Cancer Research, Genetics, Molecular Biology, Molecular Medicine
18
Scopus Publications
Scopus Publications
Ferroptosis: Basics and Role in Pathological Diseases Mehrdad Hashemi, Masoumeh Beheshti, Sina Etemadi Far, Mohammad Eslami Vaghar, Behdokht Jamali, Mitra Behroozaghdam, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari Autophagy Apoptosis and Ferroptosis in Oncology Cell Death and Cancer, 2025
Ferroptosis Mechanism in Cancer: An Overview of Resistance Mechanisms Mehrdad Hashemi, Amirmohammad Khalifehsoltani, Saba Vazirbani Arasi, Sara Karami, Mohammad Eslami Vaghar, Mahdi Moassesfar, Mitra Behroozaghdam, Behdokht Jamali, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari Autophagy Apoptosis and Ferroptosis in Oncology Cell Death and Cancer, 2025
Apoptosis and Cancer Drug Resistance Mehrdad Hashemi, Reza Akhavan-Sigari, Azarmidokht Aminazad, Mahsa Ghandi, Reza Mohammadi, Anahita Bizhanpour, Arta Setayesh, Mitra Behroozaghdam, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari Autophagy Apoptosis and Ferroptosis in Oncology Cell Death and Cancer, 2025
Natural Products in the Treatment of Cancer by Targeting Apoptosis Mehrdad Hashemi, Mahmoud Dehghani-Ghorbi, Mohammad Eslami Vaghar, Haniyeh Bakhtiari Beklar, Nastaran Dehghani, Mitra Behroozaghdam, Behdokht Jamali, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari Autophagy Apoptosis and Ferroptosis in Oncology Cell Death and Cancer, 2025
Non-Coding RNAs in the Regulation of Apoptosis in Cancer Mehrdad Hashemi, Mina Tahernejad, Sadaf Gholami, Seyedeh Sepideh Aghamirli, Parham Moradi, Reza Morovatshoar, Maedeh Chalkosh Noori, Saba Abdi, Nahid Keramati, Mitra Behroozaghdam, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari Autophagy Apoptosis and Ferroptosis in Oncology Cell Death and Cancer, 2025
Anatomy and function of prostate Mehrdad Hashemi, Vahid Tavakolpour, Sima Orouei, Mina Alimohammadi, Saba Asadi, Zeinab Khazaei Koohpar, Behdokht Jamali, Kiavash Hushmandi, Rasoul Raesi, Maliheh Entezari, Mitra Behroozaghdam Prostate Cancer Molecular Events and Therapeutic Modalities, 2024
Epidemiology, risk factors and histopathological profile of prostate cancer Mehrdad Hashemi, Farnaz Azizi, Niloofar AbolfathyNajmabady, Samira Moradi, Munes Ghorbanalinia, Sima Orouei, Behdokht Jamali, Rasoul Raesi, Faramarz Khosravi, Maliheh Entezari, Mina Alimohammadi, Kiavash Hushmandi, Mitra Behroozaghdam Prostate Cancer Molecular Events and Therapeutic Modalities, 2024
Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance Mehrdad Hashemi, Eisa Sabouni, Parham Rahmanian, Maliheh Entezari, Mahsa Mojtabavi, Behnaz Raei, Mohammad Arad Zandieh, Mitra Behroozaghdam, Sepideh Mirzaei, Kiavash Hushmandi, Noushin Nabavi, Shokooh Salimimoghadam, Jun Ren, Mohsen Rashidi, Rasoul Raesi, Afshin Taheriazam, Athanasios Alexiou, Marios Papadakis, Shing Cheng Tan Cellular and Molecular Biology Letters, 2023 Hepatocellular carcinoma (HCC) is considered one of the greatest challenges to human life and is the most common form of liver cancer. Treatment of HCC depends on chemotherapy, radiotherapy, surgery, and immunotherapy, all of which have their own drawbacks, and patients may develop resistance to these therapies due to the aggressive behavior of HCC cells. New and effective therapies for HCC can be developed by targeting molecular signaling pathways. The expression of signal transducer and activator of transcription 3 (STAT3) in human cancer cells changes, and during cancer progression, the expression tends to increase. After induction of STAT3 signaling by growth factors and cytokines, STAT3 is phosphorylated and translocated to the nucleus to regulate cancer progression. The concept of the current review revolves around the expression and phosphorylation status of STAT3 in HCC, and studies show that the expression of STAT3 is high during the progression of HCC. This review addresses the function of STAT3 as an oncogenic factor in HCC, as STAT3 is able to prevent apoptosis and thus promote the progression of HCC. Moreover, STAT3 regulates both survival- and death-inducing autophagy in HCC and promotes cancer metastasis by inducing the epithelial–mesenchymal transition (EMT). In addition, upregulation of STAT3 is associated with the occurrence of chemoresistance and radioresistance in HCC. Specifically, non-protein-coding transcripts regulate STAT3 signaling in HCC, and their inhibition by antitumor agents may affect tumor progression. In this review, all these topics are discussed in detail to provide further insight into the role of STAT3 in tumorigenesis, treatment resistance, and pharmacological regulation of HCC. Graphical Abstract
Non-coding RNA-based therapeutics in cancer therapy: An emphasis on Wnt/β-catenin control Afshin Taheriazam, Seyedeh Delaram Bayanzadeh, Melika Heydari Farahani, Sarah Mojtabavi, Mohammad Arad Zandieh, Sadaf Gholami, Mohammad Hossein Heydargoy, Maryam Jamali Hondori, Zahra Kangarloo, Mitra Behroozaghdam, Ramin Khorrami, Mohammad Ali Sheikh Beig Goharrizi, Shokooh Salimimoghadam, Mohsen Rashidi, Kiavash Hushmandi, Maliheh Entezari, Mehrdad Hashemi European Journal of Pharmacology, 2023
Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: Therapeutic targeting, challenges and future prospective Mehrdad Hashemi, Mohammad Arad Zandieh, Setayesh Ziaolhagh, Sarah Mojtabavi, Farzaneh Hasani Sadi, Zeinab Khazaei Koohpar, Maryam Ghanbarirad, Arvin Haghighatfard, Mitra Behroozaghdam, Ramin Khorrami, Noushin Nabavi, Jun Ren, Russel J. Reiter, Shokooh Salimimoghadam, Mohsen Rashidi, Kiavash Hushmandi, Afshin Taheriazam, Maliheh Entezari Biochimica Et Biophysica Acta Molecular Basis of Disease, 2023
siRNA and targeted delivery systems in breast cancer therapy Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Maliheh Entezari, Seyed Hesamoddin Bidooki, Vahideh Javadian Ghaleh, Shamin rezaei, Elahe Sadat Hejazi, Amirabbas Kakavand, Mitra Behroozaghdam, Abolfazl Movafagh, Afshin Taheriazam, Mehrdad Hashemi, Saeed Samarghandian Clinical and Translational Oncology, 2023
Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action Mitra Behroozaghdam, Maryam Dehghani, Amirhossein Zabolian, Davood Kamali, Salar Javanshir, Farzaneh Hasani Sadi, Mehrdad Hashemi, Teimour Tabari, Mohsen Rashidi, Sepideh Mirzaei, Atefeh Zarepour, Ali Zarrabi, Danielle De Greef, Anupam Bishayee Cellular and Molecular Life Sciences, 2022
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy Mehrdad Hashemi, Marzieh Sadat Moosavi, Hedyeh Maghareh Abed, Maryam Dehghani, Masoumeh Aalipour, Elaheh Ali Heydari, Mitra Behroozaghdam, Maliheh Entezari, Shokooh Salimimoghadam, Emine Selda Gunduz, Afshin Taheriazam, Sepideh Mirzaei, Saeed Samarghandian Pharmacological Research, 2022
