Nadji BELKHEIRI

@univ-djelfa.dz

Department of chemistry, Faculty of Exact Sciences and Computer Science
University of Djelfa

Nadji BELKHEIRI


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https://researchid.co/belkheirinadji

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Education, Ecology, Evolution, Behavior and Systematics, Environmental Science
7

Scopus Publications

Scopus Publications

  • High pressure dependence of optical response of cadmium oxide: A first principles investigation
    S. Djaili, N. Belkheiri, Y. Achour, K. Souleh, A. Amor, et al.
    Optik, 2026
  • COPPER CHELATION BY SYRINGIC HYDRAZONES: A PROMISING STRATEGY FOR COMBATING OXIDATIVE STRESS-RELATED DISEASES
    Nadji BELKHEIRI
    Studia Universitatis Babes Bolyai Chemia, 2026
    Oxidative stress is a critical factor in vascular damage and the development of diseases such as atherosclerosis. This study investigates the complexation properties of two syringic hydrazones, (E)-4-Hydroxy-3,5-dimethoxybenzaldehyde -1,3-benzothiazol-2-ylhydrazone 1 and (E)-4-Hydroxy-3,5-dimethoxybenzaldehyde phthalazin-1-ylhydrazone hydrochloride 2, with copper ions (CuSO4·5H2O and CuCl2·2H2O). Using UV spectrophotometry, we determined stability constants and stoichiometries of the complexes formed. Compound 1 forms three distinct types of complexes (ML, ML2, and M2L) with higher stability constants compared to those formed by compound 2, particularly when using CuCl2·2H2O. These findings extend our previous work, where syringic hydrazones demonstrated potent antioxidant properties through scavenging DPPH● and ABTS●+ radicals, inhibiting superoxide anion generation, and reducing TBARS formation in human cell-mediated LDL oxidation. These results highlight the dual potential of syringic hydrazones as radical scavengers and metal chelators.
  • CHEMISTRY IN THE KITCHEN: PRACTICAL INSIGHTS FOR HIGH SCHOOL STUDENTS
    Nadji Belkheiri, Mohamed Nadjib Rebizi
    Chemistry Didactics Ecology Metrology, 2024
    Chemistry plays a crucial role in everyday life, particularly in the kitchen, where its principles can enhance problem-solving skills and informed decision-making. This study aims to evaluate high school students’ understanding of applied chemistry in culinary contexts. A questionnaire was administered to 76 students, revealing that 42.6 % provided correct answers regarding the application of chemistry in the kitchen. The methodology involved analysing students’ responses to assess their awareness and appreciation of chemistry’s practical value. The findings suggest that promoting the application of chemistry principles not only fosters responsible citizenship but also optimises daily life benefits. Future research should explore effective strategies to enhance students’ engagement with chemistry in real-world contexts.
  • Preparation and InhA inhibitory properties of novel dehydroacetic acid-derived thiazoles
    Maamar Derdour, Zehor Belkacem, Nadji Belkheiri, Salah Karef, Mohamed Amari, et al.
    Synthetic Communications, 2024
    A series of 4-hydroxy-6-methyl-3-(1-(4-(aryl/methyl)thiazol-2-yl)-1H-pyrazol-3-yl)-2H-pyran-2-ones 3a–h have been synthesized from aryl/methyl halomethylketones and a key pyrazole intermediate 1 using a convenient one-pot synthesis method. All compounds were characterized by NMR and MS, and the structure of three of them (3a, 3b and 3f) was resolved by X-ray diffraction. These heteroatom-rich thiazole compounds were then evaluated as inhibitors of Mycobacterium tuberculosis InhA, a key enzyme involved in the type II fatty acid biosynthesis pathway of the mycobacterium. Although inhibitory activities were found to be rather weak, molecular docking studies were also been carried out to understand a possible mode of interaction with key residues in the enzyme’s active site.
  • Evaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties
    Bachar Rébat Moulkrere, Beatrice S. Orena, Giorgia Mori, Nathalie Saffon-Merceron, Frédéric Rodriguez, et al.
    Medicinal Chemistry Research, 2018
  • Antiatherogenic effect of bisvanillyl-hydralazone, a new hydralazine derivative with antioxidant, carbonyl scavenger, and antiapoptotic properties
    Benaissa Bouguerne, Nadji Belkheiri, Florence Bedos-Belval, Cécile Vindis, Koji Uchida, et al.
    Antioxidants and Redox Signaling, 2011
    Reactive oxygen species (ROS) generated within the vascular wall trigger low-density lipoprotein (LDL) oxidation, lipid peroxidation, and carbonyl stress that are involved in atherogenesis. We recently reported that the antihypertensive drug, hydralazine, exhibits carbonyl scavenger and antiatherogenic properties, but only moderate antioxidant activity, so that high concentrations are required for inhibiting LDL oxidation. We aimed to develop agents sharing both antioxidant and carbonyl scavenger properties. We have synthesized a new hydralazine derivative, the bisvanillyl-hydralazone (BVH). BVH strongly inhibited LDL oxidation induced by copper and by human endothelial cells (HMEC-1), and prevented the formation of macrophagic foam cells. BVH reduced both the extracellular generation of ROS (superoxide anion and hydrogen peroxide) induced by oxidized LDL (oxLDL), as well as intracellular oxidative stress and proteasome activation, NFkappaB activation, and oxLDL-mediated proinflammatory signaling. In parallel, BVH prevented the carbonyl stress induced by oxLDL on cellular proteins, and blocked the apoptotic cascade as assessed by the inhibition of Bid cleavage, cytochrome C release, and DEVDase activation. Lastly, BVH prevented atherogenesis and carbonyl stress in apoE(-/-) mice. In conclusion, BVH is the prototype of a new class of antioxidant and carbonyl scavenger agents designed for new therapeutical approaches in atherosclerosis.
  • Synthesis and antioxidant activity evaluation of a syringic hydrazones family
    Nadji Belkheiri, Benaissa Bouguerne, Florence Bedos-Belval, Hubert Duran, Corinne Bernis, et al.
    European Journal of Medicinal Chemistry, 2010