Dr. Ramachandran K

@smvmch.ac.in

Assistant professosr
sri manakula vinayagar medical college and hospital

Dr. Ramachandran K


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https://researchid.co/bioramk

EDUCATION

Phd in Medical Biochemistry

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry (medical), Clinical Biochemistry, Optometry, Biochemistry, Genetics and Molecular Biology
9

Scopus Publications

216

Scholar Citations

8

Scholar h-index

6

Scholar i10-index

Scopus Publications

  • Immunity, Metabolism, and Beyond Bones: Unraveling the Physiological Mysteries of Vitamin D
    Muthu Gopal, Deepika Velusamy, Soundariya Krishnamurthy, Prithiviraj Nagarajan, Ekamabaram Gayathiri, Prasad Thirumal, Suganya Kannan, Deepa Shanmugam, Ramachandran Kaliaperumal, Divya Sekar
    Advances in Biochemistry in Health and Disease, 2026
  • Narrative Review of Advancements in Stem Cell Therapy: Adipose-Derived Stem Cells for Diabetic Foot Ulcer Treatment
    Prithiviraj Nagarajan, Mani Rajarathinam, Gayathiri Ekambaram, Leena Rajathy Port Louis, Ramachandran Kaliaperumal
    International Journal of Hematology Oncology and Stem Cell Research, 2025
    Background: Activated normal platelets undergo numerous biochemical and morphological changes, some of which are apoptotic. Phosphatidylserine (PS) expression, Δψm depolarization, microparticle (MP) formation, platelet shrinkage, release of cytochrome c, and caspase activation are hallmarks of both platelet activation and apoptosis. In this study, we report the apoptotic responses of type-I Glanzmann thrombasthenic platelets.Materials and Methods: Platelets from twelve unrelated patients with type I Glanzmann thrombasthenia were examined as washed platelets. Calcium ionophore A23187 was used as an agonist to activate the platelets. Flow cytometry was employed to detect phosphatidylserine expression (Annexin A5 Alexa Fluor), Δψm depolarization (JC-10), platelet-derived MP formation (forward scatter; events <1.0 µm in size), and platelet shrinkage (mean-FSC). Anti-CD42b was used as a platelet-specific marker to distinguish platelets from other particles.Results: We determined that increased cytosolic calcium significantly increased PS exposure, depolarized mitochondrial inner membrane potential (Δψm), increased microparticle formation, and induced platelet shrinkage in type-I Glanzmann thrombasthenic platelets. Our research showed that type I Glanzmann thrombasthenic platelets exhibit characteristics of platelet apoptosis. GPIIbIIIa deficiency does not limit platelet activation or apoptosis.Conclusion: We conclude that GPIIb-IIIa-independent mechanisms may be involved in the normal apoptosis of thrombasthenic platelets. Our data deepen the understanding of the role of the platelet fibrinogen receptor in revealing aspects of normal apoptosis. However, this may help explain the normal platelet count among thrombasthenic patients.
  • Advancements in Immunology: Comprehensive Insights into Autoimmune Disorders, Diagnostic Innovations, and Emerging Therapeutic Strategies.
    Autoimmune Disorders and Secondary Plant Metabolites Part 1, 2025
  • Integrative nutrition strategies and cardiovascular therapy from macronutrients to micronutrients
    Gayathiri Ekambaram, Nagarajan Sankaranarayanan, Prithiviraj Nagarajan, Prakash Palanisamy, Thenmozhi Mani, Vinoth Raman, Ramachandran Kaliaperumal, Leena Rajathy Port Louis, Sharangouda J. Patil
    Impact of Yoga and Proper Diet on Cardiopulmonary Function, 2024
    Cardiovascular health remains a concern for individuals' health, and nutrition has a major influence on how this issue can be addressed and solved. This chapter provides a thorough interlocution of nutritional interventions that are supposed to improve cardiovascular health and their theoretical application in the cardiovascular management of patients. Therefore, assessing the effects of consuming different dietary components will help to form a coherent picture of how nutrition affects heart disease and contributes to the therapeutic process. To commence with the analysis of the different macronutrients, carbohydrates, proteins, and fats were defined together with their places in cardiovascular functionality. We explored the advantages of proper macronutrient distribution, which requires prioritizing excellent protein, carbohydrate, and fat sources including whole grains, lean meats, and omega-3 fatty acids. In addition, we focused on the negative effects of refined sugars and trans fats, drawing a relationship with cardiovascular diseases.
  • Association of Serum 8-isoprostaglandin F2α Levels with Glycemic Control in Type 2 Diabetes Patients with Senile Cataract
    Journal of the Indian Medical Association, 2022
  • Association of Serum Magnesium with Oxidative Stress in the Pathogenesis of Diabetic Cataract
    Ramachandran Kaliaperumal, Ramesh Venkatachalam, Prithiviraj Nagarajan, Satheesh Kumar Sabapathy
    Biological Trace Element Research, 2021
  • Apolipoproteins an early and better diagnostic marker for diabetic retinopathy
    Rathnakumar Krishnamoorthy
    Journal of Clinical and Diagnostic Research, 2017
    Introduction: Diabetic Retinopathy (DR) is one of the most common microvascular complications of diabetes and is the leading cause of blindness and visual impairment worldwide. Dyslipidemia is the major biochemical alteration in diabetes mellitus. Some studies have shown that traditional serum lipids are positively associated with the risk of DR whereas other studies have not consistently shown similar associations. Aim: To compare the association of DR with the serum levels of Apo- A1, Apo B, Apo B/Apo-A1 ratio and with traditional lipid profile in Type 2 Diabetes Mellitus (T2D) patients. Materials and Methods: The present study was a case-control study carried out with 100 T2D patients in ophthalmology department, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry from June 2016- December 2016. Fasting blood sugar and post-prandial blood sugar were estimated by GODPOD method and HbA1C by turbidimetric method. Serum lipid profile was assessed by autoanalyser. Serum Apo-A1 and Apo-B were measured using fully automated nephelometry. Apo-B/A1 ratio was calculated. Retinopathy was graded from the digital retinal photographs according to Early Treatment of Diabetic Retinopathy Study (ETDRS) criteria. Results: Serum Apo-A1 was significantly decreased with severity of DR levels (p<0.001). Increasing levels of Apo B (p<0.001) and Apo B-to-Apo-A1 ratio (p<0.001) were found and strongly associated with severity of DR. HDL cholesterol levels were inversely associated with the severity of DR (p<0.05). Triglyceride level was significantly associated with the increased incidence and severity of DR in T2D patients and not LDL or total cholesterol. Conclusion: There is strong association between serum apolipoproteins (Apo-A1, Apo B, and the ApoB/Apo-A1 ratio) and the progression and severity of DR in T2D patients than traditional lipids. Although apolipoprotein measurements have not been widely used in clinical practice, considering its protective mechanism further studies are needed to unravel the underlying mechanism in order to decrease the prevalence and to offer comprehensive eye care.
  • Association of serum uric acid and lipid profile in type 2 diabetic patients with and without diabetic retinopathy
    Ramesh Venkatachalam, Rathna Kumar, Ramachandran Kaliaperumal, Anitha Devaraj, Anebaracy V, Buvana Balamugundan, Poovitha R, Geetha Rajagopalan
    Asian Journal of Pharmaceutical and Clinical Research, 2017
    Objectives: Diabetic retinopathy (DR) is one of the microvascular complications in type 2 diabetes (T2D). Elevated serum uric acid (SUA) has been shown to play a significant role in diabetic neuropathy and nephropathy but there is little information on retinopathy. Therefore, the present study was aimed to investigate the SUA and lipid profile in T2D patients with and without DR and the association between SUA and severity of DR.Methods: The study was conducted in the ophthalmology OPD at Sri Lakshmi Narayana Institute of Medical Sciences. The presence of T2D was confirmed by investigating fasting blood glucose level (normal limit &lt; 110 mg/dl) in all the individuals. DR was examined by detailed dilated fundoscopic examination. Based on the fundus examination, patients were divided in to diabetes with signs of DR and those without signs of DR. Age and sex matched healthy were taken as controls. Fasting blood sugar, SUA and lipid profile were investigated for these groups. Results: The study found elevated SUA and abnormal lipid profile in DR group when compared to non-DR and control groups. We also found the significant association between SUA and severity of DR particularly in males.Conclusion: We found a significant association between SUA and severity of DR in T2D patients. Further studies with large sample size are needed to establish the role of elevated SUA and the mechanism involved in the pathogenesis of retinopathy in diabetic patients. Regular measurements of SUA level could be advised to the diabetic patients for the early management.
  • Relationship between lipoprotein(a) and thyroid hormones in hypothyroid patients
    Ramachandran Kaliaperumal
    Journal of Clinical and Diagnostic Research, 2014
    BACKGROUND AND OBJECTIVE Changes in plasma lipid concentrations are well known metabolic consequences of thyroid dysfunction. The alterations are most prominent in hypothyroidism which is typically associated with pronounced hypercholesterolaemia and frequently with moderate hypertriglyceridaemia. In cases of hypothyroidism, how the serum Lp(a) levels are influenced by thyroid hormone remains unknown and contradictory results on the effect of thyroid hormone on serum Lp(a) levels have been reported. There is substantial evidence to suggest that elevated serum Lp(a) levels contribute significantly to the development of CHD. The present study was designed to determine the lipoprotein(a) [Lp(a)], lipid profile and thyroid hormone levels in newly diagnosed hypothyroid patients and to find any correlation that existed between Lp(a) and other parameters. MATERIALS AND METHODS Untreated hypothyroid (n=50) patients were included in the study. We also included 40 normal healthy subjects as controls. Lipid profile, Lp(a) and thyroid profile were estimated by using autoanalyzers. RESULTS The results of this study showed that levels of HDL-cholesterol were significantly decreased (p<0.001), whereas those of other lipid parameters and Lp(a) levels were found to be significantly increased (p<0.001) in hypothyroid patients as compared to those in controls. Correlation study revealed a significant positive correlation between Lp(a) and TSH levels in hypothyroid patients. CONCLUSION Our present findings indicated that hypothyroidism could be strongly associated with lipid abnormalities that enhanced the development of cardiovascular diseases. Also, Lp(a) and non-HDL-C should be estimated with other lipid parameters as a useful index for measuring the cardiac risk in hypothyroid patients. A recommended screening should be advised for any patient with thyroid dysfunction, especially hypothyroidism, to assess lipid abnormalities by using Lp(a) and non- HDL-C and he/she should treated at the earliest.

RECENT SCHOLAR PUBLICATIONS

  • Immunity, Metabolism, and Beyond Bones: Unraveling the Physiological Mysteries of Vitamin D
    M Gopal, D Velusamy, S Krishnamurthy, P Nagarajan, E Gayathiri, ...
    Functional Biochemistry of Micronutrients, 297-313 , 2026
    2026
    Citations: 1
  • Narrative Review of Advancements in Stem Cell Therapy: Adipose-Derived Stem Cells for Diabetic Foot Ulcer Treatment
    P Nagarajan, M Rajarathinam, G Ekambaram, LRP Louis, R Kaliaperumal
    International Journal of Hematology-Oncology and Stem Cell Research , 2025
    2025
  • Future prospects in medicinal plant-derived drug development: unveiling opportunities and challenges
    P Nagarajan, S Kannan, A Raj, LRP Louis, AB Bazeer, R Kaliaperumal, ...
    Biotechnology and phytochemical prospects in drug discovery, 241-266 , 2025
    2025
    Citations: 13
  • Integrative Nutrition Strategies and Cardiovascular Therapy From Macronutrients to Micronutrients
    G Ekambaram, N Sankaranarayanan, P Nagarajan, P Palanisamy, T Mani, ...
    Impact of Yoga and Proper Diet on Cardiopulmonary Function, 273-304 , 2025
    2025
  • Association of Serum 8-isoprostaglandin F2? Levels with Glycemic Control in Type 2 Diabetes Patients with Senile Cataract
    R Kaliaperumal, S Krishnagopal, SA Raghavan, K Vengatapathy, A TS
    J Indian Med Assoc , 2022
    2022
    Citations: 1
  • Association of serum magnesium with oxidative stress in the pathogenesis of diabetic cataract
    K Ramachandran, V Ramesh, N Prithiviraj, SS Kumar
    Biological trace element research 199 (8), 2869-2873 , 2021
    2021
    Citations: 31
  • Impact of dyselectrolytemia in the pathogenesis of diabetic cataract
    R Kaliaperumal, R Venkatachalam, VB Sugumaran, KV Vengadapathy, ...
    Annals of the Romanian Society for Cell Biology 25 (3), 1565-1571 , 2021
    2021
    Citations: 3
  • The Impact of the Covid-19 Pandemic on Academic Research: Short Review
    P Nagarajan, SK Sabapathy, R Kaliaperumal, K Rangarajalu, ...
    Annals of the Romanian Society for Cell Biology 25 (3), 1557-1564 , 2021
    2021
    Citations: 2
  • Study of neutrophil-to-lymphocyte ratio and its correlation with glycemic status in diabetic senile cataract patients
    R Kaliaperumal, R Venkatachalam, P Nagarajan, K Rangarajalu, ...
    Annals of the Romanian Society for Cell Biology 25 (1), 6633-6656 , 2021
    2021
    Citations: 4
  • Serum Calcium-Magnesium Ratio In Patients With Senile Cataract At A Tertiary Care Hospital In Puducherry Population.
    R Kaliaperumal, R Venkatachalam, P Nagarajan, SK Sabapathy, ...
    European Journal of Molecular and Clinical Medicine 8 (1), 1154-1161 , 2021
    2021
    Citations: 1
  • Efficacy of pooled serum internal quality control in comparison with commercial internal quality control in clinical biochemistry laboratory
    S Kulkarni, SA Pierre, R Kaliaperumal
    Journal of laboratory physicians 12 (03), 191-195 , 2020
    2020
    Citations: 34
  • Prevalence of dry eye disease and its association with dyslipidemia
    K Rathnakumar, K Ramachandran, D Baba, V Ramesh, V Anebaracy, ...
    Journal of basic and clinical physiology and pharmacology 29 (2), 195-199 , 2018
    2018
    Citations: 47
  • Apolipoproteins an Early and Better Diagnostic Marker for Diabetic Retinopathy.
    R Krishnamoorthy, R Kaliaperumal, R Venkatachalam, R Poovitha, ...
    Journal of Clinical & Diagnostic Research 11 (10) , 2017
    2017
    Citations: 9
  • Prevalence of dry eye disease in type 2 diabetic patients and its association with retinopathy
    K Rathnakumar, K Ramachandran, V Ramesh, V Anebaracy, R Vidhya, ...
    Int J Pharm Sci Res 8 (10), 4298-4304 , 2017
    2017
    Citations: 11
  • Association between components of metabolic syndrome and elevated intraocular pressure
    K Rathnakumar, G Rajagopalan, K Ramachandran, V Ramesh
    International Journal of Research in Medical Sciences 5 (7), 3053 , 2017
    2017
  • Association of serum uric acid and lipid profile in type 2 diabetic patients with and without diabetic retinopathy
    R VENKATACHALAM, RK KRISHNAMOORTHY, R KALIAPERUMAL, ...
    Asian J Pharm Clin Res. 10, 112-4 , 2017
    2017
    Citations: 1
  • Relationship between lipoprotein (a) and thyroid hormones in hypothyroid patients
    R Kaliaperumal, E William, T Selvam, SM Krishnan
    Journal of clinical and diagnostic research: JCDR 8 (2), 37 , 2014
    2014
    Citations: 44
  • Response of ferritin to oxidative stress in Rheumatoid arthritis
    M Shivasekar, K Ramachandran, E William
    Asian Journal Of Pharmaceutical And Clinical Research, 93-94 , 2014
    2014
    Citations: 3
  • Relationship between lipoproteine and Thyroid Hormones in Hypothyroid Patients. Clin. Diagn. Res. 2014; 8 (2): 37-39. doi: 10.7860
    R Kaliaperumal, E William, T Selvam
    JCDR 7817 , 2014
    2014
    Citations: 3
  • Serum lactate dehydrogenase and lipid profile in breast cancer
    N Swetha, KAA Senghor, K Ramachandran
    Int J Pharm Biol Sci 3 (2), 423-32 , 2013
    2013
    Citations: 8

MOST CITED SCHOLAR PUBLICATIONS

  • Prevalence of dry eye disease and its association with dyslipidemia
    K Rathnakumar, K Ramachandran, D Baba, V Ramesh, V Anebaracy, ...
    Journal of basic and clinical physiology and pharmacology 29 (2), 195-199 , 2018
    2018
    Citations: 47
  • Relationship between lipoprotein (a) and thyroid hormones in hypothyroid patients
    R Kaliaperumal, E William, T Selvam, SM Krishnan
    Journal of clinical and diagnostic research: JCDR 8 (2), 37 , 2014
    2014
    Citations: 44
  • Efficacy of pooled serum internal quality control in comparison with commercial internal quality control in clinical biochemistry laboratory
    S Kulkarni, SA Pierre, R Kaliaperumal
    Journal of laboratory physicians 12 (03), 191-195 , 2020
    2020
    Citations: 34
  • Association of serum magnesium with oxidative stress in the pathogenesis of diabetic cataract
    K Ramachandran, V Ramesh, N Prithiviraj, SS Kumar
    Biological trace element research 199 (8), 2869-2873 , 2021
    2021
    Citations: 31
  • Future prospects in medicinal plant-derived drug development: unveiling opportunities and challenges
    P Nagarajan, S Kannan, A Raj, LRP Louis, AB Bazeer, R Kaliaperumal, ...
    Biotechnology and phytochemical prospects in drug discovery, 241-266 , 2025
    2025
    Citations: 13
  • Prevalence of dry eye disease in type 2 diabetic patients and its association with retinopathy
    K Rathnakumar, K Ramachandran, V Ramesh, V Anebaracy, R Vidhya, ...
    Int J Pharm Sci Res 8 (10), 4298-4304 , 2017
    2017
    Citations: 11
  • Apolipoproteins an Early and Better Diagnostic Marker for Diabetic Retinopathy.
    R Krishnamoorthy, R Kaliaperumal, R Venkatachalam, R Poovitha, ...
    Journal of Clinical & Diagnostic Research 11 (10) , 2017
    2017
    Citations: 9
  • Serum lactate dehydrogenase and lipid profile in breast cancer
    N Swetha, KAA Senghor, K Ramachandran
    Int J Pharm Biol Sci 3 (2), 423-32 , 2013
    2013
    Citations: 8
  • Study of neutrophil-to-lymphocyte ratio and its correlation with glycemic status in diabetic senile cataract patients
    R Kaliaperumal, R Venkatachalam, P Nagarajan, K Rangarajalu, ...
    Annals of the Romanian Society for Cell Biology 25 (1), 6633-6656 , 2021
    2021
    Citations: 4
  • Impact of dyselectrolytemia in the pathogenesis of diabetic cataract
    R Kaliaperumal, R Venkatachalam, VB Sugumaran, KV Vengadapathy, ...
    Annals of the Romanian Society for Cell Biology 25 (3), 1565-1571 , 2021
    2021
    Citations: 3
  • Response of ferritin to oxidative stress in Rheumatoid arthritis
    M Shivasekar, K Ramachandran, E William
    Asian Journal Of Pharmaceutical And Clinical Research, 93-94 , 2014
    2014
    Citations: 3
  • Relationship between lipoproteine and Thyroid Hormones in Hypothyroid Patients. Clin. Diagn. Res. 2014; 8 (2): 37-39. doi: 10.7860
    R Kaliaperumal, E William, T Selvam
    JCDR 7817 , 2014
    2014
    Citations: 3
  • The Impact of the Covid-19 Pandemic on Academic Research: Short Review
    P Nagarajan, SK Sabapathy, R Kaliaperumal, K Rangarajalu, ...
    Annals of the Romanian Society for Cell Biology 25 (3), 1557-1564 , 2021
    2021
    Citations: 2
  • Immunity, Metabolism, and Beyond Bones: Unraveling the Physiological Mysteries of Vitamin D
    M Gopal, D Velusamy, S Krishnamurthy, P Nagarajan, E Gayathiri, ...
    Functional Biochemistry of Micronutrients, 297-313 , 2026
    2026
    Citations: 1
  • Association of Serum 8-isoprostaglandin F2? Levels with Glycemic Control in Type 2 Diabetes Patients with Senile Cataract
    R Kaliaperumal, S Krishnagopal, SA Raghavan, K Vengatapathy, A TS
    J Indian Med Assoc , 2022
    2022
    Citations: 1
  • Serum Calcium-Magnesium Ratio In Patients With Senile Cataract At A Tertiary Care Hospital In Puducherry Population.
    R Kaliaperumal, R Venkatachalam, P Nagarajan, SK Sabapathy, ...
    European Journal of Molecular and Clinical Medicine 8 (1), 1154-1161 , 2021
    2021
    Citations: 1
  • Association of serum uric acid and lipid profile in type 2 diabetic patients with and without diabetic retinopathy
    R VENKATACHALAM, RK KRISHNAMOORTHY, R KALIAPERUMAL, ...
    Asian J Pharm Clin Res. 10, 112-4 , 2017
    2017
    Citations: 1
  • Narrative Review of Advancements in Stem Cell Therapy: Adipose-Derived Stem Cells for Diabetic Foot Ulcer Treatment
    P Nagarajan, M Rajarathinam, G Ekambaram, LRP Louis, R Kaliaperumal
    International Journal of Hematology-Oncology and Stem Cell Research , 2025
    2025
  • Integrative Nutrition Strategies and Cardiovascular Therapy From Macronutrients to Micronutrients
    G Ekambaram, N Sankaranarayanan, P Nagarajan, P Palanisamy, T Mani, ...
    Impact of Yoga and Proper Diet on Cardiopulmonary Function, 273-304 , 2025
    2025
  • Association between components of metabolic syndrome and elevated intraocular pressure
    K Rathnakumar, G Rajagopalan, K Ramachandran, V Ramesh
    International Journal of Research in Medical Sciences 5 (7), 3053 , 2017
    2017