Vaibhav Bhatt
@gtu.ac.in
Director, School of Applied Sciences and Technology
Gujarat Technological University
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Bhumika Bhatt, Kandarp Bhatt, Sangeeta Lal, Srinivasan R., and Vaibhav Bhatt
Elsevier BV
Bhaktiben R. Bhatt, Kamalkishor Pandey, Tarosh Patel, Anupama Modi, Chandani Halpani, Vaibhav D. Bhatt, and Bharat C. Dixit
Elsevier BV
Saif Saad Fakhrulddin, Vaibhav Bhatt, and Sadik Kamel Gharghan
AIP Publishing
Bhumi Rajguru, Manju Shri, and Vaibhav D. Bhatt
Springer Science and Business Media LLC
Aelvish D. Padariya, Nirbhay K. Savaliya, Milan P. Dhaduk, Ravi A. Dabhi, Bhupesh S. Bhatt, Vaibhav D. Bhatt, and Mohan N. Patel
Elsevier BV
Parthkumar Prajapati, Riya Desai, Mamta Varma, Ketankumar Panchal, Subhash Jakhesara, Prakash Koringa, Vaibhav Bhatt, Neelam Nathani, and Chandrashekar Mootapally
Springer Science and Business Media LLC
Udaykumar G. Vegad, Jigna Vadalia, Nira Kalwani, Bhavinkumar Gayakvad, Riya A. Desai, Vaibhav Bhatt, Sanjay P. Chauhan, and Devang J. Pandya
Springer Science and Business Media LLC
Ravi A. Dabhi, Milan P. Dhaduk, Nirbhay K. Savaliya, Aelvish D. Padariya, Aakanksha P. Patil, Riya A. Desai, Vaibhav D. Bhatt, and Bhupesh S. Bhatt
Springer Science and Business Media LLC
Priyanka Dalwadi, Neelam Nathani, Kshipra Chauhan, Jasmine Mansuri, Prakash Koringa, Vaibhav Bhatt, and Anju P. Kunjadiya
Springer Science and Business Media LLC
Aelvish D. Padariya, Nirbhay K. Savaliya, Milan P. Dhaduk, Ravi A. Dabhi, Bhupesh S. Bhatt, Vaibhav D. Bhatt, and Mohan N. Patel
Slovenian Chemical Society
The Re(I) organometallic compounds [(Re(CO)3L1–6)Cl], where ligands L are tryptanthrin derivatives, prepared and characterized by various spectroscopic techniques. To assess the binding capacities and binding manner, tests of calf thymus DNA under the impact of organometallic complexes were conducted using absorption titration and viscosity measuring techniques. Data from the research mentioned above point to an intercalation type of binding, which was verified by the docking study. Swiss ADME tools were used to carry out an ADME study. The work focuses on computing the molecular orbital energies for the synthesized compounds using the density functional theory (DFT). The compounds were tested against the MCF-7 cell line to determine their anticancer effects. It was observed that their IC50 values were equivalent to those of the standard medication, indicating that they had a similar antiproliferative impact.
Milan P. Dhaduk, Ravi A. Dabhi, Vaibhav D Bhatt, Bhupesh S. Bhatt, and Mohan N. Patel
Elsevier BV
Milan P. Dhaduk, Ravi A. Dabhi, Bhupesh S. Bhatt, Vaibhav D. Bhatt, and Mohan N. Patel
Elsevier BV
Nandan C. Pomal, Keyur D. Bhatt, Dinesh S. Kundariya, Riya A. Desai, Vaibhav Bhatt, and Anita Kongor
Wiley
Harsh C. Patel, Manan S. Patel, Jaydeepkumar N. Parekh, Dipakkumar D. Chudasama, Priyanka Dalwadi, Anju Kunjadiya, Vaibhav Bhatt, Krunal M. Modi, Chirag N. Patel, and Kesur R. Ram
Informa UK Limited
Diversely functionalized pyrazolo-pyridine fused tetrazolo-pyrimidines 10aa-am and 10ba-bn were successfully synthesized via a catalyst-free synthetic protocol with moderate to very good yields. The compounds were evaluated for cytotoxicity against MCF-7 and HEK-293 cells using MTT assay. Among the tested compounds, 10ab (IC50- 23.83 µM) and 10ah (IC50- 23.30 µM) demonstrated the highest potency against MCF-7 cells, while 10bc (IC50- 14.46 µM) and 10bh (IC50- 2.53 µM) exhibited excellent cytotoxicity against HEK-293 cells. Additionally, antibacterial screening was performed against three Gram-negative bacteria (E. coli, P. aeruginosa, and S. enterica) and three Gram-positive bacteria (S. aureus, B. megaterium, and B. subtilis) using broth dilution method, while antifungal activity was assessed against three fungal strains (A. niger, Penicillium, and S. cerevisiae) using agar well diffusion method. In antimicrobial screening, the majority of the compounds demonstrated significant antibacterial efficacy compared to antifungal activity. We also conducted comprehensive computational studies, including DFT calculations, molecular docking and dynamics, and drug-likeness assessments. In the DFT study, compounds 10ac and 10bc displayed stable conformations, indicating their potential for higher therapeutic activity. Molecular docking analyses revealed compelling interactions, with compound 10ah demonstrating docking score -7.42 kcal/mol against catalytical domain PARP1 (PDB ID: 7KK4) and 10bh exhibiting a best docking score -10.77 kcal/mol against human corticotropin-releasing factor receptor 1 (PDB ID: 4Z9G). A 100 ns molecular dynamics (MD) simulation study of compounds 10ah and 10bh revealed the stable conformation and binding energy in a stimulating environment. In drug-likeness assessments, both the compounds 10ah and 10bh adhere all the established guidelines.Communicated by Ramaswamy H. Sarma.
Mukesh N. Kher, Sandip P. Dholakia, Dipen K. Sureja, Vaibhav D. Bhatt, and Nirav V. Patel
Elsevier
Ravi A. Dabhi, Milan P. Dhaduk, Vaibhav D. Bhatt, and Bhupesh S. Bhatt
Informa UK Limited
Abstract Series of spiro quinoxaline-β-lactam based heterocyclic compounds (QL 1 – QL 21) were synthesized and characterized by spectroscopic techniques like 1H-NMR, LC-MS, FT-IR spectroscopy and elemental analysis. The binding mode and binding strength between compounds and calf thymus-DNA were estimated by UV–visible spectroscopy, viscosity measurement and molecular docking studies. The compounds bind with the DNA through partial intercalation mode. In the absorption titration experiment, the K b values for all the synthesized compounds were found in the range of 0.24–0.64 × 105 M−1. The protein binding studies of all the synthesized compounds were evaluated by absorption titration experiment, and the K b value for all the compounds was obtained in the range of 0.030–1.571 × 104 M−1. The compounds were screened against two Gram (+ve) and three Gram (–ve) bacteria for antimicrobial activity. The MIC values for all the synthesized compounds were found in 95–255 µM. The LC50 values (cytotoxicity) of the synthesized compounds (QL 1–QL 21) were found in the range of 4.00–12.89 µg/mL. The ADME study was carried out using the online platform SwissADME and admetSAR to evaluate the pharmacokinetic profile of all the synthesized compounds. All the compounds were screened for anticancer activity against the human osteosarcoma (MG-63) cell line. The result shows that all the compounds exhibit effective anticancer activity. Communicated by Ramaswamy H. Sarma
Manan S. Patel, Jaydeepkumar N. Parekh, Dipakkumar D. Chudasama, Harsh C. Patel, Priyanka Dalwadi, Anju Kunjadiya, Vaibhav Bhatt, and Kesur R. Ram
American Chemical Society (ACS)
A simple, straightforward, and energy-efficient greener route for the synthesis of a series of biologically interesting functionalized 1,1-dihomoarylmethane scaffolds has been developed in the presence of meglumine as an efficient and eco-friendly organo-catalyst via one-pot pseudo-three-component reaction at room temperature. Following this protocol, it is possible to synthesize 1,1-dihomoarylmethane scaffolds of an assortment of C–H activated acids such as dimedone, 1,3-cyclohexadione, 4-hydroxy-6-methyl-2-pyrone, 4-hydroxycoumarin, and 1-phenyl-3-methyl-pyrazolone. The salient features of the present green protocol are mild reaction conditions, good to excellent yields, operational simplicity, easy isolation of products, no cumbersome post treatment, high atom economy, and low E-factor. In addition, this chemistry portrays several green advantages including the reusability of reaction media and product scalability, which makes protocol sustainably efficient. Additionally, several control experiments such as protection of catalyst reactive site, D2O exchange, and 1H NMR studies revealed possible pathways for meglumine-promoted reactions. Inspired by the natural physiological environment of 1,1-dihomoarylmethane scaffolds, we reconnoitered the biological profile of our compounds and synthesized compounds that were promising for their antiproliferative and antibacterial activities.
Pratiksha H. Nimbkar and Vaibhav D. Bhatt
Elsevier BV
Priya Patel, Mihir Raval, Aneka Manvar, Vishal Airao, Vaibhav Bhatt, and Pranav Shah
Public Library of Science (PLoS)
Silibinin (SB) is shown to have an anticancer properties. However, its clinical therapeutic effects have been restricted due to its low water solubility and poor absorption after oral administration. The aim of this study was to develop SB-loaded PCL/Pluronic F68 nanoparticles for pulmonary delivery in the treatment of lung cancer. A modified solvent displacement process was used to make nanoparticles, which were then lyophilized to make inhalation powder, Nanoparticles were characterized with DSC, FTIR,SEM and In vitro release study. Further, a validated HPLC method was developed to investigate the Biodistribution study, pharmacokinetic parameters. Poly Caprolactone PCL / Pluronic F68 NPs showed the sustained release effect up to 48 h with an emitted (Mass median Aerodynamic diameter)MMAD and (Geometric size distribution)GSD were found to be 4.235 ±0.124 and 1.958±1.23 respectively. More specifically, the SB Loaded PCL/Pluronic F 68 NPs demonstrated long circulation and successful lung tumor-targeting potential due to their cancer-targeting capabilities. SB Loaded PCL/Pluronic F68 NPs significantly inhibited tumour growth in lung cancer-induced rats after inhalable administration. In a pharmacokinetics study, PCL/ Pluronic F68 NPs substantially improved SB bioavailability, with a more than 4-fold rise in AUC when compared to IV administration. These findings indicate that SB-loaded PCL/PluronicF68 nanoparticles may be a successful lung cancer therapy delivery system.
Mukesh N. Kher, Sandip P. Dholakia, Grisha G. Shah, Dipen K. Sureja, Vaibhav D. Bhatt, and Devang B. Sheth
Informa UK Limited
Abstract Vitamins are pivotal ingredients in dietary supplements and nutraceutical products. Since many vitamins are unstable and rapidly degraded, it’s crucial to keep track of their loss throughout processing and storage. Monitoring hydrophilic vitamins may be more crucial than monitoring those lipophilic vitamins because the body does not maintain them as well. There seems to be a need for an all-encompassing method to estimate hydrophilic vitamins. In this study, we have developed a high-performance thin layer chromatography method for estimation of four water-soluble vitamins simultaneously using HPTLC silica-gel 60GF254 plates and ethyl acetate: methanol: hydrochloric acid (0.1N) (8.5:1:0.5 v/v/v) as a mobile phase, which was successfully validated as per the ICH guideline. All the validation parameters were within the acceptable range established by the ICH guideline. The method is precise, reproducible, easy, reliable, and applicable for the estimation of water-soluble vitamins in marketed products. To best of our knowledge, it is simpler, less time-consuming, and more economical than other approaches that have been published for the same purposes GRAPHICAL ABSTRACT
Bhumi R. Rajguru and Vaibhav D. Bhatt
Korean Society of Breeding Science
Ravi A. Dabhi, Milan P. Dhaduk, Vaibhav D. Bhatt, and Bhupesh S. Bhatt
Elsevier BV
Milan P. Dhaduk, Ravi A. Dabhi, Bhupesh S. Bhatt, Vaibhav D Bhatt, and Mohan N. Patel
Elsevier BV
Tushar Patel, Navneet Chauhan, Vaibhav D. Bhatt, and Bhupesh S. Bhatt
Elsevier BV