Completed Ph.D in Bharathiar
Completed M.Sc in the year 2007 in Kuvempu University India
RESEARCH INTERESTS
Photoluminescence, dye degradation, nanoparticle
31
Scopus Publications
Scopus Publications
Enhanced targeted delivery of cisplatin via folate and boron-modified magnetic nanoparticles: A promising approach for cervical cancer treatment Popsy Raj, Manoj M. Gadewar, Prashanth Gopala Krishna, Debashish Paramanick, Srilatha Rao, Lalithamba Haraluru Shankaraiah, N.P. Bhagya Next Nanotechnology, 2026 This study aims on the development and evaluation of cisplatin-loaded nanoparticles (NPs) modified with folate (FA) and boron to enhance targeted drug delivery and therapeutic efficacy. FA and boron were employed as targeting ligands, while aldehyde sodium alginate (ASA) was used as a stabilizing modifier to improve the surface activity and stability of magnetic Fe₃O₄ nanoparticles synthesized via chemical co-precipitation. FA and boron were activated through interaction with NH₂-PEG-NH₂, through non-covalent chemical bonding, forming stable and water-soluble complexes. ASA was combined to Fe₃O₄ NPs after FA-PEG linkage via Schiff base formation. Subsequent substitution of chloride in cisplatin with the hydroxyl group of ASA yielded FA- and ASA-modified CIS-FA-ASA-MNPs, along with boron-coated counterparts. MTT assays demonstrated that cisplatin-loaded NPs significantly reduced cancer cell viability compared to other formulations, with CIS-loaded boron-coated NPs exhibiting pronounced cytotoxicity even at lower doses. The IC₅₀ value of CIS-loaded boron-coated NPs (0.61 µg/mL) was markedly lower than that of CIS-loaded FA-coated NPs (0.65 µg/mL) and free cisplatin (1.25 µg/mL), confirming superior anticancer potential. Enhanced apoptosis was observed due to improved nanocarrier internalization by CIS-loaded boron-coated NPs. These results highlight the promise of boron-coated, cisplatin-loaded NPs as a targeted therapeutic strategy for cervical cancer. The enhanced cytotoxicity compared with conventional formulations is attributed to improved cellular uptake and controlled drug release. Further in vivo and biological studies are warranted to validate the therapeutic efficacy and safety of this novel delivery system. • Folate- and boron-modified Fe₃O₄ nanoparticles were developed for targeted cisplatin delivery. • Boron-coated NPs showed higher cytotoxicity than free cisplatin and folate-coated NPs in HeLa cells. • Functionalized NPs enhanced cellular uptake and induced strong apoptotic response in cancer cells. • Nanocarriers enabled sustained and controlled release of cisplatin over 72 h. • Targeted delivery system may reduce cisplatin side effects and improve therapeutic efficiency.
Advanced Characterization Techniques for Green Nanomaterials G.K. Prashanth, Srilatha Rao, H.S. Lalithamba, N.P. Bhagya, K.V. Rashmi, Mithun Kumar Ghosh Green Chemistry in Nanotechnology for Sustainable Synthesis Characterization and Applications of Nanoparticles, 2026 The sustainable synthesis of nanomaterials using green chemistry principles has emerged as a promising alternative to conventional synthetic methods, owing to its eco-friendly nature, cost-effectiveness, and biocompatibility. Green nanomaterials, often produced using plant extracts, microorganisms, or other natural agents, exhibit unique physicochemical properties influenced by their biogenic origin. To fully understand and optimize their functionalities for diverse applications—ranging from environmental remediation and catalysis to drug delivery and biosensing—comprehensive characterization is essential. This chapter provides an in-depth overview of advanced characterization techniques used to analyze the structural, morphological, optical, thermal, surface, and electrochemical properties of green nanomaterials. Techniques such as X-ray diffraction (XRD), scanning and transmission electron microscopy (SEM/TEM), Fourier transform infrared spectroscopy (FTIR), UV-visible and photoluminescence spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and cyclic voltammetry (CV) are discussed in detail, highlighting their principles, relevance, and applications in the context of green synthesis. Case studies are included to demonstrate practical applications of these techniques. The chapter concludes with insights into emerging tools and future prospects, emphasizing the critical role of characterization in advancing green nanotechnology.
Smart nanomaterials for semiconductor applications: Recent advances in energy storage and biosensing technologies G.K. Prashanth, Srilatha Rao, H.S. Lalithamba, N.P. Bhagya, M. Mahadeva Swamy, S.R. Yashodha, H.S. Yogananda Next Materials, 2025 The evolution of nanomaterials has revolutionized the design of functional devices, particularly in semiconductor-based applications. This review critically explores recent advancements in smart nanomaterials for two transformative domains: energy storage and biosensing. Unlike earlier descriptive reviews, it integrates performance comparisons, mechanistic insights, and synthesis–structure–function relationships across diverse nanostructures such as metal oxides, quantum dots (QDs), carbon hybrids, and 2D materials. Key device configurations—including supercapacitors and field-effect transistor (FET)-based biosensors—are examined to highlight how morphological and compositional tuning of nanomaterials affects electrochemical and biorecognition performance. Comparative analysis is supported by data from recent high-impact studies, while unresolved challenges such as scalability, reproducibility, toxicity, and real-world integration are addressed. The novelty of this review lies in its dual-focus framework, juxtaposing materials and mechanisms from both energy and biomedical domains, thus providing unified insights for next-generation multifunctional semiconductor systems. This approach addresses a critical gap in the literature, where most reviews focus exclusively on either energy or biosensing platforms, without considering their overlapping synergies. The final section presents a forward-looking perspective on standardization, biocompatibility, and AI-assisted device integration, emphasizing the roadmap from laboratory research to real-world deployment.
Benzoxazoles: Diverse biological activities and therapeutic potential G. K. Prashanth, Srilatha Rao, H. S. Lalithamba, K. V. Rashmi, N. P. Bhagya, Mithun Kumar Ghosh, Manoj Gadewar, Nirmala R. Darekar Five Membered Bioactive N and O Heterocycles Models and Medical Applications, 2025
