbiology and Biotechnology , 2023
    2023
  • In Vitro Assessment of Free Radicals and Trace Metal Species in Salivary Secretions: A rapid Detection Method for the Prognosis of Oral Precancerous Cancerous Conditions
    B M
    Cutting Edge Research in Biology , 2023
    2023
  • A Textbook of Nanobiotechnology - Concepts, Techniques and its Applications
    KS S.Anandhi, M.Balasubramanian, S.G.Prabhakaran
    2023
  • Biosensors and its applications
    DM Kavitha K, Baskar M, Balasubramanian M
    Innovative trends in biologicalscience , 2023
    2023