Basel A Abdel-Wahab

Scopus Publications

Naftidrofuryl Exerts Neuroprotective Effects in a Rotenone-Induced Rat Model of Parkinson’s Disease Through Modulation of PINK1/Parkin and ER Stress Pathways
Saad Misfer Alqahtani, Ehab A. M. El-Shoura, Lobna A. Abdelzaher, Souty M. Z. Sharkawi, Ahmed M. Atwa, Maha Hosni Morsi, Hebatallah M. Saad, Basel A. Abdel-Wahab
Neuromolecular Medicine, 2026
Perindopril and L‑arginine protect against arsenic trioxide–induced neurotoxicity via Keap1/Nrf2/HO‑1 activation and suppression of neuroinflammation and apoptosis
Basel A. Abdel-Wahab, Ahmed M. Abd-Eldayem, Ehab A. M. El-Shoura, Saad Misfer, Ahmed A. N. Ahmed, Eman K. Rashwan, Hend Mostafa Selim, El-sayed Gawesh, Olfat E. Mostafa, Sabrin A. Abdel Wahab, Rania A. Gad
Naunyn Schmiedeberg S Archives of Pharmacology, 2026
Biosynthesis of Silver Nanoparticles Using Anisotes Trisulcus: Antioxidant, Antibacterial, and Anti-Proliferative Activities
Abdulsalam A. Alqahtani, Mohammad Zaki Ahmad, Ali S. Alasiri, Javed Ahmad, Hassan A. Albarqi, Basel A. Abdel‐Wahab, Saeed Alqahtani, Omaish Salman Alqahtani, Noura M. Alshiban, Shadma Wahab, Marwa B. Bakir
Chemistryselect, 2025
This study presents the first comprehensive report on the green synthesis of silver nanoparticles (AgNPs) using Anisotes trisulcus ( A. trisulcus ) leaf extract, a medicinal plant previously unexplored for nanomaterial production. Unlike conventional chemical or plant‐based methods, A. trisulcus offers a distinctive phytochemical profile that enhances the stability and bioactivity of the nanoparticles, setting this approach apart from existing literature. The biosynthesized AgNPs exhibited a strong surface plasmon resonance at 435 nm, with an average size of 70.89 ± 0.56 nm and a predominantly spherical morphology confirmed by electron microscopy. Energy‐dispersive X‐ray analysis identified silver as the primary element, while FTIR spectra revealed functional groups responsible for reduction and stabilization. X‐ray diffraction confirmed a face‐centered cubic crystalline structure. Biological evaluations demonstrated notable multifunctionality, with the AgNPs exhibiting potent antioxidant activity (IC 50 : 25.35 µg/mL for DPPH; 29.79 µg/mL for ABTS), outperforming several previously reported plant‐derived AgNPs. Antimicrobial assays showed strong, dose‐dependent inhibition of Escherichia coli ( E. coli ) (MIC: 6.25 µg/mL) and Staphylococcus aureus ( S. aureus) (MIC: 12.5 µg/mL), while cytotoxicity testing revealed selective, time‐dependent suppression of A549 lung carcinoma cells (IC 50 : 107.9 µg/mL at 24 h). By introducing an underutilized medicinal plant and demonstrating enhanced physicochemical and biofunctional properties, this work advances eco‐friendly nanotechnology. It highlights the potential of A. trisulcus ‐mediated AgNPs as promising antimicrobial, antioxidant, and anticancer agents.
Cilostazol alleviates imatinib-induced myocardial injury in rats by modulating the TGF-β1/MAPK, SHC/Grb2/SOS signaling pathways and upregulating miRNA-195-5P
Basel A. Abdel-Wahab, Ehab A. M. El-Shoura, Saad Misfer Alqahtani, Hebatallah M. Saad, Marwa B. Bakir, Dalia Zaafar
Naunyn Schmiedeberg S Archives of Pharmacology, 2025
Advances in lipid-based nanoformulations for inhaled antibiotic therapy in respiratory infections
Mohammad H. Alyami, Mohammad Zaki Ahmad, Javed Ahmad, Basel A. Abdel-Wahab, Kalyani Pathak
Drug Discovery Today, 2025
Piperazine ferulate impact on diabetes-induced testicular dysfunction: unveiling genetic insights, MAPK/ERK/JNK pathways, and TGF-β signaling
Basel A. Abdel-Wahab, Ehab A. M. El-Shoura, Mohammed S. Habeeb, Nayef A. Aldabaan, Yasmine H. Ahmed, Dalia Zaafar
Naunyn Schmiedeberg S Archives of Pharmacology, 2025
From bench to bedside: Advancing liposomal doxorubicin for targeted cancer therapy
Mohammad Zaki Ahmad, Gulam Mustafa, Basel A. Abdel-Wahab, Kalyani Pathak, Aparoop Das, Jon Jyoti Sahariah, Parimita Kalita, Afroze Alam, Partha Protim Borthakur
Results in Surfaces and Interfaces, 2025
Liposomes have emerged as a transformative platform for targeted drug delivery in cancer therapy, addressing key limitations of traditional chemotherapeutics like doxorubicin (DOX. Although conventional anthracyclines are highly effective, their severe cardiotoxicity and systemic side effects restrict their clinical use. Liposomal encapsulation enhances this approach by encapsulating drugs within lipid bilayers, enabling controlled release, improved tumor targeting, and reduced off-target toxicity. Notably, PEGylated liposomal DOX formulations, such as Doxil®, have significantly improved pharmacokinetics, extended circulation times, and decreased cardiotoxicity while maintaining strong anticancer efficacy. This review systematically analyzes the development of liposome-based formulations for DOX, from early advancements to next-generation functionalized formulations. We critically examine recent innovations, including antibody-, peptide-, aptamer-, and cell-penetrating peptide-conjugated liposomes, which have demonstrated enhanced tumor specificity and the potential to overcome multidrug resistance. Additionally, thermosensitive liposomes (TSLs), particularly lyso-thermosensitive variants, present a promising strategy for localized drug release triggered by hyperthermia. Concurrently, pH-sensitive and sugar-conjugated liposomes exploit the unique characteristics of the tumor microenvironment for precise targeting. Despite these advancements, significant challenges remain in optimizing ligand density, scalability, and long-term stability, which hinder clinical translation. This review consolidates recent progress, compares emerging strategies, and highlights critical barriers to translation. By addressing current gaps in clinical application and proposing potential solutions, this work offers a forward-looking perspective on the future of multifunctional liposomal formulations in oncology. Ultimately, this review aims to guide future research toward safer, more effective, and patient-centered cancer therapies. • Liposomal DOX formulations enhance tumor targeting while reducing cardiotoxicity. • Functionalized liposomes with ligands improve specificity and overcome drug resistance. • Thermosensitive and pH-responsive liposomes enable precise drug release at tumor sites. • Scalability, cost, and regulatory hurdles remain key challenges to clinical translation.
Cellular Epigenetic Targets and Epidrugs in Breast Cancer Therapy: Mechanisms, Challenges, and Future Perspectives
Ibrahim S. Alalhareth, Saleh M. Alyami, Ali H. Alshareef, Ahmed O. Ajeibi, Manea F. Al Munjem, Ahmad A. Elfifi, Meshal M. Alsharif, Seham A. Alzahrani, Mohammed A. Alqaad, Marwa B. Bakir, Basel A. Abdel-Wahab
Pharmaceuticals, 2025
Breast cancer is the most common malignancy affecting women, manifesting as a heterogeneous disease with diverse molecular characteristics and clinical presentations. Recent studies have elucidated the role of epigenetic modifications in the pathogenesis of breast cancer, including drug resistance and efflux characteristics, offering potential new diagnostic and prognostic markers, treatment efficacy predictors, and therapeutic agents. Key modifications include DNA cytosine methylation and the covalent modification of histone proteins. Unlike genetic mutations, reprogramming the epigenetic landscape of the cancer epigenome is a promising targeted therapy for the treatment and reversal of drug resistance. Epidrugs, which target DNA methylation and histone modifications, can provide novel options for the treatment of breast cancer by reversing the acquired resistance to treatment. Currently, the most promising approach involves combination therapies consisting of epidrugs with immune checkpoint inhibitors. This review examines the aberrant epigenetic regulation of breast cancer initiation and progression, focusing on modifications related to estrogen signaling, drug resistance, cancer progression, and the epithelial–mesenchymal transition (EMT). It examines existing epigenetic drugs for treating breast cancer, including agents that modify DNA, inhibitors of histone acetyltransferases, histone deacetylases, histone methyltransferases, and histone demethyltransferases. It also delves into ongoing studies on combining epidrugs with other therapies and addresses the upcoming obstacles in this field.
Combined bisoprolol and trimetazidine ameliorate arsenic trioxide -induced acute myocardial injury in rats: targeting PI3K/GSK-3β/Nrf2/HO-1 and NF-κB/iNOS signaling pathways, inflammatory mediators and apoptosis
Yasmin M. Ahmed, Ehab A. M. El-Shoura, Magy R. Kozman, Basel A. Abdel-Wahab, Asmaa Ramadan Abdel-Sattar
Immunopharmacology and Immunotoxicology, 2025
BACKGROUND Arsenic-trioxide (ATO) is an effective therapy for acute promyelocytic leukemia. Unfortunately, its utility is hindered by the risk of myocardial injury. Both bisoprolol (BIS) and trimetazidine (TMZ) have various pharmacological features, including anti-oxidant, anti-inflammatory, and anti-apoptotic properties. AIM The cardioprotective effects of BIS and TMZ were studied, and their mechanistic role in ameliorating ATO-induced myocardial injury. MATERIALS AND METHODS Forty male Wistar rats were randomly allotted into five groups as follows: normal control group (received normal saline, orally), ATO group (7.5 mg/kg, orally), BIS (8 mg/kg, orally), TMZ (60 mg/kg, orally), and finally combination group (BIS + TMZ + ATO). Following 21 days, samples of serum and cardiac tissues were obtained to perform biochemical, molecular, and histopathological investigations. RESULTS The present study showed that ATO caused myocardial injury evidenced by changes in serum biomarkers (Aspatate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatine kinase-MB, and cardiac troponin-1), electrolyte imbalance, and lipid profiles alongside histopathologic changes. In addition, ATO administration significantly elevated malondialdehyde, nicotinamide adenine dinucleotide phosphate hydrogen oxidase, myloperoxidase, total nitrite, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin-1β, interleukin-6, 8-Hydroxy-2'-deoxyguanosine, nuclear factor NF-kappa-B p65 subunit, glycogen synthase kinase-3 beta, and caspase-3 expression contemporaneously with down-regulation of reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase, heme oxygenase 1, nuclear factor erythroid 2-related factor 2, phosphatidylinositol-3 kinase, p-PI3K, and Bcl-2 expression. Interestingly, pre-treatment with BIS and TMZ significantly reversed the detrimental effects of ATO-induced myocardial injury at both cellular and molecular levels. Otherwise, combining the two drugs displayed more enhancement than each drug alone. CONCLUSION The present research depicted that BIS and TMZ have the potential to protect the heart and provide therapeutic benefits by preventing acute heart injury induced by ATO. This is achieved by reversing the redox-sensitive pathway, reducing inflammation, and inhibiting apoptosis.
Unraveling the impact of semaglutide in a diabetic rat model of testicular dysfunction: Insights into spermatogenesis pathways and miRNA-148a-5p
Basel A. Abdel-Wahab, Ehab A.M. El-Shoura, Mohammed S. Habeeb, Nayef A. Aldabaan, Yasmine H. Ahmed, Dalia Zaafar
Steroids, 2025
Advances in 3D printing for dentistry: clinical applications and future perspectives
Partha Protim Borthakur, Jon Jyoti Sahariah, Malita Sarma, Aparoop Das, Kalyani Pathak, Mohammad Zaki Ahmad, Basel A. Abdel-Wahab
Exploration of Medicine, 2025
Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways
Nashwa Abdelaala, Ehab A. M. El-Shoura, Marwa M. Khalaf, Dalia Zafaar, Ahmed A. N. Ahmed, Ahmed M. Atwa, Basel A. Abdel-Wahab, Yasmine H. Ahmed, Ahmed Abomandour, Esraa A. Salem
Immunopharmacology and Immunotoxicology, 2025
Nanomedicine: A New Frontier in Alzheimer’s Disease Drug Targeting
Kalyani Pathak, Mohammad Zaki Ahmad, Riya Saikia, Manash Pratim Pathak, Jon Jyoti Sahariah, Parimita Kalita, Aparoop Das, Md Ariful Islam, Pallab Pramanik, Dubom Tayeng, Basel A. Abdel-Wahab
Central Nervous System Agents in Medicinal Chemistry, 2025
Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control
Mohammad Zaki Ahmad, Kalyani Pathak, Afroze Alam, Basel A. Abdel-Wahab, Marwa B. Bakir, Aparoop Das, Manash Pratim Pathak, M. M. Abdullah, Khalid Altigani Ahmed, Mohammed Y. Alasmary, Abdulsalam A. Alqahtani, Himangshu Sarma
Journal of Drug Targeting, 2025
Nanohybrid cerasomes: Advancements in targeted drug and gene delivery
Kalyani Pathak, Mohammad Zaki Ahmad, Riya Saikia, Partha Protim Borthakur, Pallab Pramanik, Md Ariful Islam, Aparoop Das, Basel A. Abdel-Wahab, Dibyajyoti Das, Saptasikha Gogoi
European Journal of Medicinal Chemistry Reports, 2024
Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy
Mohammad Shabib Akhtar, Karthikeyan Chandrasekaran, Sharmila Saminathan, Siva Ranjani Rajalingam, Nehal Mohsin, Khalid Altigani Awad Alkarem Ahmed, Yasir Alhazmi, Ismail A. Walbi, Basel A. Abdel-Wahab, Amol D. Gholap, Md. Faiyazuddin, Gowri Sundaram
Scientific Reports, 2024
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression
Basel A. Abdel‐Wahab, Dalia Zafaar, Mohammed Shafiuddin Habeeb, Ehab A. M. El‐Shoura
British Journal of Pharmacology, 2024
Reno-protective effect of nicorandil and pentoxifylline against potassium dichromate-induced acute renal injury via modulation p38MAPK/Nrf2/HO-1 and Notch1/TLR4/NF-κB signaling pathways
Ehab A.M. El-Shoura, Lobna A. Abdelzaher, Ahmed A.N. Ahmed, Basel A. Abdel-Wahab, Souty M.Z. Sharkawi, Sally Abdelhamid Mohamed, Esraa A. Salem
Journal of Trace Elements in Medicine and Biology, 2024
Eco-friendly green synthesis of silver nanoparticles utilizing olive oil waste by-product and their incorporation into a chitosan-aloe vera gel composite for enhanced wound healing in acid burn injuries
Basel A. Abdel-Wahab, Anzarul Haque, Hadil Faris Alotaibi, Ali S. Alasiri, Osman AE Elnoubi, Mohammad Zaki Ahmad, Kalyani Pathak, Hassan A. Albarqi, Ismail A. Walbi, Shadma Wahab
Inorganic Chemistry Communications, 2024
Some promising medicinal plants used in Alzheimer’s disease: an ethnopharmacological perspective
Smita Bordoloi, Kalyani Pathak, Mary Devi, Riya Saikia, Jyotirmoy Das, Vikrant Hari Kashyap, Dibyajyoti Das, Mohammad Zaki Ahmad, Basel A. Abdel-Wahab
Discover Applied Sciences, 2024
Chitosan-based topical formulation integrated with green-synthesized silver nanoparticles utilizing Camellia sinensis leaf extracts: A promising approach for managing infected wounds
Mohammad Zaki Ahmad, Abdulhakeem Mohammed Saeed, Osman A.E. Elnoubi, Ali S. Alasiri, Basel A. Abdel-Wahab, Abdulsalam A. Alqahtani, Kalyani Pathak, Riya Saikia, Bibhuti Bhusan Kakoti, Aparoop Das
International Journal of Biological Macromolecules, 2024
Dapagliflozin alleviates arsenic trioxide-induced hepatic injury in rats via modulating PI3K/AkT/mTOR, STAT3/SOCS3/p53/MDM2 signaling pathways and miRNA-21, miRNA-122 expression
Basel A. Abdel-Wahab, Ehab A.M. El-Shoura, Mohammed S. Habeeb, Dalia Zaafar
International Immunopharmacology, 2024
Reno-protective effect of fenofibrate and febuxostat against vancomycin-induced acute renal injury in rats: Targeting PPARγ/NF-κB/COX-II and AMPK/Nrf2/HO-1 signaling pathways
Ehab A. M. El-Shoura, Souty M. Z. Sharkawi, Lobna A. Abdelzaher, Basel A. Abdel-Wahab, Yasmine H. Ahmed, Asmaa Ramadan Abdel-Sattar
Immunopharmacology and Immunotoxicology, 2024
Tea (Camellia sinensis (L.) Kuntze) as an emerging source of protein and bioactive peptides: A narrative review
Manoj Kumar, Pavidharshini Selvasekaran, Ramalingam Chidambaram, Baohong Zhang, Muzaffar Hasan, Om Prakash Gupta, Nadeem Rais, Kanika Sharma, Anshu Sharma, José M. Lorenzo, E. Parameswari, Vishal P. Deshmukh, Amr Elkelish, Basel A. Abdel-Wahab, Deepak Chandran, Abhijit Dey, Marisennayya Senapathy, Surinder Singh, Ravi Pandiselvam, Vellaikumar Sampathrajan, Sangram Dhumal, Ryszard Amarowicz
Food Chemistry, 2023
New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines
Mohamed A. A. Orabi, Esam A. Orabi, Ahmed Abdullah Al Awadh, Mohammed Merae Alshahrani, Basel A. Abdel-Wahab, Hiroshi Sakagami, Tsutomu Hatano
Antioxidants, 2023
Febuxostat alleviates Arsenic Trioxide-Induced renal injury in Rats: Insights on the crosstalk between NLRP3/TLR4, Sirt-1/NF-κB/TGF-β signaling Pathways, and miR-23b-3p, miR-181a-5b expression
Basel A. Abdel-Wahab, Ehab A.M. El-Shoura, Mohammed Shafiuddin Habeeb, Dalia Zafaar
Biochemical Pharmacology, 2023
Design and Optimization of Quercetin-Loaded Polymeric Eudragit L-100 Nanoparticles for Anti-diabetic Activity with Improved Oral Delivery: In-Vitro and In-Vivo Evaluation
Mohammad Zaki Ahmad, Kalyani Pathak, Ratna Jyoti Das, Riya Saikia, Himangshu Sarma, Neelutpal Gogoi, Urvashee Gogoi, Aparoop Das, Ali S. Alasiri, Basel A. Abdel-Wahab, M. M. Abdullah
Journal of Inorganic and Organometallic Polymers and Materials, 2023
Antioxidant Properties Mediate Nephroprotective and Hepatoprotective Activity of Essential Oil and Hydro-Alcoholic Extract of the High-Altitude Plant Skimmia anquetilia
Neha Kukreti, Havagiray R. Chitme, Vinay K. Varshney, Basel A. Abdel-Wahab, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb
Antioxidants, 2023
Biogenic Fabrication of Silver Nanoparticles Using Calotropis procera Flower Extract with Enhanced Biomimetics Attributes
Pooja V. Nagime, Sudarshan Singh, Nishat M. Shaikh, Komal S. Gomare, Havagiray Chitme, Basel A. Abdel-Wahab, Yahya S. Alqahtany, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb, Marwa B. Bakir
Materials, 2023
Alternative Non-Drug Treatment Options of the Most Neglected Parasitic Disease Cutaneous Leishmaniasis: A Narrative Review
Mohamed A. A. Orabi, Ahmed A. Lahiq, Ahmed Abdullah Al Awadh, Mohammed Merae Alshahrani, Basel A. Abdel-Wahab, El-Shaymaa Abdel-Sattar
Tropical Medicine and Infectious Disease, 2023
Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia
Ritu Rani, Havagiray R. Chitme, Neha Kukreti, Pankaj Pant, Basel A. Abdel-Wahab, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb, Marwa B. Bakir
Nutrients, 2023
Cardioprotective Effect of Flibanserin against Isoproterenol-Induced Myocardial Infarction in Female Rats: Role of Cardiac 5-HT2A Receptor Gene/5-HT/Ca2+ Pathway
Mohamed I. Ahmed, Heba M. A. Abdelrazek, Yasser M. Moustafa, Samar Z. Alshawwa, Maysa A. Mobasher, Basel A. Abdel-Wahab, Fathy Elsayed Abdelgawad, Dina M. Khodeer
Pharmaceuticals, 2023
A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species
Alok Pratap Singh, Havagiray Chitme, Rajeev Kumar Sharma, JB Kandpal, Ashok Behera, Basel A. Abdel-Wahab, Mohammed Abdelmalek Orabi, Masood Medleri Khateeb, Mohammed Habeeb, Marwa B. Bakir
Molecules, 2023
Correction to: Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF‑κB‑p65/iNOS and SIRT1/PPARγ signaling pathways in rats (Environmental Science and Pollution Research, (2022), 29, 25, (37644-37659), 10.1007/s11356-021-18252-1)
Basel A. Abdel‑Wahab, Saad A. Alkahtani, Abdulsalam A. Alqahtani, Emad H. M. Hassanein
Environmental Science and Pollution Research, 2023
Permeability-Enhanced Liposomal Emulgel Formulation of 5-Fluorouracil for the Treatment of Skin Cancer
Ankur Pachauri, Havagiray Chitme, Sharad Visht, Vijay Chidrawar, Nawaj Mohammed, Basel A. Abdel-Wahab, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb, Mohamed A. A. Orabi, Marwa B. Bakir
Gels, 2023
A Preliminary Cytotoxicity Study of Fagonia arabica against Breast (MCF-7), Oral (KB-3-1), and Lung Cancer (A-549) Cell Lines: A Study Supported by Molecular Marker Analysis Using Dual Staining Dyes
Ismail A. Walbi, Ali Mohamed Alshabi, Saad Ahmed Alkahtani, Ibrahim Ahmed Shaikh, Basel A. Abdel-Wahab, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb, Mohamed A. A. Orabi, Arun K. Shettar, Joy H. Hoskeri
Separations, 2023
Editorial: Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: current perspectives and new challenges
Basel A. Abdel-Wahab, Yosra A. Helmy, Essa M. Saied
Frontiers in Pharmacology, 2023
Predictors of antibiotic use in pregnant women attending Najran University Hospital, Saudi Arabia
Ali M. Alshabi, Majed S. Alshahrani, Basel A. Abdel-Wahab, Masood M. Khateeb, Ibrahim A. Shaikh, Basheerahmed A. Mannasaheb
Saudi Medical Journal, 2023
Canagliflozin alleviates valproic acid-induced autism in rat pups: Role of PTEN/PDK/PPAR-γ signaling pathways
Mariam A. Elgamal, Dina M. Khodeer, Basel A. Abdel-Wahab, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Yasser M. Moustafa, Azza A. Ali, Norhan M. El-Sayed
Frontiers in Pharmacology, 2023
Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling
Emad H. M. Hassanein, Ghadir A. Sayed, Abdullah M. Alzoghaibi, Abdalmohsen S. Alammar, Basel A. Abdel-Wahab, Omnia A. M. Abd El-Ghafar, Somya E. Mahdi, Ahmed M. Atwa, Mohammed A. Alzoghaibi, Ayman M. Mahmoud
Pharmaceuticals, 2023
Apoptotic Cell Death via Activation of DNA Degradation, Caspase-3 Activity, and Suppression of Bcl-2 Activity: An Evidence-Based Citrullus colocynthis Cytotoxicity Mechanism toward MCF-7 and A549 Cancer Cell Lines
Ibrahim Ahmed Shaikh, Ali Mohamed Alshabi, Saad Ahmed Alkahtani, Mohamed A. A. Orabi, Basel A. Abdel-Wahab, Ismail A. Walbi, Mohammed Shafiuddin Habeeb, Masood Medleri Khateeb, Arun K. Shettar, Joy H. Hoskeri
Separations, 2022
Tribulus terrestris Cytotoxicity against Breast Cancer MCF-7 and Lung Cancer A549 Cell Lines Is Mediated via Activation of Apoptosis, Caspase-3, DNA Degradation, and Suppressing Bcl-2 Activity
Ali Mohamed Alshabi, Saad Ahmed Alkahtani, Ibrahim Ahmed Shaikh, Mohamed A. A. Orabi, Basel A. Abdel-Wahab, Ismail A. Walbi, Mohammed Shafiuddin Habeeb, Masood Medleri Khateeb, Arun K. Shettar, Joy H. Hoskeri
Separations, 2022
Green Synthesis of Titanium Dioxide Nanoparticles Using Ocimum sanctum Leaf Extract: In Vitro Characterization and Its Healing Efficacy in Diabetic Wounds
Mohammad Zaki Ahmad, Ali S. Alasiri, Javed Ahmad, Abdulsalam A. Alqahtani, Md Margub Abdullah, Basel A. Abdel-Wahab, Kalyani Pathak, Riya Saikia, Aparoop Das, Himangshu Sarma, Seham Abdullah Alzahrani
Molecules, 2022
Onion and garlic polysaccharides: A review on extraction, characterization, bioactivity, and modifications
Neeraj Kumari, Manoj Kumar, Radha, José M. Lorenzo, Diksha Sharma, Sunil Puri, Ashok Pundir, Sangram Dhumal, Deep Jyoti Bhuyan, G. Jayanthy, Samy Selim, Basel A. Abdel-Wahab, Deepak Chandran, T. Anitha, Vishal P. Deshmukh, Ravi Pandiselvam, Abhijit Dey, Marisennayya Senapathy, Sureshkumar Rajalingam, Pran Mohankumar, John F. Kennedy
International Journal of Biological Macromolecules, 2022
In Vitro Cytotoxicity and Spectral Analysis-Based Phytochemical Profiling of Methanol Extract of Barleria hochstetteri, and Molecular Mechanisms Underlying Its Apoptosis-Inducing Effect on Breast and Lung Cancer Cell Lines
Saad Ahmed Alkahtani, Ali Mohamed Alshabi, Ibrahim Ahmed Shaikh, Mohamed A. A. Orabi, Basel A. Abdel-Wahab, Ismail A. Walbi, Mohammed Shafiuddin Habeeb, Masood Medleri Khateeb, Arun K. Shettar, Joy H. Hoskeri
Separations, 2022
Phytochemicals from Corchorus olitorius methanolic extract induce apoptotic cell death via activation of caspase-3, anti-Bcl-2 activity, and DNA degradation in breast and lung cancer cell lines
Ali Mohamed Alshabi, Saad Ahmed Alkahtani, Ibrahim Ahmed Shaikh, Mohamed A.A. Orabi, Basel A. Abdel-Wahab, Ismail A. Walbi, Mohammed S. Habeeb, Masood Medleri Khateeb, Joy H. Hoskeri, Arun K. Shettar, Syed Mohammed Basheeruddin Asdaq
Journal of King Saud University Science, 2022
Novel Exopolysaccharide from Marine Bacillus subtilis with Broad Potential Biological Activities: Insights into Antioxidant, Anti-Inflammatory, Cytotoxicity, and Anti-Alzheimer Activity
Basel A. Abdel-Wahab, Hanaa F. Abd El-Kareem, Ahmad Alzamami, Cinderella A. Fahmy, Basem H. Elesawy, Maged Mostafa Mahmoud, Ahmed Ghareeb, Ahmad El Askary, Hebatallah H. Abo Nahas, Nashwah G. M. Attallah, Najla Altwaijry, Essa M. Saied
Metabolites, 2022
Emerging advances in nanomedicine for breast cancer immunotherapy: opportunities and challenges
Mohammad Zaki Ahmad, Ali S Alasiri, Mohammed Yahia Alasmary, MM Abdullah, Javed Ahmad, Basel A Abdel Wahab, Saif Aboud M Alqahtani, Kalyani Pathak, Gulam Mustafa, Mohammad Ahmad Khan, Riya Saikia, Urvashee Gogoi
Immunotherapy, 2022
Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study
Doaa I. Mohamed, Samar F. Ezzat, Wael M. Elayat, Omnyah A. El-Kharashi, Hanaa F. Abd El-Kareem, Hebatallah H. Abo Nahas, Basel A. Abdel-Wahab, Samar Zuhair Alshawwa, Asmaa Saleh, Yosra A. Helmy, Eman Khairy, Essa M. Saied
Pharmaceuticals, 2022
Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study
Faten Al-Abkal, Basel A. Abdel-Wahab, Hanaa F. Abd El-Kareem, Yasser M. Moustafa, Dina M. Khodeer
Pharmaceuticals, 2022
Diversity of Toxigenic Fungi in Livestock and Poultry Feedstuffs
Eman Khalifa, Marwa T. Mohesien, Monga I. Mossa, Magdalena Piekutowska, Amnah Mohammed Alsuhaibani, Basel A. Abdel-Wahab, Sotohy Ahmed Sotohy, Soumya Ghosh, Yosra A. Helmy, Mohamed Hussein, Ahmed M. Abdel-Azeem
International Journal of Environmental Research and Public Health, 2022
Moringa (Moringa oleifera Lam.) polysaccharides: Extraction, characterization, bioactivities, and industrial application
K. Sharma, Manoj Kumar, Roji B. Waghmare, R. Suhag, O. Gupta, J. Lorenzo, S. Prakash, Radha, N. Rais, Vellaikumar Sampathrajan, Chandan Thappa, T. Anitha, A. A. Sayed, Basel A. Abdel-Wahab, M. Senapathy, R. Pandiselvam, Abhijit Dey, SANGRAM SAHEBRAO DHUMAL, R. Amarowicz, J. F. Kennedy
International Journal of Biological Macromolecules, 2022
Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats
Basel A. Abdel-Wahab, Saad A. Alkahtani, Abdulsalam A. Alqahtani, Emad H. M. Hassanein
Environmental Science and Pollution Research, 2022
Insights into the Antimicrobial, Antioxidant, Anti-SARS-CoV-2 and Cytotoxic Activities of Pistacia lentiscus Bark and Phytochemical Profile; In Silico and In Vitro Study
Samy Selim, Mohammed S. Almuhayawi, Mohanned T. Alharbi, Soad K. Al Jaouni, Afaf Alharthi, Basel A. Abdel-Wahab, Mervat A. R. Ibrahim, Amnah Mohammed Alsuhaibani, Mona Warrad, Khaled Rashed
Antioxidants, 2022
Publics’ Perceptions of Community Pharmacists and Satisfaction with Pharmacy Services in Al-Madinah City, Saudi Arabia: A Cross Sectional Study
Amal A. El-Kholy, Khaled Abdelaal, Hussain Alqhtani, Basel A. Abdel-Wahab, Mohamed M. M. Abdel-Latif
Medicina Lithuania, 2022
Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico Study
Doaa I. Mohamed, Dalia Alaa El-Din Aly El-Waseef, Enas S. Nabih, Omnyah A. El-Kharashi, Hanaa F. Abd El-Kareem, Hebatallah H. Abo Nahas, Basel A. Abdel-Wahab, Yosra A. Helmy, Samar Zuhair Alshawwa, Essa M. Saied
Pharmaceutics, 2022
Secondary Metabolites of Actinomycetales as Potent Quorum Sensing Inhibitors Targeting Gram-Positive Pathogens: In Vitro and In Silico Study
Said E. Desouky, Mohammed Abu-Elghait, Eman A. Fayed, Samy Selim, Basit Yousuf, Yasuhiro Igarashi, Basel A. Abdel-Wahab, Amnah Mohammed Alsuhaibani, Kenji Sonomoto, Jiro Nakayama
Metabolites, 2022
Native Rhizospheric and Endophytic Fungi as Sustainable Sources of Plant Growth Promoting Traits to Improve Wheat Growth under Low Nitrogen Input
Akram H. Mohamed, Fayrouz H. Abd El-Megeed, Naziha M. Hassanein, Sameh H. Youseif, Peter F. Farag, Saleh A. Saleh, Basel A. Abdel-Wahab, Amnah Mohammed Alsuhaibani, Yosra A. Helmy, Ahmed M. Abdel-Azeem
Journal of Fungi, 2022
Design, Characterization, and Antimicrobial Evaluation of Copper Nanoparticles Utilizing Tamarixinin a Ellagitannin from Galls of Tamarix aphylla
Mohamed A. A. Orabi, Mounir M. Salem-Bekhit, Ehab I. Taha, El-Shaymaa Abdel-Sattar, Omaish Salman Alqahtani, Fakhria A. Al-Joufi, Basel A. Abdel-Wahab, Ali Mohamed Alshabi, Hamad S. Alyami, Javed Ahmad, Tsutomu Hatano
Pharmaceuticals, 2022
Enhanced antinociceptive activity of Nigella sativa oil after its combined treatment with honey in rats
Pakistan Journal of Pharmaceutical Sciences, 2022
Progress in nanomedicine-based drug delivery in designing of chitosan nanoparticles for cancer therapy
Mohammad Zaki Ahmad, Md. Rizwanullah, Javed Ahmad, Mohammed Yahia Alasmary, Md. Habban Akhter, Basel A. Abdel-Wahab, Musarrat Husain Warsi, Anzarul Haque
International Journal of Polymeric Materials and Polymeric Biomaterials, 2022
Piclamilast mitigates 1,2-dimethylhydrazine induced colon cancer in rats through modulation of Ras/PI3K/Akt/mTOR and NF-κβ signaling
Basel A. Abdel-Wahab, Hussain Alqhtani, Ismail A. Walbi, Hassan A. Albarqi, Adel M. Aljadaan, Masood M. Khateeb, Emad H.M. Hassanein
Chemico Biological Interactions, 2021
Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1/2 signaling pathways
Emad H. M. Hassanein, Basel A. Abdel-Wahab, Fares E. M. Ali, Omnia A. M. Abd El-Ghafar, Magy R. Kozman, Souty M. Z. Sharkawi
Environmental Science and Pollution Research, 2021
Thymoquinone loaded topical nanoemulgel for wound healing: Formulation design and in-vivo evaluation
Mohammed S. Algahtani, Mohammad Zaki Ahmad, Ibrahim Ahmed Shaikh, Basel A. Abdel-Wahab, Ihab Hamed Nourein, Javed Ahmad
Molecules, 2021
Repurposed drug against COVID-19: Nanomedicine as an approach for finding new hope in old medicines
Mohammad Zaki Ahmad, Javed Ahmad, Mohammed Aslam, Mohammad Ahmed Khan, Mohammed Yahia Alasmary, Basel A Abdel-Wahab
Nano Express, 2021
Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling
Basel A. Abdel-Wahab, Ismail A. Walbi, Hassan A. Albarqi, Fares E.M. Ali, Emad H.M. Hassanein
Food and Chemical Toxicology, 2021
Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways
Fares E. M. Ali, Emad H. M. Hassanein, Ali H. El‐Bahrawy, Zainab M. M. Omar, Eman K. Rashwan, Basil A. Abdel‐Wahab, Tarek H. Abd‐Elhamid
Journal of Biochemical and Molecular Toxicology, 2021
Emerging advances in cationic liposomal cancer nanovaccines: Opportunities and challenges
Mohammad Z Ahmad, Javed Ahmad, Mohammed Y Alasmary, Basel A Abdel-Wahab, Musarrat H Warsi, Anzarul Haque, Pramila Chaubey
Immunotherapy, 2021
The role of vimentin, Connexin-43 proteins, and oxidative stress in the protective effect of propranolol against clozapine-induced myocarditis and apoptosis in rats
Basel A. Abdel-Wahab, Safaa Yousef Salem, Hala Mostafa Mohammed, Nashwa Ahmed Mohammed, Helal F. Hetta
European Journal of Pharmacology, 2021
Combined treatment of α-lipoic acid and omega-3 polyunsaturated fatty acids mitigates acetic acid-induced colitis in rats through regulating antioxidant defenses, NF-κβ signal transduction, and inflammatory cytokine profile
Latin American Journal of Pharmacy, 2021
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways
Basel A. Abdel-Wahab, Fares E. M. Ali, Saad A. Alkahtani, Ali M. Alshabi, Mater H. Mahnashi, Emad H. M. Hassanein
Immunopharmacology and Immunotoxicology, 2020
Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male rats
Basel A. Abdel-Wahab, Saad Ahmad Alkahtani, Ehab A.M. Elagab
Reproductive Toxicology, 2020
Metallic nanoparticulate delivery systems
Mohammad Zaki Ahmad, Javed Ahmad, Musarrat Husain Warsi, Basel A. Abdel-Wahab, Sohail Akhter
Nanoengineered Biomaterials for Advanced Drug Delivery, 2020
Emerging advances in synthetic cancer nano-vaccines: opportunities and challenges
Mohammad Zaki Ahmad, Javed Ahmad, Anzarul Haque, Mohammed Yahia Alasmary, Basel A. Abdel-Wahab, Sohail Akhter
Expert Review of Vaccines, 2020
Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats
Samy Ismail Ahmed, Aamir Magzoub, Mohammed Saeed Zayed Al-Ayed, Gamal Ali Attia, Basel A. Abdel-Wahab, Masood M. Khateeb, Asim M. Abdalla, Heitham M. Mohammed, Aymen N. Eldeen A. Elkareem, Ali Gadkarim A. Salih
International Journal of Endocrinology, 2020
Omega-3 fatty acids as adjunctive therapeutics: prospective of nanoparticles in its formulation development
Mohammad Zaki Ahmad, Javed Ahmad, Sobiya Zafar, Musarrat Husain Warsi, Basel A Abdel-Wahab, Sohail Akhter, Md Afroze Alam
Therapeutic Delivery, 2019
A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice
Ahmed O. Abdel-Zaher, Hanan S.M. Farghaly, Magda M.Y. Farrag, Mahran S. Abdel-Rahman, Basel A. Abdel-Wahab
Biomedicine and Pharmacotherapy, 2017
Phytochemical characterization and Antibacterial potentials of Mangifera indica L. bark oil
Chetan Savant, Anandrao R. Kulkarni, Basel A. Abdel‐Wahab, Awad Mohammed Al‐Qahtani, Basheerahmed Abdulaziz Mannasaheb, et al.
Journal of Applied Pharmaceutical Science, 2017
Toxicity of inorganic nanoparticles used in targeted drug delivery and other biomedical application: An updated account on concern of biomedical nanotoxicology
Mohammad Zaki Ahmad, Basel A Abdel-Wahab, Afroze Alam, Sobiya Zafar, Javed Ahmad, Farhan Jalees Ahmad, Patrick Midoux, Chantal Pichon, Sohail Akhter
Journal of Nanoscience and Nanotechnology, 2016
Protective effect of resveratrol against chronic intermittent hypoxia-induced spatial memory deficits, hippocampal oxidative DNA damage and increased p47Phox NADPH oxidase expression in young rats
Basel A. Abdel-Wahab, Mahmoud M. Abdel-Wahab
Behavioural Brain Research, 2016
Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: Current state-of-the-art
Mohammad Zaki Ahmad, Saad Ahmed Alkahtani, Sohail Akhter, Farhan Jalees Ahmad, Javed Ahmad, Mohammad Shabib Akhtar, Nehal Mohsin, Basel A. Abdel-Wahab
Journal of Drug Targeting, 2016
Clozapine-Induced Cardiotoxicity: Role of Oxidative Stress, Tumour Necrosis Factor Alpha and NF-κβ
Basel A. Abdel-Wahab, Metwally E. Metwally
Cardiovascular Toxicology, 2015
Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats
Basel A. Abdel-Wahab, Ibrahim A. Shaikh, Masood M. Khateeb, Shafiuddin M. Habeeb
Pharmacology Biochemistry and Behavior, 2015
Knowledge and awareness of adverse drug reactions and pharmacovigilance practices among healthcare professionals in Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia
Mohamed M.M. Abdel-Latif, Basel A. Abdel-Wahab
Saudi Pharmaceutical Journal, 2015
Omega-3 polyunsaturated fatty acids in large doses attenuate seizures, cognitive impairment, and hippocampal oxidative DNA damage in young kindled rats
Basel A. Abdel-Wahab, Jobran M. Al-Qahtani, Samy A. El-Safty
Neuroscience Letters, 2015
Clozapine-induced cardiotoxicity in rats: Involvement of tumour necrosis factor alpha, NF-κβ and caspase-3
Basel A. Abdel-Wahab, Metwally E. Metwally
Toxicology Reports, 2014
Protective effect of captopril against clozapine-induced myocarditis in rats: Role of oxidative stress, proinflammatory cytokines and DNA damage
Basel A. Abdel-Wahab, Metwally E. Metwally, Mohamed M. El-khawanki, Alaa M. Hashim
Chemico Biological Interactions, 2014
Effects of omega-3 fatty acids on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress
Life Science Journal, 2014
Does clozapine induce myocarditis, myocardial oxidative stress and DNA damage in rats?
Basel A. Abdel-Wahab, Metwally E. Abdalla, Mohamed M. El-khawanki
Egyptian Journal of Forensic Sciences, 2014
Long-term moderate dose exogenous erythropoietin treatment protects from intermittent hypoxia-induced spatial learning deficits and hippocampal oxidative stress in young rats
Jobran M. Al-Qahtani, Basel A. Abdel-Wahab, Samy M. Abd El-Aziz
Neurochemical Research, 2014
Transformation of curcumin from food additive to multifunctional medicine: Nanotechnology bridging the gap
Mohammad Ahmad, Shabib Akhter, Nehal Mohsin, Basel Abdel-Wahab, Javed Ahmad, Musarrat Warsi, Mahfoozur Rahman, Neha Mallick, Farhan Ahmad
Current Drug Discovery Technologies, 2014
Ginkgo biloba protects against intermittent hypoxia-induced memory deficits and hippocampal DNA damage in rats
Basel A. Abdel-Wahab, Samy M. Abd El-Aziz
Phytomedicine, 2012
Ginkgo biloba enhances the anticonvulsant and neuroprotective effects of sodium valproate against kainic acid-induced seizures in mice
B.A. Abdel-Waha, M.E. Metwally
Journal of Pharmacology and Toxicology, 2011
Urocortin 1 inhibits guinea pig gallbladder contractility in vitro via corticotropin-releasing factor receptor 2
Samy M Abd El-Aziz, Basel A. Abdel‐Wahab
Canadian Journal of Physiology and Pharmacology, 2011
Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice
Basel A. Abdel-Wahab, Ragaa H. Salama
Pharmacology Biochemistry and Behavior, 2011
Synthesis and docking study of some pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives as phosphodiesterase-5 inhibitors
Saudi Pharmaceutical Journal, 2009
Comparative study for brain delivery of tacrine using polysorbate 80 - Coated poly(butylcyanoacrylate) and pegylated-poly(butylcyanoacrylate) nanoparticles
Basel A. Abdel Wahab, Mohamed M. Abdel Latif, Atef A. Abdel Hafez
International Journal of Nano and Biomaterials, 2009
5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: Design, synthesis, and neuropharmacological evaluation
Atef A. Abdel-Hafez, Basel A. Abdel-Wahab
Bioorganic and Medicinal Chemistry, 2008
Antiamnesic activity of nerve growth factor adsorbed on poly(butyl) cyanoacrylate nanoparticles coated with polysorbate-80
Eksperimental Naya I Klinicheskaya Farmakologiya, 2005

Basel A Abdel-Wahab

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