Kuye -Kuku Taiwo Olufunmilayo

@lasucom.edu.ng

Senior Lecturer, Obstetrics and Gynaecology
Lagos State University College Of Medicine

Kuye -Kuku Taiwo Olufunmilayo


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https://researchid.co/bethkuku

RESEARCH, TEACHING, or OTHER INTERESTS

Obstetrics and Gynecology, Reproductive Medicine, Critical Care and Intensive Care Medicine
3

Scopus Publications

Scopus Publications

  • Intimate partner violence and relationship quality among pregnant women: insights from a multi-centre study
    Taiwo Olufunmilayo Kuku-Kuye, Ayokunle Moses Olumodeji, Joy Onyinyechi Chionuma, Oladimeji Abiodun Makinde, Isaac Ian Oloke
    Scientific Reports, 2025
    Intimate partner violence presents a complex dilemma that significantly impacts the well-being of women, particularly during pregnancy. This issue often arises from a dysfunctional relationship, characterised by inadequate emotional connections and poor-quality interactions between partners. The study identifies the interaction of intimate partner violence and the quality of the relationship between partners. A multi-centred, descriptive cross-sectional hospital-based study, in which 460 consenting pregnant women attending antenatal and postnatal care at the respective health facilities in the Obstetrics and Gynaecology Department of Lagos State University Teaching Hospital, General Hospital Ifako Ijaye, Primary Health centre Onigbogbo and were consecutively recruited over a six-month period An adapted questionnaire from the WHO Multi-Country Study on Women's Health and Domestic Violence and Revised Dyadic Adjustment Scale (RDAS) to measure the quality of marital relationships. Behavioural violence was the most commonly reported, affecting 16.1% of respondents. Psychological violence was experienced by 12.9% of the participants, while 5.3% reported physical violence. Economic and sexual violence were reported by 4.6% and 4.3% of participants, respectively. Revised Dyadic Adjustment Scale (RDAS), which includes cohesion, consensus, and satisfaction components. Cohesion, 55.2% of participants had high scores, 26.1% scored in the mid-range, and 18.7% were classified as low. Regarding consensus, 73.6% of respondents were in the high range, 17.5% in the mid-range, and 8.9% in the low range. For satisfaction, 79.6% of respondents reported high satisfaction, while 13.7% and 6.7% fell into the mid and low satisfaction categories, respectively. Religion, education level, and experiences of sexual, physical, and psychological violence show strong associations with distress in pregnant women. These insights emphasize the complex intersection of sociocultural context and intimate partner dynamics, particularly during vulnerable periods like pregnancy.
  • Association of maternal insulin resistance with neo-natal insulin resistance and body composition/size: a prospective cohort study in a sub-Saharan African population
    Ibironke J. Akinola, Peter O. Ubuane, Adeyemi O. Dada, Joy O. Chionuma, Taiwo O. Kuku-Kuye, Folasade D. Olalere
    Annals of Pediatric Endocrinology and Metabolism, 2024
    Purpose: We prospectively evaluated the association of the insulin resistance of third-trimester Nigerian pregnant women with their newborn infants' insulin resistance and birth size. Pregnancy-associated insulin resistance (IR), often assessed with homeostatic model assessment of IR (HOMA-IR), is associated, especially among women with gestational diabetes (GDM), with abnormal neonatal birth size and body composition, predisposing the baby to metabolic disorders like diabetes and obesity. The associations of maternal IR with neonatal IR, birth size and body composition are less studied in nondiabetic pregnant women, especially in sub-Saharan settings like Nigeria.Methods: We originally recruited 401 third trimester, nondiabetic pregnant women to a prospective cohort study, followed up until birth. Blood samples of mothers and babies were obtained, respectively, at recruitment and within 24 hours postbirth for fasting serum glucose (FSG) and insulin (FSI) assays, and HOMA-IR was calculated as [(FSI × FSG)/22.5)].Results: Complete data for 150 mother-baby dyads was analysed: the mothers, with a mean (standard deviation [SD]) age of 31.6 (4.5) years, had live births at a mean (SD) gestational age of 39.2 weeks. The proportions of infants with wasting, stunting, impaired fetal growth (either wasting or stunted), small-for-gestation-age, large-for-gestational-age, low birthweight, and macrosomia were 4.2% (95% confidence interval, 1.1–10.3), 19.7% (12.9–28.0), 23.1% (15.8–31.8), 10.1% (5.3–17.0), 12.6% (7.2–19.9), 0.8% (0.02–4.5), and 5.0% (1.8–10.5), respectively. Maternal HOMA-IR was not associated with neonatal HOMA-IR (<i>p</i>=0.837), birth weight (<i>p</i>=0.416) or body composition measured with weight-length ratio (<i>p</i>=0.524), but birth weight was independently predicted by maternal weight (<i>p</i>=0.006), body mass index (<i>p</i>=0.001), and parity (<i>p</i>=0.012).Conclusion: In this nondiabetic/non-GDM cohort, maternal HOMA-IR was not associated with neonatal IR, body size or body composition. Larger studies are required to confirm these findings, with addi-tional inclusion of mothers with hyperglycaemia for comparison.
  • Profile of insulin resistance of pregnant women at late third trimester in Nigeria: A descriptive cross-sectional report
    JO Chionuma, IJ Akinola, AO Dada, PO Ubuane, TO Kuku-Kuye, FD Olalere
    Nigerian Journal of Clinical Practice, 2022
    Background: Exaggerated level of insulin resistance (IR) is associated with poor pregnancy outcomes. Identifying affected women may forestall these outcomes. There are few reports on IR and its predictors among pregnant women in Nigeria. Aim: To determine the profile of IR, using the homeostatic model assessment of insulin resistance (HOMA-IR), and its predictors among parturient Nigerian women in third trimester. Patients and Methods: A cross-sectional baseline data of healthy pregnant women in third trimester, consecutively recruited into a cohort study that evaluated IR and neonatal outcomes at a tertiary maternity. Sociodemographic and clinical data were obtained. Fasting venous blood was analyzed for glucose and insulin and HOMA-IR was calculated. Results: We consecutively recruited 401 healthy pregnant women between 28 and 41 weeks [means ± SD = 37.4 ± 0.8 weeks]; mean age 31.52 ± 4.3 years (range: 20-41 years). Median (IQR) HOMA-IR was 1.15 (0.63, 1.96; range: 0.02–11.73). Binary multivariable logistic regression showed overweight- [aOR (95% CI) = 3.29 (1.18, 9.13)], hyperglycemia- [aOR (95% CI) = 2.98 (1.19, 6.90)], and hypertension as independent predictors of IR [aOR (95% CI) = 2.85 (1.18, 6.90)]. Conclusion: Among nondiabetic Nigerian pregnant women in late third trimester, IR was independently associated with overweight, hypertension, and hyperglycemia. Control of adiposity is a potential target for control of IR and consequently its outcomes.